HK1008049A1 - Transduced fibroblasts and use therefor - Google Patents

Transduced fibroblasts and use therefor

Info

Publication number
HK1008049A1
HK1008049A1 HK98107129A HK98107129A HK1008049A1 HK 1008049 A1 HK1008049 A1 HK 1008049A1 HK 98107129 A HK98107129 A HK 98107129A HK 98107129 A HK98107129 A HK 98107129A HK 1008049 A1 HK1008049 A1 HK 1008049A1
Authority
HK
Hong Kong
Prior art keywords
fibroblasts
transduced
use therefor
transduced fibroblasts
protein
Prior art date
Application number
HK98107129A
Other languages
English (en)
Inventor
Richard C Mulligan
James M Wilson
Original Assignee
Whitehead Biomedical Inst
Hughes Howard Med Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22255144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1008049(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Whitehead Biomedical Inst, Hughes Howard Med Inst filed Critical Whitehead Biomedical Inst
Publication of HK1008049A1 publication Critical patent/HK1008049A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HK98107129A 1987-09-11 1998-06-27 Transduced fibroblasts and use therefor HK1008049A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9607487A 1987-09-11 1987-09-11
PCT/US1988/003089 WO1989002468A1 (fr) 1987-09-11 1988-09-08 Fibroblastes transduits et leurs applications

Publications (1)

Publication Number Publication Date
HK1008049A1 true HK1008049A1 (en) 1999-04-30

Family

ID=22255144

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98107129A HK1008049A1 (en) 1987-09-11 1998-06-27 Transduced fibroblasts and use therefor

Country Status (8)

Country Link
US (1) US5460959A (fr)
EP (2) EP0378576B1 (fr)
JP (1) JP3015383B2 (fr)
AT (1) ATE117375T1 (fr)
CA (1) CA1341311C (fr)
DE (1) DE3852823T2 (fr)
HK (1) HK1008049A1 (fr)
WO (1) WO1989002468A1 (fr)

