FR2291200A1 - NEW BICYCLIC G-LACTONE AND G-HEMIACETAL DERIVATIVES - Google Patents

NEW BICYCLIC G-LACTONE AND G-HEMIACETAL DERIVATIVES

Info

Publication number
FR2291200A1
FR2291200A1 FR7602434A FR7602434A FR2291200A1 FR 2291200 A1 FR2291200 A1 FR 2291200A1 FR 7602434 A FR7602434 A FR 7602434A FR 7602434 A FR7602434 A FR 7602434A FR 2291200 A1 FR2291200 A1 FR 2291200A1
Authority
FR
France
Prior art keywords
lactone
new bicyclic
hemiacetal derivatives
hemiacetal
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7602434A
Other languages
French (fr)
Other versions
FR2291200B1 (en
Inventor
Haas-Jurgen Ernst Hess
Thomas Ken Schaaf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2291200A1 publication Critical patent/FR2291200A1/en
Application granted granted Critical
Publication of FR2291200B1 publication Critical patent/FR2291200B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4018—Esters of cycloaliphatic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5407—Acyclic saturated phosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
FR7602434A 1972-11-08 1976-01-29 NEW BICYCLIC G-LACTONE AND G-HEMIACETAL DERIVATIVES Granted FR2291200A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30475072A 1972-11-08 1972-11-08

Publications (2)

Publication Number Publication Date
FR2291200A1 true FR2291200A1 (en) 1976-06-11
FR2291200B1 FR2291200B1 (en) 1979-01-05

Family

ID=23177829

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7339758A Expired FR2205338B1 (en) 1972-11-08 1973-11-08
FR7602433A Granted FR2286147A1 (en) 1972-11-08 1976-01-29 NEW DERIVATIVES OF DIMETHYL ACETYLPHOSPHONATE
FR7602434A Granted FR2291200A1 (en) 1972-11-08 1976-01-29 NEW BICYCLIC G-LACTONE AND G-HEMIACETAL DERIVATIVES

Family Applications Before (2)

Application Number Title Priority Date Filing Date
FR7339758A Expired FR2205338B1 (en) 1972-11-08 1973-11-08
FR7602433A Granted FR2286147A1 (en) 1972-11-08 1976-01-29 NEW DERIVATIVES OF DIMETHYL ACETYLPHOSPHONATE

Country Status (20)

Country Link
JP (1) JPS5714347B2 (en)
AT (1) AT345999B (en)
BE (1) BE807046A (en)
CA (1) CA1033727A (en)
CH (1) CH593930A5 (en)
DE (1) DE2355731C3 (en)
DK (1) DK143499C (en)
ES (3) ES420386A1 (en)
FI (1) FI58912C (en)
FR (3) FR2205338B1 (en)
GB (1) GB1456838A (en)
IE (1) IE40043B1 (en)
IL (2) IL43571A (en)
IN (1) IN139265B (en)
NL (1) NL7315307A (en)
NO (2) NO143663C (en)
PH (2) PH13261A (en)
SE (4) SE412229B (en)
SU (2) SU667131A3 (en)
ZA (1) ZA738595B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1431561A (en) * 1973-01-31 1976-04-07 Ici Ltd Cyclopentane derivatives
US3929862A (en) * 1974-01-08 1975-12-30 Upjohn Co Substituted tolylesters of PGF{HD 2{B {60
JPS5823393B2 (en) * 1974-03-14 1983-05-14 オノヤクヒンコウギヨウ カブシキガイシヤ prostaglandin
US4028396A (en) * 1975-07-02 1977-06-07 American Cyanamid Company 16,16-Spirocycloalkyl prostaglandin derivatives
NZ183136A (en) * 1976-02-11 1978-11-13 Miles Lab Monospiroalkyl derivatives of prostaclandis and pharmaceutical compositions
US4074063A (en) * 1976-02-11 1978-02-14 Miles Laboratories, Inc. Bicycloalkyl derivatives of prostaglandins
US4404372A (en) * 1977-06-13 1983-09-13 Pfizer Inc. 15-Substituted-ω-pentanorprostaglandin derivatives
DE2753995A1 (en) * 1977-12-03 1979-06-07 Bayer Ag NEW BICYCLOALKENYL PROSTAGLANDINS AND THE METHOD OF MANUFACTURING THEM
DE69832513T2 (en) * 1997-09-09 2006-07-13 Duke University AROMATIC C16-C20 SUBSTITUTED TETRAHYDRO PROSTAGLANDINES USE AS FP AGONISTE
WO1999012895A1 (en) * 1997-09-09 1999-03-18 The Procter & Gamble Company Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
ATE227266T1 (en) * 1997-09-09 2002-11-15 Procter & Gamble AROMATIC C16-C20-SUBSTITUTED TETRAHYDRO-PROSTAGLANDINS AND THEIR USE AS PROSTAGLANDIN F AGONISTS
HUP0200258A2 (en) 1999-03-05 2002-05-29 The Procter & Gamble Co. C16 unsaturated fp-selective prostaglandins analogs, pharmaceutical compositions containing them and their use
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
EP2028153B1 (en) * 2007-11-28 2009-06-03 BAUER Maschinen GmbH Winch
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US20230097470A1 (en) * 2021-08-23 2023-03-30 Chirogate International Inc. Processes and intermediates for the preparations of carboprost and carboprost tromethamine, and carboprost tromethamine prepared therefrom

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4864073A (en) * 1971-04-30 1973-09-05

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Also Published As

Publication number Publication date
SE7701523L (en) 1977-02-10
SU667131A3 (en) 1979-06-05
IN139265B (en) 1976-05-29
IE40043L (en) 1974-05-08
SE412229B (en) 1980-02-25
ATA941073A (en) 1978-02-15
DK143499B (en) 1981-08-31
FR2286147B1 (en) 1978-09-22
NO144385B (en) 1981-05-11
FR2205338B1 (en) 1978-07-13
DE2355731C3 (en) 1981-01-15
FR2291200B1 (en) 1979-01-05
DE2355731A1 (en) 1974-05-22
AU6230273A (en) 1975-05-08
DE2355731B2 (en) 1980-04-30
SE7612262L (en) 1976-11-03
FI58912C (en) 1981-05-11
AT345999B (en) 1978-10-10
ES456279A1 (en) 1978-11-01
FR2205338A1 (en) 1974-05-31
NO144385C (en) 1981-08-19
JPS5714347B2 (en) 1982-03-24
ES420386A1 (en) 1976-07-01
GB1456838A (en) 1976-11-24
FR2286147A1 (en) 1976-04-23
CA1033727A (en) 1978-06-27
DK143499C (en) 1982-01-11
ES444398A1 (en) 1977-12-01
SE7612261L (en) 1976-11-03
IL43571A (en) 1977-08-31
CH593930A5 (en) 1977-12-30
FI58912B (en) 1981-01-30
SU704456A3 (en) 1979-12-15
NO143663B (en) 1980-12-15
PH13261A (en) 1980-02-25
SE417957B (en) 1981-04-27
JPS49133357A (en) 1974-12-21
PH13320A (en) 1980-03-13
NO143663C (en) 1981-03-25
ZA738595B (en) 1974-09-25
NO743616L (en) 1974-05-09
IL50310A (en) 1977-08-31
IE40043B1 (en) 1979-02-28
IL43571A0 (en) 1974-03-14
NL7315307A (en) 1974-05-10
BE807046A (en) 1974-05-08

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