GB0220199D0 - Mutant protein and refolding method - Google Patents

Mutant protein and refolding method

Info

Publication number
GB0220199D0
GB0220199D0 GBGB0220199.4A GB0220199A GB0220199D0 GB 0220199 D0 GB0220199 D0 GB 0220199D0 GB 0220199 A GB0220199 A GB 0220199A GB 0220199 D0 GB0220199 D0 GB 0220199D0
Authority
GB
United Kingdom
Prior art keywords
mutant protein
refolding method
refolding
frpb protein
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0220199.4A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TECHNOLOGY FOUNDATION TECHNOLO
GlaxoSmithKline Biologicals SA
Universiteit Utrecht
Original Assignee
TECHNOLOGY FOUNDATION TECHNOLO
GlaxoSmithKline Biologicals SA
Rijksuniversiteit Utrecht
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TECHNOLOGY FOUNDATION TECHNOLO, GlaxoSmithKline Biologicals SA, Rijksuniversiteit Utrecht filed Critical TECHNOLOGY FOUNDATION TECHNOLO
Priority to GBGB0220199.4A priority Critical patent/GB0220199D0/en
Publication of GB0220199D0 publication Critical patent/GB0220199D0/en
Priority to DK03784153.3T priority patent/DK1524993T3/da
Priority to CN2012102805434A priority patent/CN103007263A/zh
Priority to EP03784152.5A priority patent/EP1524992B1/en
Priority to TW092121011A priority patent/TWI360424B/zh
Priority to CNA038184540A priority patent/CN1671413A/zh
Priority to SI200332262T priority patent/SI1524993T1/sl
Priority to DE20321889U priority patent/DE20321889U1/de
Priority to PL03375382A priority patent/PL375382A1/xx
Priority to BR0313121-1A priority patent/BR0313121A/pt
Priority to JP2005506113A priority patent/JP2006500963A/ja
Priority to EP10177890.0A priority patent/EP2255826B1/en
Priority to BRPI0313120-3A priority patent/BR0313120A/pt
Priority to BR0313100-9A priority patent/BR0313100A/pt
Priority to SI200332485A priority patent/SI2255826T1/sl
Priority to PL399214A priority patent/PL220107B1/pl
Priority to CA002493092A priority patent/CA2493092A1/en
Priority to NZ574530A priority patent/NZ574530A/en
Priority to KR1020057001933A priority patent/KR20050039839A/ko
Priority to NZ537181A priority patent/NZ537181A/en
Priority to ES03784153T priority patent/ES2408251T3/es
Priority to EP10177891A priority patent/EP2258386A3/en
Priority to PL399492A priority patent/PL399492A1/pl
Priority to CN038186489A priority patent/CN1674933B/zh
Priority to MXPA05001349A priority patent/MXPA05001349A/es
Priority to KR1020057001941A priority patent/KR101140033B1/ko
Priority to DE20321890U priority patent/DE20321890U1/de
Priority to ES10177890.0T priority patent/ES2575014T3/es
Priority to NZ537904A priority patent/NZ537904A/en
Priority to JP2005506111A priority patent/JP5409986B2/ja
Priority to US10/523,044 priority patent/US7838014B2/en
Priority to NZ587398A priority patent/NZ587398A/en
Priority to NZ552686A priority patent/NZ552686A/en
Priority to DK10177890.0T priority patent/DK2255826T3/en
Priority to EP10177887A priority patent/EP2258385A3/en
Priority to US10/523,114 priority patent/US20060034854A1/en
Priority to AU2003250204A priority patent/AU2003250204B8/en
