|
US4842868A
(en)
*
|
1986-09-26 |
1989-06-27 |
Helwing Robert F |
Covalently bonded active agents with carbonium ion base groups
|
|
US5214132A
(en)
*
|
1986-12-23 |
1993-05-25 |
Kyowa Hakko Kogyo Co., Ltd. |
Polypeptide derivatives of human granulocyte colony stimulating factor
|
|
IE64284B1
(en)
*
|
1987-08-03 |
1995-07-26 |
Ddi Pharmaceuticals |
Conjugates of superoxide dismutase
|
|
NZ225880A
(en)
*
|
1987-08-21 |
1991-07-26 |
Wellcome Found |
A complex of polyethylene glycol and tissue plasminogen activator
|
|
JPH079429B2
(ja)
*
|
1988-10-12 |
1995-02-01 |
財団法人化学及血清療法研究所 |
人工担体およびその製造方法
|
|
US5091176A
(en)
*
|
1988-11-02 |
1992-02-25 |
W. R. Grace & Co.-Conn. |
Polymer-modified peptide drugs having enhanced biological and pharmacological activities
|
|
US5306500A
(en)
*
|
1988-11-21 |
1994-04-26 |
Collagen Corporation |
Method of augmenting tissue with collagen-polymer conjugates
|
|
US5510418A
(en)
*
|
1988-11-21 |
1996-04-23 |
Collagen Corporation |
Glycosaminoglycan-synthetic polymer conjugates
|
|
US5565519A
(en)
*
|
1988-11-21 |
1996-10-15 |
Collagen Corporation |
Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
|
|
US5162430A
(en)
*
|
1988-11-21 |
1992-11-10 |
Collagen Corporation |
Collagen-polymer conjugates
|
|
EP0395918A3
(en)
*
|
1989-04-13 |
1991-10-23 |
Vascular Laboratory, Inc. |
Plasminogen activator complex of pure pro-urokinase covalently bound by a disulfide bridge to human serum albumin
|
|
AU651949B2
(en)
*
|
1989-07-14 |
1994-08-11 |
American Cyanamid Company |
Cytokine and hormone carriers for conjugate vaccines
|
|
US5767072A
(en)
*
|
1989-09-14 |
1998-06-16 |
Board Of Regents, The University Of Texas System |
Therapeutic compositions comprising a CD4 peptide and methods of treatment of HIV infections
|
|
IE912365A1
(en)
*
|
1990-07-23 |
1992-01-29 |
Zeneca Ltd |
Continuous release pharmaceutical compositions
|
|
US5595732A
(en)
*
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US5382657A
(en)
*
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
WO1994011028A1
(en)
*
|
1992-11-16 |
1994-05-26 |
Centocor, Inc. |
Compounds having reduced immunogenicity and a method of reducing the immunogenicity of compounds
|
|
EP0675727B1
(en)
*
|
1992-12-10 |
2002-04-10 |
Enzon, Inc. |
Glycolipid enzyme-polymer conjugates
|
|
US5951974A
(en)
*
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
KR960705579A
(ko)
*
|
1993-11-10 |
1996-11-08 |
에릭에스. 딕커 |
개선된 인터페론 중합체 결합체(Improved interferon polymer conjugates)
|
|
US6458762B1
(en)
|
1994-03-28 |
2002-10-01 |
Baxter International, Inc. |
Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
|
|
EP0773975A4
(en)
*
|
1994-08-04 |
1998-06-10 |
Gordon George Wallace |
CONDUCTIVE ELECTROACTIVE BIOMATERIALS
|
|
US5738846A
(en)
*
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
|
US5770577A
(en)
*
|
1994-11-14 |
1998-06-23 |
Amgen Inc. |
BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
|
|
US5856451A
(en)
*
|
1994-12-07 |
1999-01-05 |
Novo Nordisk A/S |
Method for reducing respiratory allergenicity
|
|
US5695760A
(en)
*
|
1995-04-24 |
1997-12-09 |
Boehringer Inglehiem Pharmaceuticals, Inc. |
Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
|
|
US6428790B1
(en)
*
|
1995-04-27 |
2002-08-06 |
The United States Of America As Represented By The Secretary Department Of Health And Human Services |
Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use
|
|
US6458889B1
(en)
|
1995-12-18 |
2002-10-01 |
Cohesion Technologies, Inc. |
Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
|
|
US7883693B2
(en)
|
1995-12-18 |
2011-02-08 |
Angiodevice International Gmbh |
Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
|
|
US6833408B2
(en)
*
|
1995-12-18 |
2004-12-21 |
Cohesion Technologies, Inc. |
Methods for tissue repair using adhesive materials
|
|
DK0876165T3
(da)
*
|
1995-12-18 |
2007-08-06 |
Angiotech Biomaterials Corp |
Tværbundne polymersammensætninger og fremgangsmåder til deres fremstilling
|
|
BR9510676A
(pt)
*
|
1995-12-29 |
1999-11-23 |
Procter & Gamble |
Composições detergentes compreendendo enzinas imobilizadas
|
|
US6106828A
(en)
*
|
1996-02-15 |
2000-08-22 |
Novo Nordisk A/S |
Conjugation of polypeptides
|
|
AU725287B2
(en)
*
|
1996-02-15 |
2000-10-12 |
Novozymes A/S |
Conjugation of polypeptides
|
|
TW517067B
(en)
*
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
|
WO1998016201A1
(en)
|
1996-10-11 |
1998-04-23 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method
|
|
US6416756B1
(en)
|
1997-01-10 |
2002-07-09 |
Novozymes A/S |
Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care
|
|
JPH10276776A
(ja)
*
|
1997-04-07 |
1998-10-20 |
Toyobo Co Ltd |
可逆的に不活化された耐熱性dnaポリメラーゼ
|
|
CA2330859A1
(en)
*
|
1998-05-08 |
1999-11-18 |
University Of Southern California |
Size enhanced fibrinolytic enzymes
|
|
CA2334267C
(en)
*
|
1998-06-08 |
2009-02-17 |
F. Hoffmann-La Roche Ag |
Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c
|
|
US6461849B1
(en)
|
1998-10-13 |
2002-10-08 |
Novozymes, A/S |
Modified polypeptide
|
|
TWI242000B
(en)
*
|
1998-12-10 |
2005-10-21 |
Univ Southern California |
Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
|
|
US7112337B2
(en)
|
1999-04-23 |
2006-09-26 |
Alza Corporation |
Liposome composition for delivery of nucleic acid
|
|
US7238368B2
(en)
*
|
1999-04-23 |
2007-07-03 |
Alza Corporation |
Releasable linkage and compositions containing same
|
|
MXPA01010751A
(es)
*
|
1999-04-23 |
2002-05-14 |
Alza Corp |
Enlace liberable y composiciones que contienen el mismo.
|
|
US7303760B2
(en)
*
|
1999-04-23 |
2007-12-04 |
Alza Corporation |
Method for treating multi-drug resistant tumors
|
|
EP1198565A1
(en)
*
|
1999-07-07 |
2002-04-24 |
Maxygen Aps |
A method for preparing modified polypeptides
|
|
US6423666B1
(en)
|
1999-10-05 |
2002-07-23 |
Bio-Rad Laboratories, Inc. |
Large-pore chromatographic beads prepared by suspension polymerization
|
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
|
CZ20022727A3
(cs)
|
2000-01-10 |
2002-11-13 |
Maxygen Holdings Ltd |
Polypeptidový konjugát, způsob jeho výroby a farmaceutický prostředek
|
|
CA2739933A1
(en)
|
2000-02-11 |
2001-08-16 |
Bayer Healthcare Llc |
Factor vii or viia-like molecules
|
|
US7829074B2
(en)
|
2001-10-18 |
2010-11-09 |
Nektar Therapeutics |
Hydroxypatite-targeting poly(ethylene glycol) and related polymers
|
|
US6436386B1
(en)
|
2000-11-14 |
2002-08-20 |
Shearwater Corporation |
Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
|
|
CZ20032526A3
(cs)
|
2001-02-27 |
2003-12-17 |
Maxygen Aps |
Nové molekuly podobné interferonu beta
|
|
GB0123232D0
(en)
*
|
2001-09-26 |
2001-11-21 |
Smith & Nephew |
Polymers
|
|
JP2005508162A
(ja)
*
|
2001-10-02 |
2005-03-31 |
ジェネンテック・インコーポレーテッド |
Apo−2リガンド変異体とその使用法
|
|
EP1517710B1
(en)
|
2002-06-21 |
2011-03-30 |
Novo Nordisk Health Care AG |
Pegylated factor vii glycoforms
|
|
US20060141561A1
(en)
|
2002-06-24 |
2006-06-29 |
Kelley Robert F |
Apo-2 ligand/trail variants and uses thereof
|
|
AU2003285200A1
(en)
*
|
2002-11-09 |
2004-06-03 |
Nobex Corporation |
Modified carbamate-containing prodrugs and methods of synthesizing same
|
|
AU2003300076C1
(en)
*
|
2002-12-30 |
2010-03-04 |
Angiotech International Ag |
Drug delivery from rapid gelling polymer composition
|
|
WO2004060405A2
(en)
*
|
2002-12-30 |
2004-07-22 |
Angiotech International Ag |
Tissue reactive compounds and compositions and uses thereof
|
|
US20040151766A1
(en)
*
|
2003-01-30 |
2004-08-05 |
Monahan Sean D. |
Protein and peptide delivery to mammalian cells in vitro
|
|
GB0305989D0
(en)
*
|
2003-03-15 |
2003-04-23 |
Delta Biotechnology Ltd |
Agent
|
|
EP2263684A1
(en)
|
2003-10-10 |
2010-12-22 |
Novo Nordisk A/S |
IL-21 derivatives
|
|
EP2633866A3
(en)
|
2003-10-17 |
2013-12-18 |
Novo Nordisk A/S |
Combination therapy
|
|
MXPA06008506A
(es)
|
2004-02-02 |
2007-01-30 |
Ambrx Inc |
Polipeptidos de hormona de crecimiento humana modificada y sus usos.
|
|
US20100028995A1
(en)
*
|
2004-02-23 |
2010-02-04 |
Anaphore, Inc. |
Tetranectin Trimerizing Polypeptides
|
|
ZA200609638B
(en)
*
|
2004-04-21 |
2008-02-27 |
Alza Corp |
Polymer conjugate releasable under mild thiolytic conditions
|
|
BRPI0510477B1
(pt)
|
2004-04-28 |
2023-01-17 |
Angiotech Biomaterials Corporation |
Método para formar um gel e dispositivo para uso em aplicações médicas
|
|
NZ582684A
(en)
|
2004-06-18 |
2011-05-27 |
Ambrx Inc |
Use of an antibody or binding fragment thereof comprising a non naturally encoded amino acid coupled to a linker
|
|
EP1771573A4
(en)
|
2004-07-21 |
2009-02-18 |
Ambrx Inc |
BIOSYNTHETIC POLYPEPTIDES OBTAINED FROM NON-NATURALLY CITED AMINO ACIDS
|
|
WO2006034128A2
(en)
|
2004-09-17 |
2006-03-30 |
Angiotech Biomaterials Corporation |
Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
|
|
JP2008525473A
(ja)
|
2004-12-22 |
2008-07-17 |
アンブレツクス・インコーポレイテツド |
修飾されたヒト成長ホルモン
|
|
US20060188498A1
(en)
|
2005-02-18 |
2006-08-24 |
Genentech, Inc. |
Methods of using death receptor agonists and EGFR inhibitors
|
|
US8633300B2
(en)
|
2005-06-17 |
2014-01-21 |
Novo Nordisk Healthcare Ag |
Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine
|
|
PT2339014E
(pt)
|
2005-11-16 |
2015-10-13 |
Ambrx Inc |
Métodos e composições compreendendo aminoácidos não-naturais
|
|
CN101484576A
(zh)
|
2006-05-24 |
2009-07-15 |
诺沃-诺迪斯克保健股份有限公司 |
具有延长的体内半寿期的因子ix类似物
|
|
WO2008030558A2
(en)
|
2006-09-08 |
2008-03-13 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and their uses
|
|
KR20090091145A
(ko)
|
2006-10-27 |
2009-08-26 |
웨이-치앙 션 |
지질화된 인터페론 및 이의 용도
|
|
BRPI0809583B1
(pt)
|
2007-03-30 |
2022-02-22 |
Ambrx, Inc |
Polipeptídeo fgf-21 modificado, composição compreendendo o mesmo, método para produzir o referido polipetídeo fgf-21 e célula compreendendo um polinucleotídeo
|
|
EP2195333A1
(en)
*
|
2007-09-12 |
2010-06-16 |
Anaphore, Inc. |
Hsp70-based treatment for autoimmune diseases
|
|
MX2010004400A
(es)
|
2007-10-23 |
2010-05-20 |
Nektar Therapeutics |
Polimeros de multiples brazos dirigidos a la hidroxiapatita y conjugados de estos.
