BRPI0112452B8 - derivados de pleuromutilinas tendo atividade antibacteriana e composição farmacêutica contendo os mesmos - Google Patents

derivados de pleuromutilinas tendo atividade antibacteriana e composição farmacêutica contendo os mesmos

Info

Publication number
BRPI0112452B8
BRPI0112452B8 BRPI0112452A BR0112452A BRPI0112452B8 BR PI0112452 B8 BRPI0112452 B8 BR PI0112452B8 BR PI0112452 A BRPI0112452 A BR PI0112452A BR 0112452 A BR0112452 A BR 0112452A BR PI0112452 B8 BRPI0112452 B8 BR PI0112452B8
Authority
BR
Brazil
Prior art keywords
antibacterial activity
pharmaceutical composition
composition containing
pleuromutilin derivatives
mutilins
Prior art date
Application number
BRPI0112452A
Other languages
English (en)
Other versions
BRPI0112452B1 (pt
BR0112452A (pt
Inventor
Ascher Gerd
Berner Heinz
Original Assignee
Biochemie Gmbh
Nabriva Therapeutics Ag
Nabriva Therapeutics GmbH
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie Gmbh, Nabriva Therapeutics Ag, Nabriva Therapeutics GmbH, Sandoz Ag filed Critical Biochemie Gmbh
Publication of BR0112452A publication Critical patent/BR0112452A/pt
Publication of BRPI0112452B1 publication Critical patent/BRPI0112452B1/pt
Publication of BRPI0112452B8 publication Critical patent/BRPI0112452B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/53—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/95—Spiro compounds containing "not free" spiro atoms
    • C07C2603/98—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members
    • C07C2603/99—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members containing eight-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

derivados de pleuromutilinas tendo atividade antibacteriana composto selecionado entre 14-0-[(cicloalquil-sulfanil)acetil]- mutilinas; 14-0-[( cicloalquil-alquil-sulfanil)acetil]mutilinas; 14-0-[( cicloalcóxi)acetil] mutilinas; ou 14-0-[(cicloalquil-alcóxi)acetil]mutilinas e seu uso como fármaco.
BRPI0112452A 2000-07-11 2001-07-09 derivados de pleuromutilinas tendo atividade antibacteriana e composição farmacêutica contendo os mesmos BRPI0112452B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0017031.6A GB0017031D0 (en) 2000-07-11 2000-07-11 Antimicrobials
PCT/EP2001/007875 WO2002004414A1 (en) 2000-07-11 2001-07-09 Pleuromutilin derivatives having antibacterial activity

Publications (3)

Publication Number Publication Date
BR0112452A BR0112452A (pt) 2003-07-22
BRPI0112452B1 BRPI0112452B1 (pt) 2015-06-09
BRPI0112452B8 true BRPI0112452B8 (pt) 2021-05-25

Family

ID=9895454

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0112452A BRPI0112452B8 (pt) 2000-07-11 2001-07-09 derivados de pleuromutilinas tendo atividade antibacteriana e composição farmacêutica contendo os mesmos

Country Status (29)

