GB1548594A - Triiodoisophthalic acid amides - Google Patents

Triiodoisophthalic acid amides

Info

Publication number
GB1548594A
GB1548594A GB24338/76A GB2433876A GB1548594A GB 1548594 A GB1548594 A GB 1548594A GB 24338/76 A GB24338/76 A GB 24338/76A GB 2433876 A GB2433876 A GB 2433876A GB 1548594 A GB1548594 A GB 1548594A
Authority
GB
United Kingdom
Prior art keywords
acid amides
triiodoisophthalic acid
triiodoisophthalic
amides
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24338/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nyegaard and Co AS
Original Assignee
Nyegaard and Co AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard and Co AS filed Critical Nyegaard and Co AS
Priority to GB24338/76A priority Critical patent/GB1548594A/en
Priority to DK258477A priority patent/DK150504C/da
Priority to CH718677A priority patent/CH630064A5/de
Priority to JP6936377A priority patent/JPS5321137A/ja
Priority to DE2726196A priority patent/DE2726196C2/de
Priority to NLAANVRAGE7706385,A priority patent/NL175814C/xx
Priority to FR7717904A priority patent/FR2354316A1/fr
Priority to BE178353A priority patent/BE855580A/xx
Priority to SE7706792A priority patent/SE441181B/xx
Publication of GB1548594A publication Critical patent/GB1548594A/en
Priority to US06/069,589 priority patent/US4250113A/en
Priority to HK566/83A priority patent/HK56683A/xx
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB24338/76A 1976-06-11 1976-06-11 Triiodoisophthalic acid amides Expired GB1548594A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
GB24338/76A GB1548594A (en) 1976-06-11 1976-06-11 Triiodoisophthalic acid amides
NLAANVRAGE7706385,A NL175814C (nl) 1976-06-11 1977-06-10 Werkwijze voor de bereiding van een radiologisch preparaat en voor de bereiding van een daarin te gebruiken trijoodisoftaalamide.
CH718677A CH630064A5 (de) 1976-06-11 1977-06-10 Verfahren zur herstellung von jodhaltigen isophthalamidderivaten.
JP6936377A JPS5321137A (en) 1976-06-11 1977-06-10 Xxray contrast medium
DE2726196A DE2726196C2 (de) 1976-06-11 1977-06-10 2,4,6-Trijod-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide, Verfahren zu deren Herstellung und diese enthaltende radiologische Mittel
DK258477A DK150504C (da) 1976-06-11 1977-06-10 Trijodisoftalsyrederivater til anvendelse som roentgenkontrastmidler samt radiologiske praeparater indeholdende disse
FR7717904A FR2354316A1 (fr) 1976-06-11 1977-06-10 Nouveaux agents de contraste iodes non-ioniques
BE178353A BE855580A (fr) 1976-06-11 1977-06-10 Nouveaux agents de contraste iodes non-ioniques
SE7706792A SE441181B (sv) 1976-06-11 1977-06-10 Nya nonjonogena, jodhaltiga foreningar for anvendning som rontgenkontrastmedel
US06/069,589 US4250113A (en) 1976-06-11 1979-08-24 Chemical compounds
HK566/83A HK56683A (en) 1976-06-11 1983-11-17 Triiodoisophthalic acid amides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB24338/76A GB1548594A (en) 1976-06-11 1976-06-11 Triiodoisophthalic acid amides

Publications (1)

Publication Number Publication Date
GB1548594A true GB1548594A (en) 1979-07-18

Family

ID=10210154

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24338/76A Expired GB1548594A (en) 1976-06-11 1976-06-11 Triiodoisophthalic acid amides

Country Status (11)

