MX9702126A - Modelos in vitro de funcion y disfuncion del snc. - Google Patents

Modelos in vitro de funcion y disfuncion del snc.

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Publication number
MX9702126A
MX9702126A MX9702126A MX9702126A MX9702126A MX 9702126 A MX9702126 A MX 9702126A MX 9702126 A MX9702126 A MX 9702126A MX 9702126 A MX9702126 A MX 9702126A MX 9702126 A MX9702126 A MX 9702126A
Authority
MX
Mexico
Prior art keywords
cns
stem cells
neural stem
model system
tissue
Prior art date
Application number
MX9702126A
Other languages
English (en)
Other versions
MXPA97002126A (es
Inventor
Samuel Weiss
Brent Reynolds
Original Assignee
Neurospheres Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurospheres Holdings Ltd filed Critical Neurospheres Holdings Ltd
Publication of MXPA97002126A publication Critical patent/MXPA97002126A/es
Publication of MX9702126A publication Critical patent/MX9702126A/es

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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • G01N33/5026—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
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    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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  • Health & Medical Sciences (AREA)
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Abstract

Se usan células nerviosas del encéfalo multipotentes proliferantes o proliferadas para producir un sistema modelo SNC(Sistema Nervioso Central) para el estudio del desarrollo y la funcion nervioso y para determinar los efectos en el SNC de agentes terapéuticos y otros novedosos agentes biologicos. Las células nerviosas del encéfalo se obtienen en pequeñas cantidades de tejido del SNC, ya sea normal o enfermo, de individuos pre y postnatales. La invencion permite que grandes cantidades de tejido, que puede derivarse clonicamente para limitar la variabilidad, se generan a partir de una cantidad relativamente pequeña de tejido del SNC. La invencion describe un sistema de modelo del SNC mediante el cual la progenie diferenciada de las células nerviosas del encéfalo incluye tipos multiples de células del SNC, incluso neuronas, astrocitos y oligodendrocitos. Usándose este modelo, se puede realizar la seleccion de efectos de los agentes neurologicos u otros agentes biologicos y el análisis de la expresion de los genes en células nerviosas multipotentes del encéfalo y en la progenie derivada de la célula del encéfalo de un donador normal o enfermo.
MX9702126A 1994-09-23 1995-09-22 Modelos in vitro de funcion y disfuncion del snc. MX9702126A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31109994A 1994-09-23 1994-09-23
US311099 1994-09-23
US48189395A 1995-06-07 1995-06-07
US481893 1995-06-07
PCT/CA1995/000542 WO1996009543A1 (en) 1994-09-23 1995-09-22 In vitro models of cns function and dysfunction

Publications (2)

Publication Number Publication Date
MXPA97002126A MXPA97002126A (es) 1997-06-01
MX9702126A true MX9702126A (es) 1997-06-28

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Family Applications (1)

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MX9702126A MX9702126A (es) 1994-09-23 1995-09-22 Modelos in vitro de funcion y disfuncion del snc.

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EP (2) EP1130394B1 (es)
JP (1) JPH10505754A (es)
KR (1) KR970706490A (es)
AT (2) ATE345496T1 (es)
AU (1) AU714837B2 (es)
CA (1) CA2200709A1 (es)
DE (2) DE69523771T2 (es)
DK (2) DK1130394T3 (es)
ES (1) ES2167461T3 (es)
FI (1) FI971168A (es)
MX (1) MX9702126A (es)
NO (1) NO971245D0 (es)
PT (1) PT783693E (es)
WO (1) WO1996009543A1 (es)

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AU4752700A (en) 1999-05-03 2000-11-17 Karolinska Innovations Ab Materials and methods relating to neuronal development
US6878543B1 (en) 1999-10-25 2005-04-12 Nsgene Sa Cultures of GFAP+ nestin+ cells that differentiate to neurons
CA2399434C (en) 2000-02-11 2010-10-19 The Schepens Eye Research Institute, Inc. Isolation and transplantation of retinal stem cells
WO2003001202A1 (en) * 2001-06-25 2003-01-03 Cardion Ag Methods and cell populations for identifying and validating genomic targets, and for drug screening
WO2003027247A2 (en) * 2001-09-24 2003-04-03 Sangamo Biosciences, Inc. Modulation of stem cells using zinc finger proteins
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US20040185429A1 (en) 2002-12-09 2004-09-23 Judith Kelleher-Andersson Method for discovering neurogenic agents
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WO2005010524A1 (en) * 2003-06-04 2005-02-03 Curis, Inc. Stem cell-based methods for identifying and characterizing agents
WO2006055685A2 (en) 2004-11-17 2006-05-26 Neuralstem, Inc. Transplantation of human neural cells for treatment of neurodegenerative conditions
EP2077092A3 (en) * 2007-10-29 2009-10-21 Taipei Veterans General Hospital System and Methods for Screening or Analyzing Targets
GB0815224D0 (en) * 2008-08-20 2008-09-24 Eisai London Res Lab Ltd Screening assay
ES2571991T3 (es) 2010-07-28 2016-05-27 Neuralstem Inc Procedimientos para tratar y/o revertir enfermedades y/o trastornos neurodegenerativos
CN104136601A (zh) 2012-02-17 2014-11-05 斯格本斯眼科研究所 人视网膜祖细胞的表型谱
WO2016064737A1 (en) 2014-10-20 2016-04-28 Neuralstem, Inc. Stable neural stem cells comprising an exogenous polynucleotide coding for a growth factor and methods of use thereof
JP6844953B2 (ja) * 2015-04-22 2021-03-17 公益財団法人東京都医学総合研究所 アルツハイマー病研究を標的にしたグリア細胞システム
CN105861482B (zh) * 2016-04-05 2019-10-11 中国科学院广州生物医药与健康研究院 体外细胞疾病模型及其制备方法
SG11201909501TA (en) * 2017-04-13 2019-11-28 Univ Leland Stanford Junior Personalized 3d neural culture system for generating human oligodendrocytes and studying myelination in vitro

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AU665012B2 (en) * 1991-07-08 1995-12-14 Neurospheres Holdings Ltd Novel growth factor-responsive progenitor cells which can be proliferated (in vitro)
AU5367694A (en) * 1992-10-28 1994-05-24 Neurospheres Holdings Ltd Biological factors and neural stem cells

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DE69535300T2 (de) 2007-06-06
DK1130394T3 (da) 2007-01-08
EP0783693B1 (en) 2001-11-07
ATE345496T1 (de) 2006-12-15
EP0783693A1 (en) 1997-07-16
FI971168A0 (fi) 1997-03-20
ES2167461T3 (es) 2002-05-16
FI971168A (fi) 1997-03-20
DK0783693T3 (da) 2002-01-14
JPH10505754A (ja) 1998-06-09
DE69523771T2 (de) 2002-08-01
AU3515295A (en) 1996-04-09
PT783693E (pt) 2002-04-29
ATE208495T1 (de) 2001-11-15
CA2200709A1 (en) 1996-03-28
KR970706490A (ko) 1997-11-03
EP1130394B1 (en) 2006-11-15
AU714837B2 (en) 2000-01-13
DE69535300D1 (de) 2006-12-28
EP1130394A1 (en) 2001-09-05
NO971245L (no) 1997-03-18
WO1996009543A1 (en) 1996-03-28
DE69523771D1 (de) 2001-12-13
NO971245D0 (no) 1997-03-18

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