GEP20053688B - Substituted-Triazolopyrimidines as Anticancer Agents - Google Patents

Substituted-Triazolopyrimidines as Anticancer Agents

Info

Publication number
GEP20053688B
GEP20053688B GE5104A GEAP2001005104A GEP20053688B GE P20053688 B GEP20053688 B GE P20053688B GE 5104 A GE5104 A GE 5104A GE AP2001005104 A GEAP2001005104 A GE AP2001005104A GE P20053688 B GEP20053688 B GE P20053688B
Authority
GE
Georgia
Prior art keywords
substituted
triazolopyrimidines
anticancer agents
mammals
inhibiting
Prior art date
Application number
GE5104A
Other languages
English (en)
Inventor
Mark R Schmitt
Donald R Kirsch
Jane E Harris
Carl F Beyer
Klaus-Juergen Pees
Paul Carter
Waldemar Pfrengle
Guido Albert
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of GEP20053688B publication Critical patent/GEP20053688B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
GE5104A 2000-06-30 2001-06-28 Substituted-Triazolopyrimidines as Anticancer Agents GEP20053688B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21558500P 2000-06-30 2000-06-30

Publications (1)

Publication Number Publication Date
GEP20053688B true GEP20053688B (en) 2005-12-12

Family

ID=22803554

Family Applications (1)

Application Number Title Priority Date Filing Date
GE5104A GEP20053688B (en) 2000-06-30 2001-06-28 Substituted-Triazolopyrimidines as Anticancer Agents

Country Status (24)

Country Link
US (1) US7329663B2 (enExample)
EP (1) EP1307200A2 (enExample)
JP (1) JP2004502691A (enExample)
KR (1) KR20030013475A (enExample)
CN (1) CN1592624A (enExample)
AR (1) AR034553A1 (enExample)
AU (2) AU7306201A (enExample)
BG (1) BG107277A (enExample)
BR (1) BR0112038A (enExample)
CA (1) CA2413802A1 (enExample)
CZ (1) CZ20024150A3 (enExample)
EA (1) EA006483B1 (enExample)
GE (1) GEP20053688B (enExample)
HK (1) HK1052646A1 (enExample)
HU (1) HUP0300798A3 (enExample)
IL (1) IL152869A0 (enExample)
IN (1) IN2003KO00001A (enExample)
MX (1) MXPA02011913A (enExample)
NO (1) NO20026195L (enExample)
NZ (1) NZ523807A (enExample)
PL (1) PL360027A1 (enExample)
SK (1) SK18412002A3 (enExample)
WO (1) WO2002002563A2 (enExample)
ZA (1) ZA200300793B (enExample)

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DE10124208A1 (de) † 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
HUP0401746A3 (en) * 2001-07-18 2008-02-28 Basf Ag Substituted 6-(2-tolyl)-triazolopyrimidines as fungicides
WO2003080615A1 (de) 2002-03-21 2003-10-02 Basf Aktiengesellschaft Fungizide triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
JPWO2004011467A1 (ja) * 2002-07-29 2005-12-15 北興化学工業株式会社 トリアゾロピリミジン誘導体および農園芸用殺菌剤
UA80304C2 (en) * 2002-11-07 2007-09-10 Basf Ag Substituted 6-(2-halogenphenyl)triazolopyrimidines
US20060211573A1 (en) * 2003-03-31 2006-09-21 Blasco Jordi T 7-(Akenylamino)triazolopyrimidines, method for the production thereof and use thereof in controlling harmful fungi and substances containing said triazolopyrimidines
DE10325133A1 (de) * 2003-06-04 2004-12-23 Bayer Cropscience Ag Triazolopyrimidine
WO2004108136A1 (en) * 2003-06-04 2004-12-16 Vernalis (Cambridge) Limited Triazolo `1 , 5-a!pyrimidines and their use in medicine
DE10328171A1 (de) * 2003-06-24 2005-01-13 Bayer Cropscience Ag Triazolopyrimidine
DE10328173A1 (de) * 2003-06-24 2005-01-13 Bayer Cropscience Ag Triazolopyrimidine
DE10328481A1 (de) * 2003-06-25 2005-01-13 Bayer Ag Triazolopyrimidine
JP4695595B2 (ja) 2003-09-24 2011-06-08 ワイス・ホールディングズ・コーポレイション 抗癌剤としての６−アリール−７−ハロ−イミダゾ［１，２−ａ］ピリミジン類
MXPA06003206A (es) * 2003-09-24 2006-06-23 Wyeth Corp 6-[(sustituido)fenil]triazolopirimidinas como agentes anticancer.
US7419982B2 (en) 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
WO2005037837A1 (ja) * 2003-10-17 2005-04-28 Nippon Kayaku Kabushiki Kaisha 置換２−アミノ−[１，２，４]トリアゾロ[１，５−a]ピリミジン誘導体及びその用途
JP4606015B2 (ja) * 2003-11-25 2011-01-05 日本化薬株式会社 ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体の新規医薬用途
MY179926A (en) 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
CN1890243A (zh) * 2003-12-17 2007-01-03 巴斯福股份公司 6－(2,4,6－三卤代苯基)三唑并嘧啶、其制备方法及其在防治病原性真菌中的用途以及包含所述物质的组合物
US20070149588A1 (en) * 2003-12-17 2007-06-28 Tormo I Blasco Jordi 6-(2,3,6-Trifluorophenyl)triazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds
WO2005095404A2 (de) * 2004-03-30 2005-10-13 Basf Aktiengesellschaft 6-(2-fluorphenyl)-triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
BRPI0510804A (pt) * 2004-05-17 2007-11-06 Basf Ag compostos, uso de um composto, agente adequado para combater fungos nocivos, e, processo para combater fungos fitopatogênicos
CN1964629A (zh) * 2004-06-09 2007-05-16 巴斯福股份公司 三唑并嘧啶化合物及其在防治有害真菌中的用途
EA200700007A1 (ru) * 2004-06-25 2007-08-31 Басф Акциенгезельшафт Триазолопиримидиновые соединения и их применение для борьбы с патогенными грибами
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
US20060293345A1 (en) * 2005-05-20 2006-12-28 Christoph Steeneck Heterobicyclic metalloprotease inhibitors
WO2007011759A2 (en) * 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
WO2007075465A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
AR059649A1 (es) * 2006-02-28 2008-04-16 Basf Ag 6- fenil 7-amino - amino (1,2,4) -triazolo (1,5-a) pirimidinas y su su uso para el combate de hongos daninos
WO2007116011A2 (de) * 2006-04-10 2007-10-18 Basf Se Substituierte triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
JP5231829B2 (ja) 2007-02-15 2013-07-10 石原産業株式会社 ピリジル−トリアゾロピリミジン誘導体又はその塩、それらを含有する有害生物防除剤並びにそれらの製造方法
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CN103889428A (zh) * 2010-10-04 2014-06-25 肝炎与病毒研究所 乙型肝炎病毒抗原分泌的新型抑制剂
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CN103360398B (zh) * 2013-07-22 2015-03-25 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
GB201504565D0 (en) 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
KR101995533B1 (ko) * 2017-03-21 2019-07-02 한국화학연구원 [1,2,4]트리아졸로[4,3-a]퀴노잘린 아미노 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
US11390626B2 (en) 2019-01-29 2022-07-19 Tosk, Inc. Pyrazolopyrimidine modulators of RAS GTPase
US12528796B2 (en) 2019-04-15 2026-01-20 Tosk, Inc. Modulators of RAS GTPase
WO2021211408A1 (en) * 2020-04-14 2021-10-21 The Trustees Of The University Of Pennsylvania Substituted {1,2,4,} triazolo{1,5-a} pyrimidine compounds and use in stabilizing microtubules
US12110294B2 (en) 2020-05-01 2024-10-08 Gilead Sciences, Inc. CD73 compounds
US20230279006A1 (en) * 2020-07-08 2023-09-07 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
US12180220B2 (en) 2020-10-14 2024-12-31 Tosk, Inc. Heteroaryl modulators of RAS GTPase
AU2022376954B2 (en) 2021-10-29 2026-04-23 Gilead Sciences, Inc. Cd73 compounds
CN118475581A (zh) * 2022-01-25 2024-08-09 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途

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US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts

Also Published As

Publication number Publication date
HUP0300798A2 (hu) 2003-07-28
NO20026195L (no) 2003-02-27
HK1052646A1 (zh) 2003-09-26
US7329663B2 (en) 2008-02-12
EP1307200A2 (en) 2003-05-07
WO2002002563A2 (en) 2002-01-10
ZA200300793B (en) 2004-07-20
CN1592624A (zh) 2005-03-09
MXPA02011913A (es) 2003-04-22
EA006483B1 (ru) 2005-12-29
NO20026195D0 (no) 2002-12-23
US20020068744A1 (en) 2002-06-06
NZ523807A (en) 2004-09-24
KR20030013475A (ko) 2003-02-14
BG107277A (bg) 2004-01-30
AU2001273062B2 (en) 2005-11-24
PL360027A1 (en) 2004-09-06
IN2003KO00001A (enExample) 2005-12-02
AU7306201A (en) 2002-01-14
SK18412002A3 (sk) 2003-06-03
AR034553A1 (es) 2004-03-03
JP2004502691A (ja) 2004-01-29
HUP0300798A3 (en) 2006-02-28
EA200300091A1 (ru) 2003-08-28
BR0112038A (pt) 2003-04-01
CZ20024150A3 (cs) 2003-09-17
CA2413802A1 (en) 2002-01-10
WO2002002563A3 (en) 2003-01-03
IL152869A0 (en) 2003-06-24

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