ATE345496T1 - In-vitro-musters für zns - funktion und dysfunktion - Google Patents
In-vitro-musters für zns - funktion und dysfunktionInfo
- Publication number
- ATE345496T1 ATE345496T1 AT01101622T AT01101622T ATE345496T1 AT E345496 T1 ATE345496 T1 AT E345496T1 AT 01101622 T AT01101622 T AT 01101622T AT 01101622 T AT01101622 T AT 01101622T AT E345496 T1 ATE345496 T1 AT E345496T1
- Authority
- AT
- Austria
- Prior art keywords
- dysfunction
- vitro
- patterns
- biological agent
- culture
- Prior art date
Links
- 230000004064 dysfunction Effects 0.000 title 1
- 238000000338 in vitro Methods 0.000 title 1
- 239000003124 biologic agent Substances 0.000 abstract 3
- 210000003061 neural cell Anatomy 0.000 abstract 3
- 208000012902 Nervous system disease Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 210000001178 neural stem cell Anatomy 0.000 abstract 2
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000003102 growth factor Substances 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5026—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/46—Amines, e.g. putrescine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/148—Transforming growth factor alpha [TGF-a]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
- C12N2501/392—Sexual steroids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2510/00—Detection of programmed cell death, i.e. apoptosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Developmental Biology & Embryology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Animal Behavior & Ethology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31109994A | 1994-09-23 | 1994-09-23 | |
US48189395A | 1995-06-07 | 1995-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE345496T1 true ATE345496T1 (de) | 2006-12-15 |
Family
ID=26977743
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95931864T ATE208495T1 (de) | 1994-09-23 | 1995-09-22 | In vitro-modelle für cns-funktion und-dysfunktion |
AT01101622T ATE345496T1 (de) | 1994-09-23 | 1995-09-22 | In-vitro-musters für zns - funktion und dysfunktion |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95931864T ATE208495T1 (de) | 1994-09-23 | 1995-09-22 | In vitro-modelle für cns-funktion und-dysfunktion |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP0783693B1 (de) |
JP (1) | JPH10505754A (de) |
KR (1) | KR970706490A (de) |
AT (2) | ATE208495T1 (de) |
AU (1) | AU714837B2 (de) |
CA (1) | CA2200709A1 (de) |
DE (2) | DE69523771T2 (de) |
DK (2) | DK0783693T3 (de) |
ES (1) | ES2167461T3 (de) |
FI (1) | FI971168A0 (de) |
MX (1) | MX9702126A (de) |
NO (1) | NO971245L (de) |
PT (1) | PT783693E (de) |
WO (1) | WO1996009543A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5753506A (en) * | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
US7544511B2 (en) | 1996-09-25 | 2009-06-09 | Neuralstem Biopharmaceuticals Ltd. | Stable neural stem cell line methods |
US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
DK1173548T3 (da) | 1999-05-03 | 2007-10-08 | Neuro Therapeutics Ab | Materialer og fremgangsmåder til frembringelse af dopaminerge neuroner |
US6878543B1 (en) * | 1999-10-25 | 2005-04-12 | Nsgene Sa | Cultures of GFAP+ nestin+ cells that differentiate to neurons |
ATE473751T1 (de) | 2000-02-11 | 2010-07-15 | Schepens Eye Res Inst | Isolierung und transplantation von retinalen stammzellen |