Families Citing this family (257)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5219740A (en) * 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
US6048729A (en) 1987-05-01 2000-04-11 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
US6544771B1 (en) 1987-12-11 2003-04-08 Cell Genesys, Inc. Retroviral gene therapy vectors and therapeutic methods based thereon
US6140111A (en) * 1987-12-11 2000-10-31 Whitehead Institute For Biomedical Research Retroviral gene therapy vectors and therapeutic methods based thereon
US5716826A (en) * 1988-03-21 1998-02-10 Chiron Viagene, Inc. Recombinant retroviruses
US5591624A (en) * 1988-03-21 1997-01-07 Chiron Viagene, Inc. Retroviral packaging cell lines
US6133029A (en) * 1988-03-21 2000-10-17 Chiron Corporation Replication defective viral vectors for infecting human cells
US6645942B1 (en) 1988-04-28 2003-11-11 The Salk Institute For Biological Studies Somatic cell gene therapy
EP0456640A1 (fr) * 1988-12-13 1991-11-21 UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Cellules endotheliales modifiees par genie genetique et utilisation de ces cellules
US5650148A (en) * 1988-12-15 1997-07-22 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
ATE219519T1 (de) * 1989-01-23 2002-07-15 Chiron Corp Rekombinanttherapien für infektionen und hyperproliferative störungen
US7238673B2 (en) 1989-03-31 2007-07-03 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
EP0457856A4 (en) * 1989-06-13 1992-10-21 The Board Of Directors Of The Leland Stanford Junior University Isolation growth and differentiation of human muscle cells
EP0897987B1 (fr) * 1989-10-24 2001-02-28 Chiron Corporation Sécretion de protéine humaine associée au peptide-signal de l' interferon gamma
WO1991012329A2 (fr) * 1990-02-12 1991-08-22 Board Of Regents, The University Of Texas System Proliferation de cellules satellites dans les muscles squelettiques adultes
US5817491A (en) * 1990-09-21 1998-10-06 The Regents Of The University Of California VSV G pseusdotyped retroviral vectors
US5618531A (en) * 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
WO1992015676A1 (fr) * 1991-03-08 1992-09-17 The Salk Institute For Biological Studies Therapie genique par les cellules somatiques
NZ245015A (en) 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
US6692737B1 (en) 1991-11-05 2004-02-17 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
US6054288A (en) * 1991-11-05 2000-04-25 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
US6063630A (en) 1991-11-05 2000-05-16 Transkaryotic Therapies, Inc. Targeted introduction of DNA into primary or secondary cells and their use for gene therapy
ES2126606T3 (es) * 1991-11-15 1999-04-01 Univ California Terapia del sistema nervioso central mediante celulas modificadas geneticamente.
ATE152915T1 (de) * 1991-11-29 1997-05-15 Viagene Inc Immuntherapeutische vektorkonstrukte gegen krebs
US6297048B1 (en) 1992-02-04 2001-10-02 Chiron Corporation Hepatitis therapeutics
CA2130802A1 (fr) * 1992-02-28 1993-09-02 Terry Strom Methodes et composes pour prevenir le rejet de greffe
US6531124B1 (en) 1992-07-10 2003-03-11 Transkaryotic Therapies, Inc. In vivo production and delivery of insulinotropin for gene therapy
US6670178B1 (en) 1992-07-10 2003-12-30 Transkaryotic Therapies, Inc. In Vivo production and delivery of insulinotropin for gene therapy
US5591625A (en) * 1993-11-24 1997-01-07 Case Western Reserve University Transduced mesenchymal stem cells
US5656605A (en) * 1994-01-26 1997-08-12 Institute Of Molecular Biology, Inc. Device to promote drug-induced nerve regeneration
US6485721B1 (en) * 1994-04-25 2002-11-26 Research Development Corporation Of Japan Biologically active substance-secreting hybrid gel
US6150137A (en) 1994-05-27 2000-11-21 Ariad Pharmaceuticals, Inc. Immunosuppressant target proteins
US5888814A (en) * 1994-06-06 1999-03-30 Chiron Corporation Recombinant host cells encoding TNF proteins
GB9419048D0 (en) * 1994-09-20 1994-11-09 Watt Diana J Treatment of muscular disorders
US7820798B2 (en) * 1994-11-07 2010-10-26 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US7597886B2 (en) * 1994-11-07 2009-10-06 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
US6689757B1 (en) 1996-02-12 2004-02-10 M.L. Laboratories Plc Methods for vaccination and vaccines therefor
US5842477A (en) * 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
FR2746109B1 (fr) 1996-03-12 1998-04-17 Rhone Poulenc Rorer Sa Milieu pour la conservation de materiel biologique
US6210664B1 (en) * 1996-04-08 2001-04-03 New York University Medical Center Method for gene transfer to the central nervous system
AU765149B2 (en) * 1996-04-08 2003-09-11 New York University Medical Center Method for gene transfer to the central nervous system
US6027721A (en) * 1996-05-20 2000-02-22 Cytotherapeutics, Inc. Device and method for encapsulated gene therapy
US5932779A (en) 1996-06-10 1999-08-03 Millennium Pharmaceuticals, Inc. Screening methods for compounds useful in the regulation of body weight
US5830850A (en) * 1996-08-28 1998-11-03 Mount Sinai School Of Medicine Of The City Of New York Methods for the treatment of bone resorption disorders, including osteoporosis
US6544523B1 (en) 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
GB9715085D0 (en) 1997-07-18 1997-09-24 Jahoda Amanda J Gene therapy vehicle
