CN1592624A - 被取代的三唑并嘧啶类化合物作为抗癌药 - Google Patents

被取代的三唑并嘧啶类化合物作为抗癌药 Download PDF

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Publication number
CN1592624A
CN1592624A CNA018120555A CN01812055A CN1592624A CN 1592624 A CN1592624 A CN 1592624A CN A018120555 A CNA018120555 A CN A018120555A CN 01812055 A CN01812055 A CN 01812055A CN 1592624 A CN1592624 A CN 1592624A
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CN
China
Prior art keywords
chloro
carbon atoms
triazolo
pyrimidine
optionally substituted
Prior art date
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Pending
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CNA018120555A
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English (en)
Chinese (zh)
Inventor
M·R·施密特
D·R·柯施
J·E·哈里斯
C·F·贝耶尔
K·－J·佩斯
P·卡特尔
W·普夫伦格勒
G·阿尔伯特
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Wyeth LLC
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Wyeth LLC
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Publication of CN1592624A publication Critical patent/CN1592624A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNA018120555A 2000-06-30 2001-06-28 被取代的三唑并嘧啶类化合物作为抗癌药 Pending CN1592624A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21558500P 2000-06-30 2000-06-30
US60/215,585 2000-06-30

Publications (1)

Publication Number Publication Date
CN1592624A true CN1592624A (zh) 2005-03-09

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ID=22803554

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA018120555A Pending CN1592624A (zh) 2000-06-30 2001-06-28 被取代的三唑并嘧啶类化合物作为抗癌药

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Country Link
US (1) US7329663B2 (enExample)
EP (1) EP1307200A2 (enExample)
JP (1) JP2004502691A (enExample)
KR (1) KR20030013475A (enExample)
CN (1) CN1592624A (enExample)
AR (1) AR034553A1 (enExample)
AU (2) AU7306201A (enExample)
BG (1) BG107277A (enExample)
BR (1) BR0112038A (enExample)
CA (1) CA2413802A1 (enExample)
CZ (1) CZ20024150A3 (enExample)
EA (1) EA006483B1 (enExample)
GE (1) GEP20053688B (enExample)
HK (1) HK1052646A1 (enExample)
HU (1) HUP0300798A3 (enExample)
IL (1) IL152869A0 (enExample)
IN (1) IN2003KO00001A (enExample)
MX (1) MXPA02011913A (enExample)
NO (1) NO20026195L (enExample)
NZ (1) NZ523807A (enExample)
PL (1) PL360027A1 (enExample)
SK (1) SK18412002A3 (enExample)
WO (1) WO2002002563A2 (enExample)
ZA (1) ZA200300793B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103360398A (zh) * 2013-07-22 2013-10-23 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
CN104395298A (zh) * 2012-06-22 2015-03-04 住友化学株式会社 稠合杂环化合物
TWI797604B (zh) * 2020-05-01 2023-04-01 美商基利科學股份有限公司 Cd73化合物
WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途
US11919869B2 (en) 2021-10-29 2024-03-05 Gilead Sciences, Inc. CD73 compounds

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ATE287405T1 (de) * 2001-04-11 2005-02-15 Wyeth Corp 5-halogen-6-phenyl-7-fluoroalkylamino- triazolopyrimidine als fungizide
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DE10124208A1 (de) † 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
HUP0401746A3 (en) * 2001-07-18 2008-02-28 Basf Ag Substituted 6-(2-tolyl)-triazolopyrimidines as fungicides
WO2003080615A1 (de) 2002-03-21 2003-10-02 Basf Aktiengesellschaft Fungizide triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
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UA80304C2 (en) * 2002-11-07 2007-09-10 Basf Ag Substituted 6-(2-halogenphenyl)triazolopyrimidines
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DE10325133A1 (de) * 2003-06-04 2004-12-23 Bayer Cropscience Ag Triazolopyrimidine
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MXPA06003206A (es) * 2003-09-24 2006-06-23 Wyeth Corp 6-[(sustituido)fenil]triazolopirimidinas como agentes anticancer.
US7419982B2 (en) 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
WO2005037837A1 (ja) * 2003-10-17 2005-04-28 Nippon Kayaku Kabushiki Kaisha 置換２−アミノ−[１，２，４]トリアゾロ[１，５−a]ピリミジン誘導体及びその用途
JP4606015B2 (ja) * 2003-11-25 2011-01-05 日本化薬株式会社 ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体の新規医薬用途
MY179926A (en) 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
CN1890243A (zh) * 2003-12-17 2007-01-03 巴斯福股份公司 6－(2,4,6－三卤代苯基)三唑并嘧啶、其制备方法及其在防治病原性真菌中的用途以及包含所述物质的组合物
US20070149588A1 (en) * 2003-12-17 2007-06-28 Tormo I Blasco Jordi 6-(2,3,6-Trifluorophenyl)triazolopyrimidines, their preparation and their use for controlling harmful fungi, and compositions comprising these compounds
WO2005095404A2 (de) * 2004-03-30 2005-10-13 Basf Aktiengesellschaft 6-(2-fluorphenyl)-triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
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CN1964629A (zh) * 2004-06-09 2007-05-16 巴斯福股份公司 三唑并嘧啶化合物及其在防治有害真菌中的用途
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US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
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WO2007011759A2 (en) * 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
WO2007075465A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
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WO2007116011A2 (de) * 2006-04-10 2007-10-18 Basf Se Substituierte triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
JP5231829B2 (ja) 2007-02-15 2013-07-10 石原産業株式会社 ピリジル−トリアゾロピリミジン誘導体又はその塩、それらを含有する有害生物防除剤並びにそれらの製造方法
UY31293A1 (es) 2007-08-14 2009-03-31 Pirimidinas biciclicas fusionadas
CN103889428A (zh) * 2010-10-04 2014-06-25 肝炎与病毒研究所 乙型肝炎病毒抗原分泌的新型抑制剂
GB201504565D0 (en) 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
KR101995533B1 (ko) * 2017-03-21 2019-07-02 한국화학연구원 [1,2,4]트리아졸로[4,3-a]퀴노잘린 아미노 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
US11390626B2 (en) 2019-01-29 2022-07-19 Tosk, Inc. Pyrazolopyrimidine modulators of RAS GTPase
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WO2021211408A1 (en) * 2020-04-14 2021-10-21 The Trustees Of The University Of Pennsylvania Substituted {1,2,4,} triazolo{1,5-a} pyrimidine compounds and use in stabilizing microtubules
US20230279006A1 (en) * 2020-07-08 2023-09-07 Klotho Therapeutics, Inc. Novel compounds and methods for increasing klotho gene expression
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104395298A (zh) * 2012-06-22 2015-03-04 住友化学株式会社 稠合杂环化合物
CN103360398A (zh) * 2013-07-22 2013-10-23 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
CN103360398B (zh) * 2013-07-22 2015-03-25 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
TWI797604B (zh) * 2020-05-01 2023-04-01 美商基利科學股份有限公司 Cd73化合物
US12110294B2 (en) 2020-05-01 2024-10-08 Gilead Sciences, Inc. CD73 compounds
US11919869B2 (en) 2021-10-29 2024-03-05 Gilead Sciences, Inc. CD73 compounds
WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途

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HUP0300798A2 (hu) 2003-07-28
NO20026195L (no) 2003-02-27
HK1052646A1 (zh) 2003-09-26
US7329663B2 (en) 2008-02-12
EP1307200A2 (en) 2003-05-07
WO2002002563A2 (en) 2002-01-10
ZA200300793B (en) 2004-07-20
MXPA02011913A (es) 2003-04-22
EA006483B1 (ru) 2005-12-29
NO20026195D0 (no) 2002-12-23
US20020068744A1 (en) 2002-06-06
NZ523807A (en) 2004-09-24
KR20030013475A (ko) 2003-02-14
BG107277A (bg) 2004-01-30
AU2001273062B2 (en) 2005-11-24
PL360027A1 (en) 2004-09-06
IN2003KO00001A (enExample) 2005-12-02
AU7306201A (en) 2002-01-14
SK18412002A3 (sk) 2003-06-03
AR034553A1 (es) 2004-03-03
JP2004502691A (ja) 2004-01-29
HUP0300798A3 (en) 2006-02-28
EA200300091A1 (ru) 2003-08-28
BR0112038A (pt) 2003-04-01
CZ20024150A3 (cs) 2003-09-17
CA2413802A1 (en) 2002-01-10
WO2002002563A3 (en) 2003-01-03
GEP20053688B (en) 2005-12-12
IL152869A0 (en) 2003-06-24

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