WO2003001202A1 (en) * | 2001-06-25 | 2003-01-03 | Cardion Ag | Methods and cell populations for identifying and validating genomic targets, and for drug screening |
EP2266396A3 (de) * | 2001-09-24 | 2011-06-15 | Sangamo BioSciences, Inc. | Modulation von stammzellen mittels zinkfingerproteinen |
US7129034B2 (en) | 2001-10-25 | 2006-10-31 | Cedars-Sinai Medical Center | Differentiation of whole bone marrow |
WO2004053071A2 (en) | 2002-12-09 | 2004-06-24 | Judith Kelleher-Andersson | Method for discovering neurogenic agents |
US8293488B2 (en) | 2002-12-09 | 2012-10-23 | Neuralstem, Inc. | Method for screening neurogenic agents |
WO2005010524A1 (en) * | 2003-06-04 | 2005-02-03 | Curis, Inc. | Stem cell-based methods for identifying and characterizing agents |
CN101084303A (zh) | 2004-11-17 | 2007-12-05 | 神经干公司 | 用于治疗神经变性症状的人类神经细胞的移植 |
EP2515109A3 (de) * | 2007-10-29 | 2012-11-14 | Taipei Veterans General Hospital | System und Verfahren zur Abtastung oder Analyse von Zielen |
GB0815224D0 (en) * | 2008-08-20 | 2008-09-24 | Eisai London Res Lab Ltd | Screening assay |
SG187226A1 (en) | 2010-07-28 | 2013-03-28 | Neuralstem Inc | Methods for treating and/or reversing neurodegenerative diseases and/or disorders |
ES2700980T3 (es) | 2012-02-17 | 2019-02-20 | Schepens Eye Res Inst | Perfil fenotípico de células progenitoras de retina humana |
KR20190060016A (ko) | 2014-10-20 | 2019-05-31 | 뉴럴스템, 인크. | 성장 인자를 코딩하는 외인성 폴리뉴클레오티드를 포함하는 안정한 신경 줄기세포 및 그의 사용 방법 |
JP6844953B2 (ja) * | 2015-04-22 | 2021-03-17 | 公益財団法人東京都医学総合研究所 | アルツハイマー病研究を標的にしたグリア細胞システム |
CN105861482B (zh) * | 2016-04-05 | 2019-10-11 | 中国科学院广州生物医药与健康研究院 | 体外细胞疾病模型及其制备方法 |
JP2020519237A (ja) * | 2017-04-13 | 2020-07-02 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ヒトオリゴデンドロサイトを作製しインビトロでの髄鞘形成を研究するための個別化された神経系3d培養系 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0233838A3 (de) * | 1986-02-04 | 1990-01-31 | Incyte Pharmaceuticals, Inc. | Neuriten stimulierender Faktor und Prozess für seine Herstellung |
WO1991009936A1 (en) * | 1989-12-26 | 1991-07-11 | Hana Biologics, Inc. | Proliferated neuron progenitor cell product and process |
ATE240389T1 (de) * | 1991-07-08 | 2003-05-15 | Neurospheres Holdings Ltd | Auf wachstumsfaktoren reagierende neurale vorläuferzellen, die in vitro vermehrt werden können. |
CA2148138C (en) * | 1992-10-28 | 2002-01-08 | Samuel Weiss | Biological factors and neural stem cells |
-
1995
- 1995-09-22 DK DK95931864T patent/DK0783693T3/da active
- 1995-09-22 DE DE69523771T patent/DE69523771T2/de not_active Expired - Lifetime
- 1995-09-22 ES ES95931864T patent/ES2167461T3/es not_active Expired - Lifetime
- 1995-09-22 WO PCT/CA1995/000542 patent/WO1996009543A1/en active IP Right Grant
- 1995-09-22 DE DE69535300T patent/DE69535300T2/de not_active Expired - Lifetime
- 1995-09-22 KR KR1019970701845A patent/KR970706490A/ko not_active Application Discontinuation
- 1995-09-22 AU AU35152/95A patent/AU714837B2/en not_active Ceased
- 1995-09-22 JP JP8510484A patent/JPH10505754A/ja active Pending
- 1995-09-22 EP EP95931864A patent/EP0783693B1/de not_active Expired - Lifetime
- 1995-09-22 DK DK01101622T patent/DK1130394T3/da active
- 1995-09-22 CA CA002200709A patent/CA2200709A1/en not_active Abandoned