EP1027076A2 (fr) 1997-10-29 2000-08-16 University Of Pittsburgh Of The Commonwealth System Of Higher Education Utilisation de vecteurs tels que adenovirus et/ou virus adeno-associes et/ou retrovirus et/ou herpesvirus et/ou liposomes et/ou plasmides comme vehicules d'informations genetiques relatives a l'aptitude des cellules de mammiferes a produire des agents pour le traitement de pathologies osseuses
AU9363798A (en) 1997-11-06 1999-05-31 Chiron S.P.A. Neisserial antigens
EP2210945B1 (fr) 1998-01-14 2013-06-26 Novartis Vaccines and Diagnostics S.r.l. Antigènes de Neisseria meningitidis
CA2245224A1 (fr) 1998-08-14 2000-02-14 Jiang-Hong Giong Antagonistes du recepteur de la chimiokine et chimiotherapie
CA2305787A1 (fr) 2000-05-09 2001-11-09 The University Of British Columbia Traitement antagoniste cxcr4 de cellules hematopoietiques
DE69914463T2 (de) 1998-03-13 2004-11-11 The University Of British Columbia, Vancouver Therapeutische chemokine rezeptor antagonisten
EP1093457B8 (fr) 1998-03-19 2011-02-02 Human Genome Sciences, Inc. Analogue de chaine gamma commune de recepteur de cytokine
AU761780B2 (en) 1998-05-01 2003-06-12 Glaxosmithkline Biologicals Sa Neisseria meningitidis antigens and compositions
WO2000022130A2 (fr) 1998-10-15 2000-04-20 Chiron Corporation Genes regules dans les cellules du cancer du sein metastatique et du cancer du colon
WO2000024365A1 (fr) 1998-10-26 2000-05-04 University Of Massachusetts Traitement de la peau au moyen d'adenosine ou d'un analogue d'adenosine
PT1141331E (pt) 1998-12-16 2008-12-22 Novartis Vaccines & Diagnostic Quinase dependente de ciclina humana (hpnqalre)
EP2206785A1 (fr) 1998-12-31 2010-07-14 Novartis Vaccines and Diagnostics, Inc. Expression améliorée de polypeptides HIV et production de particules de type virus
US7935805B1 (en) 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
CA2363779A1 (fr) 1999-02-26 2000-08-31 Human Genome Sciences, Inc. Endokine alpha humain et methodes d'utilisation
EP1119368A2 (fr) 1999-03-03 2001-08-01 Biogen, Inc. Methodes de modulation du metabolisme et du stockage lipidiques
JP2002537835A (ja) 1999-03-12 2002-11-12 ジーピーシー バイオテク インコーポレイテッド 合成遺伝子エレメントを同定する方法及び試薬
US6328762B1 (en) 1999-04-27 2001-12-11 Sulzer Biologics, Inc. Prosthetic grafts
US7368261B1 (en) 1999-04-30 2008-05-06 Novartis Vaccines And Diagnostics Srl Conserved Neisserial antigens
GB9911683D0 (en) 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
US7396905B1 (en) 1999-05-21 2008-07-08 Mckeon Frank Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
GB9916529D0 (en) 1999-07-14 1999-09-15 Chiron Spa Antigenic peptides
EP2275559A3 (fr) 1999-09-28 2011-03-23 Shire Human Genetic Therapies, Inc. ARN messager (ARN-m) optimisé
ES2559317T3 (es) 1999-10-29 2016-02-11 Glaxosmithkline Biologicals Sa Péptidos antigénicos de Neisseria
DE10100586C1 (de) 2001-01-09 2002-04-11 Ribopharma Ag Verfahren zur Hemmung der Expression eines Ziegens
US6951839B1 (en) 1999-11-30 2005-10-04 Curis, Inc. Methods and compositions for regulating lymphocyte activity
US8168178B2 (en) 1999-11-30 2012-05-01 Curis, Inc. Methods and compositions for regulating lymphocyte activity
DK1254169T3 (da) 1999-12-30 2007-08-06 Harvard College Fremgangsmåde vedrörende modulering af aktivitet af Th2-celledelmængde ved modulering af aktivitet af XBP-1
DE60142772D1 (de) 2000-01-17 2010-09-23 Novartis Vaccines & Diagnostic Membranvesikel (omv) impfstoff, der n. meningitidis serogruppe b membranproteine enthält
US20050059584A1 (en) 2002-08-16 2005-03-17 Ahmed Merzouk Novel chemokine mimetics synthesis and their use
US7368425B2 (en) 2006-03-24 2008-05-06 Chemokine Therapeutics Corp. Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis
US7378098B2 (en) 2000-04-12 2008-05-27 The University Of British Columbia CXC chemokine receptor 4 agonist peptides
AU2001259174A1 (en) * 2000-04-28 2001-11-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education Viral and non-viral vectors as vehicles for delivering transgenes for treating bone pathologies
WO2001087238A2 (fr) 2000-05-17 2001-11-22 Oregon Health & Sciences University Induction de l'apoptose et inhibition de la croissance cellulaire par la proteine 4.33 (p4.33)
EP1294949A4 (fr) 2000-06-15 2004-08-25 Human Genome Sciences Inc Facteur de necrose tumorale humain delta et epsilon
AU2001268633A1 (en) * 2000-06-21 2002-01-02 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating breast cancer
EP2277894A1 (fr) 2000-10-27 2011-01-26 Novartis Vaccines and Diagnostics S.r.l. Acides nucléiques et protéines dérivés des groupes de streptocoques A et B
WO2002034916A2 (fr) * 2000-10-27 2002-05-02 Oregon Health And Science University Nouvelles molecules igbp-3 mutantes qui ne se lient pas aux igf, mais qui conservent leur capacite de se lier fonctionnellement au recepteur d'igfbp-3
US7423142B2 (en) 2001-01-09 2008-09-09 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US7767802B2 (en) 2001-01-09 2010-08-03 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
EP1366058B1 (fr) 2001-02-09 2011-01-26 Human Genome Sciences, Inc. Recepteur de chemokine de la g-proteine humaine (ccr5) hdgnr10
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
CA2444632A1 (fr) 2001-04-13 2002-10-24 Human Genome Sciences, Inc. Facteur de croissance 2, endothelial, vasculaire
WO2002094871A1 (fr) 2001-05-24 2002-11-28 Human Dna Technology Inc Nouvel analogue du facteur de croissance des keratinocytes-2 du follicule pileux
CA2634992C (fr) 2001-07-05 2012-10-16 Novartis Vaccines And Diagnostics, Inc. Polynucleotides codant des polypeptides de type c du vih antigeniques, polypeptides et leurs utilisations