Country Link
US (1) US4250113A (https=)
JP (1) JPS5321137A (https=)
BE (1) BE855580A (https=)
CH (1) CH630064A5 (https=)
DE (1) DE2726196C2 (https=)
DK (1) DK150504C (https=)
FR (1) FR2354316A1 (https=)
GB (1) GB1548594A (https=)
HK (1) HK56683A (https=)
NL (1) NL175814C (https=)
SE (1) SE441181B (https=)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364921A (en) 1979-03-08 1982-12-21 Schering, Aktiengesellschaft Novel triiodinated isophthalic acid diamides as nonionic X-ray contrast media
EP0105752A1 (en) * 1982-10-01 1984-04-18 NYEGAARD & CO. A/S X-ray contrast agents
US4547357A (en) * 1981-12-18 1985-10-15 Schering, Aktiengesellschaft N-Hydroxyethylated 2,4,6-triiodoaminoisophthalic acid bistrihydroxybutylamides, their preparation and x-ray contrast media containing them
DE4426818A1 (de) * 1993-07-30 1995-02-02 Zambon Spa Verfahren zur Kristallisation von Iopamidol
LT3582B (en) 1989-09-04 1995-12-27 Nycomed Imaging As Contrast media, methods for preparing and using the same
US5840967A (en) * 1996-08-29 1998-11-24 Nycomed Imaging As Process for the preparation of contrast agents
WO1998052911A1 (en) * 1997-05-23 1998-11-26 Nycomed Imaging As Yellow polymorph of 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihydroxypropyl)-isophthalamide
US5948940A (en) * 1996-08-29 1999-09-07 Nycomed Imaging As Process for iohexol manufacture
WO2000029372A1 (en) * 1998-11-16 2000-05-25 Nycomed Imaging As Preparation of 5-amino-isophthalamides
US6660248B2 (en) 2000-11-10 2003-12-09 William Marsh Rice University Fullerene (C60)-based X-ray contrast agent for diagnostic imaging
US7780875B2 (en) 2005-01-13 2010-08-24 Cinvention Ag Composite materials containing carbon nanoparticles
WO2011003894A1 (en) 2009-07-07 2011-01-13 Bracco Imaging Spa Process for the preparation of a iodinating agent
US9193659B2 (en) 2008-02-20 2015-11-24 Bracco Imaging S.P.A. Process for the iodination of aromatic compounds
CN107857714A (zh) * 2017-11-29 2018-03-30 上海司太立制药有限公司 一种碘海醇中间体杂质的制备方法和用途

