EP0619744A4 - Nonionic x-ray contrast agents, compositions and methods. - Google Patents

Nonionic x-ray contrast agents, compositions and methods.

Info

Publication number
EP0619744A4
EP0619744A4 EP93901365A EP93901365A EP0619744A4 EP 0619744 A4 EP0619744 A4 EP 0619744A4 EP 93901365 A EP93901365 A EP 93901365A EP 93901365 A EP93901365 A EP 93901365A EP 0619744 A4 EP0619744 A4 EP 0619744A4
Authority
EP
European Patent Office
Prior art keywords
nonionic
compositions
methods
contrast agents
ray contrast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93901365A
Other languages
German (de)
French (fr)
Other versions
EP0619744A1 (en
Inventor
Mills T Kneller
Youlin Lin
James Wheatley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical Inc filed Critical Mallinckrodt Medical Inc
Publication of EP0619744A1 publication Critical patent/EP0619744A1/en
Publication of EP0619744A4 publication Critical patent/EP0619744A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
EP93901365A 1991-12-03 1992-12-02 Nonionic x-ray contrast agents, compositions and methods. Withdrawn EP0619744A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80198091A 1991-12-03 1991-12-03
PCT/US1992/010629 WO1993010825A1 (en) 1991-12-03 1992-12-02 Nonionic x-ray contrast agents, compositions and methods
US801980 1997-02-19

Publications (2)

Publication Number Publication Date
EP0619744A1 EP0619744A1 (en) 1994-10-19
EP0619744A4 true EP0619744A4 (en) 1995-02-08

Family

ID=25182519

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93901365A Withdrawn EP0619744A4 (en) 1991-12-03 1992-12-02 Nonionic x-ray contrast agents, compositions and methods.

Country Status (5)

Country Link
EP (1) EP0619744A4 (en)
JP (1) JPH07501809A (en)
AU (1) AU3273993A (en)
CA (1) CA2124559A1 (en)
WO (1) WO1993010825A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622687A (en) * 1994-11-15 1997-04-22 Molecular Biosystems, Inc. Calixarene conjugates useful as MRI and CT diagnostic imaging agents
DE19510864A1 (en) * 1995-03-16 1996-09-19 Schering Ag X-ray contrast media for computed tomography and urography
IT1275429B (en) * 1995-05-18 1997-08-07 Zambon Spa PROCESS FOR THE PREPARATION OF A USEFUL INTERMEDIATE IN THE SYNTHESIS OF ORGANIC COMPOUNDS
DE19731591C2 (en) * 1997-07-17 1999-09-16 Schering Ag Pharmaceutical compositions containing triiodoaromatics containing perfluoroalkyl groups and their use in tumor therapy and interventional radiology
DE10215941A1 (en) 2002-04-11 2003-10-23 Bayer Ag Binder containing inorganic UV absorbers
CA2559628A1 (en) * 2004-03-11 2005-09-22 Mallinckrodt Inc. X-ray contrast formulation comprising a mixture of iodinated monomer and dimer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE3038853A1 (en) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW N-HYDROXY-ALKYLATED DICARBONIC ACID-BIS- (3,5-DICARBAMOYL-2,4,6-TRIJODANILIDES), THEIR PRODUCTION AND THEIR CONTAINING X-RAY CONTRAST AGENTS (II)
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9310825A1 *

Also Published As

Publication number Publication date
AU3273993A (en) 1993-06-28
JPH07501809A (en) 1995-02-23
WO1993010825A1 (en) 1993-06-10
EP0619744A1 (en) 1994-10-19
CA2124559A1 (en) 1993-06-10

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19940701

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: WHEATLEY, JAMES

Inventor name: LIN, YOULIN

Inventor name: KNELLER, MILLS, T.

A4 Supplementary search report drawn up and despatched

Effective date: 19941223

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE

17Q First examination report despatched

Effective date: 19950720

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19951201