FR2354316A1 - Nouveaux agents de contraste iodes non-ioniques - Google Patents
Nouveaux agents de contraste iodes non-ioniquesInfo
- Publication number
- FR2354316A1 FR2354316A1 FR7717904A FR7717904A FR2354316A1 FR 2354316 A1 FR2354316 A1 FR 2354316A1 FR 7717904 A FR7717904 A FR 7717904A FR 7717904 A FR7717904 A FR 7717904A FR 2354316 A1 FR2354316 A1 FR 2354316A1
- Authority
- FR
- France
- Prior art keywords
- contrast agents
- new non
- iodine contrast
- ionic iodine
- ionic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002872 contrast media Substances 0.000 title 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 title 1
- 229910052740 iodine Inorganic materials 0.000 title 1
- 239000011630 iodine Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- QZUPTXGVPYNUIT-UHFFFAOYSA-N isophthalamide Chemical class NC(=O)C1=CC=CC(C(N)=O)=C1 QZUPTXGVPYNUIT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne des isophtalamides. Les composés conformes à l'invention répondent à la formule de structure suivante :
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB24338/76A GB1548594A (en) | 1976-06-11 | 1976-06-11 | Triiodoisophthalic acid amides |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2354316A1 true FR2354316A1 (fr) | 1978-01-06 |
FR2354316B1 FR2354316B1 (fr) | 1982-11-12 |
Family
ID=10210154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7717904A Granted FR2354316A1 (fr) | 1976-06-11 | 1977-06-10 | Nouveaux agents de contraste iodes non-ioniques |
Country Status (11)
Country | Link |
---|---|
US (1) | US4250113A (fr) |
JP (1) | JPS5321137A (fr) |
BE (1) | BE855580A (fr) |
CH (1) | CH630064A5 (fr) |
DE (1) | DE2726196C2 (fr) |
DK (1) | DK150504C (fr) |
FR (1) | FR2354316A1 (fr) |
GB (1) | GB1548594A (fr) |
HK (1) | HK56683A (fr) |
NL (1) | NL175814C (fr) |
SE (1) | SE441181B (fr) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0015867A1 (fr) * | 1979-03-08 | 1980-09-17 | Schering Aktiengesellschaft | Diamides d'acides triiodo-isophtaliques, leur préparation et agents de contraste radiographiques les contenant |
EP0032387A1 (fr) * | 1980-01-11 | 1981-07-22 | Schering Aktiengesellschaft | Dérivés non ioniques d'acide 2,4,6-triiodo-isophtalique substitué en position 5, procédé pour leur préparation et agents de contraste pour rayons-X les contenant |
EP0082803A1 (fr) * | 1981-12-18 | 1983-06-29 | Schering Aktiengesellschaft | N-hydroxyéthyl 2,4,6-triiodoaminoisophtalique-bis-trihydroxy-butylamides, leur préparation et agents de contraste pour rayons X les contenant |
EP0083964A1 (fr) * | 1982-01-11 | 1983-07-20 | Mallinckrodt, Inc. (a Delaware corporation) | Composés appropriés à des méthodes de visualisation par rayons X |
EP0108638A1 (fr) * | 1982-11-08 | 1984-05-16 | NYEGAARD & CO. A/S | Agents de contraste pour rayons X |
WO1998052909A1 (fr) * | 1997-05-23 | 1998-11-26 | Nycomed Imaging As | Preparation de composes benzeniques tri-iodes |
US6137006A (en) * | 1997-05-23 | 2000-10-24 | Nycomed Imaging As | Preparation of tri-iodo benzene compounds |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH649469A5 (de) * | 1978-07-04 | 1985-05-31 | Nyegaard & Co As | Loesung eines roentgenkontrastmittels und eines puffers und ihre verwendung zur herstellung einer sterilen injizierbaren physiologisch annehmbaren loesung eines roentgenkontrastmittels. |
US4256729A (en) * | 1979-03-23 | 1981-03-17 | Mallinckrodt, Inc. | N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same |
DE2928417A1 (de) * | 1979-07-12 | 1981-01-29 | Schering Ag | Trijodierte basen |
IT1193211B (it) * | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono |
IT1207226B (it) * | 1979-08-09 | 1989-05-17 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono. |
DE3038853A1 (de) | 1980-10-10 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii) |
JPS58102200A (ja) * | 1981-12-14 | 1983-06-17 | 日本原子力事業株式会社 | 沈降分離槽 |
DK162045C (da) * | 1982-10-01 | 1992-02-10 | Nyegaard & Co As | Trijodbenzenderivater, fremgangsmaade til fremstilling deraf og radiologiske praeparater indeholdende saadanne forbindelser |
US5204086A (en) * | 1982-10-01 | 1993-04-20 | Nycomed Imaging As | X-ray contrast agent |
US4584401A (en) * | 1983-10-20 | 1986-04-22 | Biophysica Foundation | Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media |
US5191119A (en) * | 1983-10-20 | 1993-03-02 | Cook Imaging Corp. | Process for producing non-ionic radiographic contrast media utilizing N-allylation |
JPS6091807U (ja) * | 1983-11-30 | 1985-06-22 | 松下電器産業株式会社 | テ−ブル |
JPS634809Y2 (fr) * | 1984-10-04 | 1988-02-08 | ||
US5035877A (en) * | 1985-08-09 | 1991-07-30 | Cook Imaging Corporation | Non-ionic contrast media from ionic contrast media |
US4954348A (en) * | 1985-08-09 | 1990-09-04 | Cook Imaging Corporation | Non-ionic polyol contrast media from ionic contrast media |
DE3689330T2 (de) * | 1985-08-09 | 1994-05-19 | Cook Imaging Corp | Nichtionische polyolkontrastmittel aus ionischen kontrastmitteln. |
JPH0637447B2 (ja) * | 1987-10-31 | 1994-05-18 | 東洋紡績株式会社 | 新規アミド化合物 |
US5698739A (en) * | 1989-07-05 | 1997-12-16 | Schering Aktiengesellschaft | Carboxamide non-ionic contrast media |
GB8919929D0 (en) * | 1989-09-04 | 1989-10-18 | Nycomed As | Compositions |
US5232685A (en) * | 1989-11-03 | 1993-08-03 | Schering Aktiengesellschaft | Nonionic x-ray contrast medium with high iodine content |
DE3937118A1 (de) * | 1989-11-03 | 1991-05-08 | Schering Ag | Nichtionische roentgenkontrastmittel mit hohem jodgehalt |
US5869024A (en) * | 1989-11-29 | 1999-02-09 | Bracco International B.V. | Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures |
IL96324A (en) * | 1989-11-29 | 1995-01-24 | Squibb & Sons Inc | History of 5-amino-2,4,6-triadiodo-1,3-benzenecarboxylic acid, processes for their preparation, and methods used as contrast agents |
US5614638A (en) * | 1989-11-29 | 1997-03-25 | Bracco International B.V. | Nonionic radiographic contrast agents |
US5191120A (en) * | 1989-12-13 | 1993-03-02 | Mallinckrodt Medical, Inc. | Process for preparing nonionic X-ray contrast agents |
US4997983A (en) * | 1990-01-31 | 1991-03-05 | Mallinckrodt, Inc. | Process for production of ioversol |
US5527926A (en) * | 1990-11-26 | 1996-06-18 | Bracco International B.V. | Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures |
US5356613A (en) * | 1991-03-18 | 1994-10-18 | Mallinckrodt Medical, Inc. | X-ray contrast agents, compositions and methods |
DE4109169A1 (de) * | 1991-03-20 | 1992-09-24 | Koehler Chemie Dr Franz | Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung |
US5169864A (en) * | 1991-11-15 | 1992-12-08 | Baxter International Inc. | Unbuffered premixed ranitidine formulation |
WO1993010825A1 (fr) * | 1991-12-03 | 1993-06-10 | Mallinckrodt Medical, Inc. | Procedes, compositions et agents non ioniques de contraste radiographique |
US5278311A (en) * | 1992-06-05 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Nonionic radiographic contrast agents |
AU5093993A (en) * | 1992-09-02 | 1994-03-29 | Mallinckrodt Medical, Inc. | Nonionic X-ray contrast agents compositions and methods |
IL110391A (en) * | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the formation of infamidol |
US5665331A (en) * | 1995-01-10 | 1997-09-09 | Nanosystems L.L.C. | Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers |
US5662883A (en) * | 1995-01-10 | 1997-09-02 | Nanosystems L.L.C. | Microprecipitation of micro-nanoparticulate pharmaceutical agents |
US5716642A (en) * | 1995-01-10 | 1998-02-10 | Nano Systems L.L.C. | Microprecipitation of nanoparticulate pharmaceutical agents using surface active material derived from similar pharmaceutical agents |
US5560932A (en) * | 1995-01-10 | 1996-10-01 | Nano Systems L.L.C. | Microprecipitation of nanoparticulate pharmaceutical agents |
US5543133A (en) * | 1995-02-14 | 1996-08-06 | Nanosystems L.L.C. | Process of preparing x-ray contrast compositions containing nanoparticles |
DE19510864A1 (de) * | 1995-03-16 | 1996-09-19 | Schering Ag | Röntgenkontrastmittel für die Computertomographie und Urographie |
IT1275429B (it) * | 1995-05-18 | 1997-08-07 | Zambon Spa | Processo per la preparazione di un intermedio utile nella sintesi di composti organici |
CN1078201C (zh) * | 1995-11-20 | 2002-01-23 | 江苏省原子医学研究所 | 一种碘海醇的制备方法 |
GB9618055D0 (en) * | 1996-08-29 | 1996-10-09 | Nycomed Imaging As | Process |
GB9618056D0 (en) * | 1996-08-29 | 1996-10-09 | Nycomed Imaging As | Process |
US5840967A (en) | 1996-08-29 | 1998-11-24 | Nycomed Imaging As | Process for the preparation of contrast agents |
US5705692A (en) * | 1996-09-27 | 1998-01-06 | Abbott Laboratories | Process for the preparation of iohexol |
PT101919B (pt) * | 1996-09-30 | 2000-01-31 | Hovione Sociedade Quimica Sa | Um processo para a purificacao de tohexol |
US5861138A (en) * | 1996-11-20 | 1999-01-19 | Hoechst Celanese Corp. | Ligands for MRI contrast agent |
US5861140A (en) * | 1996-11-20 | 1999-01-19 | Hoechst Celanese Corp. | Tripodal paramagnetic contrast agents for MR imaging |
US5824821A (en) * | 1997-02-07 | 1998-10-20 | Nycomed Imaging As | Process for the preparation of iodinated contrast agents and intermediates therefor |
US5847212A (en) * | 1997-04-21 | 1998-12-08 | Abbott Laboratories | Process for the preparation of iohexol |
GB9710726D0 (en) | 1997-05-23 | 1997-07-16 | Nycomed Imaging As | Compound |
GB9710725D0 (en) | 1997-05-23 | 1997-07-16 | Nycomed Imaging As | Process |
IT1292037B1 (it) * | 1997-05-30 | 1999-01-25 | Bracco Spa | Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen- |
US5824288A (en) * | 1997-08-21 | 1998-10-20 | Hoechst Celanese Corporation | Thio-substituted pyridines as MRI ligand precursors |
US5820851A (en) * | 1997-08-21 | 1998-10-13 | Hoechst Celanese Corporation | Tripodal pyridine ligands as MRI contrast agents |
US5869026A (en) * | 1997-08-21 | 1999-02-09 | Hoechst Celanese Corp. | Tripodal carboxamide ligands for MRI contrast agents |
US5858329A (en) * | 1997-08-21 | 1999-01-12 | Hoechst Celanese Corporation | MRI diagnostic procedures using tripodal pyridinyl metal complexes |
US5869025A (en) * | 1997-08-21 | 1999-02-09 | Hoechst Celanese Corporation | Tripodal aromatic heterocycle carboxamide MRI contrast agents |
GB9720969D0 (en) * | 1997-10-02 | 1997-12-03 | Nycomed Imaging As | Process |
GB9725010D0 (en) * | 1997-11-26 | 1998-01-28 | Nycomed Imaging As | Process |
US6723746B2 (en) * | 1998-09-08 | 2004-04-20 | Veritas Pharmaceuticals, Inc. | Functional radiographic imaging methods and agents |
US20040170561A1 (en) * | 1998-09-08 | 2004-09-02 | Jesse Salb | Functional radiographic imaging methods and agents |
US6226352B1 (en) | 1998-09-08 | 2001-05-01 | Veritas Pharmaceuticals, Inc. | System and method for radiographic imaging of tissue |
US6751290B2 (en) | 1998-09-08 | 2004-06-15 | Veritas Pharmaceuticals, Inc. | Radiographic assessment of tissue after exposure to a compound |
GB9825095D0 (en) | 1998-11-16 | 1999-01-13 | Nycomed Imaging As | Chemical process |