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU523295B2 (en) * 1978-07-04 1982-07-22 Nycomed Imaging As X-ray contrast agent
US4256729A (en) * 1979-03-23 1981-03-17 Mallinckrodt, Inc. N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same
DE2928417A1 (de) * 1979-07-12 1981-01-29 Schering Ag Trijodierte basen
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3001292A1 (de) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin Nichtionische 5-c-substituierte 2,4,6-trijod-isophthalsaeure-derivate
DE3038853A1 (de) 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
JPS58102200A (ja) * 1981-12-14 1983-06-17 日本原子力事業株式会社 沈降分離槽
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
DK160868C (da) * 1982-11-08 1991-10-14 Nyegaard & Co As Trijodfenylderivater, fremgangsmaader til fremstilling deraf og radiologisk praeparat indeholdende dem
US5191119A (en) * 1983-10-20 1993-03-02 Cook Imaging Corp. Process for producing non-ionic radiographic contrast media utilizing N-allylation
US4584401A (en) * 1983-10-20 1986-04-22 Biophysica Foundation Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
JPS6091807U (ja) * 1983-11-30 1985-06-22 松下電器産業株式会社 テ−ブル
US4954348A (en) * 1985-08-09 1990-09-04 Cook Imaging Corporation Non-ionic polyol contrast media from ionic contrast media
JPH0813794B2 (ja) * 1985-08-09 1996-02-14 クツク イマジング，インコ−ポレイテイド イオン性コントラスト媒体からの非イオン性ポリオ−ルコントラスト媒体
US5035877A (en) * 1985-08-09 1991-07-30 Cook Imaging Corporation Non-ionic contrast media from ionic contrast media
JPH0637447B2 (ja) * 1987-10-31 1994-05-18 東洋紡績株式会社 新規アミド化合物
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
US5232685A (en) * 1989-11-03 1993-08-03 Schering Aktiengesellschaft Nonionic x-ray contrast medium with high iodine content
DE3937118A1 (de) * 1989-11-03 1991-05-08 Schering Ag Nichtionische roentgenkontrastmittel mit hohem jodgehalt
CA2029830A1 (en) * 1989-11-29 1991-05-30 Ramachandran S. Ranganathan Nonionic radiographic contrast agents
US5869024A (en) * 1989-11-29 1999-02-09 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
US5614638A (en) * 1989-11-29 1997-03-25 Bracco International B.V. Nonionic radiographic contrast agents
US5191120A (en) * 1989-12-13 1993-03-02 Mallinckrodt Medical, Inc. Process for preparing nonionic X-ray contrast agents
US4997983A (en) * 1990-01-31 1991-03-05 Mallinckrodt, Inc. Process for production of ioversol
US5527926A (en) * 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
US5356613A (en) * 1991-03-18 1994-10-18 Mallinckrodt Medical, Inc. X-ray contrast agents, compositions and methods
DE4109169A1 (de) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung
US5169864A (en) * 1991-11-15 1992-12-08 Baxter International Inc. Unbuffered premixed ranitidine formulation
EP0619744A4 (en) * 1991-12-03 1995-02-08 Mallinckrodt Medical Inc NON-ionic X-RAY CONTRASTS, COMPOSITIONS AND METHODS.
US5278311A (en) * 1992-06-05 1994-01-11 E. R. Squibb & Sons, Inc. Nonionic radiographic contrast agents
WO1994005337A1 (en) * 1992-09-02 1994-03-17 Mallinckrodt Medical, Inc. Nonionic x-ray contrast agents, compositions and methods
US5665331A (en) * 1995-01-10 1997-09-09 Nanosystems L.L.C. Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers
US5662883A (en) * 1995-01-10 1997-09-02 Nanosystems L.L.C. Microprecipitation of micro-nanoparticulate pharmaceutical agents
US5716642A (en) * 1995-01-10 1998-02-10 Nano Systems L.L.C. Microprecipitation of nanoparticulate pharmaceutical agents using surface active material derived from similar pharmaceutical agents
US5560932A (en) * 1995-01-10 1996-10-01 Nano Systems L.L.C. Microprecipitation of nanoparticulate pharmaceutical agents
US5543133A (en) * 1995-02-14 1996-08-06 Nanosystems L.L.C. Process of preparing x-ray contrast compositions containing nanoparticles
DE19510864A1 (de) * 1995-03-16 1996-09-19 Schering Ag Röntgenkontrastmittel für die Computertomographie und Urographie
IT1275429B (it) * 1995-05-18 1997-08-07 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di composti organici
CN1078201C (zh) * 1995-11-20 2002-01-23 江苏省原子医学研究所 一种碘海醇的制备方法
GB9618055D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US5705692A (en) * 1996-09-27 1998-01-06 Abbott Laboratories Process for the preparation of iohexol
PT101919B (pt) * 1996-09-30 2000-01-31 Hovione Sociedade Quimica Sa Um processo para a purificacao de tohexol
US5861140A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Tripodal paramagnetic contrast agents for MR imaging
US5861138A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Ligands for MRI contrast agent
US5824821A (en) * 1997-02-07 1998-10-20 Nycomed Imaging As Process for the preparation of iodinated contrast agents and intermediates therefor
