ECSP024400A - Derivados de pleuromutilina que tiene actividad antibacteriana - Google Patents

Derivados de pleuromutilina que tiene actividad antibacteriana

Info

Publication number
ECSP024400A
ECSP024400A EC2002004400A ECSP024400A ECSP024400A EC SP024400 A ECSP024400 A EC SP024400A EC 2002004400 A EC2002004400 A EC 2002004400A EC SP024400 A ECSP024400 A EC SP024400A EC SP024400 A ECSP024400 A EC SP024400A
Authority
EC
Ecuador
Prior art keywords
antibacterial activity
pleuromutiline
derivatives
mutilins
acetyl
Prior art date
Application number
EC2002004400A
Other languages
English (en)
Inventor
Gerd Ascher
Heinz Berner
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Publication of ECSP024400A publication Critical patent/ECSP024400A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/53—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/95—Spiro compounds containing "not free" spiro atoms
    • C07C2603/98—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members
    • C07C2603/99—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members containing eight-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a un compuesto seleccionado a partir de: 14-0-[(cicloalquil-sulfanil) acetil] mutilinas; 0 14-o-[(cicloalcoxi) acetil] mutilinas; o 14-0-[(cicloalquil-alcoxi) acetil] mutilinas, y su uso como un producto farmacéutico.
EC2002004400A 2000-07-11 2002-12-20 Derivados de pleuromutilina que tiene actividad antibacteriana ECSP024400A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0017031.6A GB0017031D0 (en) 2000-07-11 2000-07-11 Antimicrobials

Publications (1)

Publication Number Publication Date
ECSP024400A true ECSP024400A (es) 2003-02-06

Family

ID=9895454

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2002004400A ECSP024400A (es) 2000-07-11 2002-12-20 Derivados de pleuromutilina que tiene actividad antibacteriana

Country Status (29)

Country Link
US (1) US6753445B2 (es)
EP (1) EP1305282B1 (es)
JP (2) JP4255282B2 (es)
KR (1) KR100893426B1 (es)
CN (1) CN1308301C (es)
AR (1) AR029590A1 (es)
AT (1) ATE408596T1 (es)
AU (2) AU7638901A (es)
BR (1) BRPI0112452B8 (es)
CA (1) CA2412932C (es)
CZ (1) CZ200342A3 (es)
DE (1) DE60135848D1 (es)
EC (1) ECSP024400A (es)
ES (1) ES2313969T3 (es)
GB (1) GB0017031D0 (es)
HK (1) HK1052683B (es)
HU (1) HU229510B1 (es)
IL (2) IL153839A0 (es)
MX (1) MXPA02012828A (es)
NO (1) NO329091B1 (es)
NZ (1) NZ523415A (es)
PE (1) PE20020144A1 (es)
PL (1) PL209305B1 (es)
RU (1) RU2003103101A (es)
SI (1) SI1305282T1 (es)
SK (1) SK292003A3 (es)
TW (1) TWI311552B (es)
WO (1) WO2002004414A1 (es)
ZA (1) ZA200300280B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0017031D0 (en) * 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
GB0207495D0 (en) * 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
GB0209262D0 (en) * 2002-04-23 2002-06-05 Biochemie Gmbh Organic compounds
WO2007000004A1 (en) * 2005-06-27 2007-01-04 Nabriva Therapeutics Forschungs Gmbh Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
GB0513058D0 (en) * 2005-06-27 2005-08-03 Sandoz Ag Organic compounds
GB0515995D0 (en) * 2005-08-03 2005-09-07 Sandoz Ag Organic compounds
EP1808431A1 (en) * 2006-01-16 2007-07-18 Nabriva Therapeutics Forschungs GmbH Mutilin derivatives and their use as pharmaceutical
EP1972618A1 (en) * 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes
US8222407B2 (en) 2007-05-24 2012-07-17 Kyorin Pharmaceutical Co., Ltd. Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
EP2159220A1 (en) * 2008-09-02 2010-03-03 Nabriva Therapeutics AG Organic compounds
CN101671367B (zh) * 2008-09-12 2012-09-05 中国科学院上海药物研究所 截短侧耳素磷酸酯类化合物、其药物组合物及其制备方法和用途
WO2010056855A1 (en) * 2008-11-13 2010-05-20 Teva Pharmaceutical Industries Ltd. Preparation of retapamulin via its pleuromutilin-thiol precursor
EP2399904A1 (en) * 2010-05-26 2011-12-28 Nabriva Therapeutics AG Process for the preparation of pleuromutilins
CN103204787B (zh) * 2012-01-17 2014-10-01 北京艾百诺科技有限公司 含有取代方酸的乙酸妙林酯及其应用
CN102924350B (zh) * 2012-10-31 2014-04-09 中国农业科学院兰州畜牧与兽药研究所 截短侧耳素衍生物及其制备方法和应用
JP6818019B2 (ja) 2015-06-17 2021-01-20 ナブリヴァ セラピュティクス ゲーエムベーハー レファムリンの注射可能医薬組成物
TWI762573B (zh) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化
US11518740B2 (en) * 2021-04-24 2022-12-06 Shaanxi University Of Science And Technology Pleuromutilin (phenylthio)acetic acid ester with anti-drug resistant bacteria activity and a method of preparing the same
CN115850137B (zh) * 2022-11-12 2024-04-12 中国农业科学院兰州畜牧与兽药研究所 一种截短侧耳素衍生化合物及其制备方法与应用
KR20250045011A (ko) 2023-09-25 2025-04-01 박세형 피부에서 탈부착이 가능한 의료용 테이프

