GR67304B - - Google Patents

Info

Publication number
GR67304B
GR67304B GR60828A GR790160828A GR67304B GR 67304 B GR67304 B GR 67304B GR 60828 A GR60828 A GR 60828A GR 790160828 A GR790160828 A GR 790160828A GR 67304 B GR67304 B GR 67304B
Authority
GR
Greece
Prior art keywords
alkyl
group
aryl
independently selected
substituents
Prior art date
Application number
GR60828A
Other languages
Greek (el)
English (en)
Inventor
Jan Vandenberg
Ludo E I Kennis
Marcel J M C Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26669096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR67304(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of GR67304B publication Critical patent/GR67304B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
GR60828A 1979-01-08 1979-12-21 GR67304B (cg-RX-API-DMAC7.html)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US149379A 1979-01-08 1979-01-08
US06/084,272 US4335127A (en) 1979-01-08 1979-10-12 Piperidinylalkyl quinazoline compounds, composition and method of use

Publications (1)

Publication Number Publication Date
GR67304B true GR67304B (cg-RX-API-DMAC7.html) 1981-06-29

Family

ID=26669096

Family Applications (1)

Application Number Title Priority Date Filing Date
GR60828A GR67304B (cg-RX-API-DMAC7.html) 1979-01-08 1979-12-21

Country Status (32)