|
|
JP2011502520A
(ja)
*
|
2007-11-09 |
2011-01-27 |
アナフォア インコーポレイテッド |
疾患治療のためのマンノース結合レクチンの融合タンパク質
|
|
EP2217265B1
(en)
|
2007-11-20 |
2017-05-10 |
Ambrx, Inc. |
Modified insulin polypeptides and their uses
|
|
EP3103880A1
(en)
|
2008-02-08 |
2016-12-14 |
Ambrx, Inc. |
Modified leptin polypeptides and their uses
|
|
UA118536C2
(uk)
|
2008-07-23 |
2019-02-11 |
Амбркс, Інк. |
Модифікований поліпептид бичачого гранулоцитарного колонієстимулювального фактора та його застосування
|
|
ES2631915T3
(es)
|
2008-09-26 |
2017-09-06 |
Ambrx, Inc. |
Polipéptidos modificados de eritropoyetina animal y sus usos
|
|
CA2738033C
(en)
|
2008-09-26 |
2019-11-26 |
Ambrx, Inc. |
Non-natural amino acid replication-dependent microorganisms and vaccines
|
|
CN102317314A
(zh)
|
2008-10-10 |
2012-01-11 |
阿纳福公司 |
结合trail-r1和trail-r2的多肽
|
|
WO2010080720A2
(en)
*
|
2009-01-12 |
2010-07-15 |
Nektar Therapeutics |
Conjugates of a lysosomal enzyme moiety and a water soluble polymer
|
|
CA2777162A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Polypeptides that bind il-23r
|
|
US20110086806A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Polypeptides that Bind IL-23R
|
|
CN102753573A
(zh)
|
2009-12-21 |
2012-10-24 |
Ambrx公司 |
经过修饰的牛促生长素多肽和其用途
|
|
CN107056929A
(zh)
|
2009-12-21 |
2017-08-18 |
Ambrx 公司 |
经过修饰的猪促生长素多肽和其用途
|
|
US9815876B2
(en)
|
2010-03-05 |
2017-11-14 |
Omeros Corporation |
Chimeric inhibitor molecules of complement activation
|
|
JP2013528374A
(ja)
|
2010-05-10 |
2013-07-11 |
パーシード セラピューティクス リミテッド ライアビリティ カンパニー |
Vla4のポリペプチド阻害剤
|
|
FI3572091T3
(fi)
|
2010-08-17 |
2024-03-01 |
Ambrx Inc |
Muokattuja relaksiinipolypeptidejä ja niiden käyttötapoja
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
AR083006A1
(es)
|
2010-09-23 |
2013-01-23 |
Lilly Co Eli |
Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
|
|
MX2013012716A
(es)
|
2011-05-03 |
2014-03-21 |
Genentech Inc |
Agentes de disociacion vascular y sus usos.
|
|
KR20140054009A
(ko)
|
2011-07-01 |
2014-05-08 |
바이엘 인텔렉쳐 프로퍼티 게엠베하 |
릴랙신 융합 폴리펩타이드 및 그의 용도
|
|
GB201117428D0
(en)
*
|
2011-10-07 |
2011-11-23 |
Bicycle Therapeutics Ltd |
Structured polypeptides with sarcosine linkers
|
|
EP2606884A1
(en)
|
2011-12-21 |
2013-06-26 |
Ecole Polytechnique Fédérale de Lausanne (EPFL) |
Inhibitors of notch signaling pathway and use thereof in treatment of cancers
|
|
DK2859017T3
(da)
|
2012-06-08 |
2019-05-13 |
Sutro Biopharma Inc |
Antistoffer omfattrende stedsspecifikke ikke-naturlige aminosyrerester, fremgangsmåder til fremstilling heraf og fremgangsmåder til anvendelse heraf
|
|
ES2611788T3
(es)
|
2012-06-26 |
2017-05-10 |
Sutro Biopharma, Inc. |
Proteínas de Fc modificadas que comprenden residuos de aminoácidos no naturales específicos del sitio, conjugados de las mismas, métodos para su preparación y métodos para su uso
|
|
HUE045227T2
(hu)
|
2012-08-31 |
2019-12-30 |
Sutro Biopharma Inc |
Azido csoportot tartalmazó módosított aminosavak
|
|
WO2015006555A2
(en)
|
2013-07-10 |
2015-01-15 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
BR112016002845A2
