GB1456838A - 16,17,18,19,20-pentanorprostaglandins - Google Patents

16,17,18,19,20-pentanorprostaglandins

Info

Publication number
GB1456838A
GB1456838A GB5199773A GB5199773A GB1456838A GB 1456838 A GB1456838 A GB 1456838A GB 5199773 A GB5199773 A GB 5199773A GB 5199773 A GB5199773 A GB 5199773A GB 1456838 A GB1456838 A GB 1456838A
Authority
GB
United Kingdom
Prior art keywords
trans
dimethylisopropylsilyloxy
pentanor
indanyl
cis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5199773A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Priority to GB3046876A priority Critical patent/GB1456840A/en
Priority to GB3046776A priority patent/GB1456839A/en
Publication of GB1456838A publication Critical patent/GB1456838A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4018—Esters of cycloaliphatic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Abstract

1456838 Silylated prostaglandins PFIZER Inc 8 Nov 1973 [8 Nov 1972] 51997/73 Heading C3S [Also in Division C2] N - Methansulphonyl - 15 - (5,6 - dimethoxy- 2 - indanyl) - 9α,11α,15# - tris - (dimethylisopropylsilyloxy) - 16,17,18,19,20 - pentanor - 13 - trans-prostenamide is prepared by hydrogenating N-methanesulphonyl-15-(5,6-dimethoxy-2- indanyl) - 9α,11α,15# - tris - (dimethylisopropylsilyloxy) - 16,17,18,19,20 - pentanor - 5 - cis, 13- trans-prostadienamide, resulting from the reaction between dimethylisopropylchlorosilane and N - methanesulphonyl - 9α,11α,15# - trihydroxy - 16,17,18,19,20 - pentanor - 5 - cis, 13- trans - prostadienamide. 16 - (2 - Indonyl)- 11α,15α - bis - (dimethylisopropylsilyloxy) - 9- oxo - 17,18,19,20 - tetranor - 13 - trans - prostenoic acid and 16-(2-indanyl)-11α,15α-bis-(dimethylisopropylsilyloxy) - 9 - oxo - 17,18.19,20- tetranor-5-cis, 13-trans-prostadienoic acid are obtained in a similar manner.
GB5199773A 1972-11-08 1973-11-08 16,17,18,19,20-pentanorprostaglandins Expired GB1456838A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB3046876A GB1456840A (en) 1972-11-08 1973-11-08 Substituted dimethyl oxophosphonates
GB3046776A GB1456839A (en) 1972-11-08 1973-11-08 Cyclopentane derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30475072A 1972-11-08 1972-11-08

Publications (1)

Publication Number Publication Date
GB1456838A true GB1456838A (en) 1976-11-24

Family

ID=23177829

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5199773A Expired GB1456838A (en) 1972-11-08 1973-11-08 16,17,18,19,20-pentanorprostaglandins

Country Status (20)

Country Link
JP (1) JPS5714347B2 (en)
AT (1) AT345999B (en)
BE (1) BE807046A (en)
CA (1) CA1033727A (en)
CH (1) CH593930A5 (en)
DE (1) DE2355731C3 (en)
DK (1) DK143499C (en)
ES (3) ES420386A1 (en)
FI (1) FI58912C (en)
FR (3) FR2205338B1 (en)
GB (1) GB1456838A (en)
IE (1) IE40043B1 (en)
IL (2) IL50310A (en)
IN (1) IN139265B (en)
NL (1) NL7315307A (en)
NO (2) NO143663C (en)
PH (2) PH13261A (en)
SE (4) SE412229B (en)
SU (2) SU667131A3 (en)
ZA (1) ZA738595B (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115453A (en) * 1976-02-11 1978-09-19 Miles Laboratories, Inc. Bicycloalkyl derivatives of prostaglandins PGE1 alcohols
US5977173A (en) * 1997-09-09 1999-11-02 Wos; John August Aromatic C16 -C20 -substituted tetrahydro prostaglandins useful as FP agonists
US6048895A (en) * 1997-09-09 2000-04-11 The Procter & Gamble Company Aromatic C16-C20 substituted tetrahydro prostaglandins useful as FP agonists
US6107338A (en) * 1997-09-09 2000-08-22 The Procter & Gamble Company Aromatic C16 -C20 -substituted tetrahydro prostaglandins useful as FP agonists
USRE43372E1 (en) 1999-03-05 2012-05-08 Duke University C16 unsaturated FP-selective prostaglandins analogs
US8541466B2 (en) 2000-03-31 2013-09-24 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US8618086B2 (en) 2000-03-31 2013-12-31 Duke University Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US9346837B2 (en) 2000-03-31 2016-05-24 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1431561A (en) * 1973-01-31 1976-04-07 Ici Ltd Cyclopentane derivatives
US3929862A (en) * 1974-01-08 1975-12-30 Upjohn Co Substituted tolylesters of PGF{HD 2{B {60
JPS5823393B2 (en) * 1974-03-14 1983-05-14 オノヤクヒンコウギヨウ カブシキガイシヤ prostaglandin
US4028396A (en) * 1975-07-02 1977-06-07 American Cyanamid Company 16,16-Spirocycloalkyl prostaglandin derivatives
NZ183136A (en) * 1976-02-11 1978-11-13 Miles Lab Monospiroalkyl derivatives of prostaclandis and pharmaceutical compositions
US4404372A (en) * 1977-06-13 1983-09-13 Pfizer Inc. 15-Substituted-ω-pentanorprostaglandin derivatives
DE2753995A1 (en) * 1977-12-03 1979-06-07 Bayer Ag NEW BICYCLOALKENYL PROSTAGLANDINS AND THE METHOD OF MANUFACTURING THEM
EP2028153B1 (en) * 2007-11-28 2009-06-03 BAUER Maschinen GmbH Winch