Country Link
US (1) US4335127A (cg-RX-API-DMAC7.html)
EP (1) EP0013612B1 (cg-RX-API-DMAC7.html)
JP (1) JPS55105679A (cg-RX-API-DMAC7.html)
KR (3) KR850000684B1 (cg-RX-API-DMAC7.html)
AT (1) ATE5258T1 (cg-RX-API-DMAC7.html)
AU (1) AU536175B2 (cg-RX-API-DMAC7.html)
CA (1) CA1132557A (cg-RX-API-DMAC7.html)
CS (1) CS223977B2 (cg-RX-API-DMAC7.html)
CY (1) CY1252A (cg-RX-API-DMAC7.html)
DE (1) DE3065489D1 (cg-RX-API-DMAC7.html)
DK (1) DK170669B1 (cg-RX-API-DMAC7.html)
ES (1) ES487537A0 (cg-RX-API-DMAC7.html)
FI (1) FI66609C (cg-RX-API-DMAC7.html)
GR (1) GR67304B (cg-RX-API-DMAC7.html)
HK (1) HK76284A (cg-RX-API-DMAC7.html)
HU (1) HU184222B (cg-RX-API-DMAC7.html)
IE (1) IE49351B1 (cg-RX-API-DMAC7.html)
IL (1) IL59084A (cg-RX-API-DMAC7.html)
LU (1) LU88219I2 (cg-RX-API-DMAC7.html)
MA (1) MA18694A1 (cg-RX-API-DMAC7.html)
MY (1) MY8700555A (cg-RX-API-DMAC7.html)
NL (1) NL930018I2 (cg-RX-API-DMAC7.html)
NO (1) NO155243C (cg-RX-API-DMAC7.html)
NZ (1) NZ192551A (cg-RX-API-DMAC7.html)
PH (1) PH17114A (cg-RX-API-DMAC7.html)
PL (1) PL125789B1 (cg-RX-API-DMAC7.html)
PT (1) PT70662A (cg-RX-API-DMAC7.html)
RO (1) RO79148A (cg-RX-API-DMAC7.html)
SG (1) SG48684G (cg-RX-API-DMAC7.html)
SU (1) SU1041034A3 (cg-RX-API-DMAC7.html)
YU (1) YU42957B (cg-RX-API-DMAC7.html)
ZA (1) ZA8082B (cg-RX-API-DMAC7.html)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA806501B (en) * 1979-10-27 1981-10-28 Richardson Merrell Inc 4-(4-alkyl-aroyl-1-piperidino)butyrophenone antipsychotic agents
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
ZA841728B (en) * 1983-03-09 1984-11-28 Ciba Geigy Ag Novel carboxamides
DK159420C (da) * 1983-03-09 1991-03-11 Ciba Geigy Ag N-(piperidinyl-alkyl)-carboxamider og salte deraf, farmaceutiske praeparater indeholdende disse forbindelser samt anvendelsen af forbindelserne til fremstilling af antipsykotiske farmaceutiske praeparater
JPS608274A (ja) * 1983-06-27 1985-01-17 Fujisawa Pharmaceut Co Ltd 新規キナゾリノン誘導体およびその製造法・並びに抗アレルギ−剤
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
CS247557B1 (en) * 1984-04-06 1987-01-15 Ludmila Fisnerova Esters of 3-(2-hydroxyethyl)-4(3h)-quinazolinone
EP0177078A1 (en) * 1984-09-12 1986-04-09 Duphar International Research B.V Spasmolytically active tertiary amine derivatives and method of preparing the same
US4634769A (en) * 1984-09-25 1987-01-06 Ortho Pharmaceutical Corporation Process for the preparation of 8-halo-5,6-dialkoxyquinazoline-2,4-diones and their salts
US4665075A (en) * 1984-12-05 1987-05-12 Janssen Pharmaceutica N.V. Derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines
CA1246074A (en) * 1984-12-05 1988-12-06 Albertus H.M.T. Van Heertum Derivatives of hydroxy- or amino-substituted (piperidinylalkyl)quinazolines
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
JPH0615529B2 (ja) * 1985-04-01 1994-03-02 エーザイ株式会社 新規ピペリジン誘導体
FR2581993B1 (fr) * 1985-05-14 1988-03-18 Synthelabo Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
US4710502A (en) * 1985-11-04 1987-12-01 American Cyanamid Company 3-heteroarylalkyl-4-quinazolinones
US4753944A (en) * 1985-11-04 1988-06-28 American Cyanamid Company Pharmaceutical methods of using 3-heteroarylalkyl-4-quinazolinones
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
EP0268309B1 (en) * 1986-09-22 1996-12-11 Janssen Pharmaceutica N.V. Serotonin antagonists for treating wounds
US4874766A (en) * 1986-09-22 1989-10-17 Janssen Pharmaceutica N.V. Method of promoting wound-healing
AU593194B2 (en) * 1986-09-26 1990-02-01 Sumitomo Pharmaceuticals Company, Limited Imide derivatives ,and their production and use
DE3738844A1 (de) * 1987-11-16 1989-05-24 Merck Patent Gmbh Analgetikum
ATE137964T1 (de) * 1988-03-28 1996-06-15 Janssen Pharmaceutica Nv Mittel zur konservierung oder wiederherstellung der gesunden haut
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
CA1340821C (en) * 1988-10-06 1999-11-16 Nobuyuki Fukazawa Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components
FR2644786B1 (fr) * 1989-03-21 1993-12-31 Adir Cie Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
JP2744634B2 (ja) * 1989-04-14 1998-04-28 三菱重工業株式会社 ゴミ焼却装置
US5364866A (en) 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US5561128A (en) * 1989-05-19 1996-10-01 Hoechst-Roussel Pharmaceuticals, Inc. N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
IE913473A1 (en) * 1990-10-15 1992-04-22 Fujisawa Pharmaceutical Co Quinazoline derivatives and their preparation