Priority to MYPI20032904A priority patent/MY149591A/en
Priority to US10/523,055 priority patent/US20060057160A1/en
Priority to PCT/EP2003/008571 priority patent/WO2004014418A2/en
Priority to PT101778900T priority patent/PT2255826E/pt
Priority to JP2005506114A priority patent/JP2006506467A/ja
Priority to KR1020127002482A priority patent/KR101239242B1/ko
Priority to PL375407A priority patent/PL216662B1/pl
Priority to AU2003253375A priority patent/AU2003253375B2/en
Priority to CN201210028610.3A priority patent/CN102552895B/zh
Priority to EP10177881A priority patent/EP2258384A3/en
Priority to MXPA05000842A priority patent/MXPA05000842A/es
Priority to RU2007127448/15A priority patent/RU2494758C2/ru
Priority to HUE10177890A priority patent/HUE029200T2/en
Priority to PL03375408A priority patent/PL375408A1/xx
Priority to HK05109073.6A priority patent/HK1077014B/en
Priority to CA002489030A priority patent/CA2489030A1/en
Priority to PT37841533T priority patent/PT1524993E/pt
Priority to RU2005101322/15A priority patent/RU2317106C2/ru
Priority to RU2005102587/15A priority patent/RU2359696C2/ru
Priority to EP12157807.4A priority patent/EP2481419A3/en
Priority to AU2003269864A priority patent/AU2003269864A1/en
Priority to CA002493977A priority patent/CA2493977A1/en
Priority to JP2005506112A priority patent/JP4740738B2/ja
Priority to EP03750408A priority patent/EP1524990A2/en
Priority to PCT/EP2003/008567 priority patent/WO2004014419A1/en
Priority to KR1020057001924A priority patent/KR20050028051A/ko
Priority to KR1020087019883A priority patent/KR101139976B1/ko
Priority to AU2003260357A priority patent/AU2003260357B2/en
Priority to EP03784153A priority patent/EP1524993B1/en
Priority to EP03784151A priority patent/EP1524991A1/en
Priority to EP08153843A priority patent/EP1961427A3/en
Priority to PCT/EP2003/008569 priority patent/WO2004015099A2/en
Priority to EP10177892A priority patent/EP2258387A3/en
Priority to KR1020117004904A priority patent/KR101237329B1/ko
Priority to RU2005102396/13A priority patent/RU2364418C2/ru
Priority to PCT/EP2003/008568 priority patent/WO2004014417A2/en
Priority to MXPA05001265A priority patent/MXPA05001265A/es
Priority to US10/523,117 priority patent/US20060240045A1/en
Priority to ES03784152.5T priority patent/ES2537737T3/es
Priority to CA2493124A priority patent/CA2493124C/en
Priority to JP2004532151A priority patent/JP2006516183A/ja
Priority to AT03779785T priority patent/ATE481983T1/de
Priority to CA002495086A priority patent/CA2495086A1/en
Priority to EP03779785A priority patent/EP1572729B1/en
Priority to DE60334316T priority patent/DE60334316D1/de
Priority to AU2003287945A priority patent/AU2003287945A1/en
Priority to US10/526,062 priority patent/US20060141563A1/en
Priority to PCT/EP2003/009634 priority patent/WO2004020463A2/en
Priority to ES03779785T priority patent/ES2351598T3/es
Priority to IL16566004A priority patent/IL165660A0/xx
Priority to IS7593A priority patent/IS7593A/is
Priority to IS7601A priority patent/IS7601A/is
Priority to NO20050008A priority patent/NO20050008L/no
