JPS52125190A - 3,7-disubstituted-3-cephem-4-carboxylic acids, their salts and their preparation - Google Patents

3,7-disubstituted-3-cephem-4-carboxylic acids, their salts and their preparation

Info

Publication number
JPS52125190A
JPS52125190A JP12582676A JP12582676A JPS52125190A JP S52125190 A JPS52125190 A JP S52125190A JP 12582676 A JP12582676 A JP 12582676A JP 12582676 A JP12582676 A JP 12582676A JP S52125190 A JPS52125190 A JP S52125190A
Authority
JP
Japan
Prior art keywords
cephem
disubstituted
salts
carboxylic acids
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12582676A
Other languages
Japanese (ja)
Other versions
JPS5941995B2 (en
Inventor
Takao Takatani
Takashi Masugi
Hisashi Takasugi
Hiromu Kawachi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to US05/767,700 priority Critical patent/US4166115A/en
Priority to DK075077A priority patent/DK162391C/en
Priority to DE19772707565 priority patent/DE2707565A1/en
Priority to SE7701964A priority patent/SE443981B/en
Priority to CA000272430A priority patent/CA1337522C/en
Priority to CH244777A priority patent/CH638532A5/en
Priority to HU77FU348A priority patent/HU177441B/en
Priority to IE2634/80A priority patent/IE45598B1/en
Priority to IE440/77A priority patent/IE45597B1/en
Priority to AT138477A priority patent/AT358728B/en
Priority to FR7707173A priority patent/FR2348219A1/en
Priority to ES457191A priority patent/ES457191A1/en
Priority to MX775624U priority patent/MX4985E/en
Priority to MX8561A priority patent/MX155110A/en
Priority to MX856077A priority patent/MX155825A/en
Priority to NL7703969A priority patent/NL191259C/en
Priority to AR257178A priority patent/AR227864A1/en
Publication of JPS52125190A publication Critical patent/JPS52125190A/en
Priority to FR7802762A priority patent/FR2367756B1/en
Priority to US05/883,395 priority patent/US4544653A/en
Priority to US05/887,999 priority patent/US4279818A/en
Priority to AR271541A priority patent/AR223143A1/en
Priority to ES468719A priority patent/ES468719A1/en
Priority to US05/916,952 priority patent/US4316019A/en
Priority to ES477741A priority patent/ES477741A1/en
Priority to US06/040,976 priority patent/US4877873A/en
Priority to ES483628A priority patent/ES483628A1/en
Priority to US06/077,557 priority patent/US4304770A/en
Priority to ES485063A priority patent/ES485063A1/en
Priority to ES485061A priority patent/ES485061A1/en
Priority to ES485062A priority patent/ES485062A1/en
Priority to ES485064A priority patent/ES485064A1/en
Priority to AT0677579A priority patent/AT372377B/en
Priority to AT0677379A priority patent/AT372375B/en
Priority to AT677279A priority patent/AT362505B/en
Priority to US06/123,164 priority patent/US4331664A/en
Priority to US06/240,221 priority patent/US4364943A/en
Priority to US06/296,117 priority patent/US4493833A/en
Priority to US06/353,879 priority patent/US4431643A/en
Priority to CH409683A priority patent/CH643822A5/en
Priority to CH409783A priority patent/CH643823A5/en
Priority to CH409883A priority patent/CH643836A5/en
Priority to CH409583A priority patent/CH643557A5/en
Priority to SE8304465A priority patent/SE457351B/en
Priority to US06/525,499 priority patent/US4804752A/en
Priority to US06/615,721 priority patent/US4871860A/en
Publication of JPS5941995B2 publication Critical patent/JPS5941995B2/en
Priority to US07/370,873 priority patent/US5079369A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

PURPOSE: 3,7-Disubstituted-3-cephem-4-carboxylic acids and their salts I[R1 is IV(R5 is H, halogen, nitro, etc,; R6 is OH, alkoxy, etc.), V(R7 is amino, OH, etc.), etc.; R2 is aliphatic hydrocarbon residue; R3 is carboxyl, protected carboxyl, etc.; R4 is methyl, acyloxymethyl, etc.], e.g. 7-[2-methoxyimino-2(3-hydroxyphenyl)acetamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid(syn-isomer).
COPYRIGHT: (C)1977,JPO&Japio
JP51125826A 1976-04-02 1976-10-19 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and salts thereof and methods for producing them Expired JPS5941995B2 (en)

