AT353285B - Verfahren zur herstellung von neuen dimethyl- phosphonaten - Google Patents

Verfahren zur herstellung von neuen dimethyl- phosphonaten

Info

Publication number
AT353285B
AT353285B AT544676A AT544676A AT353285B AT 353285 B AT353285 B AT 353285B AT 544676 A AT544676 A AT 544676A AT 544676 A AT544676 A AT 544676A AT 353285 B AT353285 B AT 353285B
Authority
AT
Austria
Prior art keywords
producing new
new dimethyl
dimethyl phosphonates
phosphonates
producing
Prior art date
Application number
AT544676A
Other languages
English (en)
Other versions
ATA544676A (de
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ATA544676A publication Critical patent/ATA544676A/de
Application granted granted Critical
Publication of AT353285B publication Critical patent/AT353285B/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • C07F9/5407Acyclic saturated phosphonium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT544676A 1972-11-08 1976-07-23 Verfahren zur herstellung von neuen dimethyl- phosphonaten AT353285B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30481372A 1972-11-08 1972-11-08

Publications (2)

Publication Number Publication Date
ATA544676A ATA544676A (de) 1979-04-15
AT353285B true AT353285B (de) 1979-11-12

Family

ID=23178133

Family Applications (3)

Application Number Title Priority Date Filing Date
AT0936973A AT367034B (de) 1972-11-08 1973-11-07 Verfahren zur herstellung neuer derivate von prostaglandin-analoga
AT544576A AT360672B (de) 1972-11-08 1976-07-23 Verfahren zur herstellung neuer derivate von prostaglandin-analoga
AT544676A AT353285B (de) 1972-11-08 1976-07-23 Verfahren zur herstellung von neuen dimethyl- phosphonaten

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT0936973A AT367034B (de) 1972-11-08 1973-11-07 Verfahren zur herstellung neuer derivate von prostaglandin-analoga
AT544576A AT360672B (de) 1972-11-08 1976-07-23 Verfahren zur herstellung neuer derivate von prostaglandin-analoga

Country Status (29)

Country Link
JP (3) JPS5416491B2 (de)
AR (3) AR200585A1 (de)
AT (3) AT367034B (de)
AU (1) AU470375B2 (de)
BE (1) BE806995A (de)
CA (3) CA1085831A (de)
CH (1) CH597176A5 (de)
CS (3) CS182793B2 (de)
DD (4) DD118856A5 (de)
DE (1) DE2355540C2 (de)
DK (1) DK144247C (de)
ES (3) ES420325A1 (de)
FI (1) FI60389C (de)
FR (3) FR2205335B1 (de)
GB (3) GB1456513A (de)
HK (3) HK28079A (de)
HU (3) HU172703B (de)
IE (1) IE39537B1 (de)
IL (1) IL43589A (de)
IN (1) IN139384B (de)
KE (3) KE2932A (de)
MY (3) MY7900245A (de)
NL (1) NL164273C (de)
NO (3) NO147836C (de)
PH (3) PH13272A (de)
SE (4) SE448992B (de)
SU (4) SU584766A3 (de)
YU (3) YU39715B (de)
ZA (1) ZA738554B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929862A (en) * 1974-01-08 1975-12-30 Upjohn Co Substituted tolylesters of PGF{HD 2{B {60
GB1506817A (en) * 1975-03-31 1978-04-12 Upjohn Co Prostaglandins
US3986764A (en) * 1975-03-31 1976-10-19 Gte Automatic Electric Laboratories Incorporated Panel for supporting a pair of elongated mating connectors and selectively locking them together
ES449162A1 (es) * 1975-06-23 1977-12-16 Syntex Inc Un procedimiento para la preparacion de un compuesto racemi-co u 8r-antimerico.
GB1516414A (en) * 1975-08-22 1978-07-05 Ici Ltd Prostane derivatives
SE7809008L (sv) * 1977-12-12 1979-06-13 Upjohn Co Anvendning av amider av prostaglandintyp for att styra eller reglera reproduktionscykeln hos individer tillhorande deggdjursarter
DK523378A (da) * 1978-01-16 1979-07-17 Pfizer Fremgangsmaade til fremstilling af n-(tetrazol-5-yl) prostaglandin-carboxamider eller salte deraf
SK3382000A3 (en) * 1997-09-09 2000-10-09 Procter & Gamble A compound having structure of aromatic substituted prostaglandins and its use for the treatment of bone disorders
NZ513825A (en) 1999-03-05 2001-09-28 Procter & Gamble C 16 unsaturated FP-selective prostaglandins analogs
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
JP2002329615A (ja) * 2001-05-02 2002-11-15 Ohira Denshi Kk トロイダルコイル
US6476064B1 (en) * 2001-06-13 2002-11-05 Allergan, Inc. Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents
US20060135609A1 (en) 2004-10-21 2006-06-22 Duke University Ophthamological drugs
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1324737A (en) * 1970-11-02 1973-07-25 Upjohn Co Prostaglandins and the preparation thereof
IE37602B1 (en) * 1971-05-11 1977-08-31 Ici Ltd Cyclopentane derivatives