Priority to NO20050010A priority patent/NO20050010L/no
Priority to IS7658A priority patent/IS7658A/is
Priority to IL166433A priority patent/IL166433A/en
Priority to NO20050421A priority patent/NO20050421L/no
Priority to CO05007265A priority patent/CO5680454A2/es
Priority to CO05007266A priority patent/CO5680455A2/es
Priority to CO05007268A priority patent/CO5680456A2/es
Priority to AU2008202479A priority patent/AU2008202479C1/en
Priority to AU2008255270A priority patent/AU2008255270A1/en
Priority to US12/909,621 priority patent/US8221770B2/en
Priority to JP2010237357A priority patent/JP5414651B2/ja
Priority to JP2011047056A priority patent/JP2011142916A/ja
Priority to IL213264A priority patent/IL213264A0/en
Priority to US13/248,693 priority patent/US20120027800A1/en
Priority to US13/299,007 priority patent/US20120064119A1/en
Priority to US13/299,041 priority patent/US20120064120A1/en
Priority to JP2012026928A priority patent/JP5789203B2/ja
Priority to CY20131100435T priority patent/CY1114243T1/el
Priority to LU92262C priority patent/LU92262I2/fr
Priority to CY2013036C priority patent/CY2013036I1/el
Priority to US14/844,989 priority patent/US20160082097A1/en
Priority to CY20161100532T priority patent/CY1117643T1/el
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/104—Pseudomonadales, e.g. Pseudomonas
    • A61K39/1045—Moraxella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
GBGB0220199.4A 2002-08-02 2002-08-30 Mutant protein and refolding method Ceased GB0220199D0 (en)

Priority Applications (112)

Application Number Priority Date Filing Date Title
GBGB0220199.4A GB0220199D0 (en) 2002-08-30 2002-08-30 Mutant protein and refolding method
DK03784153.3T DK1524993T3 (da) 2002-08-02 2003-07-31 Neisseria-vaccinesammensætning omfattende en kombination af antigener
CN2012102805434A CN103007263A (zh) 2002-08-02 2003-07-31 疫苗组合物
EP03784152.5A EP1524992B1 (en) 2002-08-02 2003-07-31 Vaccine compositions comprising l2 and/or l3 immunotype lipooligosaccharides from lgtb- neisseria menigitidis
TW092121011A TWI360424B (en) 2002-08-02 2003-07-31 Vaccine
CNA038184540A CN1671413A (zh) 2002-08-02 2003-07-31 包含革兰氏阴性菌来源的运铁蛋白结合蛋白和hsf疫苗组合物
SI200332262T SI1524993T1 (sl) 2002-08-02 2003-07-31 Neisserijski vakcinski sestavki, ki obsegajo kombinacijo antigenov
DE20321889U DE20321889U1 (de) 2002-08-02 2003-07-31 Impfstoffzusammensetzung
PL03375382A PL375382A1 (en) 2002-08-02 2003-07-31 Vaccine
BR0313121-1A BR0313121A (pt) 2002-08-02 2003-07-31 Composição imunogênica, vacina, métodos de tratamento ou prevenção de doença neisserial, de preparação da composição imunogênica, de preparação da vacina, de preparação de uma imunoglobina para uso na prevenção ou tratamento de infecção neisserial, e de tratamento ou prevenção de infecção neisserial, usos da vacina e da preparação farmacêutica, cepa neisserial geneticamente engenheirada, imunoglobina, e, composição farmacêutica
JP2005506113A JP2006500963A (ja) 2002-08-02 2003-07-31 ワクチン組成物
EP10177890.0A EP2255826B1 (en) 2002-08-02 2003-07-31 Neisserial vaccine compositions comprising a combination of antigens
