HK1008883A1 - Process for producing n-amino- 1-hydroxy-alkyl-idene-1,1- bisphosphonic acids - Google Patents

Process for producing n-amino- 1-hydroxy-alkyl-idene-1,1- bisphosphonic acids

Info

Publication number
HK1008883A1
HK1008883A1 HK98109618A HK98109618A HK1008883A1 HK 1008883 A1 HK1008883 A1 HK 1008883A1 HK 98109618 A HK98109618 A HK 98109618A HK 98109618 A HK98109618 A HK 98109618A HK 1008883 A1 HK1008883 A1 HK 1008883A1
Authority
HK
Hong Kong
Prior art keywords
producing
amino
idene
hydroxy
alkyl
Prior art date
Application number
HK98109618A
Other languages
English (en)
Inventor
Richard R Dauer
Lisa Dimichele
Mauricio Futran
Gerard R Kieczykowski
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27381051&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1008883(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HK1008883A1 publication Critical patent/HK1008883A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK98109618A 1993-08-25 1998-08-03 Process for producing n-amino- 1-hydroxy-alkyl-idene-1,1- bisphosphonic acids HK1008883A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11175193A 1993-08-25 1993-08-25
US23964094A 1994-05-09 1994-05-09
US08/286,151 US5510517A (en) 1993-08-25 1994-08-04 Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids

Publications (1)

Publication Number Publication Date
HK1008883A1 true HK1008883A1 (en) 1999-05-21

Family

ID=27381051

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98109618A HK1008883A1 (en) 1993-08-25 1998-08-03 Process for producing n-amino- 1-hydroxy-alkyl-idene-1,1- bisphosphonic acids

Country Status (25)

Country Link
US (1) US5510517A (hu)
EP (1) EP0715631B1 (hu)
JP (1) JP3675818B2 (hu)
KR (1) KR100261202B1 (hu)
CN (2) CN1067079C (hu)
AT (1) ATE160352T1 (hu)
AU (2) AU692468B2 (hu)
BR (1) BR9407563A (hu)
CA (1) CA2169561C (hu)
CY (1) CY2086B1 (hu)
CZ (1) CZ290185B6 (hu)
DE (1) DE69406936T2 (hu)
DK (1) DK0715631T3 (hu)
ES (1) ES2109731T3 (hu)
FI (1) FI115526B (hu)
GR (1) GR3025450T3 (hu)
HK (1) HK1008883A1 (hu)
HR (1) HRP940479B1 (hu)
HU (1) HU217362B (hu)
LV (1) LV12189B (hu)
NZ (1) NZ273458A (hu)
RO (1) RO115524B1 (hu)
RU (1) RU2154647C2 (hu)
SI (1) SI0715631T1 (hu)
WO (1) WO1995006052A1 (hu)

