GEP20053688B - Substituted-Triazolopyrimidines as Anticancer Agents - Google Patents

Substituted-Triazolopyrimidines as Anticancer Agents

Info

Publication number
GEP20053688B
GEP20053688B GE5104A GEAP2001005104A GEP20053688B GE P20053688 B GEP20053688 B GE P20053688B GE 5104 A GE5104 A GE 5104A GE AP2001005104 A GEAP2001005104 A GE AP2001005104A GE P20053688 B GEP20053688 B GE P20053688B
Authority
GE
Georgia
Prior art keywords
substituted
triazolopyrimidines
anticancer agents
mammals
inhibiting
Prior art date
Application number
GE5104A
Other languages
English (en)
Inventor
Mark R Schmitt
Donald R Kirsch
Jane E Harris
Carl F Beyer
Klaus-Juergen Pees
Paul Carter
Waldemar Pfrengle
Guido Albert
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of GEP20053688B publication Critical patent/GEP20053688B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GE5104A 2000-06-30 2001-06-28 Substituted-Triazolopyrimidines as Anticancer Agents GEP20053688B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21558500P 2000-06-30 2000-06-30

Publications (1)

Publication Number Publication Date
GEP20053688B true GEP20053688B (en) 2005-12-12

Family

ID=22803554

Family Applications (1)

Application Number Title Priority Date Filing Date
GE5104A GEP20053688B (en) 2000-06-30 2001-06-28 Substituted-Triazolopyrimidines as Anticancer Agents

Country Status (24)

Country Link
US (1) US7329663B2 (enExample)
EP (1) EP1307200A2 (enExample)
JP (1) JP2004502691A (enExample)
KR (1) KR20030013475A (enExample)
CN (1) CN1592624A (enExample)
AR (1) AR034553A1 (enExample)
AU (2) AU2001273062B2 (enExample)
BG (1) BG107277A (enExample)
BR (1) BR0112038A (enExample)
CA (1) CA2413802A1 (enExample)
CZ (1) CZ20024150A3 (enExample)
EA (1) EA006483B1 (enExample)
GE (1) GEP20053688B (enExample)
HK (1) HK1052646A1 (enExample)
HU (1) HUP0300798A3 (enExample)
IL (1) IL152869A0 (enExample)
IN (1) IN2003KO00001A (enExample)
MX (1) MXPA02011913A (enExample)
NO (1) NO20026195L (enExample)
NZ (1) NZ523807A (enExample)
PL (1) PL360027A1 (enExample)
SK (1) SK18412002A3 (enExample)
WO (1) WO2002002563A2 (enExample)
ZA (1) ZA200300793B (enExample)

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UA80304C2 (en) * 2002-11-07 2007-09-10 Basf Ag Substituted 6-(2-halogenphenyl)triazolopyrimidines
MXPA05009338A (es) * 2003-03-31 2005-11-04 Basf Ag 7-alquenilamino-triazolopirimidinas, procedimientos para su obtencion y el uso de las mismas para controlar hongos nocivos, asi como productos que los contienen.
WO2004108136A1 (en) * 2003-06-04 2004-12-16 Vernalis (Cambridge) Limited Triazolo `1 , 5-a!pyrimidines and their use in medicine
DE10325133A1 (de) * 2003-06-04 2004-12-23 Bayer Cropscience Ag Triazolopyrimidine
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US20070129383A1 (en) * 2003-10-17 2007-06-07 Hiroshi Kuramochi Substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivative and use thereof
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MY179926A (en) 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
EP1697373A1 (de) * 2003-12-17 2006-09-06 Basf Aktiengesellschaft 6-(2,4,6-trihalogenphenyl)-triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bek mpfung von schadpil zen sowie sie enthaltende mittel
WO2005058902A1 (de) * 2003-12-17 2005-06-30 Basf Aktiengesellschaft 6-(2,3,6-trifluorphenyl)-triazolopyrimidine zur bekämpfung von schadpilzen
BRPI0508717A (pt) * 2004-03-30 2007-08-07 Basf Ag compostos, processo para preparar os mesmos, agente, semente, e, processo para combater fungos nocivos fitopatogênicos
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WO2007011759A2 (en) * 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
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WO2007099092A1 (de) * 2006-02-28 2007-09-07 Basf Se Substituierte 6-phenyl-7-amino-[1,2,4]-triazolo[1,5-a]pyrimidine und deren verwendung zur bekämpfung von schadpilzen
WO2007116011A2 (de) * 2006-04-10 2007-10-18 Basf Se Substituierte triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
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EP2865671B1 (en) * 2012-06-22 2017-11-01 Sumitomo Chemical Company, Ltd Fused heterocyclic compound
CN103360398B (zh) * 2013-07-22 2015-03-25 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
GB201504565D0 (en) 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
KR101995533B1 (ko) * 2017-03-21 2019-07-02 한국화학연구원 [1,2,4]트리아졸로[4,3-a]퀴노잘린 아미노 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
WO2020159942A1 (en) * 2019-01-29 2020-08-06 Tosk, Inc. Pyrazolopyrimidine modulators of ras gtpase
WO2020214537A1 (en) 2019-04-15 2020-10-22 Tosk, Inc. Modulators of ras gtpase
US20230167121A1 (en) * 2020-04-14 2023-06-01 The Trustees Of The University Of Pennsylvania Substituted {1,2,4,} triazolo{1,5-a} pyrimidine compounds and use in stabilizing microtubules
JP7564888B2 (ja) 2020-05-01 2024-10-09 ギリアード サイエンシーズ， インコーポレイテッド Ｃｄ７３阻害性２，４－ジオキソピリミジン化合物
US20230279006A1 (en) * 2020-07-08 2023-09-07 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
US12180220B2 (en) 2020-10-14 2024-12-31 Tosk, Inc. Heteroaryl modulators of RAS GTPase
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Also Published As

Publication number Publication date
EA006483B1 (ru) 2005-12-29
US7329663B2 (en) 2008-02-12
IN2003KO00001A (enExample) 2005-12-02
AR034553A1 (es) 2004-03-03
CZ20024150A3 (cs) 2003-09-17
WO2002002563A2 (en) 2002-01-10
JP2004502691A (ja) 2004-01-29
IL152869A0 (en) 2003-06-24
HK1052646A1 (zh) 2003-09-26
NO20026195L (no) 2003-02-27
HUP0300798A3 (en) 2006-02-28
NZ523807A (en) 2004-09-24
NO20026195D0 (no) 2002-12-23
AU7306201A (en) 2002-01-14
EA200300091A1 (ru) 2003-08-28
HUP0300798A2 (hu) 2003-07-28
PL360027A1 (en) 2004-09-06
CA2413802A1 (en) 2002-01-10
CN1592624A (zh) 2005-03-09
ZA200300793B (en) 2004-07-20
BG107277A (bg) 2004-01-30
AU2001273062B2 (en) 2005-11-24
MXPA02011913A (es) 2003-04-22
KR20030013475A (ko) 2003-02-14
WO2002002563A3 (en) 2003-01-03
US20020068744A1 (en) 2002-06-06
SK18412002A3 (sk) 2003-06-03
EP1307200A2 (en) 2003-05-07
BR0112038A (pt) 2003-04-01

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