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT301753B (de) * 1969-07-25 1972-09-25 Biochemie Gmbh Verfahren zur Herstellung neuer Pleuromutilin-Derivate
BE789629A (fr) * 1971-10-05 1973-04-03 Sandoz Sa Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique
FR2526019A1 (fr) * 1982-04-28 1983-11-04 Sandoz Sa Nouveaux derives de la pleuromutiline, leur preparation et leur utilisation comme medicaments
BE896512A (fr) * 1982-04-28 1983-10-20 Sandoz Ag Nouveaux derives de la pleuromutiline, leur preparation et leur utilisation comme medicaments
DE3560511D1 (en) * 1984-02-17 1987-10-01 Sandoz Ag Pleuromutilin derivatives, process for their preparation and their use
HU208115B (en) 1989-10-03 1993-08-30 Biochemie Gmbh New process for producting pleuromutilin derivatives
JP3054875B2 (ja) * 1995-02-13 2000-06-19 株式会社小松製作所 プラズマトーチ
GB9614017D0 (en) * 1996-07-04 1996-09-04 Biochemie Gmbh Organic compounds
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
WO2000027790A1 (en) 1998-11-11 2000-05-18 Smithkline Beecham P.L.C. Mutilin compounds
GB0017031D0 (en) 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials

Also Published As

Publication number Publication date
PL209305B1 (pl) 2011-08-31
ATE408596T1 (de) 2008-10-15
KR100893426B1 (ko) 2009-04-17
AR029590A1 (es) 2003-07-02
JP4255282B2 (ja) 2009-04-15
WO2002004414A1 (en) 2002-01-17
NO20030100L (no) 2003-01-09
JP2009108088A (ja) 2009-05-21
HUP0301478A2 (hu) 2003-09-29
GB0017031D0 (en) 2000-08-30
DE60135848D1 (de) 2008-10-30
RU2003103101A (ru) 2004-07-27
US6753445B2 (en) 2004-06-22
CZ200342A3 (cs) 2003-04-16
IL153839A0 (en) 2003-07-31
PE20020144A1 (es) 2002-03-08
BR0112452A (pt) 2003-07-22
JP5173763B2 (ja) 2013-04-03
HU229510B1 (en) 2014-01-28
NZ523415A (en) 2004-10-29
MXPA02012828A (es) 2003-09-05
AU7638901A (en) 2002-01-21
NO20030100D0 (no) 2003-01-09
CA2412932C (en) 2011-01-04
EP1305282B1 (en) 2008-09-17
CA2412932A1 (en) 2002-01-17
PL358674A1 (en) 2004-08-09
BRPI0112452B1 (pt) 2015-06-09
EP1305282A1 (en) 2003-05-02
HK1052683B (en) 2009-05-22
KR20030066581A (ko) 2003-08-09
SK292003A3 (en) 2003-07-01
HUP0301478A3 (en) 2006-02-28
ZA200300280B (en) 2004-04-08
US20030162831A1 (en) 2003-08-28
BRPI0112452B8 (pt) 2021-05-25
HK1052683A1 (en) 2003-09-26
CN1308301C (zh) 2007-04-04
IL153839A (en) 2012-03-29
NO329091B1 (no) 2010-08-23
AU2001276389B2 (en) 2005-03-03
SI1305282T1 (sl) 2009-02-28
CN1441778A (zh) 2003-09-10
ES2313969T3 (es) 2009-03-16
JP2004502755A (ja) 2004-01-29
TWI311552B (en) 2009-07-01

Similar Documents

Publication Publication Date Title
ECSP024400A (es) Derivados de pleuromutilina que tiene actividad antibacteriana
NO985643L (no) Antimikrobielle blandinger
BR9911724A (pt) Ciclosporina que tem um perfil de atividade melhorado
EP0695171A1 (en) GONADOTROPINE CONTAINING FREEZER DRIED DROPS
ES2195970T3 (es) L-ribavirina y usos de la misma.
BR0209242A (pt) Aminopolidiorganossiloxanos amido-funcionais
DE69001730D1 (de) Pastenfoermige, waesserige pharmazeutische zusammensetzungen.
DK1098988T4 (da) Födevare
DK1139789T3 (da) Alfa-amylase-resistent stivelse til fremstilling af nærings- og lægemidler
GT200000158A (es) Piridinas y piridacinas sustituidas con actividad de inhibicion de angiogenesis.
ID23374A (id) Halogenopirimidin
PL375874A1 (pl) Wodne kompozycje farmaceutyczne 2,6-diizopropylofenolu
DE50004334D1 (de) Desodoriende zubereitungen enthaltend wasserlösliche -(1,3)-glucane
FR2805464B1 (fr) Preparations cosmetiques contenant des extraits de la plante mourera fluviatilis
CA2327784A1 (en) Triazolones with a neuroprotective action
WO2004039326A3 (en) Propofol with cysteine
AU2094200A (en) Cosmetic or medical preparation for topical use
ATE160573T1 (de) 1,3.5 (10) - estratriene derivate mit oraler wirkung
BR0112537A (pt) Preparações cosméticas de embelezamento contendo dialquilcarbonatos e óxidos de metal
ES2157419T3 (es) Arilazadioxacicloalquenos substituidos, fungicidas.
ID27733A (id) Metoksiminofenilasetamida
BR9810407A (pt) Compostos fluormetoximino
AU3315200A (en) 1,5-anhydro-d-fructose substituted with a hydrophobic group for use as anti-oxidant and/or emulsifier
ATE275551T1 (de) Halogenpyrimidine
BR9907340A (pt) Ciclo-heptenos substituìdos, e processo para a produção de um composto