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US5449819A (en) * 1994-06-06 1995-09-12 Merck & Co., Inc. Process for removing waste pox, alendronate and its by products
US5589691A (en) * 1994-06-06 1996-12-31 Merck & Co., Inc. Process for recovery and recycle of methanesulfonic acid and phosphorous acid
BR9712197A (pt) * 1996-10-04 1999-08-31 Merck & Co Inc Formulação farmacêutica líquida aquosa e processos de preparação da mesma, e, de inibição de reabsorção de osso.
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
GB9800452D0 (en) * 1998-01-10 1998-03-04 Albright & Wilson Preparation of phosphonic acid derivatives
EP1088333A4 (en) 1998-06-24 2005-08-10 Merck & Co Inc METHOD AND COMPOSITIONS FOR CONNECTING OSTEOPROSIS
US20030078211A1 (en) * 1998-06-24 2003-04-24 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PE20011065A1 (es) 2000-02-01 2001-11-21 Procter & Gamble Proceso para fabricar bisfosfonatos geminales
PE20011061A1 (es) 2000-02-01 2001-11-20 Procter & Gamble Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
MXPA04009586A (es) * 2002-05-10 2005-01-11 Hoffmann La Roche Acidos bisfosfonicos para el tratamiento y prevencion de la osteoporosis.
JP3857706B2 (ja) * 2002-05-17 2006-12-13 テバ ファーマシューティカル インダストリーズ リミティド ビスホスホン酸作製のための特定の希釈剤の使用
WO2003103664A1 (en) * 2002-06-06 2003-12-18 Merck Frosst Canada & Co. 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
JP4485117B2 (ja) * 2002-06-27 2010-06-16 日東電工株式会社 保護剥離用フィルム
CA2495917A1 (en) * 2002-08-28 2004-03-11 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
US20040206932A1 (en) * 2002-12-30 2004-10-21 Abuelyaman Ahmed S. Compositions including polymerizable bisphosphonic acids and methods
EP1653913B1 (en) * 2003-08-12 2012-05-23 3M Innovative Properties Company Self-etching dental compositions and methods
WO2005019161A1 (en) 2003-08-21 2005-03-03 Merck Frosst Canada Ltd. Cathepsin cysteine protease inhibitors
MXPA06003063A (es) * 2003-09-19 2006-05-31 Pfizer Prod Inc Composiciones farmaceuticas y metodos que comprenden combinaciones de derivados de 2-alquiliden-19-nor-vitamina- d y un bisfosfonato.
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
US8465284B2 (en) * 2004-07-08 2013-06-18 3M Innovative Properties Company Dental methods, compositions, and kits including acid-sensitive dyes
CN101035499B (zh) * 2004-08-11 2012-09-05 3M创新有限公司 包括多种酸性化合物的自粘合组合物
CA2599572A1 (en) 2005-03-02 2007-04-26 Merck & Co., Inc. Composition for inhibition of cathepsin k
AR057291A1 (es) * 2005-05-06 2007-11-28 Medichem Sa Proceso para la preparacion de acidos bisfosfonicos geminales y las sales y/o hidratos farmaceuticamente aceptables de los mismos, una composicion farmaceutica que los contiene y el uso de esta en el tratamiento de la osteoporosis
US8003820B2 (en) 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
AR058168A1 (es) * 2005-11-07 2008-01-23 Merck & Co Inc Sintesis del alendronato de sodio trihidratado
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
CA2642321A1 (en) * 2006-02-20 2007-08-30 Alembic Limited An improved process for the preparation of biphosphonic derivatives
JP5507256B2 (ja) 2006-12-13 2014-05-28 スリーエム イノベイティブ プロパティズ カンパニー 酸性成分及び光退色性染料を有する歯科用組成物の使用方法
CA2689504A1 (en) * 2007-06-19 2008-12-24 Albemarle Corporation Processes for manufacturing bisphosphonic acids
US8354446B2 (en) * 2007-12-21 2013-01-15 Ligand Pharmaceuticals Incorporated Selective androgen receptor modulators (SARMs) and uses thereof
EP2310398A2 (en) 2008-07-11 2011-04-20 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
EP2192126B1 (en) 2008-11-26 2013-03-27 Synthon B.V. Process for making zoledronic acid
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
EA201270328A1 (ru) 2009-08-28 2012-09-28 Синтон Б. В. Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот
CN102630227B (zh) * 2009-10-26 2016-03-23 沃纳奇尔科特有限责任公司 用于治疗骨代谢紊乱的双膦酸盐化合物
CA2738045C (en) 2010-05-28 2019-02-19 Simon Fraser University Conjugate compounds, methods of making same, and uses thereof
AU2011338674B2 (en) 2010-12-06 2017-03-30 Effrx Pharmaceuticals Sa Stable effervescent bisphosphonate formulations with rapid solubilization characteristics
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
FI20115315A0 (fi) * 2011-04-01 2011-04-01 Itae Suomen Yliopisto Menetelmä metallien keräämiseksi
WO2015054089A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
WO2015181676A1 (en) 2014-05-30 2015-12-03 Pfizer Inc. Carbonitrile derivatives as selective androgen receptor modulators
CA2988523A1 (en) 2015-06-12 2016-12-15 Simon Fraser University Amide-linked ep4 agonist-bisphosphonate compounds and uses thereof
US20210309679A1 (en) 2018-07-23 2021-10-07 Guangzhou Othrotx Co., Ltd. Bisphosphonate drug conjugates
CN109456363A (zh) * 2018-11-01 2019-03-12 南京海纳医药科技股份有限公司 一种米诺膦酸工艺杂质的制备方法
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

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DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DD216465A1 (de) * 1983-07-01 1984-12-12 Agrochemie Piesteritz 4602 Wit Verfahren zur herstellung substituierter alkanphosphonsaeuren
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof

Also Published As

Publication number Publication date
EP0715631B1 (en) 1997-11-19
FI960851A0 (fi) 1996-02-23
KR100261202B1 (ko) 2000-07-01
CZ54296A3 (en) 1996-10-16
HRP940479A2 (en) 1997-02-28
BR9407563A (pt) 1996-12-31
US5510517A (en) 1996-04-23
FI115526B (fi) 2005-05-31
DK0715631T3 (da) 1997-12-22
ES2109731T3 (es) 1998-01-16
CA2169561C (en) 2007-02-20
HUT75261A (en) 1997-05-28
GR3025450T3 (en) 1998-02-27
SI0715631T1 (en) 1998-02-28
NZ273458A (en) 1998-04-27
HU9600429D0 (en) 1996-04-29
CN1134703A (zh) 1996-10-30
LV12189A (lv) 1998-12-20
JPH09501935A (ja) 1997-02-25
AU7674394A (en) 1995-03-21
HRP940479B1 (en) 2000-10-31
DE69406936T2 (de) 1998-06-04
AU7993798A (en) 1998-10-15
CY2086B1 (en) 2002-04-05
AU714996B2 (en) 2000-01-13
ATE160352T1 (de) 1997-12-15
CA2169561A1 (en) 1995-03-02
WO1995006052A1 (en) 1995-03-02
LV12189B (en) 1999-02-20
RU2154647C2 (ru) 2000-08-20
RO115524B1 (ro) 2000-03-30
CN1211392C (zh) 2005-07-20
CN1308082A (zh) 2001-08-15
JP3675818B2 (ja) 2005-07-27
CZ290185B6 (cs) 2002-06-12
FI960851A (fi) 1996-02-23
EP0715631A1 (en) 1996-06-12
HU217362B (hu) 2000-01-28
AU692468B2 (en) 1998-06-11
DE69406936D1 (de) 1998-01-02
CN1067079C (zh) 2001-06-13

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Effective date: 20140823