CA2452119C (fr) 2001-07-05 2013-10-15 Chiron Corporation Polynucleotides codant pour des polypeptides antigeniques du vih de sous-type b et/ou de sous-type c, polypeptides et leurs utilisations
KR101021695B1 (ko) 2001-07-12 2011-03-15 유니버시티 오브 매사추세츠 유전자 불활성화를 매개하는 소형 간섭 ｒｎａ의 생체내 제조
EP1900815B1 (fr) 2001-07-12 2016-09-07 University of Massachusetts Production in vivo de petits ARN interférents qui modèrent le silençage génique
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US7745418B2 (en) 2001-10-12 2010-06-29 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting viral replication
IL162269A0 (en) 2001-12-05 2005-11-20 Baylor College Medicine Methods and compositions for control of bone formation via modulation of sympathetic tone
CA2469620A1 (fr) 2001-12-12 2003-06-19 Chiron Srl. Immunisation contre chlamydia trachomatis
US7049121B2 (en) * 2001-12-20 2006-05-23 Applied Molecular Evolution Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
US6989261B2 (en) * 2001-12-20 2006-01-24 Eli Lilly And Company Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
US7255874B1 (en) 2001-12-21 2007-08-14 Closure Medical Corporation Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto
IL152904A0 (en) 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
CA2421269A1 (fr) 2002-08-09 2004-02-09 President And Fellows Of Harvard College Methodes et compositions pour prolonger la duree de vie et accroitre la resistance au stress de cellules et d'organismes
EP1572976B1 (fr) 2002-11-21 2010-09-15 Celltech R & D, Inc. Modulation de reponses immunitaires
AU2003298920A1 (en) * 2002-12-04 2004-06-23 Applied Molecular Evolution, Inc. Butyrylcholinesterase variants that alter the activity of chemotherapeutic agents
EP2561887B8 (fr) 2003-01-14 2016-12-21 Dana-Farber Cancer Institute, Inc. Sensibilisateur de thérapie anticancéreuse
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
WO2004101072A1 (fr) 2003-05-16 2004-11-25 Universite Laval Modulation de chlorure du snc et ses utilisations
ES2712695T3 (es) 2003-06-02 2019-05-14 Univ Massachusetts Métodos y composiciones para controlar la eficacia de la silenciación del ARN
ES2357116T5 (es) 2003-06-02 2021-09-03 Univ Massachusetts Métodos y composiciones para mejorar la eficacia y especificad de FNAi
US7595306B2 (en) * 2003-06-09 2009-09-29 Alnylam Pharmaceuticals Inc Method of treating neurodegenerative disease
JP4716517B2 (ja) 2003-06-09 2011-07-06 アルナイラム ファーマシューティカルズ， インコーポレイテッド 神経変性疾患を治療する方法
WO2004108760A2 (fr) 2003-06-10 2004-12-16 Nsgene A/S Secretion amelioree de neuroblastine
WO2005037232A2 (fr) 2003-10-17 2005-04-28 Joslin Diabetes Center, Inc. Methodes et compositions pour moduler la fonction des adipocytes
NZ547185A (en) 2003-10-20 2009-03-31 Nsgene As In vivo gene therapy of parkinson's disease
EP3279328A1 (fr) 2003-11-14 2018-02-07 Children's Medical Center Corporation Ribozymes à autoclivage et utilisations correspondantes
US7947659B2 (en) 2004-03-12 2011-05-24 Alnylam Pharmaceuticals, Inc. iRNA agents targeting VEGF
DK1736541T3 (da) 2004-03-29 2013-05-06 Galpharma Co Ltd Nyt modificeret galectin 9-protein og anvendelse heraf
WO2005095450A2 (fr) 2004-03-30 2005-10-13 Nsgene A/S Utilisation therapeutique d'un facteur de croissance, nsg33
CA2563433C (fr) * 2004-04-30 2010-07-13 Bas Medical, Inc. Methodes et compositions de lutte contre les maladies de la croissance foetale par modulation de la relaxine
EP2287310B1 (fr) 2004-07-22 2015-05-06 Five Prime Therapeutics, Inc. Compositions et procedes d'utilisation de MGD-CSF dans le traitement de maladies
WO2006013462A2 (fr) * 2004-07-30 2006-02-09 Nsgene A/S Facteurs de croissance nsg28, nsg30, et nsg32
JP5060293B2 (ja) 2004-08-03 2012-10-31 バイオジェン・アイデック・エムエイ・インコーポレイテッド 神経機能におけるｔａｊ
WO2006089095A2 (fr) 2005-02-17 2006-08-24 Biogen Idec Ma Inc. Traitement de troubles neurologiques
US7582745B2 (en) 2005-11-04 2009-09-01 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of Nav1.8 gene
AU2006311730B2 (en) 2005-11-09 2010-12-02 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of Factor V Leiden mutant gene
RS54111B1 (en) 2005-11-18 2015-12-31 Glenmark Pharmaceuticals S.A. ANTI-ALPHA 2 INTEGRIN ANTIBODIES AND THEIR USES
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
KR101462874B1 (ko) 2006-03-31 2014-11-18 알닐람 파마슈티칼스 인코포레이티드 Ｅｇ5 유전자의 발현을 억제하는 이본쇄 리보핵산
US7691824B2 (en) 2006-04-28 2010-04-06 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of a gene from the JC virus
EP2021507A4 (fr) 2006-05-11 2009-10-28 Alnylam Pharmaceuticals Inc Compositions et procédés d'inhibition de l'expression du gène pcsk9
BRPI0712034A2 (pt) 2006-05-19 2012-01-10 Alnylam Pharmaceuticals Inc modulação de rnai de aha e usos terapêuticos do mesmo
EP2584051B1 (fr) 2006-05-22 2014-07-16 Alnylam Pharmaceuticals Inc. Compositions et procédés d'inhibition de l'expressions du gène IKK-B
AU2007267579B2 (en) 2006-05-25 2013-05-30 Biogen Ma Inc. Methods of treating stroke
US8598333B2 (en) 2006-05-26 2013-12-03 Alnylam Pharmaceuticals, Inc. SiRNA silencing of genes expressed in cancer
PL2054431T3 (pl) 2006-06-09 2012-07-31 Novartis Ag Konformery adhezyn bakteryjnych
EP2629094A1 (fr) 2007-01-24 2013-08-21 Carnegie Mellon University Biocapteurs optiques
EP2139447A2 (fr) 2007-03-20 2010-01-06 Harold Brem Compositions gm-csf cosméceuticales et leurs procédés d'utilisation
PE20090064A1 (es) 2007-03-26 2009-03-02 Novartis Ag Acido ribonucleico de doble cadena para inhibir la expresion del gen e6ap humano y composicion farmaceutica que lo comprende
