ES461796A1 - Un procedimiento para la preparacion de nuevos derivados de tiofeno. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de tiofeno.

Info

Publication number
ES461796A1
ES461796A1 ES461796A ES461796A ES461796A1 ES 461796 A1 ES461796 A1 ES 461796A1 ES 461796 A ES461796 A ES 461796A ES 461796 A ES461796 A ES 461796A ES 461796 A1 ES461796 A1 ES 461796A1
Authority
ES
Spain
Prior art keywords
thiophene derivatives
formula
ketotetrahydrothiophene
hypolipaemic
aminothiophenes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES461796A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES461796A1 publication Critical patent/ES461796A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimiento para la preparación de nuevos derivados de tiofeno de la fórmula general **(Fórmula)** en donde R1 es alquilo inferior; arilo o aralquilo R2 es hidrógeno, hidroxilo, alcoxilo inferior o amino; R3 y R4 que pueden ser iguales o distintos, son alquilo inferior, aralquilo, acilo o hidrógeno; y sus sales.
ES461796A 1976-08-23 1977-08-22 Un procedimiento para la preparacion de nuevos derivados de tiofeno. Expired ES461796A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71685476A 1976-08-23 1976-08-23
US71685376A 1976-08-23 1976-08-23
US82052177A 1977-08-01 1977-08-01

Publications (1)

Publication Number Publication Date
ES461796A1 true ES461796A1 (es) 1978-12-16

Family

ID=27418961

Family Applications (1)

Application Number Title Priority Date Filing Date
ES461796A Expired ES461796A1 (es) 1976-08-23 1977-08-22 Un procedimiento para la preparacion de nuevos derivados de tiofeno.

Country Status (21)

Country Link
JP (1) JPS5340755A (es)
AR (1) AR222453A1 (es)
AT (1) AT359486B (es)
AU (1) AU509956B2 (es)
BE (1) BE858012A (es)
CH (1) CH628628A5 (es)
DE (1) DE2737738A1 (es)
DK (1) DK150484C (es)
ES (1) ES461796A1 (es)
FI (1) FI66859C (es)
FR (1) FR2365566A1 (es)
GB (1) GB1587084A (es)
HU (1) HU179484B (es)
IE (1) IE45470B1 (es)
IL (1) IL52792A (es)
IT (1) IT1143757B (es)
LU (1) LU78003A1 (es)
MC (1) MC1156A1 (es)
NL (1) NL7709246A (es)
NO (1) NO148673C (es)
NZ (1) NZ184981A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6232765Y2 (es) * 1981-02-28 1987-08-21
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6251920B1 (en) 1993-05-13 2001-06-26 Neorx Corporation Prevention and treatment of cardiovascular pathologies
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
JPH08510451A (ja) 1993-05-13 1996-11-05 ネオルックス コーポレイション 異常増殖性平滑筋細胞に関連した病因の予防及び治療
WO1998046588A2 (en) 1997-04-11 1998-10-22 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
DE102004063191A1 (de) 2004-12-29 2006-07-13 Bayer Cropscience Ag Verfahren zur Herstellung von substituierten 2-Alkoxycarbonyl-3-aminothiophenen
UA104286C2 (uk) * 2008-02-29 2014-01-27 Нисан Кемикал Индастрис, Лтд. Спосіб одержання тіофенової сполуки та її проміжних сполук (варіанти)
WO2024079734A1 (en) 2022-10-14 2024-04-18 Adama Agan Ltd. Process for the preparation of substituted aminothiophene

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2502421A (en) * 1944-08-28 1950-04-04 Parke Davis & Co Tetrahydrothiophenes
US2502423A (en) * 1944-12-23 1950-04-04 Parke Davis & Co 4-carbalkoxy-3-keto-2-substituted tetrahydrothiophene oximes
US2443598A (en) * 1944-12-23 1948-06-22 Parke Davis & Co 3-amino-4-carbethoxy-2-alkyl derivatives of thiophene
US2502424A (en) * 1944-12-23 1950-04-04 Parke Davis & Co 3-acylamino-4-carboalkoxy-2-omega-ralkylthiophenes

