GB1456512A - Substituted 16,17,18,19,20-pentanorprostaglandins - Google Patents

Substituted 16,17,18,19,20-pentanorprostaglandins

Info

Publication number
GB1456512A
GB1456512A GB5175873A GB5175873A GB1456512A GB 1456512 A GB1456512 A GB 1456512A GB 5175873 A GB5175873 A GB 5175873A GB 5175873 A GB5175873 A GB 5175873A GB 1456512 A GB1456512 A GB 1456512A
Authority
GB
United Kingdom
Prior art keywords
phenoxy
oxo
trans
dimethylisopropylsilyloxy
dimethylisopropylsilyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5175873A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of GB1456512A publication Critical patent/GB1456512A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB5175873A 1972-11-08 1973-11-07 Substituted 16,17,18,19,20-pentanorprostaglandins Expired GB1456512A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30481372A 1972-11-08 1972-11-08

Publications (1)

Publication Number Publication Date
GB1456512A true GB1456512A (en) 1976-11-24

Family

ID=23178133

Family Applications (3)

Application Number Title Priority Date Filing Date
GB2285876A Expired GB1456514A (en) 1972-11-08 1973-11-07 Substituted dialkyl 2-oxopropylphosphonates
GB5175873A Expired GB1456512A (en) 1972-11-08 1973-11-07 Substituted 16,17,18,19,20-pentanorprostaglandins
GB2395076A Expired GB1456513A (en) 1972-11-08 1973-11-07 Derivatives of cyclopentaneacetic acid

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB2285876A Expired GB1456514A (en) 1972-11-08 1973-11-07 Substituted dialkyl 2-oxopropylphosphonates

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB2395076A Expired GB1456513A (en) 1972-11-08 1973-11-07 Derivatives of cyclopentaneacetic acid

Country Status (29)

Country Link
JP (3) JPS5416491B2 (fr)
AR (3) AR200585A1 (fr)
AT (3) AT367034B (fr)
AU (1) AU470375B2 (fr)
BE (1) BE806995A (fr)
CA (3) CA1085831A (fr)
CH (1) CH597176A5 (fr)
CS (3) CS182794B2 (fr)
DD (4) DD118856A5 (fr)
DE (1) DE2355540C2 (fr)
DK (1) DK144247C (fr)
ES (3) ES420325A1 (fr)
FI (1) FI60389C (fr)
FR (3) FR2205335B1 (fr)
GB (3) GB1456514A (fr)
HK (3) HK27979A (fr)
HU (3) HU172703B (fr)
IE (1) IE39537B1 (fr)
IL (1) IL43589A (fr)
IN (1) IN139384B (fr)
KE (3) KE2932A (fr)
MY (3) MY7900243A (fr)
NL (1) NL164273C (fr)
NO (3) NO147836C (fr)
PH (3) PH13272A (fr)
SE (4) SE448992B (fr)
SU (4) SU584766A3 (fr)
YU (3) YU39715B (fr)
ZA (1) ZA738554B (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074315A2 (fr) * 2000-03-31 2001-10-11 The Procter & Gamble Company Compositions et methodes de traitement de la perte de cheveux au moyen de prostaglandines non naturelles
WO2002100388A2 (fr) * 2001-06-13 2002-12-19 Allergan, Inc. Derives de cyclopentane heptan(ene) acyle sulfonamide, 2-alkyle ou 2-arylalkyle, ou 2-heteroarylalcenyle en tant qu'agents therapeutiques
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
USRE43372E1 (en) 1999-03-05 2012-05-08 Duke University C16 unsaturated FP-selective prostaglandins analogs
US8618086B2 (en) 2000-03-31 2013-12-31 Duke University Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8642644B2 (en) 2004-10-21 2014-02-04 Duke University Ophthamological drugs
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US9346837B2 (en) 2000-03-31 2016-05-24 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929862A (en) * 1974-01-08 1975-12-30 Upjohn Co Substituted tolylesters of PGF{HD 2{B {60
US3986764A (en) * 1975-03-31 1976-10-19 Gte Automatic Electric Laboratories Incorporated Panel for supporting a pair of elongated mating connectors and selectively locking them together
GB1506816A (en) * 1975-03-31 1978-04-12 Upjohn Co Prostaglandins
ES449162A1 (es) * 1975-06-23 1977-12-16 Syntex Inc Un procedimiento para la preparacion de un compuesto racemi-co u 8r-antimerico.
GB1516414A (en) * 1975-08-22 1978-07-05 Ici Ltd Prostane derivatives
SE7809008L (sv) * 1977-12-12 1979-06-13 Upjohn Co Anvendning av amider av prostaglandintyp for att styra eller reglera reproduktionscykeln hos individer tillhorande deggdjursarter
IN150279B (fr) * 1978-01-16 1982-09-04 Pfizer
KR20010023838A (ko) * 1997-09-09 2001-03-26 데이비드 엠 모이어 Ｆｐ 작동약으로 유용한 방향족 ｃ16-ｃ20-치환된테트라히드로 프로스타글란딘
JP2002329615A (ja) * 2001-05-02 2002-11-15 Ohira Denshi Kk トロイダルコイル

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1324737A (en) * 1970-11-02 1973-07-25 Upjohn Co Prostaglandins and the preparation thereof
IE37602B1 (en) * 1971-05-11 1977-08-31 Ici Ltd Cyclopentane derivatives