BRPI0814189A2 (pt) 2007-07-05 2015-03-03 Novartis Ag Ácido ribonucleico de filamento duplo, composição farmacêutica e seus usos, método para inibir a expressão de fosfatidilinositol 4-cinase, vetor e uso de um composto que seletivamente inibe a atividade da fosfatidilinositol 4-cinase.
US7871985B2 (en) 2007-12-10 2011-01-18 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of factor VII gene
WO2009079399A2 (fr) * 2007-12-14 2009-06-25 Alnylam Pharmaceuticals, Inc. Méthode de traitement de maladies neurodégénératives
KR101397407B1 (ko) 2008-03-05 2014-06-19 알닐람 파마슈티칼스 인코포레이티드 Ｅｇ5 및 ＶＥＧＦ 유전자의 발현을 억제하기 위한 조성물 및 방법
JP2011523357A (ja) 2008-05-06 2011-08-11 ジョスリン ダイアビーティス センター インコーポレイテッド 褐色脂肪細胞分化を誘導するための方法および組成物
US20090291073A1 (en) * 2008-05-20 2009-11-26 Ward Keith W Compositions Comprising PKC-theta and Methods for Treating or Controlling Ophthalmic Disorders Using Same
EP2690175B1 (fr) 2008-09-02 2016-12-28 Alnylam Pharmaceuticals, Inc. Compositions et procédés d'inhibition combinée d'expression du gène mutant EGFR et IL-6
CA2738019A1 (fr) 2008-09-23 2010-04-08 President And Fellows Of Harvard College Sirt4 et utilisations de celui-ci
CA2739170A1 (fr) 2008-09-25 2010-04-01 Alnylam Pharmaceuticals, Inc. Compositions a base de preparation lipidique et methodes destinees a inhiber l'expression d'un gene de serum amyloide a
LT2937418T (lt) 2008-10-20 2018-02-12 Alnylam Pharmaceuticals, Inc. Kompozicijos ir būdas transtiretino raiškos slopinimui
LT2894165T (lt) 2008-11-10 2023-03-10 Alexion Pharmaceuticals, Inc. Būdai ir kompozicijos, skirti su komplementu susijusių sutrikimų gydymui
US8324368B2 (en) 2008-12-10 2012-12-04 Alnylam Pharmaceuticals, Inc. GNAQ targeted dsRNA compositions and methods for inhibiting expression
WO2010080985A1 (fr) 2009-01-08 2010-07-15 Dana-Farber Cancer Institute, Inc. Compositions et procédés pour induire la différenciation du tissu adipeux brun
EP2389191A2 (fr) 2009-01-23 2011-11-30 NsGene A/S Expression des neuropeptides dans les cellules des mammiféres
CA2753438A1 (fr) 2009-02-24 2010-09-02 Alexion Pharmaceuticals, Inc. Anticorps contenant des peptides therapeutiques mimetiques de tpo/epo
US20120041051A1 (en) 2009-02-26 2012-02-16 Kevin Fitzgerald Compositions And Methods For Inhibiting Expression Of MIG-12 Gene
WO2010105209A1 (fr) 2009-03-12 2010-09-16 Alnylam Pharmaceuticals, Inc. COMPOSITIONS FORMULÉES DE LIPIDES ET PROCÉDÉS D'INHIBITION DE L'EXPRESSION DE GÈNES DE Eg5 ET DE VEGF
EP3293257B1 (fr) 2009-03-20 2021-08-11 Mesoblast, Inc. Production de cellules pluripotentes reprogrammées
WO2011005496A2 (fr) 2009-06-22 2011-01-13 Massachusetts Eye & Ear Infirmary Islet1 (isl1) et perte d'audition
EP3561077B1 (fr) 2009-10-21 2022-12-21 Les Laboratoires Servier Procédés pour des troubles liés à la prolifération cellulaire
JP5894535B2 (ja) 2009-11-09 2016-03-30 ジーンポッド セラピューティクス アーベーＧｅｎｅｐｏｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ａｂ ｉｎｖｉｖｏでのニューロン特異的な最適化された連続ＤＯＰＡ合成用の新規ウイルスベクター構築物
US9745589B2 (en) 2010-01-14 2017-08-29 Cornell University Methods for modulating skeletal remodeling and patterning by modulating SHN2 activity, SHN3 activity, or SHN2 and SHN3 activity in combination
EP2526205A1 (fr) 2010-01-21 2012-11-28 Dana-Farber Cancer Institute, Inc. Plate-forme de criblage génétique spécifique du contexte pour assister la découverte de gènes et la validation de cibles
CA2792291A1 (fr) 2010-03-29 2011-10-06 Kumamoto University Therapie siarn pour amylose oculaire liee a la transthyretine (ttr)
CA2797856C (fr) 2010-04-30 2018-09-18 Alexion Pharmaceuticals, Inc. Anticorps anti-c5a et methodes pour utiliser les anticorps
KR101886029B1 (ko) 2010-10-01 2018-08-07 호바 세라퓨틱스 에이피에스 무해자극통증, 통각과민증, 자발통증 및 헛통증의 치료를 위한 메테오린의 용도
WO2012051301A1 (fr) 2010-10-12 2012-04-19 President And Fellows Of Harvard College Procédés pour identifier des modulateurs du métabolisme des triglycérides, pour moduler le métabolisme des triglycérides et pour identifier des sujets à risque pour le métabolisme anormal des triglycérides
US8815942B2 (en) 2010-10-20 2014-08-26 The Royal Institution For The Advancement Of Learning/Mcgill University Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease
WO2012064743A2 (fr) 2010-11-08 2012-05-18 The Johns Hopkins University Procédés d'amélioration de la fonction cardiaque
EP3026432A3 (fr) 2010-12-27 2016-07-27 Brown University Procédé de prévision de la réponse du patient au traitement avec biglycan
WO2012094511A2 (fr) 2011-01-05 2012-07-12 Rhode Island Hospital Compositions et procédés destinés au traitement de lésion ou de maladie orthopédique
EP2723756B1 (fr) 2011-06-21 2020-03-11 Alnylam Pharmaceuticals, Inc. Compositions et procédés d'inhibition de l'expression des gènes de l'apolipoprotéine c-iii (apoc3)
US9068184B2 (en) 2011-06-21 2015-06-30 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibition of expression of protein C (PROC) genes
JP6145667B2 (ja) 2011-09-05 2017-06-14 ホーバ セラピューティクス アンパルトセルスカブ アロディニア、痛覚過敏、自発痛、及び幻痛の治療
CA2848368C (fr) 2011-09-13 2023-02-14 Dana-Farber Cancer Institute, Inc. Compositions et procedes pour induction et activite de tissu adipeux brun a l'aide de fndc5
WO2013055911A1 (fr) 2011-10-14 2013-04-18 Dana-Farber Cancer Institute, Inc. Biomarqueur znf365/zfp365 pouvant prévoir une réponse anticancéreuse
US10047345B2 (en) 2012-02-13 2018-08-14 Gamida-Cell Ltd. Culturing of mesenchymal stem cells with FGF4 and nicotinamide
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
