SE7706792L - Rontgenkontrastmedel - Google Patents

Rontgenkontrastmedel

Info

Publication number
SE7706792L
SE7706792L SE7706792A SE7706792A SE7706792L SE 7706792 L SE7706792 L SE 7706792L SE 7706792 A SE7706792 A SE 7706792A SE 7706792 A SE7706792 A SE 7706792A SE 7706792 L SE7706792 L SE 7706792L
Authority
SE
Sweden
Prior art keywords
ray contrast
contrast agent
compounds
acetyl
isophthala
Prior art date
Application number
SE7706792A
Other languages
English (en)
Other versions
SE441181B (sv
Inventor
V Nordal
H Holtermann
Original Assignee
Nyegaard & Co As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard & Co As filed Critical Nyegaard & Co As
Publication of SE7706792L publication Critical patent/SE7706792L/sv
Publication of SE441181B publication Critical patent/SE441181B/sv

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/32Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE7706792A 1976-06-11 1977-06-10 Nya nonjonogena, jodhaltiga foreningar for anvendning som rontgenkontrastmedel SE441181B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB24338/76A GB1548594A (en) 1976-06-11 1976-06-11 Triiodoisophthalic acid amides

Publications (2)

Publication Number Publication Date
SE7706792L true SE7706792L (sv) 1977-12-12
SE441181B SE441181B (sv) 1985-09-16

Family

ID=10210154

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7706792A SE441181B (sv) 1976-06-11 1977-06-10 Nya nonjonogena, jodhaltiga foreningar for anvendning som rontgenkontrastmedel

Country Status (11)