US5158953A (en) * 1991-08-13 1992-10-27 National Science Council 2-substituted methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-ones (thiones), the preparation and use thereof
DE4138756A1 (de) * 1991-11-26 1993-05-27 Troponwerke Gmbh & Co Kg Kombination mit neuroprotektiver wirkung
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
KR100269756B1 (ko) * 1992-02-13 2000-10-16 슈테펜엘.네스비트 피페리디닐티아시클릭유도체(Piperidinyl Thiacyclic Derivatives)
FR2696744B1 (fr) * 1992-10-12 1994-12-30 Logeais Labor Jacques Dérivés de 2-pyrrolidone, leur procédé de préparation et leurs applications en thérapeutique.
ATE174908T1 (de) * 1993-05-26 1999-01-15 Sumitomo Pharma Chinazolinonderivate
KR100354270B1 (ko) * 1993-11-19 2003-02-11 알커메스 컨트롤드 테라포이틱스 인코퍼레이티드 Ii 마이크로캡슐화된3-피페리디닐-치환된1,2-벤즈이속사졸및1,2-벤즈이소티아졸
EP0661266A1 (en) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists
US6184377B1 (en) 1997-12-15 2001-02-06 Sepracor Inc. Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof
KR100607634B1 (ko) * 1998-10-16 2006-08-02 다이닛본 스미토모 세이야꾸 가부시끼가이샤 퀴나졸리논 유도체
GB9903784D0 (en) * 1999-02-18 1999-04-14 Lilly Co Eli Pharmaceutical compounds
JP2002540204A (ja) * 1999-03-26 2002-11-26 アストラゼネカ・アクチエボラーグ 新規化合物
US6476041B1 (en) * 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
GB2362381A (en) * 2000-05-18 2001-11-21 Lilly Co Eli Pharmaceutically active indolyl-piperidines
US6844338B2 (en) 2000-05-18 2005-01-18 Eli Lilly And Company Piperidyindoles as serotonin receptor ligands
GB0013060D0 (en) * 2000-05-31 2000-07-19 Astrazeneca Ab Chemical compounds
GB0021670D0 (en) * 2000-09-04 2000-10-18 Astrazeneca Ab Chemical compounds
DE10101324C1 (de) * 2001-01-13 2001-12-13 Ibfb Gmbh Privates Inst Fuer B 1-Dimercaptoalkylchinazolin-2,4-(1H,3H)-dione als Matrix-Metalloproteinase(MMP)-Inhibitoren
GB0117899D0 (en) * 2001-07-23 2001-09-12 Astrazeneca Ab Chemical compounds
SE0102809D0 (sv) * 2001-08-22 2001-08-22 Astrazeneca Ab Novel compounds
GB0126433D0 (en) * 2001-11-03 2002-01-02 Astrazeneca Ab Compounds
TW200813014A (en) * 2002-03-28 2008-03-16 Astrazeneca Ab Quinazoline derivatives
US6924285B2 (en) * 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
AU2003288017A1 (en) * 2002-11-13 2004-06-03 Synthon B.V. Process for making risperidone and intermediates therefor
WO2004094415A1 (en) * 2003-04-22 2004-11-04 Synthon B.V. Risperidone monohydrochloride
GB0309009D0 (en) * 2003-04-22 2003-05-28 Astrazeneca Ab Quinazoline derivatives
GB0309850D0 (en) * 2003-04-30 2003-06-04 Astrazeneca Ab Quinazoline derivatives
BRPI0414489A8 (pt) * 2003-09-16 2019-01-15 Astrazeneca Ab derivado de quinazolina, composição farmacêutica, uso de um derivado de quinazolina, e, processo para a preparação de um derivado de quinazolina
GB0321648D0 (en) * 2003-09-16 2003-10-15 Astrazeneca Ab Quinazoline derivatives
EP1664030A1 (en) * 2003-09-16 2006-06-07 AstraZeneca AB Quinazoline derivatives
US20070032508A1 (en) * 2003-09-16 2007-02-08 Bradbury Robert H Quinazoline derivatives as tyrosine kinase inhibitors
ATE352550T1 (de) * 2003-09-19 2007-02-15 Astrazeneca Ab Chinazolinderivate
ES2281007T3 (es) * 2003-09-19 2007-09-16 Astrazeneca Ab Derivados de quinazolina.
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
US20070043010A1 (en) * 2003-09-25 2007-02-22 Astrazeneca Uk Limited Quinazoline derivatives
CN1871222A (zh) * 2003-10-24 2006-11-29 霍夫曼-拉罗奇有限公司 Ccr3受体拮抗剂
GB0326459D0 (en) * 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
AU2004295058B9 (en) 2003-11-20 2011-06-30 Janssen Pharmaceutica N.V. 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
US7928104B2 (en) * 2003-11-20 2011-04-19 Dominique Jean-Pierre Mabire 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
SG151249A1 (en) * 2003-12-05 2009-04-30 Janssen Pharmaceutica Nv 6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
US7632840B2 (en) * 2004-02-03 2009-12-15 Astrazeneca Ab Quinazoline compounds for the treatment of hyperproliferative disorders
CN1993349A (zh) * 2004-06-04 2007-07-04 阿斯利康(瑞典)有限公司 作为erbb受体酪氨酸激酶的喹唑啉衍生物
NZ551799A (en) * 2004-06-30 2009-11-27 Janssen Pharmaceutica Nv Phthalazine derivatives as PARP inhibitors
ATE498613T1 (de) * 2004-06-30 2011-03-15 Janssen Pharmaceutica Nv Chinazolinonderivate als parp-hemmer
NZ551801A (en) 2004-06-30 2009-11-27 Janssen Pharmaceutica Nv Quinazolinedione derivatives as PARP inhibitors
CN101124228B (zh) 2004-12-14 2011-06-15 阿斯利康(瑞典)有限公司 用作抗肿瘤药物的吡唑并嘧啶化合物