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43372E1 (en) 1999-03-05 2012-05-08 Duke University C16 unsaturated FP-selective prostaglandins analogs
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US7115659B2 (en) 1999-08-04 2006-10-03 The Procter & Gamble Company Method of treating a condition by administering a prostaglandin derivative
US7074942B2 (en) 1999-08-04 2006-07-11 The Procter & Gamble Company 2-decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US8541466B2 (en) 2000-03-31 2013-09-24 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
WO2001074315A3 (fr) * 2000-03-31 2002-02-21 Procter & Gamble Compositions et methodes de traitement de la perte de cheveux au moyen de prostaglandines non naturelles
WO2001074315A2 (fr) * 2000-03-31 2001-10-11 The Procter & Gamble Company Compositions et methodes de traitement de la perte de cheveux au moyen de prostaglandines non naturelles
US8618086B2 (en) 2000-03-31 2013-12-31 Duke University Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US8906962B2 (en) 2000-03-31 2014-12-09 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US9346837B2 (en) 2000-03-31 2016-05-24 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US9579270B2 (en) 2000-03-31 2017-02-28 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US9675539B2 (en) 2000-03-31 2017-06-13 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
WO2002100388A3 (fr) * 2001-06-13 2003-11-27 Allergan Inc Derives de cyclopentane heptan(ene) acyle sulfonamide, 2-alkyle ou 2-arylalkyle, ou 2-heteroarylalcenyle en tant qu'agents therapeutiques
WO2002100388A2 (fr) * 2001-06-13 2002-12-19 Allergan, Inc. Derives de cyclopentane heptan(ene) acyle sulfonamide, 2-alkyle ou 2-arylalkyle, ou 2-heteroarylalcenyle en tant qu'agents therapeutiques
US8642644B2 (en) 2004-10-21 2014-02-04 Duke University Ophthamological drugs
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins

Also Published As

Publication number Publication date
FR2283146A1 (fr) 1976-03-26
NO148998B (no) 1983-10-17
SE445111B (sv) 1986-06-02
ES420325A1 (es) 1976-04-16
HK28179A (en) 1979-05-11
YU270780A (en) 1982-06-18
YU288073A (en) 1982-02-28
DE2355540A1 (de) 1974-05-22
IL43589A0 (en) 1974-03-14
ATA544676A (de) 1979-04-15
SU667141A3 (ru) 1979-06-05
SU745362A3 (ru) 1980-06-30
AR199966A1 (es) 1974-10-08
SE7700716L (sv) 1977-01-24
DD109212A5 (fr) 1974-10-20
YU36975B (en) 1984-08-31
IE39537B1 (en) 1978-11-08
FR2205335B1 (fr) 1978-07-13
SE448992B (sv) 1987-03-30
AT367034B (de) 1982-05-25
JPS4993342A (fr) 1974-09-05
CA1085831A (fr) 1980-09-16
AR202931A1 (es) 1975-07-31
GB1456513A (en) 1976-11-24
DE2355540C2 (de) 1982-11-18
AT360672B (de) 1981-01-26
YU37316B (en) 1984-08-31
DK144247B (da) 1982-01-25
NO148998C (no) 1984-01-25
AT353285B (de) 1979-11-12
CS182793B2 (en) 1978-05-31
HU171819B (hu) 1978-03-28
PH13110A (en) 1979-11-28
YU270680A (en) 1983-04-27
YU39715B (en) 1985-04-30
FR2279729A1 (fr) 1976-02-20
DD119411A5 (fr) 1976-04-20
KE2932A (en) 1979-03-30
SU584766A3 (ru) 1977-12-15
NO149139C (no) 1984-02-29
FR2279729B1 (fr) 1978-04-28
NO743493L (no) 1974-05-09
DD117233A5 (fr) 1976-01-05
HU173507B (hu) 1979-05-28
FR2205335A1 (fr) 1974-05-31
FI60389B (fi) 1981-09-30
NO149139B (no) 1983-11-14
ZA738554B (en) 1974-09-25
PH13272A (en) 1980-02-27
SU893130A3 (ru) 1981-12-23
DK144247C (da) 1982-07-12
ATA936973A (de) 1981-10-15
AU470375B2 (en) 1976-03-11
GB1456514A (en) 1976-11-24
ES433046A1 (es) 1977-06-16
HK27979A (en) 1979-05-11
SE436278B (sv) 1984-11-26
ES433047A1 (es) 1976-11-01
MY7900246A (en) 1979-12-31
MY7900243A (en) 1979-12-31
JPS5257147A (en) 1977-05-11
KE2931A (en) 1979-03-30
DE2365322A1 (de) 1974-11-07
JPS5253841A (en) 1977-04-30
CA1088931A (fr) 1980-11-04
NO147836C (no) 1983-06-22
NO750535L (fr) 1974-05-09
SE7700717L (sv) 1977-01-24
PH13325A (en) 1980-03-13
KE2930A (en) 1979-03-30
ATA544576A (de) 1980-06-15
AR200585A1 (es) 1974-11-22
IL43589A (en) 1980-01-31
FR2283146B1 (fr) 1981-06-19
NL7315263A (fr) 1974-05-10
SE431756B (sv) 1984-02-27
BE806995A (fr) 1974-05-07
CS182794B2 (en) 1978-05-31
CS182791B2 (en) 1978-05-31
DD118856A5 (fr) 1976-03-20
CH597176A5 (fr) 1978-03-31
NL164273C (nl) 1980-12-15
HU172703B (hu) 1978-11-28
IN139384B (fr) 1976-06-12
DE2365322B2 (de) 1977-02-24
IE39537L (en) 1974-05-08
MY7900245A (en) 1979-12-31
FI60389C (fi) 1982-01-11
HK28079A (en) 1979-05-11
AU6224773A (en) 1975-05-08
CA1088930A (fr) 1980-11-04
SE7700718L (sv) 1977-01-24
JPS5416491B2 (fr) 1979-06-22
NO147836B (no) 1983-03-14

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19921107