Country Link
US (1) US6753445B2 (pt)
EP (1) EP1305282B1 (pt)
JP (2) JP4255282B2 (pt)
KR (1) KR100893426B1 (pt)
CN (1) CN1308301C (pt)
AR (1) AR029590A1 (pt)
AT (1) ATE408596T1 (pt)
AU (2) AU2001276389B2 (pt)
BR (1) BRPI0112452B8 (pt)
CA (1) CA2412932C (pt)
CZ (1) CZ200342A3 (pt)
DE (1) DE60135848D1 (pt)
EC (1) ECSP024400A (pt)
ES (1) ES2313969T3 (pt)
GB (1) GB0017031D0 (pt)
HK (1) HK1052683B (pt)
HU (1) HU229510B1 (pt)
IL (2) IL153839A0 (pt)
MX (1) MXPA02012828A (pt)
NO (1) NO329091B1 (pt)
NZ (1) NZ523415A (pt)
PE (1) PE20020144A1 (pt)
PL (1) PL209305B1 (pt)
RU (1) RU2003103101A (pt)
SI (1) SI1305282T1 (pt)
SK (1) SK292003A3 (pt)
TW (1) TWI311552B (pt)
WO (1) WO2002004414A1 (pt)
ZA (1) ZA200300280B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0017031D0 (en) * 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
GB0207495D0 (en) * 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
GB0209262D0 (en) 2002-04-23 2002-06-05 Biochemie Gmbh Organic compounds
GB0513058D0 (en) * 2005-06-27 2005-08-03 Sandoz Ag Organic compounds
EP2298733B1 (en) * 2005-06-27 2016-05-25 Nabriva Therapeutics AG Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
GB0515995D0 (en) * 2005-08-03 2005-09-07 Sandoz Ag Organic compounds
EP1808431A1 (en) * 2006-01-16 2007-07-18 Nabriva Therapeutics Forschungs GmbH Mutilin derivatives and their use as pharmaceutical
EP1972618A1 (en) * 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes
EP2149571A4 (en) 2007-05-24 2010-09-01 Kyorin Seiyaku Kk MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14
EP2159220A1 (en) * 2008-09-02 2010-03-03 Nabriva Therapeutics AG Organic compounds
CN101671367B (zh) * 2008-09-12 2012-09-05 中国科学院上海药物研究所 截短侧耳素磷酸酯类化合物、其药物组合物及其制备方法和用途
US20100184987A1 (en) * 2008-11-13 2010-07-22 Teva Pharmaceutical Industries Ltd. Preparation of Retapamulin via its Pleuromutilin-thiol precursor
EP2399904A1 (en) * 2010-05-26 2011-12-28 Nabriva Therapeutics AG Process for the preparation of pleuromutilins
CN103204787B (zh) * 2012-01-17 2014-10-01 北京艾百诺科技有限公司 含有取代方酸的乙酸妙林酯及其应用
CN102924350B (zh) * 2012-10-31 2014-04-09 中国农业科学院兰州畜牧与兽药研究所 截短侧耳素衍生物及其制备方法和应用
TWI762573B (zh) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化
US11518740B2 (en) * 2021-04-24 2022-12-06 Shaanxi University Of Science And Technology Pleuromutilin (phenylthio)acetic acid ester with anti-drug resistant bacteria activity and a method of preparing the same
CN115850137B (zh) * 2022-11-12 2024-04-12 中国农业科学院兰州畜牧与兽药研究所 一种截短侧耳素衍生化合物及其制备方法与应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT301753B (de) * 1969-07-25 1972-09-25 Biochemie Gmbh Verfahren zur Herstellung neuer Pleuromutilin-Derivate
BE789629A (fr) * 1971-10-05 1973-04-03 Sandoz Sa Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique
FR2526019A1 (fr) * 1982-04-28 1983-11-04 Sandoz Sa Nouveaux derives de la pleuromutiline, leur preparation et leur utilisation comme medicaments
BE896512A (fr) * 1982-04-28 1983-10-20 Sandoz Ag Nouveaux derives de la pleuromutiline, leur preparation et leur utilisation comme medicaments
EP0153277B1 (de) * 1984-02-17 1987-08-26 Sandoz Ag Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
HU208115B (en) * 1989-10-03 1993-08-30 Biochemie Gmbh New process for producting pleuromutilin derivatives
JP3054875B2 (ja) * 1995-02-13 2000-06-19 株式会社小松製作所 プラズマトーチ
GB9614017D0 (en) * 1996-07-04 1996-09-04 Biochemie Gmbh Organic compounds
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
WO2000027790A1 (en) 1998-11-11 2000-05-18 Smithkline Beecham P.L.C. Mutilin compounds
GB0017031D0 (en) 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials

Also Published As

Publication number Publication date
IL153839A (en) 2012-03-29
PL209305B1 (pl) 2011-08-31
HUP0301478A2 (hu) 2003-09-29
AU7638901A (en) 2002-01-21
CZ200342A3 (cs) 2003-04-16
NO20030100D0 (no) 2003-01-09
ECSP024400A (es) 2003-02-06
PE20020144A1 (es) 2002-03-08
ZA200300280B (en) 2004-04-08
AR029590A1 (es) 2003-07-02
HU229510B1 (en) 2014-01-28
WO2002004414A1 (en) 2002-01-17
AU2001276389B2 (en) 2005-03-03
KR100893426B1 (ko) 2009-04-17
EP1305282A1 (en) 2003-05-02
HUP0301478A3 (en) 2006-02-28
HK1052683B (zh) 2009-05-22
PL358674A1 (en) 2004-08-09
IL153839A0 (en) 2003-07-31
ES2313969T3 (es) 2009-03-16
CN1441778A (zh) 2003-09-10
NO329091B1 (no) 2010-08-23
JP2009108088A (ja) 2009-05-21
BRPI0112452B1 (pt) 2015-06-09
JP4255282B2 (ja) 2009-04-15
NO20030100L (no) 2003-01-09
ATE408596T1 (de) 2008-10-15
JP5173763B2 (ja) 2013-04-03
NZ523415A (en) 2004-10-29
RU2003103101A (ru) 2004-07-27
CN1308301C (zh) 2007-04-04
US20030162831A1 (en) 2003-08-28
KR20030066581A (ko) 2003-08-09
JP2004502755A (ja) 2004-01-29
EP1305282B1 (en) 2008-09-17
TWI311552B (en) 2009-07-01
US6753445B2 (en) 2004-06-22
SI1305282T1 (sl) 2009-02-28
HK1052683A1 (en) 2003-09-26
DE60135848D1 (de) 2008-10-30
CA2412932C (en) 2011-01-04
BR0112452A (pt) 2003-07-22
SK292003A3 (en) 2003-07-01
MXPA02012828A (es) 2003-09-05
CA2412932A1 (en) 2002-01-17
GB0017031D0 (en) 2000-08-30

