GB1456513A - Derivatives of cyclopentaneacetic acid - Google Patents

Derivatives of cyclopentaneacetic acid

Info

Publication number
GB1456513A
GB1456513A GB2395076A GB2395076A GB1456513A GB 1456513 A GB1456513 A GB 1456513A GB 2395076 A GB2395076 A GB 2395076A GB 2395076 A GB2395076 A GB 2395076A GB 1456513 A GB1456513 A GB 1456513A
Authority
GB
United Kingdom
Prior art keywords
proviso
double bond
compounds
trans
trimethoxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2395076A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of GB1456513A publication Critical patent/GB1456513A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • C07F9/5407Acyclic saturated phosphonium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1456513 Cyclopenta[b]furan derivatives PFIZER Inc 7 Nov 1973 [8 Nov 1972] 23950/76 Divided out of 1456512 Heading C2C The invention comprises cyclopenta[b]furan derivatives of the Formulµ III, IV and V wherein Ar is 3,4-dimethoxyphenyl, 3,4-methylenedioxyphenyl, 3,4,5 - trimethoxyphenyl, 1- or 2-naphthyl or phenyl optionally monosubstituted by halogen, trifluoromethyl, phenyl C 1-6 alkyl or C 1-6 alkoxy; m and n each are 0 to 3 with the proviso that the sum of n and m does not exceed 3; Q is p-biphenylylcarbonyl; Z is a single or trans-double bond; R is H or C 1-6 alkyl; Q<SP>1</SP> is H or p-phenylylcarbonyl; and Y is oxo, with the proviso in compounds of Formula IV that when R and Q<SP>1</SP> are both H, Z is a trans double bond, n and m are 0, Ar is 3,4-methylenedioxyphenyl, 3,4,5 - trimethoxyphenyl, 1- or 2-naphthyl or biphenylyl; and with the proviso in compound of Formula V that when R is H Z is a trans double bond, m and n are 0, Ar is as defined immediately above; and their preparation. The compounds are obtained by known methods used to obtain analogous compounds.
GB2395076A 1972-11-08 1973-11-07 Derivatives of cyclopentaneacetic acid Expired GB1456513A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30481372A 1972-11-08 1972-11-08

Publications (1)

Publication Number Publication Date
GB1456513A true GB1456513A (en) 1976-11-24

Family

ID=23178133

Family Applications (3)

Application Number Title Priority Date Filing Date
GB2395076A Expired GB1456513A (en) 1972-11-08 1973-11-07 Derivatives of cyclopentaneacetic acid
GB5175873A Expired GB1456512A (en) 1972-11-08 1973-11-07 Substituted 16,17,18,19,20-pentanorprostaglandins
GB2285876A Expired GB1456514A (en) 1972-11-08 1973-11-07 Substituted dialkyl 2-oxopropylphosphonates

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB5175873A Expired GB1456512A (en) 1972-11-08 1973-11-07 Substituted 16,17,18,19,20-pentanorprostaglandins
GB2285876A Expired GB1456514A (en) 1972-11-08 1973-11-07 Substituted dialkyl 2-oxopropylphosphonates

Country Status (29)

Country Link
JP (3) JPS5416491B2 (en)
AR (3) AR200585A1 (en)
AT (3) AT367034B (en)
AU (1) AU470375B2 (en)
BE (1) BE806995A (en)
CA (3) CA1085831A (en)
CH (1) CH597176A5 (en)
CS (3) CS182793B2 (en)
DD (4) DD118856A5 (en)
DE (1) DE2355540C2 (en)
DK (1) DK144247C (en)
ES (3) ES420325A1 (en)
FI (1) FI60389C (en)
FR (3) FR2205335B1 (en)
GB (3) GB1456513A (en)
HK (3) HK28079A (en)
HU (3) HU172703B (en)
IE (1) IE39537B1 (en)
IL (1) IL43589A (en)
IN (1) IN139384B (en)
KE (3) KE2932A (en)
MY (3) MY7900245A (en)
NL (1) NL164273C (en)
NO (3) NO147836C (en)
PH (3) PH13272A (en)
SE (4) SE448992B (en)
SU (4) SU584766A3 (en)
YU (3) YU39715B (en)
ZA (1) ZA738554B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
USRE43372E1 (en) 1999-03-05 2012-05-08 Duke University C16 unsaturated FP-selective prostaglandins analogs
US8541466B2 (en) 2000-03-31 2013-09-24 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US8618086B2 (en) 2000-03-31 2013-12-31 Duke University Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US9346837B2 (en) 2000-03-31 2016-05-24 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929862A (en) * 1974-01-08 1975-12-30 Upjohn Co Substituted tolylesters of PGF{HD 2{B {60
GB1506817A (en) * 1975-03-31 1978-04-12 Upjohn Co Prostaglandins
US3986764A (en) * 1975-03-31 1976-10-19 Gte Automatic Electric Laboratories Incorporated Panel for supporting a pair of elongated mating connectors and selectively locking them together
ES449162A1 (en) * 1975-06-23 1977-12-16 Syntex Inc 16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
GB1516414A (en) * 1975-08-22 1978-07-05 Ici Ltd Prostane derivatives
SE7809008L (en) * 1977-12-12 1979-06-13 Upjohn Co USE OF PROSTAGLAND TYPE AMIDES TO CONTROL OR REGULATE THE REPRODUCTION CYCLE IN INDIVIDUALS OF MAMMALS
DK523378A (en) * 1978-01-16 1979-07-17 Pfizer PROCEDURE FOR THE PREPARATION OF N- (TETRAZOL-5-YL) PROSTAGLANDIN CARBOXAMIDES OR SALTS THEREOF
SK3382000A3 (en) * 1997-09-09 2000-10-09 Procter & Gamble A compound having structure of aromatic substituted prostaglandins and its use for the treatment of bone disorders
JP2002329615A (en) * 2001-05-02 2002-11-15 Ohira Denshi Kk Toroidal coil
US6476064B1 (en) * 2001-06-13 2002-11-05 Allergan, Inc. Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents
US20060135609A1 (en) 2004-10-21 2006-06-22 Duke University Ophthamological drugs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1324737A (en) * 1970-11-02 1973-07-25 Upjohn Co Prostaglandins and the preparation thereof
IE37602B1 (en) * 1971-05-11 1977-08-31 Ici Ltd Cyclopentane derivatives