Country Link
US (1) US4250113A (sv)
JP (1) JPS5321137A (sv)
BE (1) BE855580A (sv)
CH (1) CH630064A5 (sv)
DE (1) DE2726196C2 (sv)
DK (1) DK150504C (sv)
FR (1) FR2354316A1 (sv)
GB (1) GB1548594A (sv)
HK (1) HK56683A (sv)
NL (1) NL175814C (sv)
SE (1) SE441181B (sv)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
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DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
US4256729A (en) * 1979-03-23 1981-03-17 Mallinckrodt, Inc. N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same
DE2928417A1 (de) * 1979-07-12 1981-01-29 Schering Ag Trijodierte basen
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3001292A1 (de) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin Nichtionische 5-c-substituierte 2,4,6-trijod-isophthalsaeure-derivate
DE3038853A1 (de) 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
JPS58102200A (ja) * 1981-12-14 1983-06-17 日本原子力事業株式会社 沈降分離槽
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
DK162045C (da) * 1982-10-01 1992-02-10 Nyegaard & Co As Trijodbenzenderivater, fremgangsmaade til fremstilling deraf og radiologiske praeparater indeholdende saadanne forbindelser
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
NO161368C (no) * 1982-11-08 1989-08-09 Nyegaard & Co As Roentgenkontrastmidler samt radiologiske preparater derav.
US4584401A (en) * 1983-10-20 1986-04-22 Biophysica Foundation Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
US5191119A (en) * 1983-10-20 1993-03-02 Cook Imaging Corp. Process for producing non-ionic radiographic contrast media utilizing N-allylation
JPS6091807U (ja) * 1983-11-30 1985-06-22 松下電器産業株式会社 テ−ブル
JPS634809Y2 (sv) * 1984-10-04 1988-02-08
US4954348A (en) * 1985-08-09 1990-09-04 Cook Imaging Corporation Non-ionic polyol contrast media from ionic contrast media
US5035877A (en) * 1985-08-09 1991-07-30 Cook Imaging Corporation Non-ionic contrast media from ionic contrast media
EP0233249B1 (en) * 1985-08-09 1993-11-24 Cook Imaging Corporation Non-ionic polyol contrast media from ionic contrast media
JPH0637447B2 (ja) * 1987-10-31 1994-05-18 東洋紡績株式会社 新規アミド化合物
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
GB8919929D0 (en) 1989-09-04 1989-10-18 Nycomed As Compositions
DE3937118A1 (de) * 1989-11-03 1991-05-08 Schering Ag Nichtionische roentgenkontrastmittel mit hohem jodgehalt
US5232685A (en) * 1989-11-03 1993-08-03 Schering Aktiengesellschaft Nonionic x-ray contrast medium with high iodine content
CA2029830A1 (en) * 1989-11-29 1991-05-30 Ramachandran S. Ranganathan Nonionic radiographic contrast agents
US5869024A (en) * 1989-11-29 1999-02-09 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
US5614638A (en) * 1989-11-29 1997-03-25 Bracco International B.V. Nonionic radiographic contrast agents
US5191120A (en) * 1989-12-13 1993-03-02 Mallinckrodt Medical, Inc. Process for preparing nonionic X-ray contrast agents
US4997983A (en) * 1990-01-31 1991-03-05 Mallinckrodt, Inc. Process for production of ioversol
US5527926A (en) * 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
US5356613A (en) * 1991-03-18 1994-10-18 Mallinckrodt Medical, Inc. X-ray contrast agents, compositions and methods
DE4109169A1 (de) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung
US5169864A (en) * 1991-11-15 1992-12-08 Baxter International Inc. Unbuffered premixed ranitidine formulation
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US5662883A (en) * 1995-01-10 1997-09-02 Nanosystems L.L.C. Microprecipitation of micro-nanoparticulate pharmaceutical agents
US5543133A (en) * 1995-02-14 1996-08-06 Nanosystems L.L.C. Process of preparing x-ray contrast compositions containing nanoparticles
DE19510864A1 (de) * 1995-03-16 1996-09-19 Schering Ag Röntgenkontrastmittel für die Computertomographie und Urographie
IT1275429B (it) * 1995-05-18 1997-08-07 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di composti organici
CN1078201C (zh) * 1995-11-20 2002-01-23 江苏省原子医学研究所 一种碘海醇的制备方法
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US5840967A (en) * 1996-08-29 1998-11-24 Nycomed Imaging As Process for the preparation of contrast agents
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US5705692A (en) * 1996-09-27 1998-01-06 Abbott Laboratories Process for the preparation of iohexol
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US5861140A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Tripodal paramagnetic contrast agents for MR imaging
US5824821A (en) * 1997-02-07 1998-10-20 Nycomed Imaging As Process for the preparation of iodinated contrast agents and intermediates therefor
US5847212A (en) * 1997-04-21 1998-12-08 Abbott Laboratories Process for the preparation of iohexol
GB9710726D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Compound
US6137006A (en) * 1997-05-23 2000-10-24 Nycomed Imaging As Preparation of tri-iodo benzene compounds
GB9710728D0 (en) * 1997-05-23 1997-07-16 Nycomed Imaging As Method
GB9710725D0 (en) 1997-05-23 1997-07-16 Nycomed Imaging As Process
IT1292037B1 (it) * 1997-05-30 1999-01-25 Bracco Spa Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen-
US5869026A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corp. Tripodal carboxamide ligands for MRI contrast agents
US5820851A (en) * 1997-08-21 1998-10-13 Hoechst Celanese Corporation Tripodal pyridine ligands as MRI contrast agents
US5824288A (en) * 1997-08-21 1998-10-20 Hoechst Celanese Corporation Thio-substituted pyridines as MRI ligand precursors
US5858329A (en) * 1997-08-21 1999-01-12 Hoechst Celanese Corporation MRI diagnostic procedures using tripodal pyridinyl metal complexes
US5869025A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corporation Tripodal aromatic heterocycle carboxamide MRI contrast agents
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ITMI20010773A1 (it) * 2001-04-11 2002-10-11 Chemi Spa Processo per la produzione di ioexolo ad elevata purezza
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US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
US20130116554A1 (en) * 2010-07-12 2013-05-09 Ge Healthcare As X-ray imaging at low contrast agent concentrations and/or low dose radiation
CN102249948B (zh) * 2011-05-23 2014-01-29 苏州昊帆生物科技有限公司 5-乙酰氨基-n,n’-双-(2,3-二羟基丙基)-2,4,6-三碘间苯二甲酰胺的合成方法
EP2606912A1 (en) * 2011-12-23 2013-06-26 Central Medical Service Co., Ltd. Contrast medium composition with contrast enhancement effect by comprising highly concentrated agent
EP3077368B1 (en) * 2013-12-06 2018-07-11 GE Healthcare AS Alternative process for the purification of an intermediate in the synthesis of non-ionic x-ray contrast agents
WO2015082719A1 (en) * 2013-12-06 2015-06-11 Ge Healthcare As Alternative acetylation process in the synthesis of non-ionic xray contrast agents
EP3077367B1 (en) * 2013-12-06 2018-07-11 GE Healthcare AS Alternative process for the purification of an intermediate in the synthesis of non-ionic x-ray contrast agents
WO2015133651A1 (en) 2014-03-04 2015-09-11 Otsuka Pharmaceutical Co., Ltd. Iohexol powder and method of using the same
PT108524B (pt) * 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
CN107778191A (zh) * 2016-08-26 2018-03-09 正大天晴药业集团股份有限公司 一种碘普罗胺及其中间体的制备方法
RU2655619C1 (ru) * 2017-06-13 2018-05-29 Алексей Георгиевич Александров Способ получения фармацевтической субстанции на основе йогексола
CN107857714B (zh) * 2017-11-29 2020-11-13 上海司太立制药有限公司 一种碘海醇中间体杂质的制备方法和用途
CN108191690A (zh) * 2017-12-11 2018-06-22 天津河清化学工业有限公司 碘海醇节能环保的连续化制备方法
CN108191689A (zh) * 2017-12-11 2018-06-22 天津河清化学工业有限公司 一种新型碘海醇节能环保的连续化制备方法
EP4001261A1 (en) 2020-11-23 2022-05-25 Justesa Imagen S.A.U Procedure for obtaining high purity iohexol

Family Cites Families (5)

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GB1321591A (en) 1969-06-27 1973-06-27 Nyegaard & Co As Non-ionic iodinated x-ray contrast agents
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
US3701771A (en) * 1969-06-27 1972-10-31 Nyegaard & Co As N-(2,4,6-triiodobenzoyl)-sugar amines
BE788054A (fr) * 1971-08-26 1973-02-26 Bracco Ind Chimica Spa Nouvel agent de contraste radiographique et procede pour le preparer
CH608189A5 (sv) * 1974-12-13 1978-12-29 Savac Ag

Also Published As

Publication number Publication date
CH630064A5 (de) 1982-05-28
US4250113A (en) 1981-02-10
DK150504B (da) 1987-03-16
DK150504C (da) 1988-01-11
DE2726196A1 (de) 1977-12-22
SE441181B (sv) 1985-09-16
NL175814C (nl) 1985-01-02
DE2726196C2 (de) 1983-12-29
FR2354316A1 (fr) 1978-01-06
HK56683A (en) 1983-11-25
JPS5654310B2 (sv) 1981-12-24
DK258477A (da) 1977-12-12
BE855580A (fr) 1977-12-12
FR2354316B1 (sv) 1982-11-12
GB1548594A (en) 1979-07-18
NL7706385A (nl) 1977-12-13
JPS5321137A (en) 1978-02-27

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