Also Published As

Publication number Publication date
HU172703B (hu) 1978-11-28
NO149139B (no) 1983-11-14
BE806995A (fr) 1974-05-07
HK28079A (en) 1979-05-11
ES420325A1 (es) 1976-04-16
HK28179A (en) 1979-05-11
AT367034B (de) 1982-05-25
GB1456514A (en) 1976-11-24
JPS5416491B2 (de) 1979-06-22
MY7900246A (en) 1979-12-31
ES433046A1 (es) 1977-06-16
GB1456513A (en) 1976-11-24
FR2205335B1 (de) 1978-07-13
GB1456512A (en) 1976-11-24
ES433047A1 (es) 1976-11-01
DK144247B (da) 1982-01-25
CS182793B2 (en) 1978-05-31
JPS5253841A (en) 1977-04-30
SE431756B (sv) 1984-02-27
DD109212A5 (de) 1974-10-20
SU584766A3 (ru) 1977-12-15
FI60389C (fi) 1982-01-11
DE2365322A1 (de) 1974-11-07
CA1088931A (en) 1980-11-04
FR2283146A1 (fr) 1976-03-26
PH13272A (en) 1980-02-27
JPS5257147A (en) 1977-05-11
SE7700718L (sv) 1977-01-24
DK144247C (da) 1982-07-12
CS182791B2 (en) 1978-05-31
KE2932A (en) 1979-03-30
KE2930A (en) 1979-03-30
PH13325A (en) 1980-03-13
YU36975B (en) 1984-08-31
NO147836C (no) 1983-06-22
PH13110A (en) 1979-11-28
IE39537L (en) 1974-05-08
NL7315263A (de) 1974-05-10
CA1085831A (en) 1980-09-16
CS182794B2 (en) 1978-05-31
NO743493L (no) 1974-05-09
ATA544676A (de) 1979-04-15
NO148998B (no) 1983-10-17
YU288073A (en) 1982-02-28
IE39537B1 (en) 1978-11-08
YU270680A (en) 1983-04-27
ZA738554B (en) 1974-09-25
AT360672B (de) 1981-01-26
AR200585A1 (es) 1974-11-22
ATA544576A (de) 1980-06-15
NL164273C (nl) 1980-12-15
AU6224773A (en) 1975-05-08
ATA936973A (de) 1981-10-15
DE2355540C2 (de) 1982-11-18
SE7700717L (sv) 1977-01-24
FR2283146B1 (de) 1981-06-19
IL43589A (en) 1980-01-31
AU470375B2 (en) 1976-03-11
NO750535L (de) 1974-05-09
KE2931A (en) 1979-03-30
MY7900243A (en) 1979-12-31
IL43589A0 (en) 1974-03-14
SU893130A3 (ru) 1981-12-23
MY7900245A (en) 1979-12-31
IN139384B (de) 1976-06-12
DD119411A5 (de) 1976-04-20
SU745362A3 (ru) 1980-06-30
HU171819B (hu) 1978-03-28
DE2355540A1 (de) 1974-05-22
DE2365322B2 (de) 1977-02-24
JPS4993342A (de) 1974-09-05
SE445111B (sv) 1986-06-02
NO148998C (no) 1984-01-25
FR2205335A1 (de) 1974-05-31
HK27979A (en) 1979-05-11
FR2279729A1 (fr) 1976-02-20
SE7700716L (sv) 1977-01-24
AR202931A1 (es) 1975-07-31
YU270780A (en) 1982-06-18
DD117233A5 (de) 1976-01-05
FI60389B (fi) 1981-09-30
CA1088930A (en) 1980-11-04
SU667141A3 (ru) 1979-06-05
AR199966A1 (es) 1974-10-08
HU173507B (hu) 1979-05-28
SE436278B (sv) 1984-11-26
NO149139C (no) 1984-02-29
YU37316B (en) 1984-08-31
FR2279729B1 (de) 1978-04-28
NO147836B (no) 1983-03-14
YU39715B (en) 1985-04-30
SE448992B (sv) 1987-03-30
CH597176A5 (de) 1978-03-31
DD118856A5 (de) 1976-03-20

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