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43372E1 (en) 1999-03-05 2012-05-08 Duke University C16 unsaturated FP-selective prostaglandins analogs
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US7074942B2 (en) 1999-08-04 2006-07-11 The Procter & Gamble Company 2-decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US7115659B2 (en) 1999-08-04 2006-10-03 The Procter & Gamble Company Method of treating a condition by administering a prostaglandin derivative
US8541466B2 (en) 2000-03-31 2013-09-24 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US8618086B2 (en) 2000-03-31 2013-12-31 Duke University Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US8906962B2 (en) 2000-03-31 2014-12-09 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US9346837B2 (en) 2000-03-31 2016-05-24 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US9579270B2 (en) 2000-03-31 2017-02-28 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US9675539B2 (en) 2000-03-31 2017-06-13 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins

Also Published As

Publication number Publication date
HU172703B (en) 1978-11-28
NO149139B (en) 1983-11-14
BE806995A (en) 1974-05-07
HK28079A (en) 1979-05-11
ES420325A1 (en) 1976-04-16
HK28179A (en) 1979-05-11
AT367034B (en) 1982-05-25
GB1456514A (en) 1976-11-24
JPS5416491B2 (en) 1979-06-22
MY7900246A (en) 1979-12-31
ES433046A1 (en) 1977-06-16
FR2205335B1 (en) 1978-07-13
GB1456512A (en) 1976-11-24
ES433047A1 (en) 1976-11-01
DK144247B (en) 1982-01-25
CS182793B2 (en) 1978-05-31
JPS5253841A (en) 1977-04-30
SE431756B (en) 1984-02-27
DD109212A5 (en) 1974-10-20
SU584766A3 (en) 1977-12-15
FI60389C (en) 1982-01-11
DE2365322A1 (en) 1974-11-07
CA1088931A (en) 1980-11-04
FR2283146A1 (en) 1976-03-26
PH13272A (en) 1980-02-27
JPS5257147A (en) 1977-05-11
SE7700718L (en) 1977-01-24
DK144247C (en) 1982-07-12
CS182791B2 (en) 1978-05-31
KE2932A (en) 1979-03-30
KE2930A (en) 1979-03-30
PH13325A (en) 1980-03-13
YU36975B (en) 1984-08-31
NO147836C (en) 1983-06-22
PH13110A (en) 1979-11-28
IE39537L (en) 1974-05-08
NL7315263A (en) 1974-05-10
CA1085831A (en) 1980-09-16
CS182794B2 (en) 1978-05-31
NO743493L (en) 1974-05-09
ATA544676A (en) 1979-04-15
NO148998B (en) 1983-10-17
YU288073A (en) 1982-02-28
IE39537B1 (en) 1978-11-08
YU270680A (en) 1983-04-27
ZA738554B (en) 1974-09-25
AT360672B (en) 1981-01-26
AR200585A1 (en) 1974-11-22
ATA544576A (en) 1980-06-15
NL164273C (en) 1980-12-15
AU6224773A (en) 1975-05-08
ATA936973A (en) 1981-10-15
DE2355540C2 (en) 1982-11-18
SE7700717L (en) 1977-01-24
FR2283146B1 (en) 1981-06-19
IL43589A (en) 1980-01-31
AU470375B2 (en) 1976-03-11
NO750535L (en) 1974-05-09
KE2931A (en) 1979-03-30
MY7900243A (en) 1979-12-31
IL43589A0 (en) 1974-03-14
SU893130A3 (en) 1981-12-23
MY7900245A (en) 1979-12-31
IN139384B (en) 1976-06-12
DD119411A5 (en) 1976-04-20
SU745362A3 (en) 1980-06-30
HU171819B (en) 1978-03-28
DE2355540A1 (en) 1974-05-22
DE2365322B2 (en) 1977-02-24
JPS4993342A (en) 1974-09-05
SE445111B (en) 1986-06-02
NO148998C (en) 1984-01-25
FR2205335A1 (en) 1974-05-31
HK27979A (en) 1979-05-11
FR2279729A1 (en) 1976-02-20
SE7700716L (en) 1977-01-24
AT353285B (en) 1979-11-12
AR202931A1 (en) 1975-07-31
YU270780A (en) 1982-06-18
DD117233A5 (en) 1976-01-05
FI60389B (en) 1981-09-30
CA1088930A (en) 1980-11-04
SU667141A3 (en) 1979-06-05
AR199966A1 (en) 1974-10-08
HU173507B (en) 1979-05-28
SE436278B (en) 1984-11-26
NO149139C (en) 1984-02-29
YU37316B (en) 1984-08-31
FR2279729B1 (en) 1978-04-28
NO147836B (en) 1983-03-14
YU39715B (en) 1985-04-30
SE448992B (en) 1987-03-30
CH597176A5 (en) 1978-03-31
DD118856A5 (en) 1976-03-20

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19921107