WO2014113540A1 (fr) 2013-01-16 2014-07-24 Iowa State University Research Foundation, Inc. Cible intronique profonde pour la correction d'épissure sur le gène de l'amyotrophie spinale (sma)
US20160002316A1 (en) 2013-02-22 2016-01-07 Joslin Diabetes Center Serpins: methods of therapeutic beta-cell regeneration and function
EP2851086A1 (fr) 2013-09-20 2015-03-25 Sanofi Serpines Procédés de régénération thérapeutique et de fonction des cellules beta
EP2769732A1 (fr) 2013-02-22 2014-08-27 Sanofi Serpines Procédés de régénération thérapeutique et de fonction des cellules beta
DK2968424T3 (da) 2013-03-13 2020-03-30 Geneweave Biosciences Inc Ikke-replikative transduktionspartikler og transduktionspartikelbaserede reportersystemer
EP3567112A1 (fr) 2013-06-13 2019-11-13 Translate Bio, Inc. Production virale basée sur l'arn messager
WO2015048331A1 (fr) 2013-09-25 2015-04-02 Cornell University Composés pour induire une immunité anti-tumorale et procédés associés
NZ631007A (en) 2014-03-07 2015-10-30 Alexion Pharma Inc Anti-c5 antibodies having improved pharmacokinetics
WO2015164743A2 (fr) 2014-04-24 2015-10-29 Dana-Farber Cancer Institute, Inc. Suppresseur de tumeur et biomarqueurs oncogènes prédictifs de réponse à un inhibiteur de point de contrôle anti-immunitaire
JP6654760B2 (ja) 2014-07-24 2020-02-26 マサチューセッツ・アイ・アンド・イア・インファーマリー 網膜色素変性症のためのｒｐｇｒ遺伝子治療
EP3204516B1 (fr) 2014-10-06 2023-04-26 Dana-Farber Cancer Institute, Inc. Biomarqueurs à base d'angiopoïétine -2 utilisés pour la prédiction de la réponse de point de contrôle anti-immunitaire
EP3204119B1 (fr) 2014-10-09 2021-06-09 Dana-Farber Cancer Institute, Inc. Schéma posologique d'il-2 variables multiples pour le traitement de troubles immunitaires
WO2016118832A1 (fr) 2015-01-22 2016-07-28 University Of Massachusetts Immunothérapie anticancéreuse
EP3250588A1 (fr) 2015-01-29 2017-12-06 Board of Trustees of Michigan State University Polypeptides cryptiques et leurs utilisations
EP3748007B1 (fr) 2015-03-06 2024-06-26 Massachusetts Eye & Ear Infirmary Thérapies d'augmentation génétique de la dégénérescence rétinienne héréditaire causée par des mutations au niveau du gène prpf31
US10948492B2 (en) 2015-03-06 2021-03-16 Dana-Farber Cancer Institute, Inc. PD-L2 biomarkers predictive of PD-1 pathway inhibitor responses in esophagogastric cancers
ES2805206T3 (es) 2015-03-10 2021-02-11 Univ Massachusetts Enfoque dirigido a GDF6 y a señalización de BMP para la terapia contra el melanoma
EP3736287A1 (fr) 2015-05-11 2020-11-11 The Johns Hopkins University Anticorps auto-immuns destinés à être utilisés pour inhiber la croissance de cellules cancéreuses
EP3294332A4 (fr) 2015-05-14 2018-12-26 Joslin Diabetes Center, Inc. Protéine 3 de liaison au rétinol (rbp3) à utiliser en tant que facteur de protection dans la dégénérescence rétinienne non diabétique
CA2992511A1 (fr) 2015-08-03 2017-02-09 Myodopa Limited Synthese et regulation systemiques de la l-dopa
WO2017066561A2 (fr) 2015-10-16 2017-04-20 President And Fellows Of Harvard College Modulation de pd-1 des lymphocytes t régulateurs pour réguler les réponses immunitaires effectrices des lymphocytes t
WO2017066796A2 (fr) 2015-10-16 2017-04-20 The Children's Medical Center Corporation Modulateurs de maladies impliquant des télomères
WO2017066712A2 (fr) 2015-10-16 2017-04-20 The Children's Medical Center Corporation Modulateurs de maladie de télomères
CA3002676A1 (fr) 2015-10-29 2017-05-04 Dana-Farber Cancer Institute, Inc. Procedes pour identifier, evaluer, prevenir et traiter des troubles metaboliques au moyen de pm20d1 et d'acides amines n-lipides
AU2016355178B9 (en) 2015-11-19 2019-05-30 Massachusetts Institute Of Technology Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity
WO2017117218A1 (fr) 2015-12-30 2017-07-06 Momenta Pharmaceuticals, Inc. Méthodes associées à des produits biologiques
SG11201807893QA (en) * 2016-03-18 2018-10-30 Intrexon Corp Compositions and methods for treatment of type vii collagen deficiencies
CN110753755B (zh) 2016-03-21 2023-12-29 丹娜法伯癌症研究院 T细胞耗竭状态特异性基因表达调节子及其用途
EP4273248A3 (fr) 2016-05-20 2024-01-10 Braingene AB Domaines de déstabilisation pour la stabilisation conditionnelle d'une protéine
WO2018001858A1 (fr) 2016-06-27 2018-01-04 University Of Copenhagen Assemblage sur mesure d'un polypeptide modulaire de bourgeon
AU2017332721B2 (en) 2016-09-20 2023-11-09 Sara BUHRLAGE Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators
US11459568B2 (en) 2016-10-31 2022-10-04 University Of Massachusetts Targeting microRNA-101-3p in cancer therapy
EP3609577A4 (fr) 2017-04-14 2021-03-24 University of Massachusetts Adipokines sélectives vis-à-vis de la graisse brune
US11820822B2 (en) 2017-06-06 2023-11-21 Dana-Farber Cancer Institute, Inc. Methods for sensitizing cancer cells to T cell-mediated killing by modulating molecular pathways
CA3066779A1 (fr) 2017-06-28 2019-01-03 Regeneron Pharmaceuticals, Inc. Proteines de liaison a l'antigene anti-papillomavirus humain et leurs methodes d'utilisation
DK3658184T3 (da) 2017-07-27 2023-11-27 Alexion Pharma Inc Højkoncentrerede anti-c5-antistofformuleringer
US11008602B2 (en) 2017-12-20 2021-05-18 Roche Molecular Systems, Inc. Non-replicative transduction particles and transduction particle-based reporter systems
EP3801598A1 (fr) 2018-06-01 2021-04-14 Sanofi Traitement d'association pour traiter une infection au virus de l'hépatite b
CA3106612A1 (fr) 2018-07-19 2020-01-23 Regeneron Pharmaceuticals, Inc. Recepteurs antigeniques chimeriques possedant une specificite pour le bcma, et utilisations correspondantes
EA202191107A1 (ru) 2018-10-23 2021-09-17 Ридженерон Фармасьютикалз, Инк. T-клеточные рецепторы ny-eso-1 и способы их применения
WO2020120649A1 (fr) 2018-12-13 2020-06-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Cellules présentatrices d'antigène artificiel qui expriment de manière constitutive un antigène conjointement avec une molécule hla de classe ii
US20220090094A1 (en) 2018-12-27 2022-03-24 Roche Molecular Systems, Inc. Non-replicative transduction particles and transduction particle-based reporter systems for detection of acinetobacter baumannii
US11572595B2 (en) 2018-12-31 2023-02-07 Roche Molecular Systems, Inc. Non-replicative transduction particles with one or more non-native tail fibers and transduction particle-based reporter systems
WO2020223121A1 (fr) 2019-04-30 2020-11-05 Dana-Farber Cancer Institute, Inc. Méthodes de traitement du cancer à l'aide de combinaisons d'agents anti-cx3cr1 et d'agents de blocage de points de contrôle immunitaires
IT201900007060A1 (it) 2019-05-21 2020-11-21 St Superiore Di Sanita Cellule tumorali ingegnerizzate e loro usi
IT201900012540A1 (it) 2019-07-22 2021-01-22 Humanitas Mirasole Spa Inibitori di CHI3L1 e loro usi
CA3147903A1 (fr) 2019-07-24 2021-01-28 Regeneron Pharmaceuticals, Inc. Recepteurs antigeniques chimeriques presentant une specificite pour mage-a4 et utilisations associees
US20220356234A1 (en) 2019-10-02 2022-11-10 Alexion Pharmaceuticals, Inc. Complement inhibitors for treating drug-induced complement-mediated response
AU2020398327A1 (en) 2019-12-03 2022-07-14 Evotec International Gmbh Interferon-associated antigen binding proteins and uses thereof
KR20220109435A (ko) 2019-12-03 2022-08-04 에보텍 인터내셔널 게엠베하 B형 간염 감염 치료에서의 사용을 위한 인터페론-결합된 항원 결합 단백질
EP4085156B1 (fr) 2019-12-31 2023-10-25 F. Hoffmann-La Roche AG Criblage par pcr quantitative de prophages inductibles à partir d'isolats bactériens
JP2023511417A (ja) 2020-01-24 2023-03-17 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 黒色腫において優先的に発現する抗原（ｐｒａｍｅ）ｔ細胞受容体およびそれらの使用方法
KR20230005268A (ko) 2020-04-24 2023-01-09 밀레니엄 파머슈티컬스 인코퍼레이티드 항-cd19 항체 및 이의 용도
CN115485303A (zh) 2020-05-05 2022-12-16 瑞泽恩制药公司 包含CD28ζ和CD3ζ的CAR
CN116615443A (zh) 2020-09-14 2023-08-18 Vor生物制药股份有限公司 针对cd33的单结构域抗体
US20230374599A1 (en) 2020-10-19 2023-11-23 Alexander Gusev Germline biomarkers of clinical response and benefit to immune checkpoint inhibitor therapy
US20240024474A1 (en) 2020-11-13 2024-01-25 David Avigan Personalized fusion cell vaccines
IL303741A (en) 2020-12-18 2023-08-01 Momenta Pharmaceuticals Inc Antibodies against integrin alpha 11 in cell 1
US20240158864A1 (en) 2021-01-25 2024-05-16 Dana-Farber Cancer Institute, Inc. Methods and compositions for identifying neuroendocrine prostate cancer
WO2022215054A1 (fr) 2021-04-09 2022-10-13 Takeda Pharmaceutical Company Limited Anticorps ciblant le facteur d du complément et leurs utilisations
MX2023011712A (es) 2021-04-26 2023-10-12 Millennium Pharm Inc Anticuerpos anti receptor de adhesion acoplado a proteinas g e2 (adgre2) y usos de los mismos.
MX2023011710A (es) 2021-04-26 2023-10-12 Millennium Pharm Inc Anticuerpos miembro a de la familia 12 del dominio de lectina de tipo c (anti-clec12a) y usos de los mismos.
BR112023023067A2 (pt) 2021-05-04 2024-01-30 Regeneron Pharma Receptores de antigénios quiméricos com especificidade mage-a4 e usos dos mesmos
CN117940149A (zh) 2021-05-06 2024-04-26 霍巴治疗公司 化疗诱导的神经性疼痛的预防和治疗
WO2022261183A2 (fr) 2021-06-08 2022-12-15 Dana-Farber Cancer Institute, Inc. Compositions et procédés de traitement et/ou d'identification d'un agent pour le traitement de cancers intestinaux
TW202313098A (zh) 2021-06-09 2023-04-01 德商埃沃特克國際有限公司 用於冠狀病毒感染之治療或預防的干擾素相聯抗原結合蛋白
AR127408A1 (es) 2021-10-20 2024-01-17 Takeda Pharmaceuticals Co Composiciones dirigidas a bcma y métodos de uso de las mismas
WO2023097119A2 (fr) 2021-11-29 2023-06-01 Dana-Farber Cancer Institute, Inc. Méthodes et compositions pour moduler riok2
WO2023104960A1 (fr) 2021-12-10 2023-06-15 Hoba Therapeutics Aps Traitement de la douleur nociceptive
WO2023158732A1 (fr) 2022-02-16 2023-08-24 Dana-Farber Cancer Institute, Inc. Procédés de diminution de l'alpha-synucléine pathologique à l'aide d'agents qui modulent fndc5 ou des fragments biologiquement actifs de celui-ci
WO2023201238A1 (fr) 2022-04-11 2023-10-19 Vor Biopharma Inc. Agents de liaison et leurs méthodes d'utilisation
WO2023240109A1 (fr) 2022-06-07 2023-12-14 Regeneron Pharmaceuticals, Inc. Molécules multispécifiques pour moduler l'activité des lymphocytes t, et leurs utilisations
WO2024091669A1 (fr) 2022-10-28 2024-05-02 Ginkgo Bioworks, Inc. Récepteurs antigéniques chimériques comprenant une paire de domaines intracellulaires
WO2024126294A1 (fr) 2022-12-13 2024-06-20 Evotec International Gmbh Protéines de liaison à l'antigène associées à l'interféron destinées à être utilisées pour le traitement ou la prévention d'une infection au virus parainfluenza
WO2024126289A1 (fr) 2022-12-13 2024-06-20 Evotec International Gmbh Protéines de liaison à l'antigène associées à l'interféron destinées à être utilisées pour le traitement ou la prévention d'une infection par le virus de la grippe
WO2024126293A1 (fr) 2022-12-13 2024-06-20 Evotec International Gmbh Protéines de liaison à l'antigène associées à l'interféron destinées à être utilisées dans le traitement ou la prévention d'une infection par le virus respiratoire syncytial

