FR2936800B1 - Polysaccharide comportant des groupes fonctionnels carboxyles substitues par un derive d'alcool hydrophobe - Google Patents

Polysaccharide comportant des groupes fonctionnels carboxyles substitues par un derive d'alcool hydrophobe

Info

Publication number
FR2936800B1
FR2936800B1 FR0805506A FR0805506A FR2936800B1 FR 2936800 B1 FR2936800 B1 FR 2936800B1 FR 0805506 A FR0805506 A FR 0805506A FR 0805506 A FR0805506 A FR 0805506A FR 2936800 B1 FR2936800 B1 FR 2936800B1
Authority
FR
France
Prior art keywords
polysaccharide
carboxyl groups
groups substituted
alcohol derivative
hydrophobic alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0805506A
Other languages
English (en)
French (fr)
Other versions
FR2936800A1 (fr
Inventor
Olivier Soula
Remi Soula
Gerard Soula
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adocia SAS
Original Assignee
Adocia SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0805506A priority Critical patent/FR2936800B1/fr
Application filed by Adocia SAS filed Critical Adocia SAS
Priority to CN200980146012.2A priority patent/CN102216334B/zh
Priority to DK09744446.7T priority patent/DK2344547T3/en
Priority to AU2009302160A priority patent/AU2009302160B2/en
Priority to JP2011530586A priority patent/JP5695568B2/ja
Priority to ES09744446.7T priority patent/ES2527322T3/es
Priority to EP09744446.7A priority patent/EP2344547B1/fr
Priority to PL09744446T priority patent/PL2344547T3/pl
Priority to US12/588,149 priority patent/US20100167991A1/en
Priority to PCT/IB2009/007054 priority patent/WO2010041119A1/fr
Priority to RU2011118338/13A priority patent/RU2504554C2/ru
Priority to KR1020117010492A priority patent/KR101587521B1/ko
Priority to BRPI0914008A priority patent/BRPI0914008A2/pt
Priority to MX2011003650A priority patent/MX2011003650A/es
Priority to CA2739546A priority patent/CA2739546C/fr
Priority to US12/662,184 priority patent/US8426382B2/en
Publication of FR2936800A1 publication Critical patent/FR2936800A1/fr
Application granted granted Critical
Publication of FR2936800B1 publication Critical patent/FR2936800B1/fr
Priority to IL212165A priority patent/IL212165A/en
Priority to ZA2011/03176A priority patent/ZA201103176B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0018—Pullulan, i.e. (alpha-1,4)(alpha-1,6)-D-glucan; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0051—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Fructofuranans, e.g. beta-2,6-D-fructofuranan, i.e. levan; Derivatives thereof
    • C08B37/0054—Inulin, i.e. beta-2,1-D-fructofuranan; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0057—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Xylans, i.e. xylosaccharide, e.g. arabinoxylan, arabinofuronan, pentosans; (beta-1,3)(beta-1,4)-D-Xylans, e.g. rhodymenans; Hemicellulose; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR0805506A 2008-10-06 2008-10-06 Polysaccharide comportant des groupes fonctionnels carboxyles substitues par un derive d'alcool hydrophobe Expired - Fee Related FR2936800B1 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR0805506A FR2936800B1 (fr) 2008-10-06 2008-10-06 Polysaccharide comportant des groupes fonctionnels carboxyles substitues par un derive d'alcool hydrophobe
KR1020117010492A KR101587521B1 (ko) 2008-10-06 2009-10-06 소수성 알코올 유도체에 의해 치환된 카복실 관능기를 포함하는 폴리사카라이드
AU2009302160A AU2009302160B2 (en) 2008-10-06 2009-10-06 Polysaccharides containing carboxyl functional groups substituted by a hydrophobic alcohol derivative
JP2011530586A JP5695568B2 (ja) 2008-10-06 2009-10-06 疎水性アルコール誘導体により置換されたカルボキシル官能基を含有する多糖類
ES09744446.7T ES2527322T3 (es) 2008-10-06 2009-10-06 Polisacáridos que contienen los grupos funcionales carboxilos sustituidos por un derivado de alcohol hidrófobo
EP09744446.7A EP2344547B1 (fr) 2008-10-06 2009-10-06 Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive d'alcool hydrophobe
PL09744446T PL2344547T3 (pl) 2008-10-06 2009-10-06 Polisacharydy zawierające funkcyjne grupy karboksylowe podstawione przez pochodną alkoholu hydrofobowego
US12/588,149 US20100167991A1 (en) 2008-10-06 2009-10-06 Polysaccharides comprising carboxyl functional groups substituted by a hydrophobic alcohol derivative
PCT/IB2009/007054 WO2010041119A1 (fr) 2008-10-06 2009-10-06 Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive d'alcool hydrophobe
MX2011003650A MX2011003650A (es) 2008-10-06 2009-10-06 Polisacáridos que comprenden grupos funcionales carboxilo sustituidos por un derivado de alcohol hidrofóbico.
CN200980146012.2A CN102216334B (zh) 2008-10-06 2009-10-06 包含被疏水性醇的衍生物取代的羧基官能团的多糖
DK09744446.7T DK2344547T3 (en) 2008-10-06 2009-10-06 Polysaccharides comprising carboxyl functional groups substituted with a derivative of a hydrophobic alcohol
RU2011118338/13A RU2504554C2 (ru) 2008-10-06 2009-10-06 Полисахариды, содержащие карбоксильные функциональные группы, замещенные производным гидрофобного спирта
CA2739546A CA2739546C (fr) 2008-10-06 2009-10-06 Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive d'alcool hydrophobe
BRPI0914008A BRPI0914008A2 (pt) 2008-10-06 2009-10-06 polissacarídeo contendo grupos funcionais carboxila, composição farmacêutica e uso do polissacarídeo funcionalizado
US12/662,184 US8426382B2 (en) 2008-10-06 2010-04-05 Polysaccharides comprising carboxyl functional groups substituted by a hydrophobic alcohol derivative
IL212165A IL212165A (en) 2008-10-06 2011-04-06 Polysaccharides having carboxyl groups associated with hydrophobic history of alcohols
ZA2011/03176A ZA201103176B (en) 2008-10-06 2011-04-29 Polysaccharides containing carboxyl fuctional groups substituted by a hydrophobic alcohol derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0805506A FR2936800B1 (fr) 2008-10-06 2008-10-06 Polysaccharide comportant des groupes fonctionnels carboxyles substitues par un derive d'alcool hydrophobe

Publications (2)

Publication Number Publication Date
FR2936800A1 FR2936800A1 (fr) 2010-04-09
FR2936800B1 true FR2936800B1 (fr) 2010-12-31

Family

ID=40626798

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0805506A Expired - Fee Related FR2936800B1 (fr) 2008-10-06 2008-10-06 Polysaccharide comportant des groupes fonctionnels carboxyles substitues par un derive d'alcool hydrophobe

Country Status (17)

Country Link
US (1) US20100167991A1 (enExample)
EP (1) EP2344547B1 (enExample)
JP (1) JP5695568B2 (enExample)
KR (1) KR101587521B1 (enExample)
CN (1) CN102216334B (enExample)
AU (1) AU2009302160B2 (enExample)
BR (1) BRPI0914008A2 (enExample)
CA (1) CA2739546C (enExample)
DK (1) DK2344547T3 (enExample)
ES (1) ES2527322T3 (enExample)
FR (1) FR2936800B1 (enExample)
IL (1) IL212165A (enExample)
MX (1) MX2011003650A (enExample)
PL (1) PL2344547T3 (enExample)
RU (1) RU2504554C2 (enExample)
WO (1) WO2010041119A1 (enExample)
ZA (1) ZA201103176B (enExample)

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FR2948573B1 (fr) 2009-07-31 2011-11-18 Adocia Nouvelle forme d'administration de complexes de proteines osteogeniques
FR2943538B1 (fr) 2009-03-27 2011-05-20 Adocia Formulation a action rapide d'insuline recombinante humaine
FR2975099A1 (fr) * 2011-05-10 2012-11-16 Adocia Polysaccharides a degre de fonctionnalisation modulable
US9018190B2 (en) 2009-03-27 2015-04-28 Adocia Functionalized oligosaccharides
FR2952375A1 (fr) 2009-11-10 2011-05-13 Adocia Polysaccharides comportant des groupes fonctionnels carboxyles substitues par esterification par un derive d'alcool hydrophobe
FR2956116A1 (fr) * 2010-02-09 2011-08-12 Adocia Complexes polysaccharide/bmp-7 solubles a ph physiologique
FR2958647B1 (fr) 2010-04-08 2013-08-23 Adocia Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive hydrophobe porte par un spacer au moins trivalent.
US20120295833A1 (en) * 2011-05-10 2012-11-22 Adocia Polysaccharides having an adjustable degree of functionalization
CN103889442B (zh) * 2011-08-10 2016-12-28 阿道恰公司 至少一种基础胰岛素的可注射溶液
US20130231281A1 (en) 2011-11-02 2013-09-05 Adocia Rapid acting insulin formulation comprising an oligosaccharide
CN113730555A (zh) 2012-01-09 2021-12-03 阿道恰公司 Ph为7且至少含pi为5.8至8.5之基础胰岛素和取代共聚(氨基酸)的可注射溶液
US9815912B2 (en) * 2012-03-19 2017-11-14 University Of Massachusetts Hydrophilic modification of water insoluble polysaccharide as surface-active agents
US20150314003A2 (en) 2012-08-09 2015-11-05 Adocia Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer
BR112015004501B1 (pt) * 2012-09-05 2021-04-13 Chugai Seiyaku Kabushiki Kaisha Derivado de ácido hialurônico tendo aminoácidos e grupos esterila introduzidos no mesmo e composição farmacêutica que o compreende
US9084806B2 (en) * 2012-11-12 2015-07-21 Research & Business Foundation Sungkyunkwan University Hypoxia-responsive nanoparticle for therapy and imaging of hypoxia-involving diseases
FR2997952B1 (fr) * 2012-11-13 2014-11-21 Adocia Composes anioniques substitues constitues d'un squelette forme d'un nombre discret d'unites saccharidiques
US20140187499A1 (en) * 2012-11-13 2014-07-03 Adocia Substituted anionic compounds consisting of a backbone made up of a discrete number of saccharide units
WO2014076423A1 (fr) 2012-11-13 2014-05-22 Adocia Formulation à action rapide d'insuline comprenant un composé anionique substitué
US9795678B2 (en) 2014-05-14 2017-10-24 Adocia Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound
FR3020947B1 (fr) 2014-05-14 2018-08-31 Adocia Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations
FR3025428A1 (fr) 2014-09-08 2016-03-11 Adocia Composition pharmaceutique stable comprenant du pdgf
FR3043557B1 (fr) 2015-11-16 2019-05-31 Adocia Composition a action rapide d'insuline comprenant un citrate substitue
DE102016101448A1 (de) * 2016-01-27 2017-07-27 Strathmann Gmbh & Co. Kg Immunprophylaxe bei rezidivierenden bakteriellen Infektionen
CN111171174B (zh) * 2020-01-14 2022-02-01 上海图珐医药科技有限公司 葡聚糖衍生物及其制备方法和用于制备药剂的附加剂
CN111481734B (zh) * 2020-04-28 2022-04-15 北京诺康达医药科技股份有限公司 一种改性海藻酸钠自显影栓塞微球及其制备方法与应用
CN113563493B (zh) * 2021-07-01 2022-06-24 蚌埠医学院 疏水化多糖及其制备方法与应用

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Also Published As

Publication number Publication date
JP2012504697A (ja) 2012-02-23
KR20110067157A (ko) 2011-06-21
KR101587521B1 (ko) 2016-01-21
AU2009302160B2 (en) 2014-09-11
CN102216334A (zh) 2011-10-12
AU2009302160A1 (en) 2010-04-15
CA2739546C (fr) 2017-11-07
MX2011003650A (es) 2011-06-17
EP2344547A1 (fr) 2011-07-20
FR2936800A1 (fr) 2010-04-09
ZA201103176B (en) 2013-09-25
RU2011118338A (ru) 2012-11-20
BRPI0914008A2 (pt) 2015-10-27
DK2344547T3 (en) 2015-01-05
IL212165A (en) 2016-09-29
IL212165A0 (en) 2011-06-30
ES2527322T3 (es) 2015-01-22
CA2739546A1 (fr) 2010-04-15
WO2010041119A1 (fr) 2010-04-15
JP5695568B2 (ja) 2015-04-08
CN102216334B (zh) 2014-08-13
EP2344547B1 (fr) 2014-12-03
US20100167991A1 (en) 2010-07-01
RU2504554C2 (ru) 2014-01-20
PL2344547T3 (pl) 2015-03-31

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