US5847212A (en) * 1997-04-21 1998-12-08 Abbott Laboratories Process for the preparation of iohexol
GB9710728D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Method
GB9710725D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Process
US6137006A (en) * 1997-05-23 2000-10-24 Nycomed Imaging As Preparation of tri-iodo benzene compounds
IT1292037B1 (it) * 1997-05-30 1999-01-25 Bracco Spa Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen-
US5869025A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corporation Tripodal aromatic heterocycle carboxamide MRI contrast agents
US5820851A (en) * 1997-08-21 1998-10-13 Hoechst Celanese Corporation Tripodal pyridine ligands as MRI contrast agents
US5824288A (en) * 1997-08-21 1998-10-20 Hoechst Celanese Corporation Thio-substituted pyridines as MRI ligand precursors
US5869026A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corp. Tripodal carboxamide ligands for MRI contrast agents
US5858329A (en) * 1997-08-21 1999-01-12 Hoechst Celanese Corporation MRI diagnostic procedures using tripodal pyridinyl metal complexes
GB9720969D0 (en) * 1997-10-02 1997-12-03 Nycomed Imaging As Process
GB9725010D0 (en) * 1997-11-26 1998-01-28 Nycomed Imaging As Process
US20040170561A1 (en) * 1998-09-08 2004-09-02 Jesse Salb Functional radiographic imaging methods and agents
US6751290B2 (en) 1998-09-08 2004-06-15 Veritas Pharmaceuticals, Inc. Radiographic assessment of tissue after exposure to a compound
US6723746B2 (en) * 1998-09-08 2004-04-20 Veritas Pharmaceuticals, Inc. Functional radiographic imaging methods and agents
US6226352B1 (en) 1998-09-08 2001-05-01 Veritas Pharmaceuticals, Inc. System and method for radiographic imaging of tissue
AU2001245805A1 (en) 2000-03-16 2001-09-24 Veritas Pharmaceuticals Radiographic assessment of tissue response to compounds
IT1319670B1 (it) 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di 5-ammino-n,n'-bis(2-idrossi-1-(idrossimetil)etil))-1,3-benzendicarbossammide (i) e 5-ammino-n,n'-
ITMI20010773A1 (it) * 2001-04-11 2002-10-11 Chemi Spa Processo per la produzione di ioexolo ad elevata purezza
KR20030032185A (ko) * 2001-10-16 2003-04-26 동국제약 주식회사 Ｎ,ｎ'-비스[2,3-디히드록시프로필]-2,4,6-트리요오드-5-아세틸아미도 이소 프탈아미드의 결정화방법
WO2006100731A1 (ja) * 2005-03-18 2006-09-28 Manac Inc. ５−アミノ−２，４，６−トリヨードイソフタル酸誘導体のアセチル化方法
PT103391B (pt) * 2005-11-24 2008-10-30 Hovione Farmaciencia S A Processo para fabrico de lohexol
CN100344606C (zh) * 2005-12-28 2007-10-24 江苏省原子医学研究所 一种碘昔兰的制备方法
RU2325849C2 (ru) * 2006-07-04 2008-06-10 Региональный общественный фонд содействия борьбы против СПИДа и туберкулеза "В XXI веке без СПИДа и туберкулеза" Способ определения активности системы мононуклеарных фагоцитов с помощью меченых соединений
CN102271715A (zh) 2009-01-09 2011-12-07 通用电气医疗集团股份有限公司 对比剂组合物
EP2277859A1 (en) * 2009-07-21 2011-01-26 GE Healthcare AS Acetylation using reduced concentration of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents
EP2277851A1 (en) * 2009-07-21 2011-01-26 GE Healthcare AS Acetylation using reduced volume of acetic acid anhydride for synthesizing non-ionic X-ray contrast agents
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
RU2566281C2 (ru) * 2010-07-12 2015-10-20 ДжиИ Хелткер АС Рентгеновская визуализация при низких концентрациях контрастного агента и/или низкой дозе излучения
CN102249948B (zh) * 2011-05-23 2014-01-29 苏州昊帆生物科技有限公司 5-乙酰氨基-n,n’-双-(2,3-二羟基丙基)-2,4,6-三碘间苯二甲酰胺的合成方法
EP2606912A1 (en) * 2011-12-23 2013-06-26 Central Medical Service Co., Ltd. Contrast medium composition with contrast enhancement effect by comprising highly concentrated agent
EP3077368B1 (en) 2013-12-06 2018-07-11 GE Healthcare AS Alternative process for the purification of an intermediate in the synthesis of non-ionic x-ray contrast agents
ES2683712T3 (es) * 2013-12-06 2018-09-27 Ge Healthcare As Proceso alternativo para la purificación de un intermedio en la síntesis de agentes de contraste de rayos X no iónicos
ES2638645T3 (es) * 2013-12-06 2017-10-23 Ge Healthcare As Procedimiento alternativo de acetilación en la síntesis de agentes de contraste para rayos X no iónicos
AU2015224847C1 (en) * 2014-03-04 2021-03-04 Otsuka Pharmaceutical Co., Ltd. Iohexol powder and method of using the same
PT108524B (pt) * 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
CN107778191A (zh) * 2016-08-26 2018-03-09 正大天晴药业集团股份有限公司 一种碘普罗胺及其中间体的制备方法
RU2655619C1 (ru) * 2017-06-13 2018-05-29 Алексей Георгиевич Александров Способ получения фармацевтической субстанции на основе йогексола
CN108191690A (zh) * 2017-12-11 2018-06-22 天津河清化学工业有限公司 碘海醇节能环保的连续化制备方法
CN108191689A (zh) * 2017-12-11 2018-06-22 天津河清化学工业有限公司 一种新型碘海醇节能环保的连续化制备方法
EP4001261A1 (en) 2020-11-23 2022-05-25 Justesa Imagen S.A.U Procedure for obtaining high purity iohexol

