AR034553A1 - Triazolopirimidinas sustituidas, medicamento que los contienen, composiciones farmaceuticas y el uso de dichos derivados para la fabricacion de medicamentos como agentes anticancerosos - Google Patents
Triazolopirimidinas sustituidas, medicamento que los contienen, composiciones farmaceuticas y el uso de dichos derivados para la fabricacion de medicamentos como agentes anticancerososInfo
- Publication number
- AR034553A1 AR034553A1 ARP010103116A ARP010103116A AR034553A1 AR 034553 A1 AR034553 A1 AR 034553A1 AR P010103116 A ARP010103116 A AR P010103116A AR P010103116 A ARP010103116 A AR P010103116A AR 034553 A1 AR034553 A1 AR 034553A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- aryl
- atoms
- cycloalkyl
- alkyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 title 1
- -1 amino, hydroxyl Chemical group 0.000 abstract 13
- 125000000623 heterocyclic group Chemical group 0.000 abstract 13
- 239000001257 hydrogen Substances 0.000 abstract 12
- 229910052739 hydrogen Inorganic materials 0.000 abstract 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 12
- 125000004432 carbon atom Chemical group C* 0.000 abstract 11
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 9
- 125000003118 aryl group Chemical group 0.000 abstract 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 8
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 8
- 229910052801 chlorine Inorganic materials 0.000 abstract 7
- 239000000460 chlorine Substances 0.000 abstract 7
- 125000003342 alkenyl group Chemical group 0.000 abstract 6
- 125000000304 alkynyl group Chemical group 0.000 abstract 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 5
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 5
- YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical class BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 abstract 5
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 4
- 241000124008 Mammalia Species 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 4
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 3
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 abstract 3
- 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 125000001188 haloalkyl group Chemical group 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 210000004881 tumor cell Anatomy 0.000 abstract 3
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000004643 (C1-C12) haloalkoxy group Chemical group 0.000 abstract 1
- 125000006713 (C5-C10) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 abstract 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 abstract 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 abstract 1
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 abstract 1
- 102000029749 Microtubule Human genes 0.000 abstract 1
- 108091022875 Microtubule Proteins 0.000 abstract 1
- 229910003827 NRaRb Inorganic materials 0.000 abstract 1
- 102000004243 Tubulin Human genes 0.000 abstract 1
- 108090000704 Tubulin Proteins 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000006312 cyclopentyl amino group Chemical group [H]N(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 210000004688 microtubule Anatomy 0.000 abstract 1
- 230000029115 microtubule polymerization Effects 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21558500P | 2000-06-30 | 2000-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR034553A1 true AR034553A1 (es) | 2004-03-03 |