Priority Applications (46)

Application Number Priority Date Filing Date Title
US05/767,700 US4166115A (en) 1976-04-12 1977-02-11 Syn 7-oxoimino substituted derivatives of cephalosporanic acid
DK075077A DK162391C (en) 1976-04-12 1977-02-21 ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS
DE19772707565 DE2707565A1 (en) 1976-04-12 1977-02-22 SYN-ISOMERS OF 3,7-DISUBSTITUTED-3-CEPHEM-4-CARBONIC ACID COMPOUNDS, THE PROCESS FOR THEIR PRODUCTION AND THE PHARMACEUTICAL PRODUCTS CONTAINING THEM
SE7701964A SE443981B (en) 1976-04-12 1977-02-22 ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3.7 DISUBSTITUTED 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS
CA000272430A CA1337522C (en) 1976-04-12 1977-02-23 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
CH244777A CH638532A5 (en) 1976-04-12 1977-02-25 METHOD FOR PRODUCING THE SYN-ISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBONIC ACIDS.
HU77FU348A HU177441B (en) 1976-04-12 1977-02-28 Process for preparing syn isomers of 3,7-disubstituted 3-cephem-4-carboxylic acid derivatives
IE2634/80A IE45598B1 (en) 1976-04-12 1977-03-01 Intermediates in the preparation of syn-isomers of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
IE440/77A IE45597B1 (en) 1976-04-12 1977-03-01 Syn isomer of 3,7-disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
AT138477A AT358728B (en) 1976-04-12 1977-03-02 METHOD FOR PRODUCING NEW SYNISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBONIC ACID COMPOUNDS
FR7707173A FR2348219A1 (en) 1976-04-12 1977-03-10 PROCESS FOR PREPARING SYN ISOMERS OF 3,7-CEPHEM-4-CARBOXYLIC 3,7-DISUBSTITUTED ACID COMPOUNDS AND NEW PRODUCTS THUS OBTAINED, WITH ANTIBACTERIAL ACTIVITY
ES457191A ES457191A1 (en) 1976-04-12 1977-03-25 A procedure for preparing the isomero without the compounds of 3-cefem-4-carboxylic acid replaced in positions 3 and 7. (Machine-translation by Google Translate, not legally binding)
MX775624U MX4985E (en) 1976-04-12 1977-04-11 PROCEDURE FOR PREPARING THE ISOMER, WITHOUT THE ACID 3-CEFEM 4-CARBOXILICO DISUBSTITUTED IN POSITIONS 3 AND 7
MX8561A MX155110A (en) 1976-04-12 1977-04-11 PROCEDURE TO PREPARE AN INTERMEDIATE TO OBTAIN THE ISOMER WITHOUT THE ACID 3-CEFEM-4-CARBOXYLIC DISUBSTITUTED IN POSITIONS 3 AND 7
MX856077A MX155825A (en) 1976-06-07 1977-04-11 PROCEDURE FOR PREPARING THE ISOMERO-SIN OF THE ACID 3-CEFEM-4-CARBOXILICO DISUBSTITUTED IN POSITIONS 3 AND 7
NL7703969A NL191259C (en) 1976-04-12 1977-04-12 A method of preparing a medicament with an antibacterial action, and a method of preparing the syn isomer of a 7- [2-substituted-2- (etherified oxyimino) acetamido] -3- (substituted methyl) -3-cephem-4 -carboxylic acid derivative.
AR257178A AR227864A1 (en) 1976-04-12 1977-04-20 PROCEDURE FOR OBTAINING SYN ISOMERS OF 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS 3.7 DISSTITUTED
FR7802762A FR2367756B1 (en) 1976-04-12 1978-02-01 2-ALCOXYAMINO-2- (AMINO-1,3-THIAZOLYL) ACETICS DERIVATIVES AND THEIR USE
US05/883,395 US4544653A (en) 1976-04-12 1978-03-06 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
US05/887,999 US4279818A (en) 1976-04-12 1978-03-20 Syn-isomers of 7-[2-alkoxyimino-2-(2-amino-thiazol-4-yl)acetamido]-3-[nitrobenzoyl-, or benzoyl-oxymethyl]-3-cephem-4-carboxylic acid
AR271541A AR223143A1 (en) 1976-04-12 1978-03-27 A PROCEDURE FOR PREPARING THE SIN ISOMER OF THE COMPOUNDS OF THE ACID 3-CEFEM-4-CARBOXILICO SUBSTITUTED IN POSITIONS 3 AND 7
ES468719A ES468719A1 (en) 1976-04-12 1978-04-12 A procedure for preparing the isomero without the compounds of 3-cefem-4-carboxylic acid substituted in positions 3 and 7. (Machine-translation by Google Translate, not legally binding)
