GB1446341A - 15-substituted-omega-pentanorprostaglandins - Google Patents
15-substituted-omega-pentanorprostaglandinsInfo
- Publication number
- GB1446341A GB1446341A GB3121773A GB3121773A GB1446341A GB 1446341 A GB1446341 A GB 1446341A GB 3121773 A GB3121773 A GB 3121773A GB 3121773 A GB3121773 A GB 3121773A GB 1446341 A GB1446341 A GB 1446341A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tetranor
- thienyl
- oxo
- trans
- pentanorprostaglandins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 2
- YCXVDEMHEKQQCI-UHFFFAOYSA-N chloro-dimethyl-propan-2-ylsilane Chemical compound CC(C)[Si](C)(C)Cl YCXVDEMHEKQQCI-UHFFFAOYSA-N 0.000 abstract 1
- -1 dimethylisopropylsilyloxy Chemical group 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
- C07F9/4059—Compounds containing the structure (RY)2P(=X)-(CH2)n-C(=O)-(CH2)m-Ar, (X, Y = O, S, Se; n>=1, m>=0)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B63—SHIPS OR OTHER WATERBORNE VESSELS; RELATED EQUIPMENT
- B63B—SHIPS OR OTHER WATERBORNE VESSELS; EQUIPMENT FOR SHIPPING
- B63B2211/00—Applications
- B63B2211/02—Oceanography
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
1446341 Silylated prostaglandins PFIZER Inc 13 July 1973 [13 July 1972] 31217/73 Heading C3S [Also in Division C2] 11α,15α - Bis - (dimethylisopropylsilyloxy)- 9 - oxo - 16 - (2 - thienyl) - 17,18,19,20 - tetranor - trans - 13 - prostenoic acid is prepared by hydrogenating 11α,15α - bis - (dimethylisopropylsilyloxy) - 9 - oxo - 16 - (2 - thienyl)- 17,18,19,20 - tetranor - cis - 5, trans - 13- prostadienoic acid, obtained by reacting dimethylisopropyl chlorosilane with 11α,15α- dihydroxy - 9 - oxo - 16 - (2 - thienyl) - 17,18, 19,20 - tetranor - cis - 5 trans - 13 - prostadienoic acid.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1420176A GB1446343A (en) | 1972-07-13 | 1973-07-13 | Cyclopenta-6-furan derivatives |
| GB1444976A GB1446344A (en) | 1972-07-13 | 1973-07-13 | Bis-tetrahydropyranyl-ethers |
| GB1355676A GB1446342A (en) | 1972-07-13 | 1973-07-13 | Substituted alkyl phosphonate diesters |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27122072A | 1972-07-13 | 1972-07-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1446341A true GB1446341A (en) | 1976-08-18 |
Family
ID=23034697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3121773A Expired GB1446341A (en) | 1972-07-13 | 1973-07-13 | 15-substituted-omega-pentanorprostaglandins |
Country Status (25)
| Country | Link |
|---|---|
| JP (4) | JPS5241257B2 (en) |
| AR (2) | AR209064A1 (en) |
| AT (1) | AT367033B (en) |
| BE (1) | BE802231A (en) |
| CA (1) | CA1041495A (en) |
| CH (1) | CH593254A5 (en) |
| CS (1) | CS201027B2 (en) |
| DD (2) | DD109210A5 (en) |
| DE (1) | DE2334945A1 (en) |
| ES (4) | ES416865A1 (en) |
| FI (1) | FI57583C (en) |
| FR (1) | FR2192834B1 (en) |
| GB (1) | GB1446341A (en) |
| HU (4) | HU171158B (en) |
| IE (1) | IE37909B1 (en) |
| IL (2) | IL42691A (en) |
| IN (1) | IN138789B (en) |
| LU (1) | LU68015A1 (en) |
| NL (1) | NL7309792A (en) |
| NO (2) | NO143741C (en) |
| PH (1) | PH11461A (en) |
| SE (3) | SE7705947L (en) |
| SU (4) | SU644384A3 (en) |
| YU (1) | YU187773A (en) |
| ZA (1) | ZA734769B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2149788A (en) * | 1983-11-04 | 1985-06-19 | Erba Farmitalia | Furyl derivatives of 16-substituted prostaglandins and process for their preparation |
| US6310087B2 (en) * | 1992-09-21 | 2001-10-30 | Allergan Sales, Inc. | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
| US6602900B2 (en) | 1992-09-21 | 2003-08-05 | Allergan, Inc. | Cyclopentane heptan(ENE)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1386146A (en) * | 1972-05-03 | 1975-03-05 | Ici Ltd | Cyclopentane derivatives |
| DE2463432C2 (en) * | 1974-04-03 | 1987-06-19 | Hoechst Ag, 6230 Frankfurt, De | |
| DE2416193C2 (en) | 1974-04-03 | 1985-08-14 | Hoechst Ag, 6230 Frankfurt | Prostaglandin analogs, processes for their preparation and their use as cytoprotective agents |
| ZA747723B (en) * | 1974-12-11 | 1976-11-24 | Pfizer | 11-desoxy-15-substituted-omega-pentanor prostaglandins |
| US4149006A (en) * | 1977-01-24 | 1979-04-10 | G. D. Searle & Co. | Prostaglandin derivatives having alkynyl, hydroxy and aryloxy junctions in the 2β side chain |
