GB2122995B - Fused ring imidazole derivatives - Google Patents

Fused ring imidazole derivatives

Info

Publication number
GB2122995B
GB2122995B GB08317732A GB8317732A GB2122995B GB 2122995 B GB2122995 B GB 2122995B GB 08317732 A GB08317732 A GB 08317732A GB 8317732 A GB8317732 A GB 8317732A GB 2122995 B GB2122995 B GB 2122995B
Authority
GB
United Kingdom
Prior art keywords
fused ring
imidazole derivatives
ring imidazole
derivatives
fused
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08317732A
Other languages
English (en)
Other versions
GB2122995A (en
GB8317732D0 (en
Inventor
Dr Norbert Hauel
Dr Volkhard Austel
Dr Joachim Heider
Dr Manfred Reiffen
Dr Willi Diederen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of GB8317732D0 publication Critical patent/GB8317732D0/en
Publication of GB2122995A publication Critical patent/GB2122995A/en
Application granted granted Critical
Publication of GB2122995B publication Critical patent/GB2122995B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB08317732A 1982-07-01 1983-06-30 Fused ring imidazole derivatives Expired GB2122995B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823224512 DE3224512A1 (de) 1982-07-01 1982-07-01 Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (3)

Publication Number Publication Date
GB8317732D0 GB8317732D0 (en) 1983-08-03
GB2122995A GB2122995A (en) 1984-01-25
GB2122995B true GB2122995B (en) 1986-02-12

Family

ID=6167285

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08317732A Expired GB2122995B (en) 1982-07-01 1983-06-30 Fused ring imidazole derivatives

Country Status (23)

Country Link
US (2) US4582837A (Direct)
EP (1) EP0098448A3 (Direct)
JP (1) JPS5927875A (Direct)
KR (1) KR840005432A (Direct)
AU (1) AU1642883A (Direct)
CS (1) CS254319B2 (Direct)
DD (1) DD210271A5 (Direct)
DE (1) DE3224512A1 (Direct)
DK (1) DK301383A (Direct)
ES (3) ES523709A0 (Direct)
FI (1) FI832022A7 (Direct)
GB (1) GB2122995B (Direct)
GR (1) GR78598B (Direct)
HU (1) HU192152B (Direct)
IL (1) IL69111A0 (Direct)
NO (1) NO832356L (Direct)
NZ (1) NZ204766A (Direct)
PH (1) PH20810A (Direct)
PL (2) PL142880B1 (Direct)
PT (1) PT76968B (Direct)
SU (2) SU1316559A3 (Direct)
YU (1) YU143283A (Direct)
ZA (1) ZA834777B (Direct)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES517193A0 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
US4758574A (en) * 1982-05-03 1988-07-19 Eli Lilly And Company 2-phenylimidazio (4,5-c) pyridines
DE3324115A1 (de) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3346575A1 (de) * 1983-12-23 1985-07-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzimidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
GR850426B (Direct) * 1984-02-24 1985-06-18 Lilly Co Eli
PL144822B1 (en) * 1984-05-12 1988-07-30 Boehringer Mannheim Gmbh Method of obtaining novel pyrolobenzimidazoles
EP0178413A1 (en) * 1984-08-17 1986-04-23 Beecham Group Plc Benzimidazoles
LU85544A1 (fr) * 1984-09-19 1986-04-03 Cird Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
DE3445299A1 (de) * 1984-12-12 1986-06-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
NZ217755A (en) * 1985-10-09 1989-08-29 Chemie Linz Ag 2-(2-thienyl)-imidazo(4,5-c)pyridine derivatives and pharmaceutical compositions
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5466704A (en) * 1991-02-26 1995-11-14 E. R. Squibb & Sons, Inc. N-substituted imidazole and benzimidazole derivatives useful as angiotenson II antagonists
FR2677020B1 (fr) * 1991-05-31 1993-08-27 Cird Galderma Composes derives de benzimidazole, leur procede de preparation et leur utilisation dans les domaines therapeutique et cosmetique.
US6919366B2 (en) * 1998-05-22 2005-07-19 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
US6911462B2 (en) * 1998-05-22 2005-06-28 Avanir Pharmaceuticals Benzimidazole compounds for regulating IgE
UA70976C2 (uk) 1998-12-18 2004-11-15 Аксіз Фармасьютікелз, Інк. (гетеро)арилбіциклічні гетероарильні похідні, їх одержання та використання як інгібіторів протеаз
GB9914825D0 (en) * 1999-06-24 1999-08-25 Smithkline Beecham Spa Novel compounds
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
DE10015866A1 (de) * 2000-03-30 2001-10-11 Bayer Ag Aryl- und Heteroarylsulfonate
AU2001259707A1 (en) 2000-06-14 2001-12-24 Warner Lambert Company 6,5-fused bicyclic heterocycles
EP1368028B1 (en) * 2001-03-12 2007-08-15 Avanir Pharmaceuticals Benzimidazole compounds for modulating ige and inhibiting cellular proliferation
JP4416111B2 (ja) * 2002-02-14 2010-02-17 塩野義製薬株式会社 ２，３−ジアミノピリジン誘導体の製造方法
TW200304820A (en) * 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
WO2004024655A2 (en) 2002-09-12 2004-03-25 Avanir Pharmaceuticals Phenyl-indole compounds for modulating ige and inhibiting cellular proliferation
TWI276631B (en) 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
EP1651198A2 (en) * 2003-08-08 2006-05-03 Avanir Pharmaceuticals Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases
US7449481B2 (en) * 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
EP1911760A4 (en) * 2005-07-01 2010-06-02 Nippon Chemiphar Co xanthine oxidase inhibitor
KR20080035700A (ko) * 2005-08-15 2008-04-23 아이알엠 엘엘씨 Ｔｐｏ 모방체로서의 화합물 및 조성물
CN101479249B (zh) * 2006-06-29 2012-10-10 霍夫曼-拉罗奇有限公司 苯并咪唑衍生物、其制备方法、它们作为fxr激动剂的用途及含有它们的药物制剂
TW200831472A (en) * 2006-11-30 2008-08-01 Wyeth Corp Process for the synthesis of monosulfated derivatives of substituted benzoxazoles
US7816540B2 (en) * 2007-12-21 2010-10-19 Hoffmann-La Roche Inc. Carboxyl- or hydroxyl-substituted benzimidazole derivatives
WO2014151630A2 (en) 2013-03-15 2014-09-25 Irm Llc Compounds and compositions for the treatment of parasitic diseases
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US9186361B2 (en) 2013-03-15 2015-11-17 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
SG11201604618TA (en) 2013-12-19 2016-07-28 Novartis Ag [1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis
AR099677A1 (es) * 2014-03-07 2016-08-10 Sumitomo Chemical Co Compuesto heterocíclico fusionado y su uso para el control de plagas
JP2019503342A (ja) * 2015-11-16 2019-02-07 シンジェンタ パーティシペーションズ アーゲー 硫黄含有置換基を有する殺有害生物的に活性な複素環式誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985891A (en) * 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
DE2305339C3 (de) * 1973-02-03 1980-05-08 Dr. Karl Thomae Gmbh, 7950 Biberach Imidazo [4,5-b] pyridine, ihre Herstellung und ihre Verwendung als Cardiötonica
DE2927988A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 8-phenyl-purine, deren herstellung und deren verwendung als arzneimittel
DE2927987A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel
JPS5721375A (en) * 1980-07-14 1982-02-04 Yamanouchi Pharmaceut Co Ltd 2,6-di-tert-butyl-4-heterocyclic substituted phenolic derivative and its preparation
EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
ES517193A0 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.