US05/916,952 US4316019A (en) 1976-04-12 1978-06-19 Preparation of syn-isomer of 3-alkanoyloxymethyl-7-(2-alkoxyimino-2-thiazolylacetamido-3-cephem-4-carboxylic acid compounds
ES477741A ES477741A1 (en) 1976-04-12 1979-02-15 A procedure for preparing acetic acid derivatives. (Machine-translation by Google Translate, not legally binding)
US06/040,976 US4877873A (en) 1976-04-02 1979-05-21 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
ES483628A ES483628A1 (en) 1976-06-07 1979-08-24 A procedure for preparing a composite of cephalosporine (Machine-translation by Google Translate, not legally binding)
US06/077,557 US4304770A (en) 1976-04-12 1979-09-21 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
ES485063A ES485063A1 (en) 1976-04-12 1979-10-16 A procedure for preparing acetic acid derivatives (Machine-translation by Google Translate, not legally binding)
ES485061A ES485061A1 (en) 1976-04-12 1979-10-16 A procedure for preparing the siomer without 3-cefem-4-carboxylic acid decomposition replaced in positions 3 and 7 (Machine-translation by Google Translate, not legally binding)
ES485062A ES485062A1 (en) 1976-04-12 1979-10-16 A procedure for preparing acetic acid derivatives (Machine-translation by Google Translate, not legally binding)
ES485064A ES485064A1 (en) 1976-04-12 1979-10-16 A procedure for preparing acetic acid derivatives (Machine-translation by Google Translate, not legally binding)
AT0677579A AT372377B (en) 1976-04-12 1979-10-17 METHOD FOR PRODUCING NEW 1,3-THIAZOLE COMPOUNDS AND THEIR SALTS
AT0677379A AT372375B (en) 1976-04-12 1979-10-17 METHOD FOR PRODUCING NEW 1,3-THIAZOLE COMPOUNDS AND THEIR SALTS
AT677279A AT362505B (en) 1976-06-07 1979-10-17 METHOD FOR PRODUCING NEW SYNISOMERS OF 3,7-DISUBSTITUTED 3-CEPHEM-4-CARBONIC ACID COMPOUNDS
US06/123,164 US4331664A (en) 1976-04-12 1980-02-20 Syn isomer of 7-[2-cyclo(lower) alkoxyimino-2-(2-amino-or substituted aminothiazol-4-yl)acetamido]-3-lower alkanoyloxymethyl or heterocyclicthiomethyl-3-cephem-4-carboxylic acid compounds
US06/240,221 US4364943A (en) 1976-04-12 1981-03-03 Syn-isomer of 7-[2-alkoxyimino-2-(2-amino-alkanoylamino-or haloalkanoylamino-thiazol-4-yl) acetamids]-3-[hexanoyl-, or phenylalkanoyl-oxymethyl or benzothiazolylthiomethyl]-3-cephem-4-carboxylic acid
US06/296,117 US4493833A (en) 1976-04-12 1981-08-25 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds
US06/353,879 US4431643A (en) 1976-04-12 1982-03-01 Syn-isomer of 3-substituted-7-[2-cyclopentyloxyimino-2-(2-aminothiazol-4-yl)-acetamido]-3
CH409683A CH643822A5 (en) 1976-04-12 1983-07-26 Syn isomers of alkoxy-imino acetamido-cephalosporins
CH409783A CH643823A5 (en) 1976-04-12 1983-07-26 Syn isomers of alkoxy-imino acetamido-cephalosporins
CH409883A CH643836A5 (en) 1976-04-12 1983-07-26 Syn isomers of alkoxy-imino acetamido-cephalosporins
CH409583A CH643557A5 (en) 1976-04-12 1983-07-26 Process for the preparation of syn isomers of 3,7-disubstituted 3-cephem-4-carboxylic acids
SE8304465A SE457351B (en) 1976-04-12 1983-08-17 TIAZOLE DERIVATIVES USED AS INTERMEDIATE FOR THE PREPARATION OF 3.7 DISUBSTITUTED 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS AND PROCEDURES FOR PREPARING THEREOF
US06/525,499 US4804752A (en) 1976-04-12 1983-08-22 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof
US06/615,721 US4871860A (en) 1976-04-12 1984-05-31 Syn-isomer of 3,7-disubstituted-3-cephem-4-caroxylic acid compounds and processes for the preparation thereof
US07/370,873 US5079369A (en) 1976-04-12 1989-06-23 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB000001491676 1976-04-12
GB14916/76A GB1576625A (en) 1976-04-12 1976-04-12 Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
GB000002349076 1976-06-07
GB2349076 1976-06-07

