GB1576625A - Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof - Google Patents

Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof Download PDF

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Publication number
GB1576625A
GB1576625A GB14916/76A GB1491676A GB1576625A GB 1576625 A GB1576625 A GB 1576625A GB 14916/76 A GB14916/76 A GB 14916/76A GB 1491676 A GB1491676 A GB 1491676A GB 1576625 A GB1576625 A GB 1576625A
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GB
United Kingdom
Prior art keywords
compounds
group
amino
methoxyimino
acetamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB14916/76A
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English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to GB14916/76A priority Critical patent/GB1576625A/en
Priority to JP51125826A priority patent/JPS5941995B2/ja
Priority to US05/767,700 priority patent/US4166115A/en
Priority to DK075077A priority patent/DK162391C/da
Priority to ZA00771059A priority patent/ZA771059B/xx
Priority to SE7701964A priority patent/SE443981B/xx
Priority to DE19772707565 priority patent/DE2707565A1/de
Priority to CA000272430A priority patent/CA1337522C/en
Priority to CH244777A priority patent/CH638532A5/de
Priority to HU77FU362A priority patent/HU183009B/hu
Priority to HU77FU348A priority patent/HU177441B/hu
Priority to IE2634/80A priority patent/IE45598B1/en
Priority to IE440/77A priority patent/IE45597B1/en
Priority to AT138477A priority patent/AT358728B/de
Priority to FR7707173A priority patent/FR2348219A1/fr
Priority to BE175758A priority patent/BE852427A/fr
Priority to ES457191A priority patent/ES457191A1/es
Priority to MX775624U priority patent/MX4985E/es
Priority to MX8561A priority patent/MX155110A/es
Priority to NL7703969A priority patent/NL191259C/xx
Priority to KR7700883A priority patent/KR840000141B1/ko
Priority to AR257178A priority patent/AR227864A1/es
Priority to JP8249077A priority patent/JPS5368796A/ja
Priority to JP8248977A priority patent/JPS5368795A/ja
Priority to FR7802762A priority patent/FR2367756B1/fr
Priority to US05/883,395 priority patent/US4544653A/en
Priority to US05/887,999 priority patent/US4279818A/en
Priority to AR271541A priority patent/AR223143A1/es
Priority to ES468719A priority patent/ES468719A1/es
Priority to US05/916,952 priority patent/US4316019A/en
Priority to ES477741A priority patent/ES477741A1/es
Priority to US06/040,976 priority patent/US4877873A/en
Priority to US06/077,557 priority patent/US4304770A/en
Priority to ES485064A priority patent/ES485064A1/es
Priority to ES485061A priority patent/ES485061A1/es
Priority to ES485062A priority patent/ES485062A1/es
Priority to ES485063A priority patent/ES485063A1/es
Priority to AT0677379A priority patent/AT372375B/de
Priority to AT0677579A priority patent/AT372377B/de
Priority to JP15697479A priority patent/JPS5598189A/ja
Priority to US06/123,164 priority patent/US4331664A/en
Publication of GB1576625A publication Critical patent/GB1576625A/en
Priority to US06/240,221 priority patent/US4364943A/en
Priority to US06/296,117 priority patent/US4493833A/en
Priority to KR1019810003622A priority patent/KR840000142B1/ko
Priority to US06/353,879 priority patent/US4431643A/en
Priority to JP58128676A priority patent/JPS5962597A/ja
Priority to CH409583A priority patent/CH643557A5/de
Priority to CH409883A priority patent/CH643836A5/de
Priority to CH409783A priority patent/CH643823A5/de
Priority to CH409683A priority patent/CH643822A5/de
Priority to SE8304465A priority patent/SE457351B/sv
Priority to US06/525,499 priority patent/US4804752A/en
Priority to US06/615,721 priority patent/US4871860A/en
Priority to US07/370,873 priority patent/US5079369A/en
Priority to JP2261173A priority patent/JPH0684338B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
GB14916/76A 1976-04-02 1976-04-12 Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof Expired GB1576625A (en)

Priority Applications (55)

Application Number Priority Date Filing Date Title
GB14916/76A GB1576625A (en) 1976-04-12 1976-04-12 Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
JP51125826A JPS5941995B2 (ja) 1976-04-12 1976-10-19 ３，７−ジ置換−３−セフエム−４−カルボン酸化合物およびその塩類およびそれらの製造方法
US05/767,700 US4166115A (en) 1976-04-12 1977-02-11 Syn 7-oxoimino substituted derivatives of cephalosporanic acid
DK075077A DK162391C (da) 1976-04-12 1977-02-21 Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser
ZA00771059A ZA771059B (en) 1976-04-12 1977-02-22 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
SE7701964A SE443981B (sv) 1976-04-12 1977-02-22 Analogiforfarande for framstellning av syn-isomerer av 3,7 disubstituerade 3-cefem-4-karboxylsyraforeningar
DE19772707565 DE2707565A1 (de) 1976-04-12 1977-02-22 Syn-isomere von 3,7-disubstituierten-3-cephem-4-carbonsaeureverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel
CA000272430A CA1337522C (en) 1976-04-12 1977-02-23 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
CH244777A CH638532A5 (de) 1976-04-12 1977-02-25 Verfahren zur herstellung der syn-isomere von 3,7-disubstituierten 3-cephem-4-carbonsaeuren.
HU77FU362A HU183009B (en) 1976-04-12 1977-02-28 Process for producing 2-oximino-acetic acid derivatives substituted with thiazolyl-4-ring at the 2 position
HU77FU348A HU177441B (en) 1976-04-12 1977-02-28 Process for preparing syn isomers of 3,7-disubstituted 3-cephem-4-carboxylic acid derivatives
IE2634/80A IE45598B1 (en) 1976-04-12 1977-03-01 Intermediates in the preparation of syn-isomers of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
IE440/77A IE45597B1 (en) 1976-04-12 1977-03-01 Syn isomer of 3,7-disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
AT138477A AT358728B (de) 1976-04-12 1977-03-02 Verfahren zur herstellung von neuen synisomeren von 3,7-disubstituierten 3-cephem-4-carbon- saeureverbindungen
FR7707173A FR2348219A1 (fr) 1976-04-12 1977-03-10 Procede de preparation d'isomeres syn de composes d'acides 3,7-cephem-4-carboxyliques 3,7-disubstitues et nouveaux produits ainsi obtenus, a activite antibacterienne
BE175758A BE852427A (fr) 1976-04-12 1977-03-14 Procede de preparation d'isomeres syn de composes d'acides 3,7-cephem-4-carboxyliques 3,7-disubstitues et nouveaux produits ainsi obtenus
ES457191A ES457191A1 (es) 1976-04-12 1977-03-25 Un procedimiento para preparar el isomero sin de los com- puestos del acido 3-cefem-4-carboxilico sustituido en las posiciones 3 y 7.
MX775624U MX4985E (es) 1976-04-12 1977-04-11 Procedimiento para preparar el isomero,sin del acido 3-cefem 4-carboxilico disubstituido en las posiciones 3 y 7
MX8561A MX155110A (es) 1976-04-12 1977-04-11 Procedimiento para preparar un intermedio para la obtencion del isomero sin del acido 3-cefem-4-carboxilico disubstituido en las posiciones 3 y 7
NL7703969A NL191259C (nl) 1976-04-12 1977-04-12 Werkwijze ter bereiding van een geneesmiddel met antibacteriële werking, alsmede werkwijze voor het bereiden van de syn-isomeer van een 7-[2-gesubstitueerd-2-(veretherd oxyimino)aceetamido]-3-(gesubstitueerd methyl)-3-cefem-4-carbonzuurderivaat.
KR7700883A KR840000141B1 (ko) 1976-04-12 1977-04-12 3, 7-디서브스티튜티드-3-세펨-4-카르복실산화합물의 신(syn) 이성체의 제조방법
AR257178A AR227864A1 (es) 1976-04-12 1977-04-20 Procedimiento para obtener isomeros syn de compuestos del acido 3-cefem-4-carboxilicos 3,7 disustituidos
JP8249077A JPS5368796A (en) 1976-04-12 1977-07-08 Syn-isomer of 3,7-disubstd.-3-cephem-4-carboxylic acids, and their preventingor treating agents containing their salts as active constituent againstdiseases caused by bacterial infection
JP8248977A JPS5368795A (en) 1976-04-12 1977-07-08 Syn-isomer of 7-substd.-3-methyl-3-cephem-4-carboxylic acids, their salts,and their preparation
FR7802762A FR2367756B1 (fr) 1976-04-12 1978-02-01 Derives 2-alcoxyamino-2-(amino-1,3-thiazolyl) acetiques et leur utilisation
US05/883,395 US4544653A (en) 1976-04-12 1978-03-06 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
US05/887,999 US4279818A (en) 1976-04-12 1978-03-20 Syn-isomers of 7-[2-alkoxyimino-2-(2-amino-thiazol-4-yl)acetamido]-3-[nitrobenzoyl-, or benzoyl-oxymethyl]-3-cephem-4-carboxylic acid
AR271541A AR223143A1 (es) 1976-04-12 1978-03-27 Un procedimiento para preparar el isomero sin de los compuestos del acido 3-cefem-4-carboxilico sustituido en las posiciones 3 y 7
ES468719A ES468719A1 (es) 1976-04-12 1978-04-12 Un procedimiento para preparar el isomero sin de los com- puestos del acido 3-cefem-4-carboxilico sustituido en las posiciones 3 y 7.
US05/916,952 US4316019A (en) 1976-04-12 1978-06-19 Preparation of syn-isomer of 3-alkanoyloxymethyl-7-(2-alkoxyimino-2-thiazolylacetamido-3-cephem-4-carboxylic acid compounds
ES477741A ES477741A1 (es) 1976-04-12 1979-02-15 Un procedimiento para preparar derivados de acido acetico.
US06/040,976 US4877873A (en) 1976-04-02 1979-05-21 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
US06/077,557 US4304770A (en) 1976-04-12 1979-09-21 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
ES485064A ES485064A1 (es) 1976-04-12 1979-10-16 Un procedimiento para preparar derivados de acido acetico
ES485061A ES485061A1 (es) 1976-04-12 1979-10-16 Un procedimiento para preparar el siomero sin descompuestos de acido 3-cefem-4-carboxilico sustituido en las posiciones 3 y 7
ES485062A ES485062A1 (es) 1976-04-12 1979-10-16 Un procedimiento para preparar derivados de acido acetico
ES485063A ES485063A1 (es) 1976-04-12 1979-10-16 Un procedimiento para preparar derivados de acido acetico
AT0677379A AT372375B (de) 1976-04-12 1979-10-17 Verfahren zur herstellung von neuen 1,3-thiazol- verbindungen und von deren salzen
AT0677579A AT372377B (de) 1976-04-12 1979-10-17 Verfahren zur herstellung von neuen 1,3-thiazol- verbindungen und von deren salzen
JP15697479A JPS5598189A (en) 1976-04-12 1979-12-03 Syn-isomer of 3, 7-di-substituted-3-cephem-4-carboxylic acid compound, its salt, and their preparation
US06/123,164 US4331664A (en) 1976-04-12 1980-02-20 Syn isomer of 7-[2-cyclo(lower) alkoxyimino-2-(2-amino-or substituted aminothiazol-4-yl)acetamido]-3-lower alkanoyloxymethyl or heterocyclicthiomethyl-3-cephem-4-carboxylic acid compounds
US06/240,221 US4364943A (en) 1976-04-12 1981-03-03 Syn-isomer of 7-[2-alkoxyimino-2-(2-amino-alkanoylamino-or haloalkanoylamino-thiazol-4-yl) acetamids]-3-[hexanoyl-, or phenylalkanoyl-oxymethyl or benzothiazolylthiomethyl]-3-cephem-4-carboxylic acid
US06/296,117 US4493833A (en) 1976-04-12 1981-08-25 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds
KR1019810003622A KR840000142B1 (ko) 1976-04-12 1981-09-28 3,7-이치환-3-세펨-4-카르복실산화합물의 syn-이성체의 제조방법
US06/353,879 US4431643A (en) 1976-04-12 1982-03-01 Syn-isomer of 3-substituted-7-[2-cyclopentyloxyimino-2-(2-aminothiazol-4-yl)-acetamido]-3
JP58128676A JPS5962597A (ja) 1976-04-12 1983-07-13 ３，７−ジ置換−３−セフエム−４−カルボン酸化合物のシン異性体およびその塩類およびそれらを製造する方法
CH409583A CH643557A5 (en) 1976-04-12 1983-07-26 Process for the preparation of syn isomers of 3,7-disubstituted 3-cephem-4-carboxylic acids
CH409883A CH643836A5 (de) 1976-04-12 1983-07-26 Verfahren zur herstellung der syn-isomeren von 2-oxyiminoessigsaeuren.
CH409783A CH643823A5 (de) 1976-04-12 1983-07-26 Verfahren zur herstellung der syn-isomeren von 2-oxyiminoessigsaeuren.
CH409683A CH643822A5 (de) 1976-04-12 1983-07-26 Verfahren zur herstellung der syn-isomeren von 2-oxyiminoessigsaeuren.
SE8304465A SE457351B (sv) 1976-04-12 1983-08-17 Tiazolderivat till anvaendning som mellanprodukt foer framstaellning av 3,7 disubstituerade 3-cefem-4-karboxylsyrafoereningar samt foerfarande foer framstaellning daerav
US06/525,499 US4804752A (en) 1976-04-12 1983-08-22 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
US06/615,721 US4871860A (en) 1976-04-12 1984-05-31 Syn-isomer of 3,7-disubstituted-3-cephem-4-caroxylic acid compounds and processes for the preparation thereof
US07/370,873 US5079369A (en) 1976-04-12 1989-06-23 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
JP2261173A JPH0684338B2 (ja) 1976-04-12 1990-09-28 置換酢酸誘導体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB14916/76A GB1576625A (en) 1976-04-12 1976-04-12 Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
GB2349076 1976-06-07

Publications (1)

Publication Number Publication Date
GB1576625A true GB1576625A (en) 1980-10-08

Family

ID=26250890

Family Applications (1)

Application Number Title Priority Date Filing Date
GB14916/76A Expired GB1576625A (en) 1976-04-02 1976-04-12 Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof

Country Status (3)

Country Link
JP (6) JPS5941995B2 (enrdf_load_stackoverflow)
GB (1) GB1576625A (enrdf_load_stackoverflow)
HU (1) HU183009B (enrdf_load_stackoverflow)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2188046A (en) * 1985-05-30 1987-09-23 Shionogi & Co Hydroxymethylcephem compounds and their preparation
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4866055A (en) * 1986-11-25 1989-09-12 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives and their crystalline derivatives
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US4888332A (en) * 1983-12-29 1989-12-19 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US5064953A (en) * 1983-12-29 1991-11-12 Mochida Pharmaceutical Co., Ltd. Intermediates cephalosporin derivatives
US5189157A (en) * 1987-06-16 1993-02-23 Hoffmann La Roche Inc. Antibacterial cephalosporin compounds
EP0832893A1 (en) * 1996-09-25 1998-04-01 Eisai Chemical Co., Ltd. Process for the production of cephem compounds
CN112480024A (zh) * 2020-12-11 2021-03-12 山东金城医药化工有限公司 生产氨噻肟酸反式异构体的方法

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE878433A (fr) * 1978-08-31 1980-02-25 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
BE878514A (fr) * 1978-09-04 1980-02-29 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3-cephem-4-carboxylique a disubstitution en positions 3 et 7, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
SE439312B (sv) * 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
NL7805715A (nl) * 1977-06-03 1978-12-05 Hoffmann La Roche Werkwijze voor het bereiden van acylderivaten.
FR2410655A1 (fr) * 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
JPS54128594A (en) * 1978-03-27 1979-10-05 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid derivative
FR2432521A1 (fr) * 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2421907A1 (fr) * 1978-04-07 1979-11-02 Roussel Uclaf Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments
GB1604722A (en) * 1978-05-26 1981-12-16 Glaxo Operations Ltd 7-(2-(2-amino-4-thiozolyl)-2-oxymino-acetamido)-cephem derivatives
GB1604723A (en) * 1978-05-26 1981-12-16 Glaxo Operations Ltd 7-(2-aminothiazol-4-yl)-2-oxyimino-acetamido)-cephem derivatives
EP0009548B1 (en) * 1978-07-17 1985-01-16 Fujisawa Pharmaceutical Co., Ltd. Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them
US4703046A (en) * 1978-09-08 1987-10-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and processes for preparation thereof
BE878637A (fr) * 1978-09-11 1980-03-06 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3-cephem-4-carboxylique 3,7-disubstitue et de leurs sels pharmaceutiquement acceptables, nouveaux produits ainsi obtenus et leur utilisation pour leurs activites antimicrobiennes
JPH02111750A (ja) * 1978-09-12 1990-04-24 Fujisawa Pharmaceut Co Ltd 酪酸誘導体
JPS5585594A (en) * 1978-11-13 1980-06-27 Fujisawa Pharmaceut Co Ltd Cephem compound and their preparation
JPS5579393A (en) * 1978-12-11 1980-06-14 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
JPS5616490A (en) * 1979-07-18 1981-02-17 Hoechst Ag Cephem compound manufacture
IL61458A0 (en) * 1979-12-07 1980-12-31 Erba Farmitalia N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them
DE3165922D1 (en) * 1980-03-28 1984-10-18 Biochemie Gmbh New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
IL63207A (en) * 1980-07-24 1985-09-29 Lonza Ag Process for the preparation of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyiminoacetic acid esters
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US4888332A (en) * 1983-12-29 1989-12-19 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US5064953A (en) * 1983-12-29 1991-11-12 Mochida Pharmaceutical Co., Ltd. Intermediates cephalosporin derivatives
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
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CN112480024A (zh) * 2020-12-11 2021-03-12 山东金城医药化工有限公司 生产氨噻肟酸反式异构体的方法

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JPS6137250B2 (enrdf_load_stackoverflow) 1986-08-22
JPS5962597A (ja) 1984-04-10
JPS5598189A (en) 1980-07-25
JPS52125190A (en) 1977-10-20
JPS6141516B2 (enrdf_load_stackoverflow) 1986-09-16
JPH0684338B2 (ja) 1994-10-26
JPS5941995B2 (ja) 1984-10-11
JPH03135946A (ja) 1991-06-10
JPS5368796A (en) 1978-06-19
JPH0373553B2 (enrdf_load_stackoverflow) 1991-11-22
JPS5368795A (en) 1978-06-19
HU183009B (en) 1984-04-28

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Effective date: 19970208