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE392100B (sv) * 1969-06-27 1977-03-14 Nyegaard & Co As Trijodbensoylaminer till anvendning sasom rontgenkontrastmedel eller for separation av biologiska material
GB1321591A (en) 1969-06-27 1973-06-27 Nyegaard & Co As Non-ionic iodinated x-ray contrast agents
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
BE788054A (fr) * 1971-08-26 1973-02-26 Bracco Ind Chimica Spa Nouvel agent de contraste radiographique et procede pour le preparer
CH608189A5 (https=) * 1974-12-13 1978-12-29 Savac Ag

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364921A (en) 1979-03-08 1982-12-21 Schering, Aktiengesellschaft Novel triiodinated isophthalic acid diamides as nonionic X-ray contrast media
US4547357A (en) * 1981-12-18 1985-10-15 Schering, Aktiengesellschaft N-Hydroxyethylated 2,4,6-triiodoaminoisophthalic acid bistrihydroxybutylamides, their preparation and x-ray contrast media containing them
EP0105752A1 (en) * 1982-10-01 1984-04-18 NYEGAARD & CO. A/S X-ray contrast agents
LT3582B (en) 1989-09-04 1995-12-27 Nycomed Imaging As Contrast media, methods for preparing and using the same
DE4426818A1 (de) * 1993-07-30 1995-02-02 Zambon Spa Verfahren zur Kristallisation von Iopamidol
US6153796A (en) * 1996-08-29 2000-11-28 Nycomed Imaging As Process for iohexol manufacture
US5840967A (en) * 1996-08-29 1998-11-24 Nycomed Imaging As Process for the preparation of contrast agents
US6610885B1 (en) 1996-08-29 2003-08-26 Amersham Health As Process for the preparation of contrast agents
US5948940A (en) * 1996-08-29 1999-09-07 Nycomed Imaging As Process for iohexol manufacture
US6337422B1 (en) 1997-05-23 2002-01-08 Nycomed Imaging As Yellow polymorph of 5-amino-2,4,6-triiodo-n,n′-bis(2-3-dihydroxypropy)-isophthalamide
WO1998052911A1 (en) * 1997-05-23 1998-11-26 Nycomed Imaging As Yellow polymorph of 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihydroxypropyl)-isophthalamide
CZ297243B6 (cs) * 1997-05-23 2006-10-11 Ge Healthcare As Zlutý polymorf 5-amino-2,4,6-trijod-N,N'-bis(2,3-dihydroxypropyl)izoftalamidu
WO2000029372A1 (en) * 1998-11-16 2000-05-25 Nycomed Imaging As Preparation of 5-amino-isophthalamides
US6441235B1 (en) 1998-11-16 2002-08-27 Amersha, Health As Preparation of 5-amino-isophthalamides
US6660248B2 (en) 2000-11-10 2003-12-09 William Marsh Rice University Fullerene (C60)-based X-ray contrast agent for diagnostic imaging
US7780875B2 (en) 2005-01-13 2010-08-24 Cinvention Ag Composite materials containing carbon nanoparticles
US9193659B2 (en) 2008-02-20 2015-11-24 Bracco Imaging S.P.A. Process for the iodination of aromatic compounds
WO2011003894A1 (en) 2009-07-07 2011-01-13 Bracco Imaging Spa Process for the preparation of a iodinating agent
US9157156B2 (en) 2009-07-07 2015-10-13 Bracco Imaging S.P.A. Process for the preparation of a iodinating agent
CN107857714A (zh) * 2017-11-29 2018-03-30 上海司太立制药有限公司 一种碘海醇中间体杂质的制备方法和用途
CN107857714B (zh) * 2017-11-29 2020-11-13 上海司太立制药有限公司 一种碘海醇中间体杂质的制备方法和用途