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP8248977A Division JPS5368795A (en) 1976-04-12 1977-07-08 Syn-isomer of 7-substd.-3-methyl-3-cephem-4-carboxylic acids, their salts,and their preparation
JP8249077A Division JPS5368796A (en) 1976-04-12 1977-07-08 Syn-isomer of 3,7-disubstd.-3-cephem-4-carboxylic acids, and their preventingor treating agents containing their salts as active constituent againstdiseases caused by bacterial infection
JP15697479A Division JPS5598189A (en) 1976-04-12 1979-12-03 Syn-isomer of 3, 7-di-substituted-3-cephem-4-carboxylic acid compound, its salt, and their preparation

Publications (2)

Publication Number Publication Date
JPS52125190A true JPS52125190A (en) 1977-10-20
JPS5941995B2 JPS5941995B2 (en) 1984-10-11

Family

ID=26250890

Family Applications (6)

Application Number Title Priority Date Filing Date
JP51125826A Expired JPS5941995B2 (en) 1976-04-02 1976-10-19 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and salts thereof and methods for producing them
JP8248977A Pending JPS5368795A (en) 1976-04-12 1977-07-08 Syn-isomer of 7-substd.-3-methyl-3-cephem-4-carboxylic acids, their salts,and their preparation
JP8249077A Granted JPS5368796A (en) 1976-04-12 1977-07-08 Syn-isomer of 3,7-disubstd.-3-cephem-4-carboxylic acids, and their preventingor treating agents containing their salts as active constituent againstdiseases caused by bacterial infection
JP15697479A Granted JPS5598189A (en) 1976-04-12 1979-12-03 Syn-isomer of 3, 7-di-substituted-3-cephem-4-carboxylic acid compound, its salt, and their preparation
JP58128676A Granted JPS5962597A (en) 1976-04-12 1983-07-13 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt and their preparation
JP2261173A Expired - Lifetime JPH0684338B2 (en) 1976-04-12 1990-09-28 Substituted acetic acid derivative

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP8248977A Pending JPS5368795A (en) 1976-04-12 1977-07-08 Syn-isomer of 7-substd.-3-methyl-3-cephem-4-carboxylic acids, their salts,and their preparation
JP8249077A Granted JPS5368796A (en) 1976-04-12 1977-07-08 Syn-isomer of 3,7-disubstd.-3-cephem-4-carboxylic acids, and their preventingor treating agents containing their salts as active constituent againstdiseases caused by bacterial infection
JP15697479A Granted JPS5598189A (en) 1976-04-12 1979-12-03 Syn-isomer of 3, 7-di-substituted-3-cephem-4-carboxylic acid compound, its salt, and their preparation
JP58128676A Granted JPS5962597A (en) 1976-04-12 1983-07-13 Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt and their preparation
JP2261173A Expired - Lifetime JPH0684338B2 (en) 1976-04-12 1990-09-28 Substituted acetic acid derivative