Family
ID=22803554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010103116A AR034553A1 (es) | 2000-06-30 | 2001-06-29 | Triazolopirimidinas sustituidas, medicamento que los contienen, composiciones farmaceuticas y el uso de dichos derivados para la fabricacion de medicamentos como agentes anticancerosos |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7329663B2 (enExample) |
| EP (1) | EP1307200A2 (enExample) |
| JP (1) | JP2004502691A (enExample) |
| KR (1) | KR20030013475A (enExample) |
| CN (1) | CN1592624A (enExample) |
| AR (1) | AR034553A1 (enExample) |
| AU (2) | AU2001273062B2 (enExample) |
| BG (1) | BG107277A (enExample) |
| BR (1) | BR0112038A (enExample) |
| CA (1) | CA2413802A1 (enExample) |
| CZ (1) | CZ20024150A3 (enExample) |
| EA (1) | EA006483B1 (enExample) |
| GE (1) | GEP20053688B (enExample) |
| HK (1) | HK1052646A1 (enExample) |
| HU (1) | HUP0300798A3 (enExample) |
| IL (1) | IL152869A0 (enExample) |
| IN (1) | IN2003KO00001A (enExample) |
| MX (1) | MXPA02011913A (enExample) |
| NO (1) | NO20026195L (enExample) |
| NZ (1) | NZ523807A (enExample) |
| PL (1) | PL360027A1 (enExample) |
| SK (1) | SK18412002A3 (enExample) |
| WO (1) | WO2002002563A2 (enExample) |
| ZA (1) | ZA200300793B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6255309B1 (en) * | 1999-03-19 | 2001-07-03 | American Cyanomid Co. | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
| JP2004513170A (ja) * | 2000-11-13 | 2004-04-30 | ビーエーエスエフ アクチェンゲゼルシャフト | ７−（ｒ）−アミノトリアゾロピリミジン類、それらの製造及び植物病原性真菌を防除するためのそれらの使用 |
| US7105664B2 (en) * | 2001-04-11 | 2006-09-12 | Basf Aktiengesellschaft | 5-Halogen-6-phenyl-7-fluoroalkylamino-triazolopyrimidines as fungicides |
| US7071334B2 (en) * | 2001-04-11 | 2006-07-04 | Basf Aktiengesellschaft | 6-(2-chloro-6-fluoro-phenyl)-triazolopyrimidines |
| DE10121101A1 (de) * | 2001-04-27 | 2002-10-31 | Bayer Ag | Triazolopyrimidine |
| DE10121162A1 (de) * | 2001-04-30 | 2002-10-31 | Bayer Ag | Triazolopyrimidine |
| DE10124208A1 (de) | 2001-05-18 | 2002-11-21 | Bayer Ag | Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide |
| US20040162286A1 (en) * | 2001-07-18 | 2004-08-19 | Tormo I Blasco Jordi | Substituted 6-(2-tolyl)-triazolopyrimidines as fungicides |
| PL372978A1 (en) | 2002-03-21 | 2005-08-08 | Basf Aktiengesellschaft | Fungicidal triazolopyrimidines, methods for producing the same, use thereof for combating harmful fungi and agents containing said substances |
| JPWO2004011467A1 (ja) * | 2002-07-29 | 2005-12-15 | 北興化学工業株式会社 | トリアゾロピリミジン誘導体および農園芸用殺菌剤 |
| UA80304C2 (en) * | 2002-11-07 | 2007-09-10 | Basf Ag | Substituted 6-(2-halogenphenyl)triazolopyrimidines |
| MXPA05009338A (es) * | 2003-03-31 | 2005-11-04 | Basf Ag | 7-alquenilamino-triazolopirimidinas, procedimientos para su obtencion y el uso de las mismas para controlar hongos nocivos, asi como productos que los contienen. |
| WO2004108136A1 (en) * | 2003-06-04 | 2004-12-16 | Vernalis (Cambridge) Limited | Triazolo `1 , 5-a!pyrimidines and their use in medicine |
| DE10325133A1 (de) * | 2003-06-04 | 2004-12-23 | Bayer Cropscience Ag | Triazolopyrimidine |
| DE10328173A1 (de) * | 2003-06-24 | 2005-01-13 | Bayer Cropscience Ag | Triazolopyrimidine |
| DE10328171A1 (de) * | 2003-06-24 | 2005-01-13 | Bayer Cropscience Ag | Triazolopyrimidine |
| DE10328481A1 (de) * | 2003-06-25 | 2005-01-13 | Bayer Ag | Triazolopyrimidine |