Also Published As

Publication number Publication date
JPS5927875A (ja) 1984-02-14
ZA834777B (en) 1985-03-27
YU143283A (en) 1986-06-30
US4696931A (en) 1987-09-29
GR78598B (Direct) 1984-09-27
DK301383D0 (da) 1983-06-30
GB2122995A (en) 1984-01-25
ES8500056A1 (es) 1984-10-01
AU1642883A (en) 1984-01-05
PT76968B (de) 1986-04-09
NO832356L (no) 1984-01-02
EP0098448A3 (de) 1985-04-03
FI832022L (fi) 1984-01-02
KR840005432A (ko) 1984-11-12
PT76968A (de) 1983-07-01
FI832022A0 (fi) 1983-06-06
EP0098448A2 (de) 1984-01-18
PH20810A (en) 1987-04-24
PL142880B1 (en) 1987-12-31
ES8500241A1 (es) 1984-10-01
SU1316559A3 (ru) 1987-06-07
US4582837A (en) 1986-04-15
DE3224512A1 (de) 1984-01-05
ES8500242A1 (es) 1984-10-01
PL242770A1 (en) 1986-10-21
PL144589B1 (en) 1988-06-30
FI832022A7 (fi) 1984-01-02
ES529175A0 (es) 1984-10-01
GB8317732D0 (en) 1983-08-03
IL69111A0 (en) 1983-10-31
ES529174A0 (es) 1984-10-01
SU1179924A3 (ru) 1985-09-15
HU192152B (en) 1987-05-28
CS254319B2 (en) 1988-01-15
ES523709A0 (es) 1984-10-01
NZ204766A (en) 1986-09-10
DK301383A (da) 1984-01-02
DD210271A5 (de) 1984-06-06

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee