JPH0373553B2 - - Google Patents

Info

Publication number
JPH0373553B2
JPH0373553B2 JP58128676A JP12867683A JPH0373553B2 JP H0373553 B2 JPH0373553 B2 JP H0373553B2 JP 58128676 A JP58128676 A JP 58128676A JP 12867683 A JP12867683 A JP 12867683A JP H0373553 B2 JPH0373553 B2 JP H0373553B2
Authority
JP
Japan
Prior art keywords
group
acid
add
spectrum
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58128676A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5962597A (ja
Inventor
Takao Takatani
Takashi Masugi
Hisashi Takasugi
Hiromu Kawachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPS5962597A publication Critical patent/JPS5962597A/ja
Publication of JPH0373553B2 publication Critical patent/JPH0373553B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP58128676A 1976-04-12 1983-07-13 ３，７−ジ置換−３−セフエム−４−カルボン酸化合物のシン異性体およびその塩類およびそれらを製造する方法 Granted JPS5962597A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB14916/76A GB1576625A (en) 1976-04-12 1976-04-12 Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
GB14916/76 1976-04-12
GB2349076 1976-06-07
GB23490/76 1976-06-07

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2261173A Division JPH0684338B2 (ja) 1976-04-12 1990-09-28 置換酢酸誘導体

Publications (2)

Publication Number Publication Date
JPS5962597A JPS5962597A (ja) 1984-04-10
JPH0373553B2 true JPH0373553B2 (enrdf_load_stackoverflow) 1991-11-22

Family

ID=26250890

Family Applications (6)

Application Number Title Priority Date Filing Date
JP51125826A Expired JPS5941995B2 (ja) 1976-04-02 1976-10-19 ３，７−ジ置換−３−セフエム−４−カルボン酸化合物およびその塩類およびそれらの製造方法
JP8248977A Pending JPS5368795A (en) 1976-04-12 1977-07-08 Syn-isomer of 7-substd.-3-methyl-3-cephem-4-carboxylic acids, their salts,and their preparation
JP8249077A Granted JPS5368796A (en) 1976-04-12 1977-07-08 Syn-isomer of 3,7-disubstd.-3-cephem-4-carboxylic acids, and their preventingor treating agents containing their salts as active constituent againstdiseases caused by bacterial infection
JP15697479A Granted JPS5598189A (en) 1976-04-12 1979-12-03 Syn-isomer of 3, 7-di-substituted-3-cephem-4-carboxylic acid compound, its salt, and their preparation
JP58128676A Granted JPS5962597A (ja) 1976-04-12 1983-07-13 ３，７−ジ置換−３−セフエム−４−カルボン酸化合物のシン異性体およびその塩類およびそれらを製造する方法
JP2261173A Expired - Lifetime JPH0684338B2 (ja) 1976-04-12 1990-09-28 置換酢酸誘導体

Family Applications Before (4)

Application Number Title Priority Date Filing Date
JP51125826A Expired JPS5941995B2 (ja) 1976-04-02 1976-10-19 ３，７−ジ置換−３−セフエム−４−カルボン酸化合物およびその塩類およびそれらの製造方法
JP8248977A Pending JPS5368795A (en) 1976-04-12 1977-07-08 Syn-isomer of 7-substd.-3-methyl-3-cephem-4-carboxylic acids, their salts,and their preparation
JP8249077A Granted JPS5368796A (en) 1976-04-12 1977-07-08 Syn-isomer of 3,7-disubstd.-3-cephem-4-carboxylic acids, and their preventingor treating agents containing their salts as active constituent againstdiseases caused by bacterial infection
JP15697479A Granted JPS5598189A (en) 1976-04-12 1979-12-03 Syn-isomer of 3, 7-di-substituted-3-cephem-4-carboxylic acid compound, its salt, and their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2261173A Expired - Lifetime JPH0684338B2 (ja) 1976-04-12 1990-09-28 置換酢酸誘導体

Country Status (3)

