ES2126606T3 - Terapia del sistema nervioso central mediante celulas modificadas geneticamente. - Google Patents
Terapia del sistema nervioso central mediante celulas modificadas geneticamente.Info
- Publication number
- ES2126606T3 ES2126606T3 ES92925278T ES92925278T ES2126606T3 ES 2126606 T3 ES2126606 T3 ES 2126606T3 ES 92925278 T ES92925278 T ES 92925278T ES 92925278 T ES92925278 T ES 92925278T ES 2126606 T3 ES2126606 T3 ES 2126606T3
- Authority
- ES
- Spain
- Prior art keywords
- nervous system
- central nervous
- therapy
- genetically modified
- modified cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/33—Fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/16—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced pteridine as one donor, and incorporation of one atom of oxygen (1.14.16)
- C12Y114/16002—Tyrosine 3-monooxygenase (1.14.16.2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
SE EXPONEN METODOS PARA MODIFICACION GENETICA DE LAS CELULAS DEL DONANTE POR TRANSFERENCIA DE GENES CON INJERTO EN EL SISTEMA NERVIOSO CENTRAL PARA TRATAR CELULAS DEFECTUOSAS, ENFERMAS O DAÑADAS. LAS CELULAS MODIFICADAS DEL DONANTE PRODUCEN MOLECULAS FUNCIONALES QUE LLEVAN A CABO LA RECUPERACION O LA FUNCION MEJORADA DE LAS CELULAS DEL SNC. SE DESCRIBEN METODOS Y VECTORES PARA REALIZAR LA TRANSFERENCIA E INJERTO DEL GEN.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79289491A | 1991-11-15 | 1991-11-15 | |
CA002095300A CA2095300C (en) | 1991-11-15 | 1993-04-30 | Use of genetically modified cells to treat defects, disease or damage of the central nervous system |
JP5136554A JPH06329559A (ja) | 1991-11-15 | 1993-05-14 | 遺伝子的に修飾された細胞を移植して中枢神経系における欠陥、疾病、あるいは損傷を治療するための方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2126606T3 true ES2126606T3 (es) | 1999-04-01 |
Family
ID=27169416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92925278T Expired - Lifetime ES2126606T3 (es) | 1991-11-15 | 1992-11-13 | Terapia del sistema nervioso central mediante celulas modificadas geneticamente. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0625195B1 (es) |
JP (1) | JPH06329559A (es) |
AT (1) | ATE175442T1 (es) |
CA (1) | CA2095300C (es) |
DE (1) | DE69228127T2 (es) |
DK (1) | DK0625195T3 (es) |
ES (1) | ES2126606T3 (es) |
GR (1) | GR3029362T3 (es) |
WO (1) | WO1993010234A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6103226A (en) * | 1994-08-12 | 2000-08-15 | Arch Development Corporation | Genetically engineered cells that produce produce L. Dopa |
US6204053B1 (en) | 1994-11-08 | 2001-03-20 | Diacrin, Inc. | Porcine cortical cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
US6294383B1 (en) | 1994-11-08 | 2001-09-25 | The Mclean Hospital Corporation | Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
WO1996022112A1 (en) | 1995-01-17 | 1996-07-25 | Genetic Therapy, Inc. | Delivery of therapeutic agents by gene therapy |
US5753505A (en) * | 1995-07-06 | 1998-05-19 | Emory University | Neuronal progenitor cells and uses thereof |
CA2305787A1 (en) | 2000-05-09 | 2001-11-09 | The University Of British Columbia | Cxcr4 antagonist treatment of hematopoietic cells |
CA2245224A1 (en) | 1998-08-14 | 2000-02-14 | Jiang-Hong Giong | Chemokine receptor antagonists and chemotherapeutics |
DE69914463T2 (de) | 1998-03-13 | 2004-11-11 | The University Of British Columbia, Vancouver | Therapeutische chemokine rezeptor antagonisten |
US6444205B2 (en) | 1998-09-30 | 2002-09-03 | Diacrin, Inc. | Transplantation of neural cells for the treatment of chronic pain or spasticity |
US20040120891A1 (en) | 1998-12-21 | 2004-06-24 | Craig Hill | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
US6652864B1 (en) | 1998-12-21 | 2003-11-25 | Asilomar Pharmaceuticals, Inc. | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
DK1159415T3 (da) * | 1999-03-04 | 2010-05-03 | Revivicor Inc | Genetisk modifikation af somatiske celler og anvendelse deraf |
WO2001075094A1 (en) * | 2000-04-04 | 2001-10-11 | Thomas Jefferson University | Application of myeloid-origin cells to the nervous system |
US7368425B2 (en) | 2006-03-24 | 2008-05-06 | Chemokine Therapeutics Corp. | Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis |
US20050059584A1 (en) | 2002-08-16 | 2005-03-17 | Ahmed Merzouk | Novel chemokine mimetics synthesis and their use |
US7378098B2 (en) | 2000-04-12 | 2008-05-27 | The University Of British Columbia | CXC chemokine receptor 4 agonist peptides |
