IL152869A0 - Substituted triazolopyrimidines as anticancer agents - Google Patents

Substituted triazolopyrimidines as anticancer agents

Info

Publication number
IL152869A0
IL152869A0 IL15286901A IL15286901A IL152869A0 IL 152869 A0 IL152869 A0 IL 152869A0 IL 15286901 A IL15286901 A IL 15286901A IL 15286901 A IL15286901 A IL 15286901A IL 152869 A0 IL152869 A0 IL 152869A0
Authority
IL
Israel
Prior art keywords
anticancer agents
substituted triazolopyrimidines
triazolopyrimidines
substituted
anticancer
Prior art date
Application number
IL15286901A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of IL152869A0 publication Critical patent/IL152869A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL15286901A 2000-06-30 2001-06-28 Substituted triazolopyrimidines as anticancer agents IL152869A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21558500P 2000-06-30 2000-06-30
PCT/US2001/020672 WO2002002563A2 (en) 2000-06-30 2001-06-28 Substituted-triazolopyrimidines as anticancer agents

Publications (1)

Publication Number Publication Date
IL152869A0 true IL152869A0 (en) 2003-06-24

Family

ID=22803554

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15286901A IL152869A0 (en) 2000-06-30 2001-06-28 Substituted triazolopyrimidines as anticancer agents

Country Status (24)

Country Link
US (1) US7329663B2 (xx)
EP (1) EP1307200A2 (xx)
JP (1) JP2004502691A (xx)
KR (1) KR20030013475A (xx)
CN (1) CN1592624A (xx)
AR (1) AR034553A1 (xx)
AU (2) AU7306201A (xx)
BG (1) BG107277A (xx)
BR (1) BR0112038A (xx)
CA (1) CA2413802A1 (xx)
CZ (1) CZ20024150A3 (xx)
EA (1) EA006483B1 (xx)
GE (1) GEP20053688B (xx)
HK (1) HK1052646A1 (xx)
HU (1) HUP0300798A3 (xx)
IL (1) IL152869A0 (xx)
IN (1) IN2003KO00001A (xx)
MX (1) MXPA02011913A (xx)
NO (1) NO20026195L (xx)
NZ (1) NZ523807A (xx)
PL (1) PL360027A1 (xx)
SK (1) SK18412002A3 (xx)
WO (1) WO2002002563A2 (xx)
ZA (1) ZA200300793B (xx)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
WO2002038565A2 (de) * 2000-11-13 2002-05-16 Basf Aktiengesellschaft 7-(r)-amino-triazolopyrimidine, deren herstellung und verwendung zur bekämpfung von pflanzenpathogenen pilzen
US7105664B2 (en) * 2001-04-11 2006-09-12 Basf Aktiengesellschaft 5-Halogen-6-phenyl-7-fluoroalkylamino-triazolopyrimidines as fungicides
US7071334B2 (en) * 2001-04-11 2006-07-04 Basf Aktiengesellschaft 6-(2-chloro-6-fluoro-phenyl)-triazolopyrimidines
DE10121101A1 (de) * 2001-04-27 2002-10-31 Bayer Ag Triazolopyrimidine
DE10121162A1 (de) * 2001-04-30 2002-10-31 Bayer Ag Triazolopyrimidine
DE10124208A1 (de) 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
IL159606A0 (en) * 2001-07-18 2004-06-01 Basf Ag Substituted 6-(2-tolyl)-triazolopyrimidines as fungicides
IL163709A0 (en) * 2002-03-21 2005-12-18 Basf Ag Fungicidal triazolopyrimidines, methods for producing the same, use thereof for combating harmful fungiand agents containing said substances
WO2004011467A1 (ja) * 2002-07-29 2004-02-05 Hokko Chemical Industry Co., Ltd. トリアゾロピリミジン誘導体および農園芸用殺菌剤
UA80304C2 (en) * 2002-11-07 2007-09-10 Basf Ag Substituted 6-(2-halogenphenyl)triazolopyrimidines
EA200501388A1 (ru) * 2003-03-31 2006-02-24 Басф Акциенгезельшафт 7-алкениламинотриазолопиримидины, способ их получения и их применение для борьбы с фитопатогенными грибами, а также содержащие их средства
US20070275961A1 (en) * 2003-06-04 2007-11-29 Vernalis (Cambridge) Limited. Triazolo ' 1, 5-A ! Pyrimidines and Their Use in Medicine
DE10325133A1 (de) * 2003-06-04 2004-12-23 Bayer Cropscience Ag Triazolopyrimidine
DE10328173A1 (de) * 2003-06-24 2005-01-13 Bayer Cropscience Ag Triazolopyrimidine
DE10328171A1 (de) * 2003-06-24 2005-01-13 Bayer Cropscience Ag Triazolopyrimidine
DE10328481A1 (de) * 2003-06-25 2005-01-13 Bayer Ag Triazolopyrimidine
US7419982B2 (en) 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
ES2279452T3 (es) * 2003-09-24 2007-08-16 Wyeth Holdings Corporation 6-((sustituido)fenil)triazolopirimidinas como agentes antineoplasicos.
DK1684763T3 (da) * 2003-09-24 2008-09-01 Wyeth Corp 6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel
JPWO2005037837A1 (ja) * 2003-10-17 2006-12-28 日本化薬株式会社 置換２−アミノ−［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体及びその用途
JP4606015B2 (ja) * 2003-11-25 2011-01-05 日本化薬株式会社 ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体の新規医薬用途
MY179926A (en) 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
EP1751160A1 (de) * 2003-12-17 2007-02-14 Basf Aktiengesellschaft 6-(2,3,6-trifluorphenyl) -triazolopyrimidine zur bekämpfung von schadpilzen
WO2005058903A1 (de) * 2003-12-17 2005-06-30 Basf Aktiengesellschaft 6-(2,4,6-trihalogenphenyl)-triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
WO2005095404A2 (de) * 2004-03-30 2005-10-13 Basf Aktiengesellschaft 6-(2-fluorphenyl)-triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
JP2007538028A (ja) * 2004-05-17 2007-12-27 ビーエーエスエフ　アクチェンゲゼルシャフト トリアゾロピリミジン化合物および病原菌を制御するためのそれらの使用
JP2008501754A (ja) * 2004-06-09 2008-01-24 ビーエーエスエフ　アクチェンゲゼルシャフト トリアゾロピリミジン化合物および有害菌類を防除するためのその使用
TW200605792A (en) * 2004-06-25 2006-02-16 Basf Ag Triazolopyrimidine compounds and their use for controlling harmful fungi
BRPI0609802A2 (pt) * 2005-05-20 2017-05-02 Alantos Pharmaceuticals Holding Inc composto, composição farmacêutica e uso de um composto
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
WO2007011759A2 (en) * 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
JP2009519954A (ja) * 2005-12-16 2009-05-21 ワイス 抗癌剤として有用な６−［（置換）フェニル］トリアゾロピリミジンの二量体および付加物
AR059649A1 (es) * 2006-02-28 2008-04-16 Basf Ag 6- fenil 7-amino - amino (1,2,4) -triazolo (1,5-a) pirimidinas y su su uso para el combate de hongos daninos
WO2007116011A2 (de) * 2006-04-10 2007-10-18 Basf Se Substituierte triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
JP5231829B2 (ja) 2007-02-15 2013-07-10 石原産業株式会社 ピリジル−トリアゾロピリミジン誘導体又はその塩、それらを含有する有害生物防除剤並びにそれらの製造方法
RS52559B (en) 2007-08-14 2013-04-30 Bayer Intellectual Property Gmbh FUSIONED BICYCLIC PYRIMIDINES
US8921381B2 (en) 2010-10-04 2014-12-30 Baruch S. Blumberg Institute Inhibitors of secretion of hepatitis B virus antigens
CN104395298A (zh) * 2012-06-22 2015-03-04 住友化学株式会社 稠合杂环化合物
CN103360398B (zh) * 2013-07-22 2015-03-25 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
GB201504565D0 (en) 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
KR101995533B1 (ko) * 2017-03-21 2019-07-02 한국화학연구원 [1,2,4]트리아졸로[4,3-a]퀴노잘린 아미노 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
WO2022011171A1 (en) * 2020-07-08 2022-01-13 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
US11390626B2 (en) 2019-01-29 2022-07-19 Tosk, Inc. Pyrazolopyrimidine modulators of RAS GTPase
EP4136089A4 (en) * 2020-04-14 2024-05-29 Univ Pennsylvania SUBSTITUTED {1,2,4,} TRIAZOLO{1,5-A} PYRIMIDINE COMPOUNDS AND USE IN STABILIZATION OF MICROTUBULES
KR20230006891A (ko) * 2020-05-01 2023-01-11 길리애드 사이언시즈, 인코포레이티드 Cd73를 억제하는 2,4-다이옥소피리미딘 화합물
AU2022376954A1 (en) 2021-10-29 2024-05-02 Gilead Sciences, Inc. Cd73 compounds
WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD55956A (xx) *
DD61269A (xx) *
DE55956C (de) CH. GROOMBRIDGE und W. A. SOUTH in London, 40 New Bond Street Bremskurbel für Pferdebahn- und andere Wagen
DE61269C (de) 1891-04-01 1892-03-23 J. NEWBURG in Berlin O., Am Schlesischen Bahnhof Nr. 5 Waschmaschine
JPS5827773B2 (ja) * 1980-02-08 1983-06-11 持田製薬株式会社 癌転移抑制剤
US4444774A (en) * 1982-07-29 1984-04-24 American Cyanamid Company 7-Heteroaryl[1,2,4]triazolo[1,5-a]pyrimidines
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
JPH02212488A (ja) * 1989-02-13 1990-08-23 Shinichiro Shimizu トリアゾールピリミジン誘導体
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
US5387747A (en) * 1992-02-24 1995-02-07 Laboratoires Upsa Triazolopyrimidine derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present
IL108747A (en) * 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
GB9321162D0 (en) * 1993-10-13 1993-12-01 Boots Co Plc Therapeutic agents
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
US5948783A (en) * 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6117876A (en) * 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) * 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US6020338A (en) * 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
US6380202B1 (en) * 1998-09-25 2002-04-30 Basf Aktiengesellschaft Fungicidal fluoro-substituted 7-heterocyclyl-triazolopyrimidines
FR2784380B1 (fr) * 1998-09-25 2002-09-06 American Cyanamid Co Triazolopyrimidines 7-oxy- et 7-thio-substituees fongicides
US6165940A (en) * 1998-09-25 2000-12-26 American Cyanamid Co. Non-aqueous suspension concentrate
MY125533A (en) * 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
JP2001322933A (ja) * 2000-05-15 2001-11-20 Ucb Sa Ｃｄ４０シグナル遮断剤
DE10121102A1 (de) * 2001-04-27 2002-11-07 Bayer Ag Triazolopyrimidine
DE10121101A1 (de) * 2001-04-27 2002-10-31 Bayer Ag Triazolopyrimidine
DE10121162A1 (de) * 2001-04-30 2002-10-31 Bayer Ag Triazolopyrimidine
US7037902B2 (en) * 2002-07-03 2006-05-02 Receptron, Inc. Affinity small molecules for the EPO receptor
ES2279452T3 (es) * 2003-09-24 2007-08-16 Wyeth Holdings Corporation 6-((sustituido)fenil)triazolopirimidinas como agentes antineoplasicos.
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts

Also Published As

Publication number Publication date
AU7306201A (en) 2002-01-14
AU2001273062B2 (en) 2005-11-24
BR0112038A (pt) 2003-04-01
HUP0300798A2 (hu) 2003-07-28
JP2004502691A (ja) 2004-01-29
NO20026195L (no) 2003-02-27
EA006483B1 (ru) 2005-12-29
SK18412002A3 (sk) 2003-06-03
WO2002002563A3 (en) 2003-01-03
EP1307200A2 (en) 2003-05-07
US20020068744A1 (en) 2002-06-06
HUP0300798A3 (en) 2006-02-28
ZA200300793B (en) 2004-07-20
CA2413802A1 (en) 2002-01-10
CN1592624A (zh) 2005-03-09
HK1052646A1 (zh) 2003-09-26
NZ523807A (en) 2004-09-24
AR034553A1 (es) 2004-03-03
CZ20024150A3 (cs) 2003-09-17
EA200300091A1 (ru) 2003-08-28
IN2003KO00001A (xx) 2005-12-02
BG107277A (bg) 2004-01-30
NO20026195D0 (no) 2002-12-23
GEP20053688B (en) 2005-12-12
MXPA02011913A (es) 2003-04-22
PL360027A1 (en) 2004-09-06
KR20030013475A (ko) 2003-02-14
US7329663B2 (en) 2008-02-12
WO2002002563A2 (en) 2002-01-10

Similar Documents

Publication Publication Date Title
IL152869A0 (en) Substituted triazolopyrimidines as anticancer agents
IL155885A0 (en) Substituted imidazopyridines
HK1043795A1 (en) Substituted bicyclic derivatives useful as anticancer agents.
MXPA02002898A (es) Pirazolopirimidinas como agentes terapeuticos.
IL144171A0 (en) Quinolinecarboxamides as antiviral agents
GB0107758D0 (en) Anti-cancer compounds
HK1090374A1 (en) 6-Ä(substituted)phenylÜ triazolopyrimidines as anticancer agents
AU2002231676A1 (en) Triazolopyrimidines
MXPA03000107A (es) Pirroloquinolonas como agentes antivirales.
TWI315197B (en) Combinations
AU7489101A (en) Tricyclic compounds as mrp1-inhibitors
GB9929801D0 (en) Anti-cancer agents iii
AU2002222344A1 (en) Triazolopyrimidines
GB2365891B (en) Ground preparation
AU2001295326A1 (en) Chloramines as antiviral agents
AU2001263820A1 (en) Fairground ride arrangement
AU2001281142A1 (en) Diazepinones as antiviral agents
GB0001833D0 (en) Clavams
AU1968P (en) UoM95-157-6 Chrysanthemum hybrid
AU1967P (en) UoM92-333-2 Chrysanthemum hybrid
GB0002903D0 (en) Amusement apparaatus
GB0015186D0 (en) Entertainment arrangement
GB9910462D0 (en) Two by two pushbike
AU143572S (en) Travel airer
HU0402189D0 (en) Intermediate compounds