Country Link
JP (6) JPS5941995B2 (enrdf_load_stackoverflow)
GB (1) GB1576625A (enrdf_load_stackoverflow)
HU (1) HU183009B (enrdf_load_stackoverflow)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE878433A (fr) * 1978-08-31 1980-02-25 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
BE878514A (fr) * 1978-09-04 1980-02-29 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3-cephem-4-carboxylique a disubstitution en positions 3 et 7, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
SE439312B (sv) * 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
GB1599232A (en) * 1977-06-03 1981-09-30 Hoffmann La Roche 7-(2-oximinoacetamido)-cephalosporin derivatives
FR2410655A1 (fr) * 1977-12-05 1979-06-29 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
JPS54128594A (en) * 1978-03-27 1979-10-05 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid derivative
FR2432521A1 (fr) * 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2421907A1 (fr) * 1978-04-07 1979-11-02 Roussel Uclaf Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments
GB1604722A (en) * 1978-05-26 1981-12-16 Glaxo Operations Ltd 7-(2-(2-amino-4-thiozolyl)-2-oxymino-acetamido)-cephem derivatives
GB1604723A (en) * 1978-05-26 1981-12-16 Glaxo Operations Ltd 7-(2-aminothiazol-4-yl)-2-oxyimino-acetamido)-cephem derivatives
DE2967356D1 (en) * 1978-07-17 1985-02-28 Fujisawa Pharmaceutical Co Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them
US4703046A (en) * 1978-09-08 1987-10-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and processes for preparation thereof
BE878637A (fr) * 1978-09-11 1980-03-06 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3-cephem-4-carboxylique 3,7-disubstitue et de leurs sels pharmaceutiquement acceptables, nouveaux produits ainsi obtenus et leur utilisation pour leurs activites antimicrobiennes
JPH02111750A (ja) * 1978-09-12 1990-04-24 Fujisawa Pharmaceut Co Ltd 酪酸誘導体
JPS5585594A (en) * 1978-11-13 1980-06-27 Fujisawa Pharmaceut Co Ltd Cephem compound and their preparation
JPS5579393A (en) * 1978-12-11 1980-06-14 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
JPS5616490A (en) * 1979-07-18 1981-02-17 Hoechst Ag Cephem compound manufacture
IL61458A0 (en) * 1979-12-07 1980-12-31 Erba Farmitalia N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them
CY1365A (en) * 1980-03-28 1987-08-07 Biochemie Gmbh New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
IL63207A (en) * 1980-07-24 1985-09-29 Lonza Ag Process for the preparation of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyiminoacetic acid esters
JPS57154175A (en) * 1981-03-16 1982-09-22 Mitsui Toatsu Chem Inc 2-thiazoleamine derivative, its preparation, and drug composition comprising it
JPS57157594U (enrdf_load_stackoverflow) * 1981-03-31 1982-10-04
WO1984004305A1 (en) * 1983-05-02 1984-11-08 Takeda Chemical Industries Ltd Process for preparing aminothiazoleacetic acid derivatives
WO1984002703A1 (en) * 1983-01-07 1984-07-19 Takeda Chemical Industries Ltd Process for preparing aminothiazolylacetic acid derivatives
EP0115770B2 (en) * 1983-01-07 1996-06-19 Takeda Chemical Industries, Ltd. Thiazole Derivatives
GB8318846D0 (en) * 1983-07-12 1983-08-10 Fujisawa Pharmaceutical Co Prophylactic/therapeutic agent against fish diseases
JPS60142987A (ja) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd セフアロスポリン誘導体
DE150507T1 (de) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
JPS60178891A (ja) * 1984-02-24 1985-09-12 Kureha Chem Ind Co Ltd セファロスポリン誘導体及び該誘導体を含有する医薬
JPS60155167A (ja) * 1984-07-31 1985-08-15 Fujisawa Pharmaceut Co Ltd 置換イミノ酢酸誘導体およびその塩類
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
AU579469B2 (en) * 1985-05-30 1988-11-24 Shionogi & Co., Ltd. A process for preparing hydroxymethylcephem compounds
JPS6236386A (ja) * 1985-08-09 1987-02-17 Kureha Chem Ind Co Ltd セフアロスポリン誘導体、その製造方法及び該誘導体を含有する医薬
JPS6332235A (ja) * 1986-07-25 1988-02-10 アトラス・エア・（オ−ストラリア）・ピ−テイ−ワイ・リミテツド 区域空調方法及びその装置
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS63132893A (ja) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
US5189157A (en) * 1987-06-16 1993-02-23 Hoffmann La Roche Inc. Antibacterial cephalosporin compounds
CA2216259A1 (en) * 1996-09-25 1998-03-25 Eisai Chemical Co., Ltd. Production process of cephem compound
CN112480024A (zh) * 2020-12-11 2021-03-12 山东金城医药化工有限公司 生产氨噻肟酸反式异构体的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1445979A (en) * 1972-10-25 1976-08-11 Glaxo Lab Ltd Cephalosporin derivatives
GB1453049A (en) * 1973-08-21 1976-10-20 Glaxo Lab Ltd Cephalosporing antibiotics
JPS4849789A (enrdf_load_stackoverflow) * 1971-10-25 1973-07-13
JPS50111093A (enrdf_load_stackoverflow) * 1974-02-20 1975-09-01
GB1536281A (en) * 1975-06-09 1978-12-20 Takeda Chemical Industries Ltd Cephem compounds
SE440655B (sv) * 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra
FR2345153A1 (fr) * 1976-03-25 1977-10-21 Roussel Uclaf Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
JPS52125190A (en) 1977-10-20
GB1576625A (en) 1980-10-08
HU183009B (en) 1984-04-28
JPS5962597A (ja) 1984-04-10
JPS5368796A (en) 1978-06-19
JPS6141516B2 (enrdf_load_stackoverflow) 1986-09-16
JPH03135946A (ja) 1991-06-10
JPS5598189A (en) 1980-07-25
JPS6137250B2 (enrdf_load_stackoverflow) 1986-08-22
JPS5941995B2 (ja) 1984-10-11
JPH0684338B2 (ja) 1994-10-26
JPS5368795A (en) 1978-06-19

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