BRPI0313120-3A BR0313120A (pt) 2002-08-02 2003-07-31 preparações de bleb e de los, cepa(s) neisserial/neisseriais, composição imunogênica ou vacina, e, processos de fabricação da vacina de preparação de bleb neisserial e de produção de uma preparação de bleb
BR0313100-9A BR0313100A (pt) 2002-08-02 2003-07-31 Composição imunogênica, composição imunogênica isolada, vacina, método de tratamento ou prevenção de doença bacteriana gram-negativa, uso da vacina, cepa bacteriana gram-negativa geneticamente manipulada, método para preparar a composição imunogênica, método para preparar a vacina, método de preparar uma imunoglobulina para uso na prevenção ou tratamento de infecção neisserial, preparação de imunoglobulina, preparação farmacêutica, e, uso da preparação farmacêutica
SI200332485A SI2255826T1 (sl) 2002-08-02 2003-07-31 Neisserijski vakcinski sestavki, ki obsegajo kombinacijo antigenov
PL399214A PL220107B1 (pl) 2002-08-02 2003-07-31 Preparat immunogenny, szczepionka oraz zastosowanie tej szczepionki
CA002493092A CA2493092A1 (en) 2002-08-02 2003-07-31 Neisserial vaccine compositions comprising a combination of antigens
NZ574530A NZ574530A (en) 2002-08-02 2003-07-31 Vaccine compositions comprising L2 and/or L3 immunotype lipooligosaccharides from lgtB-neisseria minigitidis
KR1020057001933A KR20050039839A (ko) 2002-08-02 2003-07-31 Ｌｇｔｂ- 나이세리아 메닌기티디스로부터의 ｌ2 및/또는ｌ3 면역유형 리포올리고사카라이드를 포함하는 백신 조성물
NZ537181A NZ537181A (en) 2002-08-02 2003-07-31 Vaccine composition comprising transferrin binding protein and Hsf from gram negative bacteria
ES03784153T ES2408251T3 (es) 2002-08-02 2003-07-31 Composiciones de vacuna contra Neisseria que comprenden una combinación de antígenos
EP10177891A EP2258386A3 (en) 2002-08-02 2003-07-31 Neisseria Vaccine composition
PL399492A PL399492A1 (pl) 2002-08-02 2003-07-31 Szczepionka
CN038186489A CN1674933B (zh) 2002-08-02 2003-07-31 疫苗组合物
MXPA05001349A MXPA05001349A (es) 2002-08-02 2003-07-31 Composiciones de vacunas que contienen lipooligosacaridos de inmunotipo l2 y/o l3 de minigitidis neiseria lgtb.
KR1020057001941A KR101140033B1 (ko) 2002-08-02 2003-07-31 항원 조합물을 포함하는 나이세리아 백신 조성물
DE20321890U DE20321890U1 (de) 2002-08-02 2003-07-31 Impfstoffzusammensetzung
ES10177890.0T ES2575014T3 (es) 2002-08-02 2003-07-31 Composiciones de vacuna contra Neisseria que comprenden una combinación de antígenos
NZ537904A NZ537904A (en) 2002-08-02 2003-07-31 Neisserial vaccine compositions comprising a combination of antigens
JP2005506111A JP5409986B2 (ja) 2002-08-02 2003-07-31 グラム陰性細菌由来のトランスフェリン結合タンパク質およびＨｓｆを含んでなるワクチン組成物
US10/523,044 US7838014B2 (en) 2002-08-02 2003-07-31 Vaccine compositions comprising L2 and/or L3 immunotype lipooligosaccharides from LGTB- Neisseria meningitidis
NZ587398A NZ587398A (en) 2002-08-02 2003-07-31 Neisserial bleb preparations and vaccines comprising them
NZ552686A NZ552686A (en) 2002-08-02 2003-07-31 Neisserial vaccine compositions comprising a combination of antigens
DK10177890.0T DK2255826T3 (en) 2002-08-02 2003-07-31 Neisserial vaccine compositions comprising a combination of antigens.
