GEP19960641B - Process for production of [3h]-imidazo[5,1-d]-1,2,3,5-tetrazin-4-one derivatives - Google Patents
Process for production of [3h]-imidazo[5,1-d]-1,2,3,5-tetrazin-4-one derivativesInfo
- Publication number
- GEP19960641B GEP19960641B GEAP19931653A GEAP1993001653A GEP19960641B GE P19960641 B GEP19960641 B GE P19960641B GE AP19931653 A GEAP19931653 A GE AP19931653A GE AP1993001653 A GEAP1993001653 A GE AP1993001653A GE P19960641 B GEP19960641 B GE P19960641B
- Authority
- GE
- Georgia
- Prior art keywords
- carbon atoms
- groups
- group
- denotes
- tetrazin
- Prior art date
Links
- DXVWMLQMDGMWEQ-UHFFFAOYSA-N 1h-imidazo[5,1-d][1,2,3,5]tetrazin-4-one Chemical class O=C1NN=NC2=CN=CN12 DXVWMLQMDGMWEQ-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000000118 anti-neoplastic effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8125791 | 1981-08-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GEP19960641B true GEP19960641B (en) | 1996-11-15 |
Family
ID=10524141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP19931653A GEP19960641B (en) | 1981-08-24 | 1993-11-16 | Process for production of [3h]-imidazo[5,1-d]-1,2,3,5-tetrazin-4-one derivatives |
Country Status (29)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260291A (en) * | 1981-08-24 | 1993-11-09 | Cancer Research Campaign Technology Limited | Tetrazine derivatives |
| FR2531958B1 (fr) * | 1982-08-17 | 1986-10-31 | May & Baker Ltd | Nouveaux derive |
| GB2125402B (en) * | 1982-08-17 | 1985-11-13 | May & Baker Ltd | New tetrazine derivatives |
| US4517182A (en) * | 1983-05-24 | 1985-05-14 | Warner-Lambert Company | 3-(Haloethyl)-4-oxopyrazolo-[5,1-d]-1,2,3,5-tetrazine-8-carboxamide composition |
| GB8616125D0 (en) * | 1986-07-02 | 1986-08-06 | May & Baker Ltd | Compositions of matter |
| AU622330B2 (en) * | 1989-06-23 | 1992-04-02 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides |
| RU2166946C2 (ru) * | 1995-09-25 | 2001-05-20 | Санофи-Синтелабо Инк. | Состав, содержащий 1,2,4-бензотриазин-3-амин-1,4-диоксид, для парентерального введения и способ лечения с его применением |
| CA2552095A1 (en) * | 2003-12-30 | 2005-07-14 | Chemagis Ltd. | Novel crystalline forms of temozolomide |
| MX2007008781A (es) | 2005-01-21 | 2007-09-11 | Astex Therapeutics Ltd | Compuestos farmaceuticos. |
| AR060635A1 (es) | 2006-04-27 | 2008-07-02 | Banyu Pharma Co Ltd | Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer |
| JP2008081492A (ja) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体 |
| US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
| EP2073807A1 (en) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Pharmaceutical combinations |
| US8329711B2 (en) | 2007-10-23 | 2012-12-11 | Msd K.K. | Pyridone-substituted-dihydropyrazolopyrimidinone derivative |
| PE20091101A1 (es) | 2007-12-18 | 2009-07-26 | Pharminox Ltd | AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO |
| CN102256978A (zh) * | 2008-11-24 | 2011-11-23 | 利莱恩斯生命科学有限公司 | 制备四嗪衍生物的工艺 |
| US8481503B2 (en) | 2009-03-06 | 2013-07-09 | Merck Sharp & Dohme Corp. | Combination cancer therapy with an AKT inhibitor and other anticancer agents |
| CA2763766A1 (en) | 2009-06-23 | 2010-12-29 | Pharminox Limited | 3-substituted-8-substituted-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-one compounds and their use |
| RU2462466C1 (ru) * | 2011-06-24 | 2012-09-27 | Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" | Замещенные азоло[1,2,4,5]тетразины - ингибиторы актинобактериальных серин-треониновых протеинкиназ |
| WO2013055985A1 (en) | 2011-10-12 | 2013-04-18 | Children's Medical Center Corporation | Combinatorial compositions and methods of treating hemoglobinopathies |
| WO2017157825A1 (en) | 2016-03-15 | 2017-09-21 | F. Hoffmann-La Roche Ag | Combinations of lsd1 inhibitors for use in the treatment of solid tumors |
| KR101847342B1 (ko) * | 2017-05-08 | 2018-04-11 | (주)센텍코리아 | 웨어러블 체지방 연소량 측정기 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2932305A1 (de) * | 1979-08-09 | 1981-02-26 | Basf Ag | Azolo- eckige klammer auf 5,1-d eckige klammer zu - eckige klammer auf 1,2,3,5 eckige klammer zu -tetrazin-4-one und verfahren zur herstellung dieser verbindungen |
-
1982
- 1982-08-05 OA OA57766BISD patent/OA07174A/xx unknown
- 1982-08-12 IL IL66606A patent/IL66606A/xx not_active IP Right Cessation
- 1982-08-23 FI FI822921A patent/FI73434C/fi not_active IP Right Cessation
- 1982-08-23 NL NL8203286A patent/NL192739C/nl not_active IP Right Cessation
- 1982-08-23 BE BE0/208860A patent/BE894175A/fr not_active IP Right Cessation
- 1982-08-23 IT IT22938/82A patent/IT1152505B/it active Protection Beyond IP Right Term
- 1982-08-23 GB GB08224155A patent/GB2104522B/en not_active Expired
- 1982-08-23 DE DE19823231255 patent/DE3231255A1/de active Granted
- 1982-08-23 UA UA3482389A patent/UA5971A1/uk unknown
- 1982-08-23 CA CA000409950A patent/CA1197247A/fr not_active Expired
- 1982-08-23 AU AU87493/82A patent/AU571430B2/en not_active Expired
- 1982-08-23 SU SU823482389A patent/SU1447284A3/ru active
- 1982-08-23 LU LU84347A patent/LU84347A1/fr unknown
- 1982-08-23 ES ES515176A patent/ES515176A0/es active Granted
- 1982-08-23 KR KR8203774A patent/KR890000094B1/ko not_active Expired
- 1982-08-23 IE IE2026/82A patent/IE53408B1/en not_active IP Right Cessation
- 1982-08-23 ZA ZA826120A patent/ZA826120B/xx unknown
- 1982-08-23 SE SE8204817A patent/SE448543B/sv not_active IP Right Cessation
- 1982-08-23 CH CH5007/82A patent/CH655114A5/fr not_active IP Right Cessation
- 1982-08-23 GR GR69093A patent/GR76863B/el unknown
- 1982-08-23 JP JP57144902A patent/JPS5843975A/ja active Granted
- 1982-08-23 NZ NZ201668A patent/NZ201668A/en unknown
- 1982-08-23 HU HU822708A patent/HU186107B/hu unknown
- 1982-08-23 DK DK377882A patent/DK161147C/da not_active IP Right Cessation
- 1982-08-23 DE DE1999175037 patent/DE19975037I2/de active Active
- 1982-08-23 AT AT0319182A patent/AT380256B/de not_active IP Right Cessation
- 1982-08-23 FR FR8214461A patent/FR2511679A1/fr active Granted
-
1993
- 1993-06-19 LV LV930621A patent/LV5511A3/xx unknown
- 1993-09-29 LT LTRP1286A patent/LT2436B/xx not_active IP Right Cessation
- 1993-11-16 GE GEAP19931653A patent/GEP19960641B/en unknown
- 1993-12-03 LV LV931303A patent/LV5621A3/xx unknown
-
1999
- 1999-04-01 NL NL990010C patent/NL990010I2/nl unknown
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