(pt)
|
2013-08-12 |
2017-09-12 |
Genentech Inc |
composições e métodos para tratar condições associadas ao complemento
|
|
WO2015054658A1
(en)
|
2013-10-11 |
2015-04-16 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
CA2944712A1
(en)
|
2014-05-01 |
2015-11-05 |
Genentech, Inc. |
Anti-factor d antibody variants and uses thereof
|
|
EP3209316A2
(en)
|
2014-10-24 |
2017-08-30 |
Bristol-Myers Squibb Company |
Modified fgf-21 polypeptides and uses thereof
|
|
JP6823055B2
(ja)
|
2015-06-15 |
2021-01-27 |
アンジオケム インコーポレーテッド |
軟髄膜癌腫症の治療方法
|
|
JP2018536650A
(ja)
|
2015-10-30 |
2018-12-13 |
ジェネンテック, インコーポレイテッド |
抗d因子抗体変異体コンジュゲート及びその使用
|
|
WO2017075173A2
(en)
|
2015-10-30 |
2017-05-04 |
Genentech, Inc. |
Anti-factor d antibodies and conjugates
|
|
EP3474901B1
(en)
|
2016-06-27 |
2025-08-06 |
Tagworks Pharmaceuticals B.V. |
Cleavable tetrazine used in bio-orthogonal drug activation
|
|
JP7372837B2
(ja)
|
2017-02-08 |
2023-11-01 |
ブリストル-マイヤーズ スクイブ カンパニー |
薬物動態エンハンサーを含む修飾リラキシンポリペプチドおよびその使用
|
|
WO2019243523A1
(en)
|
2018-06-21 |
2019-12-26 |
Cellestia Biotech Ag |
Process for making amino diaryl ethers and amino diaryl ethers hydrochloride salts
|
|
HRP20240016T1
(hr)
|
2018-09-11 |
2024-03-29 |
Ambrx, Inc. |
Konjugati polipeptida interleukina-2 i njihove uporabe
|
|
US20220009986A1
(en)
|
2018-10-19 |
2022-01-13 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
|
KR20210136014A
(ko)
|
2019-02-12 |
2021-11-16 |
암브룩스, 인코포레이티드 |
항체-tlr 작용제 콘쥬게이트를 함유하는 조성물, 방법 및 이의 용도
|
|
MX2021012359A
(es)
|
2019-04-10 |
2022-01-19 |
Cellestia Biotech Ag |
Inhibidores de la vía de señalización de notch y su uso en el tratamiento de cánceres.
|
|
CN120682337A
(zh)
|
2020-03-11 |
2025-09-23 |
北京泰德制药股份有限公司 |
白介素-2多肽偶联物及其使用方法
|
|
BR112022018847A2
(pt)
|
2020-03-24 |
2022-11-22 |
Genentech Inc |
Anticorpos, ácido nucleico, célula hospedeira, conjugados, composição farmacêutica, dispositivo de entrega de ação prolongada para entrega ocular, método para tratar um distúrbio e uso do anticorpo
|
|
WO2022040596A1
(en)
|
2020-08-20 |
2022-02-24 |
Ambrx, Inc. |
Antibody-tlr agonist conjugates, methods and uses thereof
|
|
US20240041884A1
(en)
|
2020-12-07 |
2024-02-08 |
Cellestia Biotech Ag |
Pharmaceutical Combinations for Treating Cancer
|
|
EP4008324A1
(en)
|
2020-12-07 |
2022-06-08 |
Cellestia Biotech AG |
Combinations comprising an inhibitor of an anti-apoptotic protein, such as bcl-2, bcl-xl, bclw or mcl-1, and a notch signaling pathway inhibitor for treating cancer
|
|
CN112451681B
(zh)
*
|
2020-12-09 |
2023-08-25 |
苏州大学 |
酸敏感型聚合物-药物偶联物及其制备和应用
|
|
MX2023011480A
(es)
|
2021-04-03 |
2023-12-06 |
Ambrx Inc |
Conjugados anticuerpo anti-her2-fármaco y usos de estos.
|
|
WO2022253794A2
(en)
|
2021-06-02 |
2022-12-08 |
Cellestia Biotech Ag |
Method for treating an autoimmune and inflammatory disease
|
|
US20250000870A1
(en)
|
2021-11-08 |
2025-01-02 |
Cellestia Biotech Ag |
Pharmaceutical Combinations for Treating Cancer
|
|
EP4223292A1
(en)
|
2022-02-07 |
2023-08-09 |
Cellestia Biotech AG |
Pharmaceutical combinations for treating cancer
|