EP10177887A EP2258385A3 (en) 2002-08-02 2003-07-31 Neisseria vaccine composition
US10/523,114 US20060034854A1 (en) 2002-08-02 2003-07-31 Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria
AU2003250204A AU2003250204B8 (en) 2002-08-02 2003-07-31 Neisserial vaccine compositions comprising a combination of antigens
MYPI20032904A MY149591A (en) 2002-08-02 2003-07-31 Vaccines comprising l2 and/or l3 los from neisseria
US10/523,055 US20060057160A1 (en) 2002-08-02 2003-07-31 Vaccine composition
PCT/EP2003/008571 WO2004014418A2 (en) 2002-08-02 2003-07-31 Neisserial vaccine compositions comprising a combination of antigens
PT101778900T PT2255826E (pt) 2002-08-02 2003-07-31 Composições de vacina de neisseria compreendendo uma combinação de antigénios
JP2005506114A JP2006506467A (ja) 2002-08-02 2003-07-31 ワクチン組成物
KR1020127002482A KR101239242B1 (ko) 2002-08-02 2003-07-31 항원 조합물을 포함하는 나이세리아 백신 조성물
PL375407A PL216662B1 (pl) 2002-08-02 2003-07-31 Preparat immunogenny
AU2003253375A AU2003253375B2 (en) 2002-08-02 2003-07-31 Vaccine composition comprising transferrin binding protein and Hsf from Gram negative bacteria
CN201210028610.3A CN102552895B (zh) 2002-08-02 2003-07-31 疫苗组合物
EP10177881A EP2258384A3 (en) 2002-08-02 2003-07-31 Neisseria vaccine composition
MXPA05000842A MXPA05000842A (es) 2002-08-02 2003-07-31 Composicion de vacuna que comprende proteina de enlace de transferrina y hsf de bacteria gram-negativa.
RU2007127448/15A RU2494758C2 (ru) 2002-08-02 2003-07-31 Нейссериальные вакцинные композиции, содержащие комбинацию антигенов
HUE10177890A HUE029200T2 (en) 2002-08-02 2003-07-31 Neisseria vaccine preparations containing a combination of antigens
PL03375408A PL375408A1 (en) 2002-08-02 2003-07-31 Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria
HK05109073.6A HK1077014B (en) 2002-08-02 2003-07-31 Neisserial vaccine compositions comprising a combination of antigens
CA002489030A CA2489030A1 (en) 2002-08-02 2003-07-31 Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria
PT37841533T PT1524993E (pt) 2002-08-02 2003-07-31 Composições de vacina de neisseria compreendendo uma combinação de antigénios
RU2005101322/15A RU2317106C2 (ru) 2002-08-02 2003-07-31 Нейссериальные вакцинные композиции, содержащие комбинацию антигенов
RU2005102587/15A RU2359696C2 (ru) 2002-08-02 2003-07-31 Вакцинная композиция, содержащая трансферрин-связывающий белок и hsf из грамотрицательных бактерий
EP12157807.4A EP2481419A3 (en) 2002-08-02 2003-07-31 Neisserial vaccines
AU2003269864A AU2003269864A1 (en) 2002-08-02 2003-07-31 Vaccine composition comprising lipooligosaccharide with reduced phase variability
CA002493977A CA2493977A1 (en) 2002-08-02 2003-07-31 Vaccine composition comprising lipooligosaccharide with reduced phase variability
JP2005506112A JP4740738B2 (ja) 2002-08-02 2003-07-31 ワクチン
EP03750408A EP1524990A2 (en) 2002-08-02 2003-07-31 Vaccine composition comprising lipooligosaccharide with reduced phase variability