EP1263324B1 (fr) | 2000-03-16 | 2009-12-02 | Veritas Pharmaceuticals | Evaluation radiographique de la reponse tissulaire a des composes |
US6660248B2 (en) | 2000-11-10 | 2003-12-09 | William Marsh Rice University | Fullerene (C60)-based X-ray contrast agent for diagnostic imaging |
IT1319670B1 (it) | 2000-12-01 | 2003-10-23 | Bracco Spa | Processo per la preparazione di 5-ammino-n,n'-bis(2-idrossi-1-(idrossimetil)etil))-1,3-benzendicarbossammide (i) e 5-ammino-n,n'- |
ITMI20010773A1 (it) * | 2001-04-11 | 2002-10-11 | Chemi Spa | Processo per la produzione di ioexolo ad elevata purezza |
KR20030032185A (ko) * | 2001-10-16 | 2003-04-26 | 동국제약 주식회사 | N,n'-비스[2,3-디히드록시프로필]-2,4,6-트리요오드-5-아세틸아미도 이소 프탈아미드의 결정화방법 |
CN101098916A (zh) | 2005-01-13 | 2008-01-02 | 金文申有限公司 | 含有碳纳米颗粒的复合材料 |
WO2006100731A1 (fr) * | 2005-03-18 | 2006-09-28 | Manac Inc. | Procede d'acetylation d’un derive acide 5-amino-2,4,6-triiodoisophtalique |
PT103391B (pt) | 2005-11-24 | 2008-10-30 | Hovione Farmaciencia S A | Processo para fabrico de lohexol |
CN100344606C (zh) * | 2005-12-28 | 2007-10-24 | 江苏省原子医学研究所 | 一种碘昔兰的制备方法 |
EP2093206A1 (fr) | 2008-02-20 | 2009-08-26 | BRACCO IMAGING S.p.A. | Procédé d'iodation de composés aromatiques |
JP2012514622A (ja) | 2009-01-09 | 2012-06-28 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影製剤組成物 |
DK2451994T3 (da) | 2009-07-07 | 2014-01-20 | Bracco Imaging Spa | Fremgangsmåde til fremstilling af et ioderende middel |
US20110021821A1 (en) * | 2009-07-21 | 2011-01-27 | Ge Healthcare As | Continuous acetylation process in synthesis of non-ionic x-ray contrast agents |
EP2277851A1 (fr) * | 2009-07-21 | 2011-01-26 | GE Healthcare AS | Acetylation à volume reduit d'anhydride acétique pour la préparation des agents de contraste en radiologie X non ioniques |
EP2277859A1 (fr) * | 2009-07-21 | 2011-01-26 | GE Healthcare AS | Acétylation utilisant une concentration réduite d'anhydride d'acide acétique pour la synthèse d'agents de contraste pour rayons X non ioniques |
KR101585751B1 (ko) * | 2010-07-12 | 2016-01-14 | 지이 헬스케어 에이에스 | 저농도의 조영제 및/또는 저방사선량의 x-선 영상화 |
CN102249948B (zh) * | 2011-05-23 | 2014-01-29 | 苏州昊帆生物科技有限公司 | 5-乙酰氨基-n,n’-双-(2,3-二羟基丙基)-2,4,6-三碘间苯二甲酰胺的合成方法 |
EP2606912A1 (fr) * | 2011-12-23 | 2013-06-26 | Central Medical Service Co., Ltd. | Composition de substance de contraste avec effet d'amélioration de contraste comprenant un agent hautement concentré |
ES2683712T3 (es) * | 2013-12-06 | 2018-09-27 | Ge Healthcare As | Proceso alternativo para la purificación de un intermedio en la síntesis de agentes de contraste de rayos X no iónicos |
US9834504B2 (en) | 2013-12-06 | 2017-12-05 | Ge Healthcare As | Alternative process for the purification of an intermediate in the synthesis of non-ionic X-ray contrast agents |
ES2638645T3 (es) * | 2013-12-06 | 2017-10-23 | Ge Healthcare As | Procedimiento alternativo de acetilación en la síntesis de agentes de contraste para rayos X no iónicos |
JP6571100B2 (ja) * | 2014-03-04 | 2019-09-04 | 大塚製薬株式会社 | イオヘキソール粉末及びそれを使用する方法 |
PT108524B (pt) * | 2015-06-02 | 2017-12-15 | Hovione Farmaciência S A | Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos |
CN107778191A (zh) * | 2016-08-26 | 2018-03-09 | 正大天晴药业集团股份有限公司 | 一种碘普罗胺及其中间体的制备方法 |
RU2655619C1 (ru) * | 2017-06-13 | 2018-05-29 | Алексей Георгиевич Александров | Способ получения фармацевтической субстанции на основе йогексола |
CN107857714B (zh) * | 2017-11-29 | 2020-11-13 | 上海司太立制药有限公司 | 一种碘海醇中间体杂质的制备方法和用途 |
CN108191689A (zh) * | 2017-12-11 | 2018-06-22 | 天津河清化学工业有限公司 | 一种新型碘海醇节能环保的连续化制备方法 |
CN108191690A (zh) * | 2017-12-11 | 2018-06-22 | 天津河清化学工业有限公司 | 碘海醇节能环保的连续化制备方法 |