Also Published As

Publication number Publication date
FR2365566B1 (es) 1980-12-26
NO148673C (no) 1983-11-23
DE2737738A1 (de) 1978-03-09
FI772494A (fi) 1978-02-24
DK372177A (da) 1978-02-24
HU179484B (en) 1982-10-28
DK150484C (da) 1987-10-05
FI66859C (fi) 1984-12-10
IL52792A0 (en) 1977-10-31
LU78003A1 (es) 1978-09-14
DE2737738C2 (es) 1987-01-29
MC1156A1 (fr) 1978-04-17
GB1587084A (en) 1981-03-25
ATA607477A (de) 1980-04-15
JPS6121235B2 (es) 1986-05-26
BE858012A (fr) 1978-02-22
FR2365566A1 (fr) 1978-04-21
NZ184981A (en) 1980-08-26
NO148673B (no) 1983-08-15
CH628628A5 (en) 1982-03-15
FI66859B (fi) 1984-08-31
IL52792A (en) 1981-06-29
AT359486B (de) 1980-11-10
IE45470L (en) 1978-02-23
AU509956B2 (en) 1980-06-05
DK150484B (da) 1987-03-09
AU2809277A (en) 1979-03-01
NL7709246A (nl) 1978-02-27
AR222453A1 (es) 1981-05-29
IE45470B1 (en) 1982-09-08
JPS5340755A (en) 1978-04-13
IT1143757B (it) 1986-10-22
NO772917L (no) 1978-02-24

Similar Documents

Publication Publication Date Title
ES461796A1 (es) Un procedimiento para la preparacion de nuevos derivados de tiofeno.
GB1053085A (es)
GB1373382A (en) Substituted thiazoles
IE800449L (en) Pyrazoline derivatives.
ES433148A1 (es) Procedimiento para preparar derivados de pirazol.
ES426303A1 (es) Procedimiento para la obtencion de derivados de oxazolidi- na.
IE44711L (en) 17ó-hydroxypropyl-delta 4-3-keto-steroids and esters and¹ethers thereof
ES445775A1 (es) Un procedimiento para la preparacion de nuevos derivados de 2-hidroxi-4-fluor-butirofenona.
IE41151B1 (en) New derivatives of 2-amino-1,3-thiazine
IE45696L (en) Derivatives of 2-(3-phenyl-2-amino-propionyloxy)-acetic acid
ES433680A1 (es) Procedimiento para la preparacion de derivados de arilpipe-razinicos de la adenina.
IE45222L (en) 2-loweralkyl-2- or -3-cephem-4-carboxylic acids.
ES481264A1 (es) Procedimiento para fabricar derivados del acido arilacetico.
GB1498535A (en) Heterocyclic compounds
ES437803A1 (es) Procedimiento para la preparacion de derivados de tiofeno.
GB1361249A (en) 3-sulphoalkyl-6-hydroxy-pyrid--2--ones their manufacture and use
ES455261A1 (es) Un procedimiento para la preparacion de un derivado de peni-cilina o de cefalosporina.
ES448696A1 (es) Procedimiento para la preparacion de 4-fenil-imidazolinas sustituidas.
ES477962A1 (es) Un procedimiento para preparar derivados de acido 3-cloro-3-cefem-4-carboxilico sustituido en 7b con imidazolidinilo.
ES428672A1 (es) Procedimiento para la obtencion de diamino-benzofenonas.
ES480329A1 (es) Procedimiento para la preparacion de derivados de acidos benzoilfenoxialcanoicos.
JPS52100473A (en) Novel azimidebenzamide derivative and its production
DE3061435D1 (en) Process for the preparation of 5-(2,2,2,-trihalogen-ethyl)-dialkyl-tetrahydrofuran-2-ones
JPS5283677A (en) Derivative of 2-(7-indenyloxymethyl)-4-substituted morpholine
JPS5359664A (en) Novel imidazole derivatives