Country Status (3)

Country Link
JP (6) JPS5941995B2 (en)
GB (1) GB1576625A (en)
HU (1) HU183009B (en)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS549296A (en) * 1977-04-02 1979-01-24 Hoechst Ag Cephem derivative and its preparation
JPS5412394A (en) * 1977-06-03 1979-01-30 Hoffmann La Roche Acyl derivative
JPS5484595A (en) * 1977-12-05 1979-07-05 Roussel Uclaf Novel oxime derivatives of 33substituted 77aminothiazolyl acetoamide cephalosporanic acid*their manufacture and pharmateutical composition containing them
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
JPS54128594A (en) * 1978-03-27 1979-10-05 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid derivative
JPS54132593A (en) * 1978-03-31 1979-10-15 Roussel Uclaf Novel oosubstituted oxime derivatives of 77aminothiazolylacetoamidecephalosporanic acid*their manufacture*their use as drug and composition containing them
JPS54135793A (en) * 1978-04-07 1979-10-22 Roussel Uclaf Novel cephalosporin derived from 33substitutedd77*22*22aminoo44thiazolyl**22*carboxymethoxy imino*acetoamide* cephalosporanic acid*its manufacture and use as drug and pharmaceutical composition contai
JPS54154787A (en) * 1978-05-26 1979-12-06 Glaxo Group Ltd Cephalosporanic compound
JPS54154788A (en) * 1978-05-26 1979-12-06 Glaxo Group Ltd Cephalosporin antibiotic
JPS5519267A (en) * 1978-07-17 1980-02-09 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid, its salts, their preparation, and preventive and remedy for microbism comprising them as active constituents
JPS5533500A (en) * 1978-08-31 1980-03-08 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid, its salt, their preparation, and preventive and remedy for microbism
JPS5535096A (en) * 1978-09-04 1980-03-11 Fujisawa Pharmaceut Co Ltd 3-cephem compound, its salt, their preparation, and preventive and remedy for microbism comprising thema active constituent
JPS5547690A (en) * 1978-09-11 1980-04-04 Fujisawa Pharmaceut Co Ltd Cephem compound, its salt, their preparation, and preventives and remedies for microbism comprising them as active constituents
JPS5547688A (en) * 1978-09-08 1980-04-04 Fujisawa Pharmaceut Co Ltd Novel cephem compound and its preparation
JPS5579393A (en) * 1978-12-11 1980-06-14 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
JPS5616490A (en) * 1979-07-18 1981-02-17 Hoechst Ag Cephem compound manufacture
JPS56152488A (en) * 1980-03-28 1981-11-26 Biochemie Gmbh Novel manufacture of cephalosporin type antibiotics and novel intermediate therefor and manufacture of intermediate
JPS5753474A (en) * 1980-07-24 1982-03-30 Lonza Ag Manufacture of 2-(2-aminothiazole-4-yl)-2- (syn)-methoxyiminoacetic acid ester
JPS57154175A (en) * 1981-03-16 1982-09-22 Mitsui Toatsu Chem Inc 2-thiazoleamine derivative, its preparation, and drug composition comprising it
JPS57157594U (en) * 1981-03-31 1982-10-04
JPS6023317A (en) * 1983-07-12 1985-02-05 Fujisawa Pharmaceut Co Ltd Preventive and remedy for bacteriosis of fish
JPS60155167A (en) * 1984-07-31 1985-08-15 Fujisawa Pharmaceut Co Ltd Substituted iminoacetic acid derivative and its salt
JPS60178891A (en) * 1984-02-24 1985-09-12 Kureha Chem Ind Co Ltd Cephalosporin derivative, preparation thereof and medicine containing said derivative
JPS6236386A (en) * 1985-08-09 1987-02-17 Kureha Chem Ind Co Ltd Cephalosporin derivative, production thereof and drug containing said derivative
JPS6425768A (en) * 1977-03-25 1989-01-27 Roussel Uclaf 2-(2-amino-4-thiazolyl)-2-methoxyiminoacetic acid derivative and manufacture
JPH02111750A (en) * 1978-09-12 1990-04-24 Fujisawa Pharmaceut Co Ltd Butyric acid derivative