PCT/EP2003/008567 WO2004014419A1 (en) 2002-08-02 2003-07-31 Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria
KR1020057001924A KR20050028051A (ko) 2002-08-02 2003-07-31 그램 음성 박테리아로부터 유래된 트랜스페린 결합 단백질및 ｈｓｆ를 포함하는 백신 조성물
KR1020087019883A KR101139976B1 (ko) 2002-08-02 2003-07-31 항원 조합물을 포함하는 나이세리아 백신 조성물
AU2003260357A AU2003260357B2 (en) 2002-08-02 2003-07-31 Vaccine compositions comprising L2 and/or L3 immunotype lipooligosaccharides from lgtB- Neisseria minigitidis
EP03784153A EP1524993B1 (en) 2002-08-02 2003-07-31 Neisserial vaccine compositions comprising a combination of antigens
EP03784151A EP1524991A1 (en) 2002-08-02 2003-07-31 Vaccine composition comprising transferrin binding protein and hsf from gram negative bacteria
EP08153843A EP1961427A3 (en) 2002-08-02 2003-07-31 Neisserial vaccine compositions comprising a combination of antigens
PCT/EP2003/008569 WO2004015099A2 (en) 2002-08-02 2003-07-31 Vaccine composition comprising lipooligosaccharide with reduced phase variability
EP10177892A EP2258387A3 (en) 2002-08-02 2003-07-31 Neisseria vaccine composition
KR1020117004904A KR101237329B1 (ko) 2002-08-02 2003-07-31 항원 조합물을 포함하는 나이세리아 백신 조성물
RU2005102396/13A RU2364418C2 (ru) 2002-08-02 2003-07-31 ВАКЦИННЫЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ЛИПОПОЛИСАХАРИДЫ ИММУНОТИПА L2 И/ИЛИ L3, ПРОИСХОДЯЩИЕ ИЗ ШТАММА NEISSERIA MENINGITIDIS IgtB-
PCT/EP2003/008568 WO2004014417A2 (en) 2002-08-02 2003-07-31 Vaccine compositions comprising l2 and/or l3 immunotype lipooligosaccharides from lgtb- neisseria minigitidis
MXPA05001265A MXPA05001265A (es) 2002-08-02 2003-07-31 Composiciones de vacuna de neisserial que comprenden una combinacion de antigenos.
US10/523,117 US20060240045A1 (en) 2002-08-02 2003-07-31 Neisserial vaccine compositions comprising a combination of antigens
ES03784152.5T ES2537737T3 (es) 2002-08-02 2003-07-31 Composiciones de vacuna que comprenden lipooligosacáridos de inmunotipo L2 y/o L3 de Neisseria meningitidis de IgtB
CA2493124A CA2493124C (en) 2002-08-02 2003-07-31 Vaccine
JP2004532151A JP2006516183A (ja) 2002-08-30 2003-08-28 突然変異型タンパク質およびリフォールディング方法
AT03779785T ATE481983T1 (de) 2002-08-30 2003-08-28 Frpb proteinmutante und verfahren zur erneuten faltung
CA002495086A CA2495086A1 (en) 2002-08-30 2003-08-28 Mutant protein and refolding method
EP03779785A EP1572729B1 (en) 2002-08-30 2003-08-28 Mutant frpb protein and refolding method
DE60334316T DE60334316D1 (de) 2002-08-30 2003-08-28 Frpb proteinmutante und verfahren zur erneuten faltung
AU2003287945A AU2003287945A1 (en) 2002-08-30 2003-08-28 Mutant protein and refolding method
US10/526,062 US20060141563A1 (en) 2002-08-30 2003-08-28 Mutant protein and refolding method
PCT/EP2003/009634 WO2004020463A2 (en) 2002-08-30 2003-08-28 Mutant protein and refolding method
ES03779785T ES2351598T3 (es) 2002-08-30 2003-08-28 Proteína frpb mutante y procedimiento de replegamiento.
