GB0226593D0 - Compounds - Google Patents

Compounds

Info

Publication number
GB0226593D0
GB0226593D0 GBGB0226593.2A GB0226593A GB0226593D0 GB 0226593 D0 GB0226593 D0 GB 0226593D0 GB 0226593 A GB0226593 A GB 0226593A GB 0226593 D0 GB0226593 D0 GB 0226593D0
Authority
GB
United Kingdom
Prior art keywords
group
sup
formula
optionally substituted
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0226593.2A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CONSULTANTS Ltd
ADC Products UK Ltd
Original Assignee
CONSULTANTS Ltd
ADC Products UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CONSULTANTS Ltd, ADC Products UK Ltd filed Critical CONSULTANTS Ltd
Priority to GBGB0226593.2A priority Critical patent/GB0226593D0/en
Publication of GB0226593D0 publication Critical patent/GB0226593D0/en
Priority to EP03773870A priority patent/EP1575955B1/en
Priority to NZ540050A priority patent/NZ540050A/en
Priority to AU2003282251A priority patent/AU2003282251B2/en
Priority to US10/534,825 priority patent/US7407951B2/en
Priority to JP2004550845A priority patent/JP4750418B2/ja
Priority to CA2505489A priority patent/CA2505489C/en
Priority to BR0316241-9A priority patent/BR0316241A/pt
Priority to AT03773870T priority patent/ATE497963T1/de
Priority to MXPA05005179A priority patent/MXPA05005179A/es
Priority to KR1020057008663A priority patent/KR101059183B1/ko
Priority to PCT/GB2003/004963 priority patent/WO2004043963A1/en
Priority to CNB2003801083730A priority patent/CN100396683C/zh
Priority to DE60336014T priority patent/DE60336014D1/de
Priority to ZA200504432A priority patent/ZA200504432B/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GBGB0226593.2A 2002-11-14 2002-11-14 Compounds Ceased GB0226593D0 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GBGB0226593.2A GB0226593D0 (en) 2002-11-14 2002-11-14 Compounds
DE60336014T DE60336014D1 (de) 2002-11-14 2003-11-14 Pyrrolobenzodiazepine zur behandlung proliferativer erkrankungen
CA2505489A CA2505489C (en) 2002-11-14 2003-11-14 Pyrrolobenzodiazepines
AT03773870T ATE497963T1 (de) 2002-11-14 2003-11-14 Pyrrolobenzodiazepine zur behandlung proliferativer erkrankungen
AU2003282251A AU2003282251B2 (en) 2002-11-14 2003-11-14 Pyrrolobenzodiazepines
US10/534,825 US7407951B2 (en) 2002-11-14 2003-11-14 Pyrrolobenzodiazepines
JP2004550845A JP4750418B2 (ja) 2002-11-14 2003-11-14 ピロロベンゾジアゼピン
EP03773870A EP1575955B1 (en) 2002-11-14 2003-11-14 Pyrrolobenzodiazepines for the treatment of proliferative diseases
BR0316241-9A BR0316241A (pt) 2002-11-14 2003-11-14 Pirrolobenzodiazepinas
NZ540050A NZ540050A (en) 2002-11-14 2003-11-14 Pyrrolobenzodiazepines having activity against cancer cell lines
MXPA05005179A MXPA05005179A (es) 2002-11-14 2003-11-14 Pirrolobenzodiazepinas.
KR1020057008663A KR101059183B1 (ko) 2002-11-14 2003-11-14 피롤로벤조디아제핀
PCT/GB2003/004963 WO2004043963A1 (en) 2002-11-14 2003-11-14 Pyrrolobenzodiazepines
CNB2003801083730A CN100396683C (zh) 2002-11-14 2003-11-14 吡咯并苯并二氮杂䓬
ZA200504432A ZA200504432B (en) 2002-11-14 2005-05-31 Pyrrolobenzodiazepines.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0226593.2A GB0226593D0 (en) 2002-11-14 2002-11-14 Compounds

Publications (1)

Publication Number Publication Date
GB0226593D0 true GB0226593D0 (en) 2002-12-24

Family

ID=9947829

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0226593.2A Ceased GB0226593D0 (en) 2002-11-14 2002-11-14 Compounds

Country Status (15)

Country Link
US (1) US7407951B2 (https=)
EP (1) EP1575955B1 (https=)
JP (1) JP4750418B2 (https=)
KR (1) KR101059183B1 (https=)
CN (1) CN100396683C (https=)
AT (1) ATE497963T1 (https=)
AU (1) AU2003282251B2 (https=)
BR (1) BR0316241A (https=)
CA (1) CA2505489C (https=)
DE (1) DE60336014D1 (https=)
GB (1) GB0226593D0 (https=)
MX (1) MXPA05005179A (https=)
NZ (1) NZ540050A (https=)
WO (1) WO2004043963A1 (https=)
ZA (1) ZA200504432B (https=)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
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GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
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PL1879901T3 (pl) * 2005-04-21 2010-06-30 Medimmune Ltd Pirolobenzodiazepiny
US8637664B2 (en) * 2005-10-05 2014-01-28 Spirogen Sarl Alkyl 4- [4- (5-oxo-2,3,5, 11a-tetrahydo-5H-pyrrolo [2, 1-c] [1,4] benzodiazepine-8-yloxy)-butyrylamino]-1H-pyrrole-2-carboxylate derivatives and related compounds for the treatment of a proliferative disease
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MX2019011655A (es) 2017-03-29 2019-12-19 Legochem Biosciences Inc Profarmaco de dimero de pirrolobenzodiazepina y compuesto conjugado ligando-conector de este.
PT3612537T (pt) 2017-04-18 2022-08-29 Medimmune Ltd Conjugados de pirrolobenzodiazepina
ES2977788T3 (es) 2017-04-20 2024-08-30 Adc Therapeutics Sa Terapia combinada con un conjugado de anticuerpo anti-AXL y fármaco
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KR20200084802A (ko) 2019-01-03 2020-07-13 주식회사 레고켐 바이오사이언스 안전성이 향상된 피롤로벤조디아제핀 이량체 화합물 및 이의 용도
WO2020141923A2 (ko) 2019-01-03 2020-07-09 주식회사 레고켐 바이오사이언스 안전성이 향상된 피롤로벤조디아제핀 이량체 화합물 및 이의 용도
KR102890251B1 (ko) 2019-03-15 2025-11-25 메드임뮨 리미티드 암의 치료에 사용하기 위한 아제티도벤조디아제핀 이량체 및 이를 포함하는 컨쥬게이트
WO2021137646A1 (ko) 2019-12-31 2021-07-08 주식회사 레고켐바이오사이언스 피롤로벤조디아제핀 유도체 및 이의 리간드-링커 접합체
CN111410599A (zh) * 2020-03-21 2020-07-14 浙江华贝药业有限责任公司 一种化合物的纯化方法
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联
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AU2003282251A1 (en) 2004-06-03
CA2505489C (en) 2011-11-15
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CN100396683C (zh) 2008-06-25
ZA200504432B (en) 2006-02-22
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KR20050086643A (ko) 2005-08-30
US7407951B2 (en) 2008-08-05
ATE497963T1 (de) 2011-02-15
KR101059183B1 (ko) 2011-08-25
BR0316241A (pt) 2005-10-04
CA2505489A1 (en) 2004-05-27
CN1735616A (zh) 2006-02-15
AU2003282251B2 (en) 2010-03-18
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