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4864073A (en) * 1971-04-30 1973-09-05

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115453A (en) * 1976-02-11 1978-09-19 Miles Laboratories, Inc. Bicycloalkyl derivatives of prostaglandins PGE1 alcohols
US5977173A (en) * 1997-09-09 1999-11-02 Wos; John August Aromatic C16 -C20 -substituted tetrahydro prostaglandins useful as FP agonists
US6048895A (en) * 1997-09-09 2000-04-11 The Procter & Gamble Company Aromatic C16-C20 substituted tetrahydro prostaglandins useful as FP agonists
US6107338A (en) * 1997-09-09 2000-08-22 The Procter & Gamble Company Aromatic C16 -C20 -substituted tetrahydro prostaglandins useful as FP agonists
USRE43372E1 (en) 1999-03-05 2012-05-08 Duke University C16 unsaturated FP-selective prostaglandins analogs
US8618086B2 (en) 2000-03-31 2013-12-31 Duke University Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US8541466B2 (en) 2000-03-31 2013-09-24 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US8906962B2 (en) 2000-03-31 2014-12-09 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US9346837B2 (en) 2000-03-31 2016-05-24 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US9579270B2 (en) 2000-03-31 2017-02-28 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US9675539B2 (en) 2000-03-31 2017-06-13 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins

Also Published As

Publication number Publication date
FI58912C (en) 1981-05-11
ES456279A1 (en) 1978-11-01
IL50310A (en) 1977-08-31
CA1033727A (en) 1978-06-27
DE2355731C3 (en) 1981-01-15
ZA738595B (en) 1974-09-25
JPS49133357A (en) 1974-12-21
PH13320A (en) 1980-03-13
FR2205338A1 (en) 1974-05-31
DE2355731A1 (en) 1974-05-22
CH593930A5 (en) 1977-12-30
FR2291200A1 (en) 1976-06-11
BE807046A (en) 1974-05-08
FI58912B (en) 1981-01-30
NO143663B (en) 1980-12-15
AU6230273A (en) 1975-05-08
NO144385B (en) 1981-05-11
ES420386A1 (en) 1976-07-01
SU667131A3 (en) 1979-06-05
NO143663C (en) 1981-03-25
DE2355731B2 (en) 1980-04-30
PH13261A (en) 1980-02-25
ATA941073A (en) 1978-02-15
ES444398A1 (en) 1977-12-01
SE7612261L (en) 1976-11-03
SE7701523L (en) 1977-02-10
SU704456A3 (en) 1979-12-15
IE40043L (en) 1974-05-08
IL43571A (en) 1977-08-31
DK143499C (en) 1982-01-11
FR2205338B1 (en) 1978-07-13
FR2286147B1 (en) 1978-09-22
FR2291200B1 (en) 1979-01-05
NL7315307A (en) 1974-05-10
SE412229B (en) 1980-02-25
IN139265B (en) 1976-05-29
AT345999B (en) 1978-10-10
NO743616L (en) 1974-05-09
DK143499B (en) 1981-08-31
IE40043B1 (en) 1979-02-28
SE417957B (en) 1981-04-27
IL43571A0 (en) 1974-03-14
NO144385C (en) 1981-08-19
FR2286147A1 (en) 1976-04-23
JPS5714347B2 (en) 1982-03-24
SE7612262L (en) 1976-11-03

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
48S Specification amended (sect. 8/1949)
SP Amendment (slips) printed
PCNP Patent ceased through non-payment of renewal fee