IL16566004A IL165660A0 (en) 2002-08-02 2004-12-09 Vaccine composition comprising transferrin bindin g protein and HSF from gram negative bacteria
IS7593A IS7593A (is) 2002-08-02 2004-12-13 Bólusetningasamsetning sem samanstendur af transferrín bindi prótíni og HSF úr gram-neikvæðum bakteríum
IS7601A IS7601A (is) 2002-08-02 2004-12-16 Neisser-bóluefnasamsetningar sem innihalda blönduaf mótefnavökvum
NO20050008A NO20050008L (no) 2002-08-02 2005-01-03 Neisserial vaksinesammensetninger omfattende en kombinasjon av antigener
NO20050010A NO20050010L (no) 2002-08-02 2005-01-03 Vaksineblandinger omfattende transferrin-bindende protein og HSF fra gram-negative bakterier
IS7658A IS7658A (is) 2002-08-02 2005-01-20 Bóluefna samsetningar sem samanstanda af fitufásykrum af L2 og/eða L3 ónæmisgerð úr 1gtB mengishnettlu
IL166433A IL166433A (en) 2002-08-02 2005-01-20 Vaccine compositions comprising l2 or l3 immunotype lipooligosaccharides from lgtb neisseria menigitidis and process for their preparation
NO20050421A NO20050421L (no) 2002-08-02 2005-01-25 Vaksine
CO05007265A CO5680454A2 (es) 2002-08-02 2005-01-28 Composicion de vacuna que comprende proteina de enlace de transferrina y hsf de bacteria gram-negativa
CO05007266A CO5680455A2 (es) 2002-08-02 2005-01-28 Composiciones de vacuna de neisserial que comprende una com binacion de antigenos
CO05007268A CO5680456A2 (es) 2002-08-02 2005-01-28 Composiciones de vacunas que comprenden lipooligosacaridos del inmunotipo l2 y/o l3 a partir de lgtb-neisseria minigitidis
AU2008202479A AU2008202479C1 (en) 2002-08-02 2008-06-04 Neisserial vaccine compositions comprising a combination of antigens
AU2008255270A AU2008255270A1 (en) 2002-08-02 2008-12-12 Vaccine composition
US12/909,621 US8221770B2 (en) 2002-08-02 2010-10-21 Vaccine compositions comprising L2 and/or L3 immunotype lipooligosaccharides from LGTB-neisseria meningitidis
JP2010237357A JP5414651B2 (ja) 2002-08-02 2010-10-22 ワクチン組成物
JP2011047056A JP2011142916A (ja) 2002-08-02 2011-03-04 ワクチン
IL213264A IL213264A0 (en) 2002-08-02 2011-05-31 Vaccine compositions comprising l2 and/or l3 immunotype lipooligosaccharides from lgtb neisseria minigitidis
US13/248,693 US20120027800A1 (en) 2002-08-02 2011-09-29 Neisserial vaccine compositions comprising a combination of antigens
US13/299,007 US20120064119A1 (en) 2002-08-02 2011-11-17 Neisserial vaccine compositions comprising a combination of antigens
US13/299,041 US20120064120A1 (en) 2002-08-02 2011-11-17 Neisserial vaccine compositions comprising a combination of antigens
JP2012026928A JP5789203B2 (ja) 2002-08-02 2012-02-10 ワクチン組成物
CY20131100435T CY1114243T1 (el) 2002-08-02 2013-05-31 Συνθεσεις εμβολιου κατα της ναϊσσερια, που περιεχουν εναν συνδυασμο αντιγονων
LU92262C LU92262I2 (fr) 2002-08-02 2013-07-31 Vaccin méningococcique groupe B (ADNr, composant, adsorbé) et ses dérivés pharmaceutiquement acceptables (BEXSERO)
CY2013036C CY2013036I1 (el) 2002-08-02 2013-09-05 Συνθεσεις εμβολιου κατα της ναϊσσερια, που περιεχουν εναν συνδυασμο αντιγονων
US14/844,989 US20160082097A1 (en) 2002-08-02 2015-09-03 Neisserial vaccine compositions comprising a combination of antigens
CY20161100532T CY1117643T1 (el) 2002-08-02 2016-06-15 Συνθεσεις νεϊσσεριακου εμβολιου που περιλαμβανουν συνδυασμο αντιγονων

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ES2537426T3 (es) * 2008-12-25 2015-06-08 The Chemo-Sero-Therapeutic Research Institute Vacuna recombinante para la rinitis infecciosa aviar y método para producirla
US9259462B2 (en) * 2010-09-10 2016-02-16 Glaxosmithkline Biologicals Sa Developments in meningococcal outer membrane vesicles
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EP1572729B1 (en) 2010-09-22
ES2351598T3 (es) 2011-02-08
WO2004020463A3 (en) 2005-08-18
WO2004020463A2 (en) 2004-03-11
CA2495086A1 (en) 2004-03-11
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US20060141563A1 (en) 2006-06-29
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