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5585594A (en) * 1978-11-13 1980-06-27 Fujisawa Pharmaceut Co Ltd Cephem compound and their preparation
IL61458A0 (en) * 1979-12-07 1980-12-31 Erba Farmitalia N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them
WO1984002703A1 (en) * 1983-01-07 1984-07-19 Takeda Chemical Industries Ltd Process for preparing aminothiazolylacetic acid derivatives
EP0115770B2 (en) * 1983-01-07 1996-06-19 Takeda Chemical Industries, Ltd. Thiazole Derivatives
WO1984004305A1 (en) * 1983-05-02 1984-11-08 Takeda Chemical Industries Ltd Process for preparing aminothiazoleacetic acid derivatives
DE150507T1 (en) * 1983-12-29 1987-02-26 Mochida Pharmaceutical Co., Ltd., Tokio/Tokyo CEPHALOSPORINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS.
JPS60142987A (en) * 1983-12-29 1985-07-29 Mochida Pharmaceut Co Ltd Cephalosporin derivative
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
AU579469B2 (en) * 1985-05-30 1988-11-24 Shionogi & Co., Ltd. A process for preparing hydroxymethylcephem compounds
JPS6332235A (en) * 1986-07-25 1988-02-10 アトラス・エア・（オ−ストラリア）・ピ−テイ−ワイ・リミテツド Zone air-conditioning method and device
JPS63132893A (en) * 1986-11-25 1988-06-04 Mochida Pharmaceut Co Ltd Novel cephalosporin derivative, production thereof and antibacterial agent containing said derivative as active ingredient
US4880798A (en) * 1986-11-25 1989-11-14 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
US5189157A (en) * 1987-06-16 1993-02-23 Hoffmann La Roche Inc. Antibacterial cephalosporin compounds
CA2216259A1 (en) * 1996-09-25 1998-03-25 Eisai Chemical Co., Ltd. Production process of cephem compound
CN112480024A (en) * 2020-12-11 2021-03-12 山东金城医药化工有限公司 Method for producing trans isomer of aminothiazoly loximate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5052083A (en) * 1973-08-21 1975-05-09
JPS50111093A (en) * 1974-02-20 1975-09-01
JPS51149296A (en) * 1975-06-09 1976-12-22 Takeda Chem Ind Ltd Cephems or penams and their preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1445979A (en) * 1972-10-25 1976-08-11 Glaxo Lab Ltd Cephalosporin derivatives
JPS4849789A (en) * 1971-10-25 1973-07-13
SE440655B (en) * 1976-01-23 1985-08-12 Roussel Uclaf SET TO MAKE NEW OXIME DERIVATIVES OF 7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID
FR2345153A1 (en) * 1976-03-25 1977-10-21 Roussel Uclaf NEW ALCOYLOXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5052083A (en) * 1973-08-21 1975-05-09
JPS50111093A (en) * 1974-02-20 1975-09-01
JPS51149296A (en) * 1975-06-09 1976-12-22 Takeda Chem Ind Ltd Cephems or penams and their preparation