US20030124095A1 (en) | 2001-12-31 | 2003-07-03 | Regents Of The University Of California | Methods for therapeutic use of brain derived neurotrophic factor in the entorhinal cortex |
KR101226702B1 (ko) * | 2010-10-08 | 2013-01-25 | 충북대학교 산학협력단 | 인간 콜린 아세틸트랜스퍼라아제를 발현하는 인간 신경줄기세포 및 이의 용도 |
JP2021530507A (ja) | 2018-07-18 | 2021-11-11 | マンザニータ ファーマシューティカルズ,インク. | 神経細胞に抗がん剤を送達するためのコンジュゲート、その使用方法及び製造方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3015383B2 (ja) * | 1987-09-11 | 2000-03-06 | ホワイトヘツド・インスチチユート・フオー・バイオメデイカル・リサーチ | 形質導入した線維芽およびそれらの使用 |
US5082670A (en) * | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
US6511823B1 (en) * | 1990-08-20 | 2003-01-28 | American Cyanamid Corporation | Heparin binding neurotrophic factor gene sequence |
WO1992009688A1 (en) * | 1990-11-21 | 1992-06-11 | Massachusetts Institute Of Technology | MICE HAVING β2 MICROGLOBULIN GENE DISRUPTION |
-
1992
- 1992-11-13 ES ES92925278T patent/ES2126606T3/es not_active Expired - Lifetime
- 1992-11-13 EP EP92925278A patent/EP0625195B1/en not_active Expired - Lifetime
- 1992-11-13 AT AT92925278T patent/ATE175442T1/de not_active IP Right Cessation
- 1992-11-13 DE DE69228127T patent/DE69228127T2/de not_active Expired - Lifetime
- 1992-11-13 DK DK92925278T patent/DK0625195T3/da active
- 1992-11-13 WO PCT/US1992/009896 patent/WO1993010234A1/en active IP Right Grant
-
1993
- 1993-04-30 CA CA002095300A patent/CA2095300C/en not_active Expired - Fee Related
- 1993-05-14 JP JP5136554A patent/JPH06329559A/ja active Pending
-
1999
- 1999-02-10 GR GR990400449T patent/GR3029362T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH06329559A (ja) | 1994-11-29 |
EP0625195B1 (en) | 1999-01-07 |
CA2095300C (en) | 2002-06-25 |
WO1993010234A1 (en) | 1993-05-27 |
EP0625195A1 (en) | 1994-11-23 |
DK0625195T3 (da) | 1999-08-30 |
CA2095300A1 (en) | 1994-10-31 |
GR3029362T3 (en) | 1999-05-28 |
DE69228127D1 (de) | 1999-02-18 |
ATE175442T1 (de) | 1999-01-15 |
DE69228127T2 (de) | 1999-09-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2126606T3 (es) | Terapia del sistema nervioso central mediante celulas modificadas geneticamente. | |
DE68929077T2 (de) | Transplantieren von genetisch modifizierten zellen zur behandlung von krankheiten des zentralen nervensystems | |
DK0918848T3 (da) | Fremgangsmåder til at behandle kræftsygdomme og patogene infektioner ved anvendelse af antigenpræsenterende celler påfyldt med RNA | |
NO844579L (no) | Enzymresistente immunomodulerende peptider. | |
DK193788A (da) | Fremgangsmaade til isolering af nucleinsyrer | |
GB8308236D0 (en) | Dna vectors | |
NO874393L (no) | Fremgangsmaate for nedsetting av paaler i grunnen, samt apparat for utfoerelse av fremgangsmaaten. | |
ATE142266T1 (de) | Verfahren zum transport von molekülen in eukaryotenzellen | |
SE8000435L (sv) | N-bensylimidazoler med selektivt inhiberande verkan pa tromboxansyntetasenzymet jemte farmaceutiska beredningar innehallande sadana n-bensylimidazoler och sett for deras framstellning | |
CA2346644A1 (en) | Method for preventing xenograft transplant rejection using photodynamic therapy | |
EP0653491A4 (en) | METHOD FOR INTRODUCING FOREIGN DNA IN CELLS. | |
ES2133714T3 (es) | Compuestos heterociclicos para el tratamiento de trastornos del snc y cardiovasculares. | |
BR8100869A (pt) | Processo para o isolamento de substancia solida de caldo de cultura de salinomicina e substancia solida de caldo de cultura de salinomicina | |
DK0768886T3 (da) | Endothelforingseffekter og behandling af vasospastiske lidelser | |
NO20002412D0 (no) | FremgangsmÕte for behandling av tumorer og tumorceller ved anvendelse av ex vivo aktiverte T celler | |
NO864020L (no) | Promoter-anordning for streptomycetes-vektorer. | |
Jamieson | An application of Morita techniques in a university counseling center setting. | |
JPS6464672A (en) | Impact medical treatment device | |
DK232090D0 (da) | Fremgangsmaade og apparat til aftastning af straalingskildefordelingen i et medium, f.eks. proteinfordelingen i en gel | |
SU1022361A1 (ru) | Способ получения капсульного антигена | |
SU1596731A1 (ru) | Способ выделения гормона роста человека | |
IT8119917A0 (it) | Metodo per il trattamento di disturbi del sistema pilifero in mammiferi. | |
RU97107873A (ru) | Способ повышения иммунных свойств переливаемой аутокрови |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 625195 Country of ref document: ES |