DE69832402D1 - Erzeugung von hämatopoietischen zellen aus multipotenten neuronalen stammzellen - Google Patents
Erzeugung von hämatopoietischen zellen aus multipotenten neuronalen stammzellenInfo
- Publication number
- DE69832402D1 DE69832402D1 DE69832402T DE69832402T DE69832402D1 DE 69832402 D1 DE69832402 D1 DE 69832402D1 DE 69832402 T DE69832402 T DE 69832402T DE 69832402 T DE69832402 T DE 69832402T DE 69832402 D1 DE69832402 D1 DE 69832402D1
- Authority
- DE
- Germany
- Prior art keywords
- hematopoietic
- cells
- mnsc
- progeny
- vivo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/08—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Developmental Biology & Embryology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US100679 | 1987-09-29 | ||
US6028997P | 1997-09-29 | 1997-09-29 | |
US60289P | 1997-09-29 | ||
US09/100,679 US6093531A (en) | 1997-09-29 | 1998-06-19 | Generation of hematopoietic cells from multipotent neural stem cells |
PCT/CA1998/000916 WO1999016863A1 (en) | 1997-09-29 | 1998-09-28 | Generation of hematopoietic cells from multipotent neural stem cells |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69832402D1 true DE69832402D1 (de) | 2005-12-22 |
DE69832402T2 DE69832402T2 (de) | 2006-08-10 |
Family
ID=26739784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69832402T Expired - Fee Related DE69832402T2 (de) | 1997-09-29 | 1998-09-28 | Erzeugung von hämatopoietischen zellen aus multipotenten neuronalen stammzellen |
Country Status (11)
Country | Link |
---|---|
US (3) | US6093531A (de) |
EP (1) | EP1019493B1 (de) |
JP (1) | JP2001518289A (de) |
AT (1) | ATE310077T1 (de) |
AU (1) | AU9249598A (de) |
CA (1) | CA2304007A1 (de) |
DE (1) | DE69832402T2 (de) |
DK (1) | DK1019493T3 (de) |
ES (1) | ES2255179T3 (de) |
NO (1) | NO324708B1 (de) |
WO (1) | WO1999016863A1 (de) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6787355B1 (en) | 1996-08-26 | 2004-09-07 | Mcgill University | Multipotent neural stem cells from peripheral tissues and uses thereof |
US7795202B2 (en) | 1997-08-04 | 2010-09-14 | Neurorepair, Inc. | Methods for treating a neurological disorder by peripheral administration of a transforming growth factor alpha (TGF-a) |
CN1273534A (zh) * | 1997-08-04 | 2000-11-15 | 加利福尼亚大学董事会 | 治疗神经缺损的方法 |
US20010007657A1 (en) * | 1997-08-04 | 2001-07-12 | Reid James Steven | Compositions and methods for manipulating glial progenitor cells and treating neurological deficits |
US20020123143A1 (en) * | 1997-08-22 | 2002-09-05 | Jean Toma | Multipotent stem cells from peripheral tissues and uses thereof |
US20020016002A1 (en) * | 2000-01-24 | 2002-02-07 | Jean Toma | Multipotent neural stem cells from peripheral tissues and uses thereof |
US6093531A (en) * | 1997-09-29 | 2000-07-25 | Neurospheres Holdings Ltd. | Generation of hematopoietic cells from multipotent neural stem cells |
US6638501B1 (en) * | 1997-09-29 | 2003-10-28 | Neurospheres Holdings Ltd. | Use of multipotent neural stem cell progeny to augment non-neural tissues |
SE9802264D0 (sv) | 1998-06-25 | 1998-06-25 | Neuronova Ab | A method of isolating cells |
US6541247B1 (en) | 1998-06-25 | 2003-04-01 | Neuronova Ab | Method of isolating ependymal neural stem cells |
US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
US8075881B2 (en) | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
US8609412B2 (en) | 1999-08-05 | 2013-12-17 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
US10638734B2 (en) | 2004-01-05 | 2020-05-05 | Abt Holding Company | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
WO2001011011A2 (en) | 1999-08-05 | 2001-02-15 | Mcl Llc | Multipotent adult stem cells and methods for isolation |
US8252280B1 (en) | 1999-08-05 | 2012-08-28 | Regents Of The University Of Minnesota | MAPC generation of muscle |
US7514259B2 (en) * | 2000-02-11 | 2009-04-07 | Schepens Eye Research Institute | Isolation and transplantation of retinal stem cells |
AU2001284923A1 (en) * | 2000-08-15 | 2002-02-25 | Geron Corporation | Reprogramming cells for enhanced differentiation capacity using pluripotent stemcells |
JP4294316B2 (ja) | 2000-12-06 | 2009-07-08 | ハリリ,ロバート,ジェイ. | 胎盤幹細胞の回収方法 |
US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
CA2438501C (en) | 2001-02-14 | 2014-09-16 | Leo T. Furcht | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
EP2316918B1 (de) | 2001-02-14 | 2015-07-01 | Anthrogenesis Corporation | Post-Partum Säugetier-Plazenta, deren Verwendung und daraus gewonnene Stammzellen |
US7838292B1 (en) * | 2001-03-29 | 2010-11-23 | University Of Louisville Research Foundation, Inc. | Methods for obtaining adult human olfactory progenitor cells |
US20030017587A1 (en) * | 2001-07-18 | 2003-01-23 | Rader William C. | Embryonic stem cells, clinical applications and methods for expanding in vitro |
US20030211603A1 (en) * | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
US20050064587A1 (en) * | 2001-09-07 | 2005-03-24 | Lawrence Rosenberg | Pancreatic small cells and uses thereof |
US20030099621A1 (en) * | 2001-11-29 | 2003-05-29 | Robert Chow | Stem cell screening and transplantation therapy for HIV infection |
DE10162080A1 (de) * | 2001-12-10 | 2003-06-26 | Albrecht Mueller | Verfahren zur Herstellung von Stammzellen mit erhöhtem Entwicklungspotential |
JP4374469B2 (ja) * | 2002-01-09 | 2009-12-02 | 独立行政法人科学技術振興機構 | 記憶障害治療剤 |
US7682803B2 (en) | 2005-10-13 | 2010-03-23 | Anthrogenesis Corporation | Immunomodulation using placental stem cells |
WO2003080818A1 (fr) * | 2002-03-27 | 2003-10-02 | Institute Of Gene And Brain Science | Methode permettant d'induire la croissance des cellules souches nerveuses |
US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
CN1668733A (zh) * | 2002-05-30 | 2005-09-14 | 细胞基因公司 | 利用jnk或mkk抑制剂调节细胞分化并治疗骨髓增生异常和脊髓发育不良综合症的方法 |
EP2095823A1 (de) * | 2002-07-30 | 2009-09-02 | Stem Cell Therapeutics Inc. | Oligodendrozytenherstellung aus multipotenten neuralen Stammzellen |
BR0316695A (pt) | 2002-11-26 | 2005-10-18 | Anthrogenesis Corp | Unidade citoterapêutica, kit para tratamento, método de tratamento de uma enfermidade, biblioteca de unidades citoterapêuticas e método de tratamento de um paciente |
WO2004050859A2 (en) | 2002-11-27 | 2004-06-17 | Regents Of The University Of Minnesota | Homologous recombination in multipotent adult progenitor cells |
US20040219608A1 (en) * | 2003-04-29 | 2004-11-04 | Der-Balian Georges Puzant | Method of cell analysis using small volume of blood |
JP4620052B2 (ja) * | 2003-09-12 | 2011-01-26 | ステムセル テクノロジーズ インコーポレーティッド | 神経コロニー形成アッセイ法 |
US8187875B2 (en) * | 2004-02-26 | 2012-05-29 | Reliance Life Sciences Pvt. Ltd. | Dopaminergic neurons derived from corneal limbus, methods of isolation and uses thereof |
AU2005251379B2 (en) * | 2004-06-01 | 2011-03-31 | Kwalata Trading Limited | In vitro techniques for use with stem cells |
US20060110374A1 (en) * | 2004-11-24 | 2006-05-25 | Dudy Czeiger | Method to accelerate stem cell recruitment and homing |
EP1941032A2 (de) | 2005-10-14 | 2008-07-09 | Regents Of The University Of Minnesota | Differenzierung nichtembryonaler stammzellen zu zellen mit einem pankreatischen phänotyp |
AU2006315601A1 (en) * | 2005-11-14 | 2007-05-24 | Enterprise Partners Venture Capital | Stem cell factor therapy for tissue injury |
ES2706726T3 (es) | 2005-12-29 | 2019-04-01 | Celularity Inc | Poblaciones de células madre placentarias |
WO2007079184A2 (en) | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
TW200734462A (en) | 2006-03-08 | 2007-09-16 | In Motion Invest Ltd | Regulating stem cells |
KR100838013B1 (ko) * | 2006-06-07 | 2008-06-12 | 제일약품주식회사 | 인간배아줄기세포로부터 단계적 선별법을 통해 고수율로신경전구세포, 신경세포 및 기능성 도파민신경세포를생성하는 방법 |
CA2655990A1 (en) * | 2006-06-22 | 2007-12-27 | Tai June Yoo | Restoration of hearing loss |
AU2007321928A1 (en) | 2006-11-24 | 2008-05-29 | Regents Of The University Of Minnesota | Endodermal progenitor cells |
NZ579050A (en) * | 2007-02-06 | 2012-10-26 | Tai June Yoo | Treatment and prevention of neurodegenerative diseases using gene therapy |
JP5979811B2 (ja) | 2007-02-12 | 2016-08-31 | アンスロジェネシス コーポレーション | 胎盤幹細胞を使用した炎症性疾患の治療 |
US20080233088A1 (en) * | 2007-02-16 | 2008-09-25 | Varian Medical Systems Technologies, Inc. | Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo after transplantation |
EP2136646A1 (de) * | 2007-03-08 | 2009-12-30 | Raymond F. Sekula Jr. | Verfahren zur herstellung von gereinigten neuralen stammzellen und damit verwandte verfahren für die behandlung eines patienten |
EP2607477B1 (de) | 2007-05-03 | 2020-09-23 | The Brigham and Women's Hospital, Inc. | Multipotente stammzellen und ihre verwendung |
US8574567B2 (en) * | 2007-05-03 | 2013-11-05 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
CA2689484A1 (en) * | 2007-06-06 | 2008-12-11 | The Hospital For Sick Children | Skin-derived precursor cells and uses thereof |
US9200253B1 (en) | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
EP2203176B1 (de) | 2007-09-28 | 2014-11-26 | Anthrogenesis Corporation | Tumorsuppression mit menschlichem plazentaperfusat und menschlichen natürlichen killerzellen eines zwischenproduktes aus der plazenta |
EP2245141B1 (de) | 2008-01-18 | 2018-03-14 | Regents of the University of Minnesota | Stammzellenaggregate und verfahren zur herstellung und verwendung |
WO2010021714A2 (en) | 2008-08-20 | 2010-02-25 | Anthrogenesis Corporation | Improved cell composition and methods of making the same |
PE20110399A1 (es) | 2008-08-20 | 2011-06-22 | Anthrogenesis Corp | Tratamiento de la apoplejia utilizando celulas placentarias aisladas |
JP2012500792A (ja) | 2008-08-22 | 2012-01-12 | アンスロジェネシス コーポレーション | 胎盤細胞集団による骨欠損の治療のための方法および組成物 |
US8748177B2 (en) | 2008-09-30 | 2014-06-10 | The Hospital For Sick Children | Compositions for proliferation of cells and related methods |
WO2010049752A1 (en) | 2008-10-31 | 2010-05-06 | Katholieke Universiteit Leuven | Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells |
KR20110086176A (ko) | 2008-11-19 | 2011-07-27 | 안트로제네시스 코포레이션 | 양막 유래 부착성 세포 |
MX353489B (es) | 2009-07-02 | 2018-01-16 | Anthrogenesis Corp | Metodo para producir eritrocitos sin celulas alimentadoras. |
EP2529007B1 (de) | 2010-01-26 | 2017-07-12 | Anthrogenesis Corporation | Behandlung von knochenbedingten karzinomen mit plazentastammzellen |
MX347451B (es) | 2010-04-07 | 2017-04-27 | Anthrogenesis Corp | Angiogenesis utilizando celulas madre placentarias. |
JP2013523823A (ja) | 2010-04-08 | 2013-06-17 | アントフロゲネシス コーポレーション | 胎盤幹細胞を用いるサルコイドーシスの治療 |
SG10201913920PA (en) | 2010-05-12 | 2020-03-30 | Abt Holding Co | Modulation of splenocytes in cell therapy |
WO2011158125A2 (en) | 2010-06-17 | 2011-12-22 | Katholieke Universiteit Leuven | Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells |
KR20180099915A (ko) | 2010-07-13 | 2018-09-05 | 안트로제네시스 코포레이션 | 천연 킬러 세포의 생성 방법 |
SG10201914007YA (en) | 2010-08-24 | 2020-03-30 | Univ Minnesota | Non-static suspension culture of cell aggregates |
AR093183A1 (es) | 2010-12-31 | 2015-05-27 | Anthrogenesis Corp | Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras |
DK2714059T3 (en) | 2011-06-01 | 2019-01-21 | Celularity Inc | TREATMENT OF PAIN WHEN USING PLACENT STAM CELLS |
US9925221B2 (en) | 2011-09-09 | 2018-03-27 | Celularity, Inc. | Treatment of amyotrophic lateral sclerosis using placental stem cells |
EP2814947B1 (de) | 2012-02-17 | 2018-11-21 | Schepens Eye Research Institute | Phänotypenprofil menschlicher retina-vorläuferzellen |
CN115137753A (zh) | 2013-02-05 | 2022-10-04 | 细胞结构公司 | 来自胎盘的自然杀伤细胞 |
CA2909267C (en) | 2013-04-12 | 2022-10-25 | Saverio LA FRANCESCA | Improving organs for transplantation |
FR3026744B1 (fr) | 2014-10-06 | 2024-04-19 | Hopitaux Paris Assist Publique | Methode de generation de progeniteurs de cellules t |