TW200640904A (en) * 2005-02-26 2006-12-01 Astrazeneca Ab Quinazoline derivatives
GB0504474D0 (en) * 2005-03-04 2005-04-13 Astrazeneca Ab Chemical compounds
GB0508717D0 (en) * 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
GB0508715D0 (en) * 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
EP1940825A1 (en) * 2005-09-20 2008-07-09 Astra Zeneca AB Quinazoline derivatives as anticancer agents
ATE488513T1 (de) * 2005-09-20 2010-12-15 Astrazeneca Ab 4-(1h-indazol-5-ylamino)chinazolinverbindungen als inhibitoren der erbb-rezeptortyrosinkinase zur behandlung von krebs
DE602006009304D1 (de) * 2005-12-02 2009-10-29 Astrazeneca Ab Chinazoleinderivate
WO2007063291A1 (en) * 2005-12-02 2007-06-07 Astrazeneca Ab 4-anilino-substituted quinazoline derivatives as tyrosine kinase inhibitors
EP1921070A1 (de) * 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
AU2008212999A1 (en) * 2007-02-06 2008-08-14 Boehringer Ingelheim International Gmbh Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
JP5545955B2 (ja) 2007-03-08 2014-07-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐおよびｔａｎｋ阻害剤としてのキノリノン誘導体
EP2215075B1 (en) * 2007-10-26 2013-12-11 Janssen Pharmaceutica, N.V. Quinolinone derivatives as parp inhibitors
EP2245026B1 (de) 2008-02-07 2012-08-01 Boehringer Ingelheim International GmbH Spirocyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
WO2009118384A1 (en) * 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
RU2490260C2 (ru) 2008-03-27 2013-08-20 Янссен Фармацевтика Нв Тетрагидрофенантридиноны и тетрагидроциклопентахинолиноны в качестве ингибиторов parp и ингибиторов полимеризации тубулина
EP2303276B1 (en) 2008-05-13 2013-11-13 AstraZeneca AB Fumarate salt of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(n-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
US8648191B2 (en) * 2008-08-08 2014-02-11 Boehringer Ingelheim International Gmbh Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
US8440693B2 (en) * 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
CU24130B1 (es) 2009-12-22 2015-09-29 Novartis Ag Isoquinolinonas y quinazolinonas sustituidas
BRPI1003506B1 (pt) 2010-09-24 2019-12-03 Ache Int Bvi Ltd composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a
EP2855483B1 (en) 2012-05-24 2017-10-25 Novartis AG Pyrrolopyrrolidinone compounds
WO2014115080A1 (en) 2013-01-22 2014-07-31 Novartis Ag Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction
WO2014115077A1 (en) 2013-01-22 2014-07-31 Novartis Ag Substituted purinone compounds
EA029312B1 (ru) 2013-05-27 2018-03-30 Новартис Аг Производные имидазопирролидинона и их применение при лечении заболеваний
AU2014272695B2 (en) 2013-05-28 2016-10-20 Novartis Ag Pyrazolo-pyrrolidin-4-one derivatives as BET inhibitors and their use in the treatment of disease
WO2014191911A1 (en) 2013-05-28 2014-12-04 Novartis Ag Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease
AU2014351413B2 (en) 2013-11-21 2017-06-01 Novartis Ag Pyrrolopyrrolone derivatives and their use as BET inhibitors
US9902703B2 (en) 2015-07-01 2018-02-27 Crinetics Pharmaceuticals, Inc. Somatostatin modulators and uses thereof
CN106866625B (zh) * 2017-01-17 2019-12-13 上海鼎雅药物化学科技有限公司 酮色林的制备方法
US11028068B2 (en) 2017-07-25 2021-06-08 Crinetics Pharmaceuticals, Inc. Somatostatin modulators and uses thereof
CN109157507A (zh) * 2018-09-14 2019-01-08 上海禾丰制药有限公司 酒石酸酮色林注射液及其制备方法
CN112142760A (zh) * 2020-10-20 2020-12-29 江苏法安德医药科技有限公司 一种酮色林中间体以及酮色林的制备方法
WO2023133524A1 (en) * 2022-01-06 2023-07-13 Terran Biosciences, Inc. A process for synthesizing ketanserin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322766A (en) * 1964-11-13 1967-05-30 Shulton Inc 3-beta-(4-pyridyl) ethyl-2, 3-dihydro-4(1h)-quinazolinones
US3635976A (en) * 1967-12-20 1972-01-18 Pennwalt Corp 1 - heterocyclic alkyl-1 2 3 4-tetrahydroquinazolinones and analgesic intermediates thereof
US4096144A (en) * 1970-12-08 1978-06-20 Sumitomo Chemical Company, Limited Process for preparing quinazolinone derivatives and their 2-(N-mono-substituted amino)-phenyl ketone intermediate derivatives
US4099002A (en) * 1970-12-23 1978-07-04 Sumitomo Chemical Company, Limited Quinazolinone derivatives and a process for production thereof
US4146717A (en) * 1972-04-07 1979-03-27 Sumitomo Chemical Company, Limited Nitroquinazolinone compounds having antiviral properties
US4035369A (en) * 1975-10-08 1977-07-12 Janssen Pharmaceutica N.V. 1-Benzazolylalkyl-4-substituted-piperidines