| WO2005030218A1 (en) * | 2003-09-24 | 2005-04-07 | Wyeth Holdings Corporation | 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agent |
| ES2279452T3 (es) | 2003-09-24 | 2007-08-16 | Wyeth Holdings Corporation | 6-((sustituido)fenil)triazolopirimidinas como agentes antineoplasicos. |
| US7419982B2 (en) | 2003-09-24 | 2008-09-02 | Wyeth Holdings Corporation | Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts |
| US20070129383A1 (en) * | 2003-10-17 | 2007-06-07 | Hiroshi Kuramochi | Substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivative and use thereof |
| JP4606015B2 (ja) * | 2003-11-25 | 2011-01-05 | 日本化薬株式会社 | ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体の新規医薬用途 |
| MY179926A (en) | 2003-12-08 | 2020-11-19 | Wyeth Corp | Process for the preparation of tubulin inhibitors |
| EP1697373A1 (de) * | 2003-12-17 | 2006-09-06 | Basf Aktiengesellschaft | 6-(2,4,6-trihalogenphenyl)-triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bek mpfung von schadpil zen sowie sie enthaltende mittel |
| WO2005058902A1 (de) * | 2003-12-17 | 2005-06-30 | Basf Aktiengesellschaft | 6-(2,3,6-trifluorphenyl)-triazolopyrimidine zur bekämpfung von schadpilzen |
| BRPI0508717A (pt) * | 2004-03-30 | 2007-08-07 | Basf Ag | compostos, processo para preparar os mesmos, agente, semente, e, processo para combater fungos nocivos fitopatogênicos |
| WO2005113555A1 (de) * | 2004-05-17 | 2005-12-01 | Basf Aktiengesellschaft | Triazolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen |
| EP1758457A1 (de) * | 2004-06-09 | 2007-03-07 | Basf Aktiengesellschaft | Triazolopyrimidin-verbindungen und ihre verwendung zur bekämpfung von schadpilzen |
| KR20070024646A (ko) * | 2004-06-25 | 2007-03-02 | 바스프 악티엔게젤샤프트 | 트리아졸로피리미딘 화합물 및 그의 병원성 진균류 방제를위한 용도 |
| US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| JP5463034B2 (ja) * | 2005-05-20 | 2014-04-09 | アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド | ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬 |
| WO2007011759A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
| JP2009519954A (ja) * | 2005-12-16 | 2009-05-21 | ワイス | 抗癌剤として有用な６−［（置換）フェニル］トリアゾロピリミジンの二量体および付加物 |
| WO2007099092A1 (de) * | 2006-02-28 | 2007-09-07 | Basf Se | Substituierte 6-phenyl-7-amino-[1,2,4]-triazolo[1,5-a]pyrimidine und deren verwendung zur bekämpfung von schadpilzen |
| WO2007116011A2 (de) * | 2006-04-10 | 2007-10-18 | Basf Se | Substituierte triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel |
| JP5231829B2 (ja) | 2007-02-15 | 2013-07-10 | 石原産業株式会社 | ピリジル−トリアゾロピリミジン誘導体又はその塩、それらを含有する有害生物防除剤並びにそれらの製造方法 |
| CA2694058C (en) | 2007-08-14 | 2016-06-07 | Bayer Schering Pharma Aktiengesellschaft | Fused bicyclic pyrimidines |
| CN103889428A (zh) * | 2010-10-04 | 2014-06-25 | 肝炎与病毒研究所 | 乙型肝炎病毒抗原分泌的新型抑制剂 |
| EP2865671B1 (en) * | 2012-06-22 | 2017-11-01 | Sumitomo Chemical Company, Ltd | Fused heterocyclic compound |
| CN103360398B (zh) * | 2013-07-22 | 2015-03-25 | 山东大学 | 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用 |
| GB201504565D0 (en) | 2015-03-18 | 2015-05-06 | Takeda Pharmaceutical | Novel compounds |
| KR101995533B1 (ko) * | 2017-03-21 | 2019-07-02 | 한국화학연구원 | [1,2,4]트리아졸로[4,3-a]퀴노잘린 아미노 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물 |
| WO2020159942A1 (en) * | 2019-01-29 | 2020-08-06 | Tosk, Inc. | Pyrazolopyrimidine modulators of ras gtpase |
| WO2020214537A1 (en) | 2019-04-15 | 2020-10-22 | Tosk, Inc. | Modulators of ras gtpase |
| US20230167121A1 (en) * | 2020-04-14 | 2023-06-01 | The Trustees Of The University Of Pennsylvania | Substituted {1,2,4,} triazolo{1,5-a} pyrimidine compounds and use in stabilizing microtubules |
| JP7564888B2 (ja) | 2020-05-01 | 2024-10-09 | ギリアード サイエンシーズ， インコーポレイテッド | Ｃｄ７３阻害性２，４－ジオキソピリミジン化合物 |
| US20230279006A1 (en) * | 2020-07-08 | 2023-09-07 | Klotho Therapeutics, Inc. | Novel compounds and methods for increasing klotho gene expression |
| US12180220B2 (en) | 2020-10-14 | 2024-12-31 | Tosk, Inc. | Heteroaryl modulators of RAS GTPase |
| PE20241186A1 (es) | 2021-10-29 | 2024-06-03 | Gilead Sciences Inc | Compuestos de cd73 |
| CN118475581A (zh) * | 2022-01-25 | 2024-08-09 | 瑞石生物医药有限公司 | 一种ccr4小分子拮抗剂及其用途 |
| CN118359616A (zh) * | 2023-01-19 | 2024-07-19 | 中国科学院上海有机化学研究所 | 一种作为治疗神经系统疾病和肿瘤的多环化合物 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD55956A (enExample) * | ||||
| DE55956C (de) | CH. GROOMBRIDGE und W. A. SOUTH in London, 40 New Bond Street | Bremskurbel für Pferdebahn- und andere Wagen | ||
| DE61269C (de) | 1891-04-01 | 1892-03-23 | J. NEWBURG in Berlin O., Am Schlesischen Bahnhof Nr. 5 | Waschmaschine |
| JPS5827773B2 (ja) * | 1980-02-08 | 1983-06-11 | 持田製薬株式会社 | 癌転移抑制剤 |
| US4444774A (en) * | 1982-07-29 | 1984-04-24 | American Cyanamid Company | 7-Heteroaryl[1,2,4]triazolo[1,5-a]pyrimidines |
| GB8719368D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Heterocyclic compounds |
| JPH02212488A (ja) * | 1989-02-13 | 1990-08-23 | Shinichiro Shimizu | トリアゾールピリミジン誘導体 |
| US5593996A (en) * | 1991-12-30 | 1997-01-14 | American Cyanamid Company | Triazolopyrimidine derivatives |
| US5387747A (en) * | 1992-02-24 | 1995-02-07 | Laboratoires Upsa | Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present |
| IL108747A (en) * | 1993-03-04 | 1999-03-12 | Shell Int Research | Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation |
| GB9321162D0 (en) * | 1993-10-13 | 1993-12-01 | Boots Co Plc | Therapeutic agents |
| US5869486A (en) * | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
| US5948783A (en) * | 1997-04-14 | 1999-09-07 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
| US6255309B1 (en) * | 1999-03-19 | 2001-07-03 | American Cyanomid Co. | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
| US6117876A (en) * | 1997-04-14 | 2000-09-12 | American Cyanamid Company | Fungicidal trifluorophenyl-triazolopyrimidines |
| US5994360A (en) * | 1997-07-14 | 1999-11-30 | American Cyanamid Company | Fungicidal 5-alkyl-triazolopyrimidines |
| US6020338A (en) * | 1998-02-11 | 2000-02-01 | American Cyanamid Company | Fungicidal 7-alkyl-triazolopyrimidines |
| FR2784380B1 (fr) * | 1998-09-25 | 2002-09-06 | American Cyanamid Co | Triazolopyrimidines 7-oxy- et 7-thio-substituees fongicides |
| US6165940A (en) * | 1998-09-25 | 2000-12-26 | American Cyanamid Co. | Non-aqueous suspension concentrate |
| US6380202B1 (en) * | 1998-09-25 | 2002-04-30 | Basf Aktiengesellschaft | Fungicidal fluoro-substituted 7-heterocyclyl-triazolopyrimidines |
| MY125533A (en) * | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| JP2001322933A (ja) * | 2000-05-15 | 2001-11-20 | Ucb Sa | Ｃｄ４０シグナル遮断剤 |
| DE10121101A1 (de) * | 2001-04-27 | 2002-10-31 | Bayer Ag | Triazolopyrimidine |
| DE10121102A1 (de) * | 2001-04-27 | 2002-11-07 | Bayer Ag | Triazolopyrimidine |
| DE10121162A1 (de) * | 2001-04-30 | 2002-10-31 | Bayer Ag | Triazolopyrimidine |
| US7037902B2 (en) * | 2002-07-03 | 2006-05-02 | Receptron, Inc. | Affinity small molecules for the EPO receptor |
| ES2279452T3 (es) * | 2003-09-24 | 2007-08-16 | Wyeth Holdings Corporation | 6-((sustituido)fenil)triazolopirimidinas como agentes antineoplasicos. |
| US7419982B2 (en) * | 2003-09-24 | 2008-09-02 | Wyeth Holdings Corporation | Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts |
-
2001
- 2001-06-28 NZ NZ523807A patent/NZ523807A/en unknown
- 2001-06-28 SK SK1841-2002A patent/SK18412002A3/sk not_active Application Discontinuation
- 2001-06-28 AU AU2001273062A patent/AU2001273062B2/en not_active Ceased
- 2001-06-28 GE GE5104A patent/GEP20053688B/en unknown
- 2001-06-28 CA CA002413802A patent/CA2413802A1/en not_active Abandoned
- 2001-06-28 EP EP01952295A patent/EP1307200A2/en not_active Withdrawn
- 2001-06-28 HK HK03104812.5A patent/HK1052646A1/zh unknown
- 2001-06-28 WO PCT/US2001/020672 patent/WO2002002563A2/en not_active Ceased
- 2001-06-28 MX MXPA02011913A patent/MXPA02011913A/es not_active Application Discontinuation
- 2001-06-28 EA EA200300091A patent/EA006483B1/ru not_active IP Right Cessation
- 2001-06-28 CZ CZ20024150A patent/CZ20024150A3/cs unknown
- 2001-06-28 BR BR0112038-7A patent/BR0112038A/pt not_active IP Right Cessation
- 2001-06-28 IL IL15286901A patent/IL152869A0/xx unknown
- 2001-06-28 AU AU7306201A patent/AU7306201A/xx active Pending
- 2001-06-28 HU HU0300798A patent/HUP0300798A3/hu unknown
- 2001-06-28 KR KR1020027017998A patent/KR20030013475A/ko not_active Ceased
- 2001-06-28 JP JP2002507815A patent/JP2004502691A/ja active Pending
- 2001-06-28 CN CNA018120555A patent/CN1592624A/zh active Pending
- 2001-06-28 PL PL36002701A patent/PL360027A1/xx not_active Application Discontinuation
- 2001-06-29 AR ARP010103116A patent/AR034553A1/es not_active Application Discontinuation
- 2001-06-29 US US09/895,975 patent/US7329663B2/en not_active Expired - Fee Related
-
2002
- 2002-11-15 BG BG107277A patent/BG107277A/bg unknown
- 2002-12-23 NO NO20026195A patent/NO20026195L/no not_active Application Discontinuation
-
2003
- 2003-01-01 IN IN1KO2003 patent/IN2003KO00001A/en unknown
- 2003-01-29 ZA ZA200300793A patent/ZA200300793B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA006483B1 (ru) | 2005-12-29 |
| US7329663B2 (en) | 2008-02-12 |
| IN2003KO00001A (enExample) | 2005-12-02 |
| CZ20024150A3 (cs) | 2003-09-17 |
| WO2002002563A2 (en) | 2002-01-10 |
| JP2004502691A (ja) | 2004-01-29 |
| IL152869A0 (en) | 2003-06-24 |
| HK1052646A1 (zh) | 2003-09-26 |
| NO20026195L (no) | 2003-02-27 |
| HUP0300798A3 (en) | 2006-02-28 |
| NZ523807A (en) | 2004-09-24 |
| NO20026195D0 (no) | 2002-12-23 |
| AU7306201A (en) | 2002-01-14 |
| EA200300091A1 (ru) | 2003-08-28 |
| HUP0300798A2 (hu) | 2003-07-28 |
| PL360027A1 (en) | 2004-09-06 |
| CA2413802A1 (en) | 2002-01-10 |
| CN1592624A (zh) | 2005-03-09 |
| ZA200300793B (en) | 2004-07-20 |
| BG107277A (bg) | 2004-01-30 |
| AU2001273062B2 (en) | 2005-11-24 |
| MXPA02011913A (es) | 2003-04-22 |
| KR20030013475A (ko) | 2003-02-14 |
| WO2002002563A3 (en) | 2003-01-03 |
| GEP20053688B (en) | 2005-12-12 |
| US20020068744A1 (en) | 2002-06-06 |
| SK18412002A3 (sk) | 2003-06-03 |
| EP1307200A2 (en) | 2003-05-07 |
| BR0112038A (pt) | 2003-04-01 |
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