ES493011A0 - Procedimiento para la preparacion de derivados de pirimi- do-(6,1-a)-isoquinolein-4-onas - Google Patents

Procedimiento para la preparacion de derivados de pirimi- do-(6,1-a)-isoquinolein-4-onas

Info

Publication number
ES493011A0
ES493011A0 ES493011A ES493011A ES493011A0 ES 493011 A0 ES493011 A0 ES 493011A0 ES 493011 A ES493011 A ES 493011A ES 493011 A ES493011 A ES 493011A ES 493011 A0 ES493011 A0 ES 493011A0
Authority
ES
Spain
Prior art keywords
preparation
pirimido
isoquinolein
onas
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES493011A
Other languages
English (en)
Other versions
ES8103083A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES493011A0 publication Critical patent/ES493011A0/es
Publication of ES8103083A1 publication Critical patent/ES8103083A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
ES493011A 1978-11-03 1980-07-01 Procedimiento para la preparacion de derivados de pirimi- do-(6,1-a)-isoquinolein-4-onas Expired ES8103083A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782847693 DE2847693A1 (de) 1978-11-03 1978-11-03 Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen

Publications (2)

Publication Number Publication Date
ES493011A0 true ES493011A0 (es) 1981-02-16
ES8103083A1 ES8103083A1 (es) 1981-02-16

Family

ID=6053766

Family Applications (2)

Application Number Title Priority Date Filing Date
ES485489A Expired ES8102125A1 (es) 1978-11-03 1979-10-29 Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas
ES493011A Expired ES8103083A1 (es) 1978-11-03 1980-07-01 Procedimiento para la preparacion de derivados de pirimi- do-(6,1-a)-isoquinolein-4-onas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES485489A Expired ES8102125A1 (es) 1978-11-03 1979-10-29 Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas

Country Status (18)

Country Link
US (1) US4400506A (es)
EP (1) EP0010759B1 (es)
JP (1) JPS5564587A (es)
AT (1) ATE21104T1 (es)
AU (1) AU538039B2 (es)
CA (1) CA1123434A (es)
DE (2) DE2847693A1 (es)
DK (1) DK465879A (es)
ES (2) ES8102125A1 (es)
FI (1) FI66865C (es)
GR (1) GR74082B (es)
HU (1) HU181884B (es)
IL (1) IL58609A0 (es)
NO (1) NO793537L (es)
NZ (1) NZ191994A (es)
PH (1) PH15281A (es)
PT (1) PT70401A (es)
ZA (1) ZA795888B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI64370C (fi) * 1977-05-05 1983-11-10 Hoechst Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
DE2847693A1 (de) 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
FR2470130A2 (fr) * 1979-11-21 1981-05-29 Hoechst Ag Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique
DE3126837A1 (de) * 1981-07-08 1983-01-27 Hoechst Ag, 6000 Frankfurt Triazino-(2,1-a)isochinolinderivate
DE3135831A1 (de) * 1981-09-10 1983-04-28 Hoechst Ag, 6230 Frankfurt 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4612376A (en) * 1983-03-25 1986-09-16 Fujisawa Pharmaceutical Co., Ltd. Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent
CA1237429A (en) * 1983-05-05 1988-05-31 Frank Kienzle Pyrimidone derivatives
ES2208310T3 (es) * 1999-03-31 2004-06-16 Vernalis Limited Derivados de pirimido(6,1-a) isoquinolin-4-ona.
TR200909479T2 (tr) * 1999-08-21 2012-02-21 Nycomed Gmbh Sinerjistik kombinasyon.
TWI347845B (en) * 2002-03-06 2011-09-01 Nycomed Gmbh Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP6251038B2 (ja) 2011-03-01 2017-12-20 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃアゴニストの調製方法
EP2958577A2 (en) 2013-02-25 2015-12-30 Synergy Pharmaceuticals Inc. Guanylate cyclase receptor agonists for use in colonic cleansing
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
KR20160042039A (ko) 2013-08-09 2016-04-18 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
GB201613054D0 (en) 2016-07-28 2016-09-14 Verona Pharma Plc New compound and process
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE590405A (es) * 1959-05-02
US3081306A (en) * 1959-11-04 1963-03-12 Pfizer & Co C 2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines
GB1062357A (en) * 1965-03-23 1967-03-22 Pfizer & Co C Quinazolone derivatives
US3476755A (en) * 1967-01-17 1969-11-04 Edward C Taylor 8,13-diazasteroids
US3594379A (en) * 1968-09-16 1971-07-20 Sandoz Ag 2,3-dihydroimidazo(1,2-c)quinazolines
US3876788A (en) * 1970-08-27 1975-04-08 Burroughs Wellcome Co Heterocyclic compounds in the treatment of inflammatory of arthritic conditions
IN147624B (es) 1976-12-10 1980-05-03 Hoechst Pharma
DE2720085A1 (de) * 1977-05-05 1978-11-16 Hoechst Ag Pyrimido(6,1-a)isochinolin-2-on- derivate
FI64370C (fi) * 1977-05-05 1983-11-10 Hoechst Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
DE2847693A1 (de) 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen

Also Published As

Publication number Publication date
ES485489A0 (es) 1980-12-16
JPS5564587A (en) 1980-05-15
FI66865C (fi) 1984-12-10
ATE21104T1 (de) 1986-08-15
FI66865B (fi) 1984-08-31
GR74082B (es) 1984-06-06
NZ191994A (en) 1982-09-07
IL58609A0 (en) 1980-02-29
HU181884B (en) 1983-11-28
DE2967610D1 (en) 1986-09-04
DE2847693A1 (de) 1980-05-22
EP0010759B1 (de) 1986-07-30
ES8102125A1 (es) 1980-12-16
EP0010759A3 (en) 1981-08-19
AU5245379A (en) 1980-05-08
AU538039B2 (en) 1984-07-26
ZA795888B (en) 1980-10-29
PH15281A (en) 1982-11-02
CA1123434A (en) 1982-05-11
NO793537L (no) 1980-05-06
DK465879A (da) 1980-05-04
EP0010759A2 (de) 1980-05-14
FI793430A (fi) 1980-05-04
US4400506A (en) 1983-08-23
PT70401A (de) 1979-12-01
ES8103083A1 (es) 1981-02-16

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