Also Published As

Publication number Publication date
AU536175B2 (en) 1984-04-19
YU42957B (en) 1989-02-28
MY8700555A (en) 1987-12-31
JPS6346753B2 (cg-RX-API-DMAC7.html) 1988-09-19
MA18694A1 (fr) 1980-10-01
KR850000684B1 (ko) 1985-05-14
JPS55105679A (en) 1980-08-13
EP0013612A3 (en) 1980-10-15
FI66609C (fi) 1984-11-12
CS223977B2 (en) 1983-11-25
ES8101586A1 (es) 1980-12-16
CA1132557A (en) 1982-09-28
PH17114A (en) 1984-06-01
KR850000683B1 (ko) 1985-05-14
FI800047A7 (fi) 1980-07-09
IL59084A (en) 1984-02-29
PL125789B1 (en) 1983-06-30
ZA8082B (en) 1981-08-26
SG48684G (en) 1985-03-29
YU4680A (en) 1983-06-30
PL221249A1 (cg-RX-API-DMAC7.html) 1980-12-01
CY1252A (en) 1984-08-31
EP0013612A2 (en) 1980-07-23
NO155243B (no) 1986-11-24
IE800021L (en) 1980-07-08
HK76284A (en) 1984-10-19
DE3065489D1 (en) 1983-12-15
SU1041034A3 (ru) 1983-09-07
DK7280A (da) 1980-07-09
HU184222B (en) 1984-07-30
NZ192551A (en) 1984-07-06
KR830001926A (ko) 1983-05-19
NL930018I1 (nl) 1993-05-03
EP0013612B1 (en) 1983-11-09
NL930018I2 (nl) 1993-09-16
FI66609B (fi) 1984-07-31
NO800034L (no) 1980-07-09
RO79148A (ro) 1982-08-17
KR850000677B1 (ko) 1985-05-10
KR850002015A (ko) 1985-04-10
DK170669B1 (da) 1995-11-27
PT70662A (en) 1980-02-01
ATE5258T1 (de) 1983-11-15
IE49351B1 (en) 1985-09-18
AU5438180A (en) 1980-07-17
LU88219I2 (cg-RX-API-DMAC7.html) 1994-02-03
US4335127A (en) 1982-06-15
IL59084A0 (en) 1980-05-30
ES487537A0 (es) 1980-12-16
NO155243C (no) 1987-03-04

Similar Documents

Publication Publication Date Title
AU536175B2 (en) (piperidinylalky) quinazoline derivatives
NZ330656A (en) Tricyclic compounds, their production and use
ES8504130A1 (es) Un metodo para preparar derivados de 4-hidroxi-2-quinolona
IE802684L (en) Quinoline derivatives
ATE247660T1 (de) Furopyridinderivate und ihre therapeutische verwendung
IE780577L (en) Propanolamines
ES8103747A1 (es) Procedimiento para la preparacion de 5,6,7,8-tetrahidropira-zolo (3,4-b)(1,5)diazepin-1h,4h-5,7-dionas
AU557502B2 (en) Dithiino(1,4)(2,3-c)pyrrole derivatives
DE3775905D1 (de) Purin-histamin-h1-antagonisten, ihre herstellung und sie enthaltende pharmazeutische praeparate.