- 1995-09-22 MX MX9702126A patent/MX9702126A/es unknown
- 1995-09-22 AT AT95931864T patent/ATE208495T1/de not_active IP Right Cessation
- 1995-09-22 AT AT01101622T patent/ATE345496T1/de not_active IP Right Cessation
- 1995-09-22 PT PT95931864T patent/PT783693E/pt unknown
- 1995-09-22 EP EP01101622A patent/EP1130394B1/de not_active Expired - Lifetime
-
1997
- 1997-03-18 NO NO971245A patent/NO971245L/no unknown
- 1997-03-20 FI FI971168A patent/FI971168A0/fi unknown
Also Published As
Publication number | Publication date |
---|---|
EP0783693A1 (de) | 1997-07-16 |
NO971245D0 (no) | 1997-03-18 |
NO971245L (no) | 1997-03-18 |
CA2200709A1 (en) | 1996-03-28 |
WO1996009543A1 (en) | 1996-03-28 |
DK1130394T3 (da) | 2007-01-08 |
EP0783693B1 (de) | 2001-11-07 |
DE69523771T2 (de) | 2002-08-01 |
PT783693E (pt) | 2002-04-29 |
KR970706490A (ko) | 1997-11-03 |
FI971168A (fi) | 1997-03-20 |
MX9702126A (es) | 1997-06-28 |
FI971168A0 (fi) | 1997-03-20 |
ATE208495T1 (de) | 2001-11-15 |
AU714837B2 (en) | 2000-01-13 |
EP1130394A1 (de) | 2001-09-05 |
DK0783693T3 (da) | 2002-01-14 |
DE69535300T2 (de) | 2007-06-06 |
ES2167461T3 (es) | 2002-05-16 |
DE69535300D1 (de) | 2006-12-28 |
EP1130394B1 (de) | 2006-11-15 |
JPH10505754A (ja) | 1998-06-09 |
AU3515295A (en) | 1996-04-09 |
DE69523771D1 (de) | 2001-12-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE345496T1 (de) | In-vitro-musters für zns - funktion und dysfunktion | |
DE69332759D1 (de) | Biologische faktoren und neuronale stammzellen | |
DE60017875D1 (de) | Verwendung von collagenase in der zubereitung von neuralen stammzellkulturen | |
FI961855A0 (fi) | Hermostojärjestelmään kuuluvien kantasolujen manipulointi ja modifiointi | |
DK0664832T3 (da) | Remyelinisering med anvendelse af neurale stamceller | |
DE60044655D1 (de) | Angereicherte Zellpopulationen des zentralen Nervensystems | |
ATE207539T1 (de) | Zusammensetzung und verfahren zur regulierung der gehalte an endogenen cytokininen | |
ATE234965T1 (de) | Träger zur herstellung eines fahrwegs für spurgebundene fahrzeuge, insbesondere einer magnetschwebebahn, und damit hergestellter fahrweg | |
WO2000005343A3 (en) | Cell expansion system for use in neural transplantation | |
DE3871530D1 (de) | Vorrichtung zum kultivieren von ruhenden zellen in einem bioreaktor. | |
DE69331696D1 (de) | Stabilisierte kultur von zellularaggregaten und verfahren zur entwicklung von embryos aus proembryogenen stämmen für die regeneration von weinreben | |
ATE58397T1 (de) | Monoklonaler antikoerper geeignet zur spezifischen unterscheidung von humanen hepatokarzinomzellen. | |
Barashkov et al. | Toxicity of Copper Compounds for Chlorella Pyrenoidosa Beyer | |
ATE50286T1 (de) | Cosmid mit wasserstoffaufnehmenden genen und verfahren zu dessen herstellung. | |
Song et al. | The Mouse Embryo Culture System: Improving the Sensitivity for Use as a Quality Control Assay for Human in vitro Fertilization | |
JACOBY | FRANCOIS BOUCHER'S EARLY DEVELOPMENT AS A DRAUGHTSMAN: 1720-1734 (FRANCE) | |
IL129028A0 (en) | Method for in vitro determination of erythropoietin bioactivity | |
DE3668469D1 (de) | Verfahren zur zuechtung von hepatozyten und cozuechtung von hepatozyten und von behandelten epithelien leberzellen. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |