CN1592624A - 被取代的三唑并嘧啶类化合物作为抗癌药 - Google Patents

被取代的三唑并嘧啶类化合物作为抗癌药 Download PDF

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Publication number
CN1592624A
CN1592624A CNA018120555A CN01812055A CN1592624A CN 1592624 A CN1592624 A CN 1592624A CN A018120555 A CNA018120555 A CN A018120555A CN 01812055 A CN01812055 A CN 01812055A CN 1592624 A CN1592624 A CN 1592624A
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CN
China
Prior art keywords
chloro
carbon atoms
triazolo
pyrimidine
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CNA018120555A
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English (en)
Chinese (zh)
Inventor
M·R·施密特
D·R·柯施
J·E·哈里斯
C·F·贝耶尔
K·－J·佩斯
P·卡特尔
W·普夫伦格勒
G·阿尔伯特
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Wyeth LLC
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Wyeth LLC
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Publication of CN1592624A publication Critical patent/CN1592624A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNA018120555A 2000-06-30 2001-06-28 被取代的三唑并嘧啶类化合物作为抗癌药 Pending CN1592624A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21558500P 2000-06-30 2000-06-30
US60/215,585 2000-06-30

Publications (1)

Publication Number Publication Date
CN1592624A true CN1592624A (zh) 2005-03-09

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ID=22803554

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA018120555A Pending CN1592624A (zh) 2000-06-30 2001-06-28 被取代的三唑并嘧啶类化合物作为抗癌药

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Country Link
US (1) US7329663B2 (enExample)
EP (1) EP1307200A2 (enExample)
JP (1) JP2004502691A (enExample)
KR (1) KR20030013475A (enExample)
CN (1) CN1592624A (enExample)
AR (1) AR034553A1 (enExample)
AU (2) AU7306201A (enExample)
BG (1) BG107277A (enExample)
BR (1) BR0112038A (enExample)
CA (1) CA2413802A1 (enExample)
CZ (1) CZ20024150A3 (enExample)
EA (1) EA006483B1 (enExample)
GE (1) GEP20053688B (enExample)
HK (1) HK1052646A1 (enExample)
HU (1) HUP0300798A3 (enExample)
IL (1) IL152869A0 (enExample)
IN (1) IN2003KO00001A (enExample)
MX (1) MXPA02011913A (enExample)
NO (1) NO20026195L (enExample)
NZ (1) NZ523807A (enExample)
PL (1) PL360027A1 (enExample)
SK (1) SK18412002A3 (enExample)
WO (1) WO2002002563A2 (enExample)
ZA (1) ZA200300793B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103360398A (zh) * 2013-07-22 2013-10-23 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
CN104395298A (zh) * 2012-06-22 2015-03-04 住友化学株式会社 稠合杂环化合物
TWI797604B (zh) * 2020-05-01 2023-04-01 美商基利科學股份有限公司 Cd73化合物
WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途
US11919869B2 (en) 2021-10-29 2024-03-05 Gilead Sciences, Inc. CD73 compounds

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DE10124208A1 (de) † 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
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BRPI0414700A (pt) 2003-09-24 2006-11-14 Wyeth Corp 6-[(substituìdo)fenil]triazolopirimidinas como agentes anti-cáncer
US7419982B2 (en) 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
EP1674454A4 (en) * 2003-10-17 2006-12-27 Nippon Kayaku Kk SUBSTITUTED 2-AMINO-1,2,4-TRIAZOLO 1,5-A-PYRIMIDINE DERIVATIVE AND THE USE THEREOF
JP4606015B2 (ja) * 2003-11-25 2011-01-05 日本化薬株式会社 ［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体の新規医薬用途
MY179926A (en) 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
JP2007514680A (ja) * 2003-12-17 2007-06-07 ビーエーエスエフ　アクチェンゲゼルシャフト ６−（２，４，６−トリハロフェニル）トリアゾロピリミジン、その製造方法、および植物病原性真菌類を防除するためのその使用、ならびにその物質を含有している農薬
CN1894254A (zh) * 2003-12-17 2007-01-10 巴斯福股份公司 用于防治病原性真菌的6－(2,3,6－三氟苯基)三唑并嘧啶
BRPI0508717A (pt) * 2004-03-30 2007-08-07 Basf Ag compostos, processo para preparar os mesmos, agente, semente, e, processo para combater fungos nocivos fitopatogênicos
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WO2007011759A2 (en) * 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
WO2007075465A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
AR059649A1 (es) * 2006-02-28 2008-04-16 Basf Ag 6- fenil 7-amino - amino (1,2,4) -triazolo (1,5-a) pirimidinas y su su uso para el combate de hongos daninos
WO2007116011A2 (de) * 2006-04-10 2007-10-18 Basf Se Substituierte triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
JP5231829B2 (ja) * 2007-02-15 2013-07-10 石原産業株式会社 ピリジル−トリアゾロピリミジン誘導体又はその塩、それらを含有する有害生物防除剤並びにそれらの製造方法
MY169738A (en) 2007-08-14 2019-05-14 Bayer Ip Gmbh Fused bicyclic pyrimidines
EP2624837A4 (en) 2010-10-04 2014-03-26 Inst Hepatitis & Virus Res NEW HEMMER OF THE SECRETION OF HEPATITIS B VIRUS ANTIGENES
GB201504565D0 (en) 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
KR101995533B1 (ko) * 2017-03-21 2019-07-02 한국화학연구원 [1,2,4]트리아졸로[4,3-a]퀴노잘린 아미노 페닐 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 BET 단백질 관련 질환의 예방 또는 치료용 약학적 조성물
WO2020159942A1 (en) * 2019-01-29 2020-08-06 Tosk, Inc. Pyrazolopyrimidine modulators of ras gtpase
AU2021255495A1 (en) * 2020-04-14 2022-12-15 The Regents Of The University Of California Substituted {1,2,4,} triazolo{1,5-a} pyrimidine compounds and use in stabilizing microtubules
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104395298A (zh) * 2012-06-22 2015-03-04 住友化学株式会社 稠合杂环化合物
CN103360398A (zh) * 2013-07-22 2013-10-23 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
CN103360398B (zh) * 2013-07-22 2015-03-25 山东大学 一种三唑并嘧啶类hiv-1逆转录酶抑制剂及其制备方法与应用
TWI797604B (zh) * 2020-05-01 2023-04-01 美商基利科學股份有限公司 Cd73化合物
US12110294B2 (en) 2020-05-01 2024-10-08 Gilead Sciences, Inc. CD73 compounds
US11919869B2 (en) 2021-10-29 2024-03-05 Gilead Sciences, Inc. CD73 compounds
WO2023143194A1 (zh) * 2022-01-25 2023-08-03 瑞石生物医药有限公司 一种ccr4小分子拮抗剂及其用途

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BR0112038A (pt) 2003-04-01
AU7306201A (en) 2002-01-14
NZ523807A (en) 2004-09-24
WO2002002563A3 (en) 2003-01-03
SK18412002A3 (sk) 2003-06-03
CZ20024150A3 (cs) 2003-09-17
KR20030013475A (ko) 2003-02-14
MXPA02011913A (es) 2003-04-22
HK1052646A1 (zh) 2003-09-26
PL360027A1 (en) 2004-09-06
AR034553A1 (es) 2004-03-03
HUP0300798A3 (en) 2006-02-28
IN2003KO00001A (enExample) 2005-12-02
NO20026195L (no) 2003-02-27
EA200300091A1 (ru) 2003-08-28
GEP20053688B (en) 2005-12-12
US20020068744A1 (en) 2002-06-06
ZA200300793B (en) 2004-07-20
JP2004502691A (ja) 2004-01-29
IL152869A0 (en) 2003-06-24
EA006483B1 (ru) 2005-12-29
BG107277A (bg) 2004-01-30
NO20026195D0 (no) 2002-12-23
WO2002002563A2 (en) 2002-01-10
CA2413802A1 (en) 2002-01-10
AU2001273062B2 (en) 2005-11-24
HUP0300798A2 (hu) 2003-07-28
US7329663B2 (en) 2008-02-12
EP1307200A2 (en) 2003-05-07

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