Also Published As

Publication number Publication date
HK56683A (en) 1983-11-25
FR2354316B1 (https=) 1982-11-12
SE7706792L (sv) 1977-12-12
JPS5654310B2 (https=) 1981-12-24
US4250113A (en) 1981-02-10
DK150504C (da) 1988-01-11
DE2726196C2 (de) 1983-12-29
DK150504B (da) 1987-03-16
DK258477A (da) 1977-12-12
NL7706385A (nl) 1977-12-13
SE441181B (sv) 1985-09-16
CH630064A5 (de) 1982-05-28
DE2726196A1 (de) 1977-12-22
BE855580A (fr) 1977-12-12
JPS5321137A (en) 1978-02-27
FR2354316A1 (fr) 1978-01-06
NL175814C (nl) 1985-01-02

Similar Documents

Publication Publication Date Title
GB1548594A (en) Triiodoisophthalic acid amides
NZ193353A (en) Herbicidal -azolyloxyalkanoic acid amides
ZA77564B (en) Carboxyalkylacylamino acids
EG12712A (en) Phenoxy-phenoxypropionic acid derivatives
IL51926A0 (en) Phenoxy-phenoxypropionic acid derivatives
JPS52144669A (en) 122azaprostanic acid
ZA772310B (en) New-m-substituted phenoxy-propionic acid derivatives
GB2058782B (en) Polyprenylcarboxylic acid amides
JPS535119A (en) Ureidoacetohydroxamic acid
AU1934976A (en) N-phenyl-maleic acid amides
IL52244A0 (en) Clavam-3-carboxylic acid derivatives
ZA774388B (en) Novel phenoxy-phenoxy-alkanecarboxylic acid derivatives
PH12483A (en) Pesticidal thionophosphonic acid amides
JPS5334726A (en) Phosphonoacetic acid amides
JPS527991A (en) Clavalanic acid amides
JPS5318543A (en) Cyclopropyllmethyllphosphoric acid derivative
IL51605A0 (en) Phenoxyphenoxy-alkanecarboxylic acid derivatives
JPS52111556A (en) Glycylretinic acid derivatives
JPS5331630A (en) Sulfurrcontaining nnbenzylamino acid
JPS5392783A (en) Nnsubstituted benzamide
JPS5283613A (en) Novel benzylaminoalkane acid
JPS5297919A (en) Substituted ooalkylsulfonylglycolic acid anilide
JPS5283607A (en) Betaaacyloxyycrotonic acid amideennsulfohalogenide
ZA776594B (en) 1-carba-2-penem-3-carboxylic acid
ZA773852B (en) Amides

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19970609