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634665A (en) * 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
GB8424757D0 (en) * 1984-10-01 1984-11-07 Pasteur Institut Retroviral vector
JP2703893B2 (ja) * 1985-07-05 1998-01-26 ホワイトヘッド・インスティテュ−ト・フォ−・バイオメディカル・リサ−チ 外来遺伝子物質を発現する上皮細胞
US4861719A (en) * 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
US5219740A (en) * 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
US5399346A (en) * 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy

Also Published As

Publication number Publication date
JPH03500124A (ja) 1991-01-17
EP0378576B1 (fr) 1995-01-18
EP0378576A1 (fr) 1990-07-25
WO1989002468A1 (fr) 1989-03-23
ATE117375T1 (de) 1995-02-15
JP3015383B2 (ja) 2000-03-06
DE3852823D1 (de) 1995-03-02
EP0633318A1 (fr) 1995-01-11
CA1341311C (fr) 2001-10-30
US5460959A (en) 1995-10-24
DE3852823T2 (de) 1995-05-24

Similar Documents

Publication Publication Date Title
HK1008049A1 (en) Transduced fibroblasts and use therefor
HK1008400A1 (en) Genetic modification of endothelial cells
CA2095153A1 (fr) Modification genetique de cellules endotheliales
IE820069L (en) Recombinant dna encoding a polypeptide
KR100221404B1 (en) Production of recombinant human lactoferrin
IL94361A0 (en) Polypeptides,recombinant dna molecules and method of producing a human hemoglobin like protein
ES8704976A1 (es) Metodo pra la fabricacion de un polipeptido firiologicamente activo en el hombre.
IE881755L (en) Novel proteins with factor viii activity, process for their¹preparation using genetically engineered cells and¹pharmaceutical compositions containing them
NZ227788A (en) Peptide having growth hormone regulatory effects, and compositions
HK38297A (en) Preparation of functional human urokinase polypeptides
AU682140B2 (en) Multidrug resistance gene
CA2015994A1 (fr) Sequence d'adn-c de lactoferrine humaine
DE68922917D1 (de) KEX2-Endoprotease und Verfahren zu ihrer Herstellung.
ES8506347A1 (es) Un metodo para producir un polipeptido de tipo il-2-".
HUT44615A (en) Process for preparing gm-cst protein and its derivatives
EP0336779A3 (fr) Polypeptides stabilisés par remplacements covalents des liaisons d'hydrogène
EP0147178A3 (en) Expression plasmids for improved production of heterologous protein in bacteria
GB8819826D0 (en) Glycosylated igf-1
AU1847092A (en) Implant compositions containing a biologically active protein, peptide or polypeptide
EP0315118A3 (fr) ADN codant pour endothéline et son utilisant
DE68923496D1 (de) Verfahren zur Herstellung von motilinähnlichen Polypeptiden und seine Expression.

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20040908