Cited By (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0362711B2 (en) * 1977-03-25 1991-09-26 Roussel Uclaf
JPS6425768A (en) * 1977-03-25 1989-01-27 Roussel Uclaf 2-(2-amino-4-thiazolyl)-2-methoxyiminoacetic acid derivative and manufacture
JPS6228153B2 (en) * 1977-04-02 1987-06-18 Hoechst Ag
JPS5858354B2 (en) * 1977-04-02 1983-12-24 ヘキスト・アクチ−エンゲゼルシヤフト Cephem derivatives
JPS5716887A (en) * 1977-04-02 1982-01-28 Hoechst Ag Cephem derivative and manufacture
JPS549296A (en) * 1977-04-02 1979-01-24 Hoechst Ag Cephem derivative and its preparation
JPS5412394A (en) * 1977-06-03 1979-01-30 Hoffmann La Roche Acyl derivative
JPS5484595A (en) * 1977-12-05 1979-07-05 Roussel Uclaf Novel oxime derivatives of 33substituted 77aminothiazolyl acetoamide cephalosporanic acid*their manufacture and pharmateutical composition containing them
JPS6360992A (en) * 1977-12-05 1988-03-17 ルセル・ユクラフ Novel oxime derivative of 3-substituted 7-aminothiazolylacetamide cephalosporinic acid
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
JPH0142955B2 (en) * 1978-01-13 1989-09-18 Takeda Chemical Industries Ltd
JPS54128594A (en) * 1978-03-27 1979-10-05 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid derivative
JPS54132593A (en) * 1978-03-31 1979-10-15 Roussel Uclaf Novel oosubstituted oxime derivatives of 77aminothiazolylacetoamidecephalosporanic acid*their manufacture*their use as drug and composition containing them
JPH0314039B2 (en) * 1978-03-31 1991-02-25 Roussel Uclaf
JPS6360758B2 (en) * 1978-04-07 1988-11-25
JPS54135793A (en) * 1978-04-07 1979-10-22 Roussel Uclaf Novel cephalosporin derived from 33substitutedd77*22*22aminoo44thiazolyl**22*carboxymethoxy imino*acetoamide* cephalosporanic acid*its manufacture and use as drug and pharmaceutical composition contai
JPS54154788A (en) * 1978-05-26 1979-12-06 Glaxo Group Ltd Cephalosporin antibiotic
JPS54154787A (en) * 1978-05-26 1979-12-06 Glaxo Group Ltd Cephalosporanic compound
JPS5519267A (en) * 1978-07-17 1980-02-09 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid, its salts, their preparation, and preventive and remedy for microbism comprising them as active constituents
JPS5533500A (en) * 1978-08-31 1980-03-08 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid, its salt, their preparation, and preventive and remedy for microbism
JPS6361954B2 (en) * 1978-08-31 1988-11-30
JPH0240678B2 (en) * 1978-09-04 1990-09-12 Fujisawa Pharmaceutical Co
JPS5535096A (en) * 1978-09-04 1980-03-11 Fujisawa Pharmaceut Co Ltd 3-cephem compound, its salt, their preparation, and preventive and remedy for microbism comprising thema active constituent
JPH0121154B2 (en) * 1978-09-08 1989-04-19 Fujisawa Pharmaceutical Co
JPS5547688A (en) * 1978-09-08 1980-04-04 Fujisawa Pharmaceut Co Ltd Novel cephem compound and its preparation
JPH0144716B2 (en) * 1978-09-11 1989-09-29 Fujisawa Pharmaceutical Co
JPS5547690A (en) * 1978-09-11 1980-04-04 Fujisawa Pharmaceut Co Ltd Cephem compound, its salt, their preparation, and preventives and remedies for microbism comprising them as active constituents
JPS62289584A (en) * 1978-09-11 1987-12-16 Fujisawa Pharmaceut Co Ltd Cephem compound and salt thereof
JPH02111750A (en) * 1978-09-12 1990-04-24 Fujisawa Pharmaceut Co Ltd Butyric acid derivative
JPS636552B2 (en) * 1978-12-11 1988-02-10 Takeda Chemical Industries Ltd
JPS5579393A (en) * 1978-12-11 1980-06-14 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
JPS5616490A (en) * 1979-07-18 1981-02-17 Hoechst Ag Cephem compound manufacture
JPH0313237B2 (en) * 1980-03-28 1991-02-22 Biochemie Gmbh
JPS56152488A (en) * 1980-03-28 1981-11-26 Biochemie Gmbh Novel manufacture of cephalosporin type antibiotics and novel intermediate therefor and manufacture of intermediate
JPH0567632B2 (en) * 1980-03-28 1993-09-27 Biochemie Gmbh
JPH02177A (en) * 1980-03-28 1990-01-05 Biochem Gmbh Intermediate for manufacture of cephalosporin antibiotic
JPS5753474A (en) * 1980-07-24 1982-03-30 Lonza Ag Manufacture of 2-(2-aminothiazole-4-yl)-2- (syn)-methoxyiminoacetic acid ester
JPH027953B2 (en) * 1980-07-24 1990-02-21 Lonza Ag
JPS57154175A (en) * 1981-03-16 1982-09-22 Mitsui Toatsu Chem Inc 2-thiazoleamine derivative, its preparation, and drug composition comprising it
JPH0254348B2 (en) * 1981-03-16 1990-11-21 Mitsui Toatsu Chemicals
JPS57157594U (en) * 1981-03-31 1982-10-04
JPS6023317A (en) * 1983-07-12 1985-02-05 Fujisawa Pharmaceut Co Ltd Preventive and remedy for bacteriosis of fish
JPH0528207B2 (en) * 1983-07-12 1993-04-23 Fujisawa Pharmaceutical Co
JPS60178891A (en) * 1984-02-24 1985-09-12 Kureha Chem Ind Co Ltd Cephalosporin derivative, preparation thereof and medicine containing said derivative
JPS60155167A (en) * 1984-07-31 1985-08-15 Fujisawa Pharmaceut Co Ltd Substituted iminoacetic acid derivative and its salt
JPS6236386A (en) * 1985-08-09 1987-02-17 Kureha Chem Ind Co Ltd Cephalosporin derivative, production thereof and drug containing said derivative

