GB1587084A - Thiophene derivatives - Google Patents

Thiophene derivatives Download PDF

Info

Publication number
GB1587084A
GB1587084A GB35098/77A GB3509877A GB1587084A GB 1587084 A GB1587084 A GB 1587084A GB 35098/77 A GB35098/77 A GB 35098/77A GB 3509877 A GB3509877 A GB 3509877A GB 1587084 A GB1587084 A GB 1587084A
Authority
GB
United Kingdom
Prior art keywords
amino
group
formula
compound
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35098/77A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1587084A publication Critical patent/GB1587084A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB35098/77A 1976-08-23 1977-08-22 Thiophene derivatives Expired GB1587084A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71685476A 1976-08-23 1976-08-23
US71685376A 1976-08-23 1976-08-23
US82052177A 1977-08-01 1977-08-01

Publications (1)

Publication Number Publication Date
GB1587084A true GB1587084A (en) 1981-03-25

Family

ID=27418961

Family Applications (1)

Application Number Title Priority Date Filing Date
GB35098/77A Expired GB1587084A (en) 1976-08-23 1977-08-22 Thiophene derivatives

Country Status (21)

Country Link
JP (1) JPS5340755A (de)
AR (1) AR222453A1 (de)
AT (1) AT359486B (de)
AU (1) AU509956B2 (de)
BE (1) BE858012A (de)
CH (1) CH628628A5 (de)
DE (1) DE2737738A1 (de)
DK (1) DK150484C (de)
ES (1) ES461796A1 (de)
FI (1) FI66859C (de)
FR (1) FR2365566A1 (de)
GB (1) GB1587084A (de)
HU (1) HU179484B (de)
IE (1) IE45470B1 (de)
IL (1) IL52792A (de)
IT (1) IT1143757B (de)
LU (1) LU78003A1 (de)
MC (1) MC1156A1 (de)
NL (1) NL7709246A (de)
NO (1) NO148673C (de)
NZ (1) NZ184981A (de)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046588A2 (en) * 1997-04-11 1998-10-22 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6166090A (en) 1993-05-13 2000-12-26 Neorx Corporation Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
CN101959875A (zh) * 2008-02-29 2011-01-26 日产化学工业株式会社 噻吩化合物及其中间体的制造方法
US7923571B2 (en) 2004-12-29 2011-04-12 Bayer Cropscience Ag Process for preparing substituted 2-alkoxycarbonyl-3-aminothiophenes
US8067022B2 (en) 1992-09-25 2011-11-29 Boston Scientific Scimed, Inc. Therapeutic inhibitor of vascular smooth muscle cells
US8097642B2 (en) 1995-02-15 2012-01-17 Boston Scientific Scimed, Inc. Therapeutic inhibitor of vascular smooth muscle cells
WO2024079734A1 (en) 2022-10-14 2024-04-18 Adama Agan Ltd. Process for the preparation of substituted aminothiophene

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6232765Y2 (de) * 1981-02-28 1987-08-21

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2502421A (en) * 1944-08-28 1950-04-04 Parke Davis & Co Tetrahydrothiophenes
US2502423A (en) * 1944-12-23 1950-04-04 Parke Davis & Co 4-carbalkoxy-3-keto-2-substituted tetrahydrothiophene oximes
US2443598A (en) * 1944-12-23 1948-06-22 Parke Davis & Co 3-amino-4-carbethoxy-2-alkyl derivatives of thiophene
US2502424A (en) * 1944-12-23 1950-04-04 Parke Davis & Co 3-acylamino-4-carboalkoxy-2-omega-ralkylthiophenes

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067022B2 (en) 1992-09-25 2011-11-29 Boston Scientific Scimed, Inc. Therapeutic inhibitor of vascular smooth muscle cells
US6569441B2 (en) 1993-01-28 2003-05-27 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6166090A (en) 1993-05-13 2000-12-26 Neorx Corporation Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US8097642B2 (en) 1995-02-15 2012-01-17 Boston Scientific Scimed, Inc. Therapeutic inhibitor of vascular smooth muscle cells
US8158670B2 (en) 1995-02-15 2012-04-17 Boston Scientific Scimed, Inc. Therapeutic inhibitor of vascular smooth muscle cells
WO1998046588A3 (en) * 1997-04-11 1999-01-07 Neorx Corp Compounds and therapies for the prevention of vascular and non-vascular pathologies
US6734208B2 (en) 1997-04-11 2004-05-11 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
WO1998046588A2 (en) * 1997-04-11 1998-10-22 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
US7923571B2 (en) 2004-12-29 2011-04-12 Bayer Cropscience Ag Process for preparing substituted 2-alkoxycarbonyl-3-aminothiophenes
CN101959875A (zh) * 2008-02-29 2011-01-26 日产化学工业株式会社 噻吩化合物及其中间体的制造方法
CN101959875B (zh) * 2008-02-29 2013-10-16 日产化学工业株式会社 噻吩化合物及其中间体的制造方法
CN103360290A (zh) * 2008-02-29 2013-10-23 日产化学工业株式会社 噻吩化合物及其中间体的制造方法
CN103435593B (zh) * 2008-02-29 2015-01-28 日产化学工业株式会社 噻吩化合物及其中间体的制造方法
CN103360290B (zh) * 2008-02-29 2015-04-01 日产化学工业株式会社 噻吩化合物及其中间体的制造方法
WO2024079734A1 (en) 2022-10-14 2024-04-18 Adama Agan Ltd. Process for the preparation of substituted aminothiophene

Also Published As

Publication number Publication date
FR2365566B1 (de) 1980-12-26
NO148673C (no) 1983-11-23
DE2737738A1 (de) 1978-03-09
FI772494A (fi) 1978-02-24
DK372177A (da) 1978-02-24
HU179484B (en) 1982-10-28
DK150484C (da) 1987-10-05
FI66859C (fi) 1984-12-10
IL52792A0 (en) 1977-10-31
LU78003A1 (de) 1978-09-14
DE2737738C2 (de) 1987-01-29
MC1156A1 (fr) 1978-04-17
ATA607477A (de) 1980-04-15
JPS6121235B2 (de) 1986-05-26
BE858012A (fr) 1978-02-22
FR2365566A1 (fr) 1978-04-21
NZ184981A (en) 1980-08-26
NO148673B (no) 1983-08-15
CH628628A5 (en) 1982-03-15
FI66859B (fi) 1984-08-31
IL52792A (en) 1981-06-29
ES461796A1 (es) 1978-12-16
AT359486B (de) 1980-11-10
IE45470L (en) 1978-02-23
AU509956B2 (en) 1980-06-05
DK150484B (da) 1987-03-09
AU2809277A (en) 1979-03-01
NL7709246A (nl) 1978-02-27
AR222453A1 (es) 1981-05-29
IE45470B1 (en) 1982-09-08
JPS5340755A (en) 1978-04-13
IT1143757B (it) 1986-10-22
NO772917L (no) 1978-02-24

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee