GT200000158A - Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis. - Google Patents

Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis.

Info

Publication number
GT200000158A
GT200000158A GT200000158A GT200000158A GT200000158A GT 200000158 A GT200000158 A GT 200000158A GT 200000158 A GT200000158 A GT 200000158A GT 200000158 A GT200000158 A GT 200000158A GT 200000158 A GT200000158 A GT 200000158A
Authority
GT
Guatemala
Prior art keywords
piridines
replaced
inhibition activity
pyridacines
angiogenesis inhibition
Prior art date
Application number
GT200000158A
Other languages
English (en)
Spanish (es)
Inventor
Jaques P Dumas
Stephen James Boyer
Julie A Dixon
Teddy Kite Joe
Harold C E Kluender
Wendy Lee
Dhanapalan Nagarathnam
Robert N Sibley
Ning Su
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200000158A publication Critical patent/GT200000158A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
GT200000158A 1999-09-28 2000-09-22 Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis. GT200000158A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40760099A 1999-09-28 1999-09-28

Publications (1)

Publication Number Publication Date
GT200000158A true GT200000158A (es) 2002-03-16

Family

ID=23612752

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200000158A GT200000158A (es) 1999-09-28 2000-09-22 Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis.

Country Status (35)

Country Link
EP (1) EP1228063B1 (en:Method)
JP (1) JP4919567B2 (en:Method)
KR (3) KR100895572B1 (en:Method)
CN (3) CN100422173C (en:Method)
AR (3) AR025752A1 (en:Method)
AT (1) ATE422494T1 (en:Method)
AU (1) AU782820B2 (en:Method)
BG (1) BG65860B1 (en:Method)
BR (1) BRPI0014382B8 (en:Method)
CA (1) CA2385817C (en:Method)
CO (1) CO5200835A1 (en:Method)
CZ (1) CZ304767B6 (en:Method)
DE (1) DE60041548D1 (en:Method)
DO (1) DOP2000000070A (en:Method)
EE (1) EE05258B1 (en:Method)
ES (1) ES2320525T3 (en:Method)
GT (1) GT200000158A (en:Method)
HR (1) HRP20020308A2 (en:Method)
HU (1) HU230223B1 (en:Method)
IL (3) IL148880A0 (en:Method)
MA (1) MA25563A1 (en:Method)
MX (1) MXPA02003156A (en:Method)
MY (3) MY143377A (en:Method)
NO (1) NO20021520L (en:Method)
NZ (1) NZ518589A (en:Method)
PA (1) PA8503201A1 (en:Method)
PE (1) PE20010607A1 (en:Method)
PL (1) PL205957B1 (en:Method)
RS (1) RS50369B (en:Method)
RU (1) RU2260008C2 (en:Method)
SK (1) SK287417B6 (en:Method)
TW (1) TW593315B (en:Method)
UA (1) UA75053C2 (en:Method)
WO (1) WO2001023375A2 (en:Method)
ZA (1) ZA200202760B (en:Method)

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RU2264389C3 (ru) 2000-10-20 2018-06-01 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Азотсодержащие ароматические производные, их применение, лекарственное средство на их основе и способ лечения
AU2002364102A1 (en) * 2001-12-21 2003-07-30 Bayer Pharmaceuticals Corporation Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives
TWI299664B (en) 2003-01-06 2008-08-11 Osi Pharm Inc (2-carboxamido)(3-amino)thiophene compounds
PL1603566T3 (pl) * 2003-03-11 2009-07-31 Novartis Ag Zastosowanie pochodnych izochinoliny do leczenia raka i chorób związanych z kinezą MAP
US20070082910A1 (en) * 2003-04-08 2007-04-12 Mitsubishi Pharma Corporation Specific nad(p)h oxidase inhibitor
CN100450998C (zh) 2003-11-11 2009-01-14 卫材R&D管理有限公司 脲衍生物的制备方法
KR100553398B1 (ko) * 2004-03-12 2006-02-16 한미약품 주식회사 티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
EP2364699A1 (en) 2004-09-13 2011-09-14 Eisai R&D Management Co., Ltd. Joint use of sulfonamide based compound with angiogenesis inhibitor
US8772269B2 (en) 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
CN101001629B (zh) 2004-09-17 2010-05-05 卫材R&D管理有限公司 药物组合物
JP4989476B2 (ja) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
EP2010173A1 (en) * 2006-04-15 2009-01-07 Bayer HealthCare AG Compounds for treating pulmonary hypertension
CA2652442C (en) 2006-05-18 2014-12-09 Eisai R & D Management Co., Ltd. Antitumor agent for thyroid cancer
EP2065372B1 (en) 2006-08-28 2012-11-28 Eisai R&D Management Co., Ltd. Antitumor agent for undifferentiated gastric cancer
CN101600694A (zh) 2007-01-29 2009-12-09 卫材R&D管理有限公司 未分化型胃癌治疗用组合物
CA2704000C (en) 2007-11-09 2016-12-13 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
CN101481380B (zh) * 2008-01-08 2012-10-17 浙江医药股份有限公司新昌制药厂 噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
BR112012032462A2 (pt) 2010-06-25 2016-11-08 Eisai R&D Man Co Ltd agente antitumoral empregando compostos que, em combinação, têm efeito inibidor de quinase.
US8962650B2 (en) 2011-04-18 2015-02-24 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
JP6038128B2 (ja) 2011-06-03 2016-12-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
BR112015009004A8 (pt) 2012-12-21 2021-07-20 Eisai R&D Man Co Ltd forma amorfa de derivado de quinolina e método de produção da mesma
CA2912219C (en) 2013-05-14 2021-11-16 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
CN103396361B (zh) * 2013-07-24 2016-05-04 中国人民解放军第二军医大学 3,4-二氢异喹啉类抗肿瘤化合物及其制备方法与应用
JO3783B1 (ar) 2014-08-28 2021-01-31 Eisai R&D Man Co Ltd مشتق كوينولين عالي النقاء وطريقة لإنتاجه
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BR112019014127A2 (pt) 2017-02-08 2020-02-11 Eisai R&D Management Co., Ltd. Composição farmacêutica para tratamento de tumores
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ES2241781T3 (es) * 2000-02-09 2005-11-01 Novartis Ag Derivados de piridina inhibidores de la angiogenesis y/o del receptor tirosina quinasa de vegf.