Also Published As

Publication number Publication date
JPS6141516B2 (en) 1986-09-16
JPH03135946A (en) 1991-06-10
JPS5368796A (en) 1978-06-19
JPS5368795A (en) 1978-06-19
GB1576625A (en) 1980-10-08
JPS6137250B2 (en) 1986-08-22
JPS5598189A (en) 1980-07-25
JPH0684338B2 (en) 1994-10-26
JPH0373553B2 (en) 1991-11-22
JPS5962597A (en) 1984-04-10
JPS5941995B2 (en) 1984-10-11
HU183009B (en) 1984-04-28

Similar Documents

Publication Publication Date Title
JPS52125190A (en) 3,7-disubstituted-3-cephem-4-carboxylic acids, their salts and their preparation
JPS53137988A (en) Cephem and cepham compounds and process for their preparation
JPS535193A (en) 2-alkyl-7-substituted-2 or 3-cephem-4-carboxlic acids, their salts and their preparation
JPS5323993A (en) 7-(n-substituted-2-phenylglycineamido)-3-substituted-3-cephem-4-caroxyli acids
JPS5444695A (en) 3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation
JPS53111096A (en) 1-azaxanthone-3-carboxylic acid derivative and its preparation
JPS5246093A (en) 2-alkyl-7-substituted-2, or 3-cephem-4-carboxylic compounds, their sal ts, and preparation thereof
JPS523099A (en) Pyrido 2,3-c acridine-1-hydroxy-2-carboxylic preparing the same
JPS5331697A (en) N4,3 , 3 -tri-o-acyl-2 , 2 -cyclocytidines and their preparation
JPS55122758A (en) Racemization of l-alpha-methyl-beta-acylthiopropionic acid
JPS53101392A (en) Cephalosporin derivatives and process for their preparation
JPS5344572A (en) 5-alkoxy-picolic acid, its preparation and hypotensives containing the same
JPS5219681A (en) Preparation of thiouridine derivatives
JPS5248640A (en) Process for preparation of alpha-substituted-phenyl-alkane-carboxylic acids their derivatives
JPS5328195A (en) N4-acyloxy-2, n -acyloxy-2, 2 -cyclocytidines and their preparation
JPS5283515A (en) N-dimethyl-1- (l-(-)-alpha-hydroxy-omega-aminoalkanoyl) -xk-62-2
JPS5427594A (en) Penicillin derivative
JPS5315395A (en) Cephalosporin derivatives and their preparation
JPS52142089A (en) Preparation of cephalosporanic acid derivatives
JPS5350193A (en) Antibacterials
JPS52122387A (en) 7alpha-methoxycephalosporin derivatives and their preparation
JPS5287140A (en) Preparation of optically active p-hydroxyphenylglycine
JPS53101388A (en) Novel cephalosporanic acid derivatives and process for their preparation
JPS5356695A (en) Pyridobenzoazepines and their preparation
JPS5334772A (en) Preparation of 2-benzothiazolines