EP4001261A1 (fr) | 2020-11-23 | 2022-05-25 | Justesa Imagen S.A.U | Procédé d'obtention d'iohexol de grande pureté |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2053037A1 (fr) * | 1969-06-27 | 1971-04-16 | Nyegaard & Co As | |
BE836355A (fr) * | 1974-12-13 | 1976-06-08 | Agents de constraste radiographique non ioniques facilement solubles dans l'eau et procede pour les preparer |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4021481A (en) * | 1969-06-27 | 1977-05-03 | Nyegaard & Co. A/S | Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups |
GB1321591A (en) | 1969-06-27 | 1973-06-27 | Nyegaard & Co As | Non-ionic iodinated x-ray contrast agents |
BE788054A (fr) * | 1971-08-26 | 1973-02-26 | Bracco Ind Chimica Spa | Nouvel agent de contraste radiographique et procede pour le preparer |
-
1976
- 1976-06-11 GB GB24338/76A patent/GB1548594A/en not_active Expired
-
1977
- 1977-06-10 CH CH718677A patent/CH630064A5/de not_active IP Right Cessation
- 1977-06-10 FR FR7717904A patent/FR2354316A1/fr active Granted
- 1977-06-10 DK DK258477A patent/DK150504C/da not_active IP Right Cessation
- 1977-06-10 SE SE7706792A patent/SE441181B/xx not_active IP Right Cessation
- 1977-06-10 JP JP6936377A patent/JPS5321137A/ja active Granted
- 1977-06-10 NL NLAANVRAGE7706385,A patent/NL175814C/xx not_active IP Right Cessation
- 1977-06-10 BE BE178353A patent/BE855580A/fr not_active IP Right Cessation
- 1977-06-10 DE DE2726196A patent/DE2726196C2/de not_active Expired
-
1979
- 1979-08-24 US US06/069,589 patent/US4250113A/en not_active Expired - Lifetime
-
1983
- 1983-11-17 HK HK566/83A patent/HK56683A/xx unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2053037A1 (fr) * | 1969-06-27 | 1971-04-16 | Nyegaard & Co As | |
BE836355A (fr) * | 1974-12-13 | 1976-06-08 | Agents de constraste radiographique non ioniques facilement solubles dans l'eau et procede pour les preparer |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0015867A1 (fr) * | 1979-03-08 | 1980-09-17 | Schering Aktiengesellschaft | Diamides d'acides triiodo-isophtaliques, leur préparation et agents de contraste radiographiques les contenant |
EP0032387A1 (fr) * | 1980-01-11 | 1981-07-22 | Schering Aktiengesellschaft | Dérivés non ioniques d'acide 2,4,6-triiodo-isophtalique substitué en position 5, procédé pour leur préparation et agents de contraste pour rayons-X les contenant |
EP0082803A1 (fr) * | 1981-12-18 | 1983-06-29 | Schering Aktiengesellschaft | N-hydroxyéthyl 2,4,6-triiodoaminoisophtalique-bis-trihydroxy-butylamides, leur préparation et agents de contraste pour rayons X les contenant |
EP0083964A1 (fr) * | 1982-01-11 | 1983-07-20 | Mallinckrodt, Inc. (a Delaware corporation) | Composés appropriés à des méthodes de visualisation par rayons X |
EP0108638A1 (fr) * | 1982-11-08 | 1984-05-16 | NYEGAARD & CO. A/S | Agents de contraste pour rayons X |
WO1998052909A1 (fr) * | 1997-05-23 | 1998-11-26 | Nycomed Imaging As | Preparation de composes benzeniques tri-iodes |
US6137006A (en) * | 1997-05-23 | 2000-10-24 | Nycomed Imaging As | Preparation of tri-iodo benzene compounds |
Also Published As
Publication number | Publication date |
---|---|
DK258477A (da) | 1977-12-12 |
DE2726196C2 (de) | 1983-12-29 |
JPS5321137A (en) | 1978-02-27 |
DK150504B (da) | 1987-03-16 |
HK56683A (en) | 1983-11-25 |
DK150504C (da) | 1988-01-11 |
NL7706385A (nl) | 1977-12-13 |
CH630064A5 (de) | 1982-05-28 |
DE2726196A1 (de) | 1977-12-22 |
FR2354316B1 (fr) | 1982-11-12 |
GB1548594A (en) | 1979-07-18 |
SE7706792L (sv) | 1977-12-12 |
NL175814C (nl) | 1985-01-02 |
US4250113A (en) | 1981-02-10 |
BE855580A (fr) | 1977-12-12 |
JPS5654310B2 (fr) | 1981-12-24 |
SE441181B (sv) | 1985-09-16 |
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