EP4067482A1 (de) * | 2017-02-13 | 2022-10-05 | Assistance Publique - Hôpitaux de Paris | Verfahren zur erzeugung von t-zellen-vorläufern |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4714680B1 (en) * | 1984-02-06 | 1995-06-27 | Univ Johns Hopkins | Human stem cells |
US5082670A (en) * | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
US5635386A (en) * | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
US5437994A (en) * | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
JPH05509096A (ja) * | 1990-06-08 | 1993-12-16 | ニューヨークユニバーシティ | 骨髄間質細胞及び始原細胞の刺激 |
US5618531A (en) * | 1990-10-19 | 1997-04-08 | New York University | Method for increasing the viability of cells which are administered to the brain or spinal cord |
US5851832A (en) * | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
US6497872B1 (en) * | 1991-07-08 | 2002-12-24 | Neurospheres Holdings Ltd. | Neural transplantation using proliferated multipotent neural stem cells and their progeny |
US5589376A (en) * | 1992-07-27 | 1996-12-31 | California Institute Of Technology | Mammalian neural crest stem cells |
US5766948A (en) * | 1993-01-06 | 1998-06-16 | The Regents Of The University Of California | Method for production of neuroblasts |
US6432711B1 (en) * | 1993-11-03 | 2002-08-13 | Diacrin, Inc. | Embryonic stem cells capable of differentiating into desired cell lines |
ES2189807T3 (es) * | 1993-11-09 | 2003-07-16 | Neurospheres Holdings Ltd | Modificacion y manipulacion in situ de celulas madre del sistema nervioso central. |
US5591625A (en) * | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
US5639618A (en) * | 1994-05-13 | 1997-06-17 | Plurion, Inc. | Method of isolating a lineage specific stem cell in vitro |
AU716811B2 (en) * | 1994-11-14 | 2000-03-09 | Neurospheres Holdings Ltd | Regulation of neural stem cell proliferation |
US6890724B2 (en) * | 1996-09-06 | 2005-05-10 | California Institute Of Technology | Methods and compositions for neural progenitor cells |
US5968829A (en) * | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
US6093531A (en) | 1997-09-29 | 2000-07-25 | Neurospheres Holdings Ltd. | Generation of hematopoietic cells from multipotent neural stem cells |
US6638501B1 (en) * | 1997-09-29 | 2003-10-28 | Neurospheres Holdings Ltd. | Use of multipotent neural stem cell progeny to augment non-neural tissues |
-
1998
- 1998-06-19 US US09/100,679 patent/US6093531A/en not_active Expired - Fee Related
- 1998-09-28 DK DK98944943T patent/DK1019493T3/da active
- 1998-09-28 WO PCT/CA1998/000916 patent/WO1999016863A1/en active IP Right Grant
- 1998-09-28 CA CA002304007A patent/CA2304007A1/en not_active Abandoned
- 1998-09-28 AU AU92495/98A patent/AU9249598A/en not_active Abandoned
- 1998-09-28 JP JP2000513934A patent/JP2001518289A/ja active Pending
- 1998-09-28 DE DE69832402T patent/DE69832402T2/de not_active Expired - Fee Related
- 1998-09-28 EP EP98944943A patent/EP1019493B1/de not_active Expired - Lifetime
- 1998-09-28 ES ES98944943T patent/ES2255179T3/es not_active Expired - Lifetime
- 1998-09-28 AT AT98944943T patent/ATE310077T1/de not_active IP Right Cessation
-
2000
- 2000-03-23 NO NO20001509A patent/NO324708B1/no unknown
- 2000-07-24 US US09/624,199 patent/US6897060B1/en not_active Expired - Fee Related
-
2003
- 2003-02-21 US US10/371,779 patent/US7204979B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2255179T3 (es) | 2006-06-16 |
DK1019493T3 (da) | 2006-04-03 |
NO20001509D0 (no) | 2000-03-23 |
US6093531A (en) | 2000-07-25 |
EP1019493A1 (de) | 2000-07-19 |
ATE310077T1 (de) | 2005-12-15 |
US20030148515A1 (en) | 2003-08-07 |
US6897060B1 (en) | 2005-05-24 |
AU9249598A (en) | 1999-04-23 |
EP1019493B1 (de) | 2005-11-16 |
NO324708B1 (no) | 2007-12-03 |
NO20001509L (no) | 2000-05-23 |
WO1999016863A1 (en) | 1999-04-08 |
CA2304007A1 (en) | 1999-04-08 |
JP2001518289A (ja) | 2001-10-16 |
DE69832402T2 (de) | 2006-08-10 |
US7204979B2 (en) | 2007-04-17 |
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