Also Published As

Publication number Publication date
MA25563A1 (fr) 2002-10-01
CO5200835A1 (es) 2002-09-27
CA2385817C (en) 2010-05-04
CN100422173C (zh) 2008-10-01
BR0014382B1 (pt) 2014-04-01
RS50369B (sr) 2009-11-10
HK1091818A1 (zh) 2007-01-26
EE05258B1 (et) 2010-02-15
ATE422494T1 (de) 2009-02-15
IL193368A0 (en) 2009-02-11
MY135058A (en) 2008-01-31
PL366342A1 (en) 2005-01-24
NZ518589A (en) 2005-03-24
AR082231A2 (es) 2012-11-21
SK287417B6 (sk) 2010-09-07
EE200200161A (et) 2003-08-15
CZ20021444A3 (cs) 2002-08-14
DE60041548D1 (de) 2009-03-26
AU1569601A (en) 2001-04-30
PA8503201A1 (es) 2002-08-26
BG106637A (bg) 2003-02-28
KR100895572B1 (ko) 2009-04-29
KR100895571B1 (ko) 2009-04-29
IL148880A0 (en) 2002-09-12
CZ304767B6 (cs) 2014-10-08
WO2001023375A3 (en) 2002-05-02
IL193367A (en) 2011-03-31
KR20020038775A (ko) 2002-05-23
EP1228063B1 (en) 2009-02-11
HRP20020308B1 (en:Method) 2013-01-31
MY143580A (en) 2011-05-31
DOP2000000070A (es) 2002-02-28
JP2003526632A (ja) 2003-09-09
MXPA02003156A (es) 2002-09-30
CA2385817A1 (en) 2001-04-05
PE20010607A1 (es) 2001-07-12
RU2260008C2 (ru) 2005-09-10
ES2320525T3 (es) 2009-05-25
SK5912002A3 (en) 2003-01-09
MY143377A (en) 2011-05-13
JP4919567B2 (ja) 2012-04-18
PL205957B1 (pl) 2010-06-30
TW593315B (en) 2004-06-21
NO20021520L (no) 2002-05-23
CN1420879A (zh) 2003-05-28
NO20021520D0 (no) 2002-03-26
BG65860B1 (bg) 2010-03-31
AR082232A2 (es) 2012-11-21
HK1091819A1 (zh) 2007-01-26
AR025752A1 (es) 2002-12-11
UA75053C2 (en) 2006-03-15
HUP0202704A3 (en) 2003-12-29
BR0014382A (pt) 2003-06-24
CN1769282A (zh) 2006-05-10
EP1228063A2 (en) 2002-08-07
AU782820B2 (en) 2005-09-01
KR20080086547A (ko) 2008-09-25
KR100890473B1 (ko) 2009-03-26
IL193367A0 (en) 2009-02-11
ZA200202760B (en) 2003-10-29
HRP20020308A2 (en) 2004-06-30
YU22902A (sh) 2004-12-31
HU230223B1 (en) 2015-10-28
CN100422172C (zh) 2008-10-01
BRPI0014382B8 (pt) 2021-05-25
WO2001023375A2 (en) 2001-04-05
HUP0202704A2 (hu) 2002-12-28
IL193368A (en) 2011-05-31
KR20080091505A (ko) 2008-10-13
CN1769283A (zh) 2006-05-10
CN100374435C (zh) 2008-03-12

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