Similar Documents

Publication Publication Date Title
BRPI0112452B8 (pt) derivados de pleuromutilinas tendo atividade antibacteriana e composição farmacêutica contendo os mesmos
BR9713734A (pt) Derivados de sulfonamidas, processo para sua preparação, e seu uso como medicamentos
AR066982A2 (es) Compuestos heteroaromaticos sustituidos como inhibidoress tirosin quinasa, composiciones farmaceuticas que los contiene y su uso en la preparacion de medicamentos
AR006678A1 (es) Derivados de macrolidas triciclicas, una composicion farmaceutica que los contiene, uso de los mismos para preparar medicamentos y procedimientopara su preparacion
BR9915247B1 (pt) compostos biaromáticos análogos da vitamina d, seus usos, composição farmacêutica e composição cosmética contendo os mesmos, e uso da composição cosmética.
BR0110767A (pt) Derivados de piperidina farmaceuticamente ativos, em particular como moduladores da atividade de receptor de quimiocina
ES2164182T3 (es) Benzociclopentanoxazolidinonas que contienen heteroatomos con actividad antibacteriana.
BR9909565A (pt) Derivados bicìclicos do ácido hidroxâmico
BR0111667A (pt) Novos compostos
EA200200571A1 (ru) Новая композиция и ее применение
BR0017030B8 (pt) derivados de tiazolilamida, processo para sua preparação, composição farmacêutica que os compreende e uso dos mesmos
EE03692B1 (et) 19-nor-pregneeni derivaadid, mis omavad progestaatilist toimet ja neid sisaldavad farmatseutilised kompositsioonid
HN2000000115A (es) Formulacion de sal comun y moxifloxacina
BR0015256A (pt) Composições farmacêuticas contendo uma droga de antibiótico de fluoroquinolona e uma goma de xantano
BR0012610A (pt) Novo derivado de difenilpiperidina
BR0007514A (pt) Macrolìdeos com atividade anti-inflamatória
ES2080037T1 (es) Medicamento de uso topico con actividad cicatrizante.
BR0014826A (pt) Imidazo-3-il-aminas bicìclicas, procedimento de sua preparação e medicamentos que as contêm
HRP20010684B1 (en) Directly compressible matrix for controlled release of single daily doses of clarithromycin
BRPI0406824A (pt) Indolonaoxazoldinonas antiibacterianas, intermediários para seu preparo e composições farmacêuticas que as contêm
IT1301968B1 (it) Derivati di eritromicina ad attivita' antibiotica
PT101444A (pt) Associacao sinergizante com efeito antagonista dos receptores nk1 e nk2, uso de produtos com actividade antagonista dos receptores nk1 e nk2 na sua preparacao e composicao farmaceutica contendo a referida associacao
ES2064398T3 (es) Un nuevo antibiotico, mersacidina, un procedimiento para su preparacion y su utilizacion como medicamento.
ES2171669T3 (es) Composicion farmaceutica que contiene hidrocloruro de tiagabina y su procedimiento de preparacion.
BR9812443A (pt) 1-2-3-4-5-6-hexahidro-2,6-metano-3-benzazocin-10-óis substituìdos, processos para sua preparação e seu emprego como medicamentos

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25D Requested change of name of applicant approved

Owner name: BIOCHEMIE GMBH (AT)

Free format text: NOME ALTERADO DE: BIOCHEMIE GESELLSCHAFT M.B.H.

B25D Requested change of name of applicant approved

Owner name: SANDOZ GMBH (AT)

Free format text: NOME ALTERADO DE: BIOCHEMIE GMBH

B25A Requested transfer of rights approved

Owner name: NABRIVA THERAPEUTICS AG (AT)

Free format text: TRANSFERIDO DE: SANDOZ GMBH

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/06/2015, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved
B25G Requested change of headquarter approved
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/07/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 21A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2678 DE 03-05-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.