| SE9002596D0 (en) * | 1990-08-08 | 1990-08-08 | Pharmacia Ab | A METHOD OF SYNTHESIS OF PROSTAGLANDIN DERIVATIVES |
| KR100578616B1 (en) * | 2004-07-23 | 2006-05-10 | 한미약품 주식회사 | Method for the preparation of d-erythro-2,2-difluoro-2-deoxy-1-oxoribose |
| BR112016013594A8 (en) * | 2013-12-13 | 2020-05-19 | Allergan Inc | crystalline forms of a dihydroxy cyclopentyl alpha compound, omega-disubstituted, pharmaceutical composition, methods for preparing and using them |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1324737A (en) * | 1970-11-02 | 1973-07-25 | Upjohn Co | Prostaglandins and the preparation thereof |
| GB1386146A (en) * | 1972-05-03 | 1975-03-05 | Ici Ltd | Cyclopentane derivatives |
| IL42373A (en) * | 1972-06-02 | 1977-08-31 | Pfizer | Oxaprostagliandins and their preparation |
-
1973
- 1973-07-03 NO NO2724/73A patent/NO143741C/en unknown
- 1973-07-03 ES ES416865A patent/ES416865A1/en not_active Expired
- 1973-07-05 FI FI2162/73A patent/FI57583C/en active
- 1973-07-06 IN IN1575/CAL/73A patent/IN138789B/en unknown
- 1973-07-09 IL IL42691A patent/IL42691A/en unknown
- 1973-07-09 PH PH14802A patent/PH11461A/en unknown
- 1973-07-10 DE DE19732334945 patent/DE2334945A1/en not_active Withdrawn
- 1973-07-11 CS CS734994A patent/CS201027B2/en unknown
- 1973-07-12 SU SU731948945A patent/SU644384A3/en active
- 1973-07-12 HU HU73PI00000480A patent/HU171158B/en unknown
- 1973-07-12 HU HU73PI00000387A patent/HU171156B/en unknown
- 1973-07-12 CH CH1020673A patent/CH593254A5/xx not_active IP Right Cessation
- 1973-07-12 DD DD172243A patent/DD109210A5/xx unknown
- 1973-07-12 HU HU73PI00000481A patent/HU171946B/en unknown
- 1973-07-12 HU HU73PI00000482A patent/HU172058B/en unknown
- 1973-07-12 BE BE1005234A patent/BE802231A/en unknown
- 1973-07-12 CA CA176,270A patent/CA1041495A/en not_active Expired
- 1973-07-12 DD DD180811*A patent/DD116459A5/xx unknown
- 1973-07-13 GB GB3121773A patent/GB1446341A/en not_active Expired
- 1973-07-13 FR FR7325835A patent/FR2192834B1/fr not_active Expired
- 1973-07-13 AT AT0620773A patent/AT367033B/en not_active IP Right Cessation
- 1973-07-13 JP JP48079214A patent/JPS5241257B2/ja not_active Expired
- 1973-07-13 LU LU68015A patent/LU68015A1/xx unknown
- 1973-07-13 AR AR249095A patent/AR209064A1/en active
- 1973-07-13 ZA ZA734769A patent/ZA734769B/en unknown
- 1973-07-13 IE IE1186/73A patent/IE37909B1/en unknown
- 1973-07-13 NL NL7309792A patent/NL7309792A/xx not_active Application Discontinuation
- 1973-11-07 YU YU01877/73A patent/YU187773A/en unknown
-
1974
- 1974-05-06 AR AR253775A patent/AR214383A1/en active
- 1974-09-26 NO NO743492A patent/NO144830C/en unknown
-
1975
- 1975-04-26 ES ES437038A patent/ES437038A1/en not_active Expired
- 1975-04-26 ES ES437037A patent/ES437037A1/en not_active Expired
- 1975-04-26 ES ES437039A patent/ES437039A1/en not_active Expired
- 1975-09-05 SU SU752169008A patent/SU645563A3/en active
- 1975-09-09 SU SU7502170659A patent/SU584791A3/en active
- 1975-09-11 SU SU752171155A patent/SU645564A3/en active
-
1976
- 1976-08-19 IL IL50308A patent/IL50308A0/en unknown
- 1976-11-22 JP JP14060576A patent/JPS5297958A/en active Pending
- 1976-11-22 JP JP14060676A patent/JPS52122349A/en active Pending
- 1976-11-22 JP JP14060776A patent/JPS5293753A/en active Pending
-
1977
- 1977-05-20 SE SE7705947A patent/SE7705947L/en not_active Application Discontinuation
- 1977-05-20 SE SE7705945A patent/SE7705945L/en not_active Application Discontinuation
- 1977-05-20 SE SE7705946A patent/SE7705946L/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2149788A (en) * | 1983-11-04 | 1985-06-19 | Erba Farmitalia | Furyl derivatives of 16-substituted prostaglandins and process for their preparation |
| US4585791A (en) * | 1983-11-04 | 1986-04-29 | Farmitalia Carlo Erba, S.P.A. | Furyl derivatives of 16-substituted prostaglandins |
| US6310087B2 (en) * | 1992-09-21 | 2001-10-30 | Allergan Sales, Inc. | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
| US6602900B2 (en) | 1992-09-21 | 2003-08-05 | Allergan, Inc. | Cyclopentane heptan(ENE)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |