FR2843964B1 - Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique - Google Patents

Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique

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Publication number
FR2843964B1
FR2843964B1 FR0210707A FR0210707A FR2843964B1 FR 2843964 B1 FR2843964 B1 FR 2843964B1 FR 0210707 A FR0210707 A FR 0210707A FR 0210707 A FR0210707 A FR 0210707A FR 2843964 B1 FR2843964 B1 FR 2843964B1
Authority
FR
France
Prior art keywords
alkylcarbamates
dioxane
derivatives
preparation
therapeutic application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0210707A
Other languages
English (en)
French (fr)
Other versions
FR2843964A1 (fr
Inventor
Ahmed Abouabdellah
Michele Bas
Gihad Dargazanli
Christian Hoornaert
Adrien Tak Li
Florence Medaisko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Priority to FR0210707A priority Critical patent/FR2843964B1/fr
Priority to ARP030103063A priority patent/AR041053A1/es
Priority to SI200331666T priority patent/SI1840125T1/sl
Priority to CN2010101829555A priority patent/CN101906071A/zh
Priority to ES03758282T priority patent/ES2312808T3/es
Priority to YUP-2005/0182A priority patent/RS51085B/sr
Priority to DE60323754T priority patent/DE60323754D1/de
Priority to DK03758282T priority patent/DK1537096T3/da
Priority to CA2700319A priority patent/CA2700319C/en
Priority to AT03758282T priority patent/ATE409184T1/de
Priority to HRP20090270AA priority patent/HRP20090270B1/hr
Priority to SI200331438T priority patent/SI1537096T1/sl
Priority to PCT/FR2003/002590 priority patent/WO2004020430A2/fr
Priority to PT03758282T priority patent/PT1537096E/pt
Priority to AU2003274292A priority patent/AU2003274292B2/en
Priority to ZA200501537A priority patent/ZA200501537B/en
Priority to MEP-242/08A priority patent/MEP24208A/xx
Priority to HK05108400.2A priority patent/HK1074445B/xx
Priority to DK07013954T priority patent/DK1840125T3/da
Priority to AT07013954T priority patent/ATE434598T1/de
Priority to CN200810186321XA priority patent/CN101445504B/zh
Priority to EA200500268A priority patent/EA008218B1/ru
Priority to NZ538404A priority patent/NZ538404A/en
Priority to EP03758282A priority patent/EP1537096B1/fr
Priority to MXPA05002319A priority patent/MXPA05002319A/es
Priority to PL375753A priority patent/PL209339B1/pl
Priority to CA2496040A priority patent/CA2496040C/en
Priority to RSP-2010/0169A priority patent/RS20100169A/sr
Priority to JP2004532233A priority patent/JP4585854B2/ja
Priority to UAA200501766A priority patent/UA82847C2/uk
Priority to ES07013954T priority patent/ES2329181T3/es
Priority to EP07013954A priority patent/EP1840125B1/fr
Priority to KR1020107028059A priority patent/KR101139160B1/ko
Priority to BR0313846-1A priority patent/BR0313846A/pt
Priority to KR1020057003244A priority patent/KR101051192B1/ko
Priority to HRP20050190AA priority patent/HRP20050190B1/hr
Priority to DE60328138T priority patent/DE60328138D1/de
Priority to PT07013954T priority patent/PT1840125E/pt
Priority to CNB038241056A priority patent/CN100491368C/zh
Priority to TW096123915A priority patent/TWI337606B/zh
Priority to TW092123746A priority patent/TWI294878B/zh
Publication of FR2843964A1 publication Critical patent/FR2843964A1/fr
Priority to MEP-2008-242A priority patent/ME00108B/me
Application granted granted Critical
Publication of FR2843964B1 publication Critical patent/FR2843964B1/fr
Priority to IL166882A priority patent/IL166882A/en
Priority to IS7699A priority patent/IS2733B/is
Priority to US11/062,541 priority patent/US7119116B2/en
Priority to CO05017682A priority patent/CO5700820A2/es
Priority to NO20051051A priority patent/NO331165B1/no
Priority to TNP2005000057A priority patent/TNSN05057A1/fr
Priority to MA28125A priority patent/MA27390A1/fr
Priority to HK08101677.0A priority patent/HK1108157B/xx
Priority to US11/426,964 priority patent/US20060247290A1/en
Priority to CY20081101445T priority patent/CY1108792T1/el
Priority to US12/510,326 priority patent/US7777057B2/en
Priority to CY20091100995T priority patent/CY1109441T1/el
Priority to JP2010139427A priority patent/JP5244863B2/ja
Priority to US12/834,268 priority patent/US8119687B2/en
Priority to NO20110598A priority patent/NO335866B1/no
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
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    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Cardiology (AREA)
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  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Anesthesiology (AREA)
FR0210707A 2002-08-29 2002-08-29 Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique Expired - Fee Related FR2843964B1 (fr)

Priority Applications (57)

Application Number Priority Date Filing Date Title
FR0210707A FR2843964B1 (fr) 2002-08-29 2002-08-29 Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
ARP030103063A AR041053A1 (es) 2002-08-29 2003-08-26 Derivados de dioxan-2-alquilcarbamatos, su preparacion y su aplicacion de terapeutica
SI200331666T SI1840125T1 (sl) 2002-08-29 2003-08-27 Intermediati za pripravo dioksan-2-alkil karbamatov
CN2010101829555A CN101906071A (zh) 2002-08-29 2003-08-27 二噁烷-2-烷基氨基甲酸酯衍生物
ES03758282T ES2312808T3 (es) 2002-08-29 2003-08-27 Derivados de dioxano-2-alquilcarbamatos, su preparacion y su aplicacion en terapeutica.
YUP-2005/0182A RS51085B (sr) 2002-08-29 2003-08-27 Derivati dioksan-2-alkilkarbamata, postupak za njihovo dobijanje i primena istih u terapeuticima
DE60323754T DE60323754D1 (de) 2002-08-29 2003-08-27 Dioxan-2-alkylkarbamaten derivaten, deren herstellung und deren therapeutischen verwendung
DK03758282T DK1537096T3 (da) 2002-08-29 2003-08-27 Derivater af dioxan-2-alkylcarbamater, fremstilling og terapeutisk anvendelse heraf
CA2700319A CA2700319C (en) 2002-08-29 2003-08-27 Carbonates for use in the preparation of derivatives of dioxan-2-alkyl carbamates
AT03758282T ATE409184T1 (de) 2002-08-29 2003-08-27 Dioxan-2-alkylkarbamaten derivaten, deren herstellung und deren therapeutischen verwendung
HRP20090270AA HRP20090270B1 (hr) 2002-08-29 2003-08-27 Derivati dioksan-2-alkil karbamata, metoda njihove pripreme i primjena istih u terapeutske svrhe
SI200331438T SI1537096T1 (sl) 2002-08-29 2003-08-27 Dioksan-2-alkilkarbamatni derivati, njihova priprava in njihova terapevtska uporaba
PCT/FR2003/002590 WO2004020430A2 (fr) 2002-08-29 2003-08-27 Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
PT03758282T PT1537096E (pt) 2002-08-29 2003-08-27 Derivados de dioxano-2-alquilcarbamatos, sua preparação e sua aplicação em terapia
AU2003274292A AU2003274292B2 (en) 2002-08-29 2003-08-27 Derivatives of dioxane-2-alkyl carbamates, preparation method thereof and application of same in therapeutics
ZA200501537A ZA200501537B (en) 2002-08-29 2003-08-27 Derivatives of dioxane-2-alkyl carbamates, preparation method thereof and application of same in therapeutics
MEP-242/08A MEP24208A (en) 2002-08-29 2003-08-27 Derivatives of dioxane-2-alkyl carbamates, preparation method thereof and application of same in therapeutics
HK05108400.2A HK1074445B (en) 2002-08-29 2003-08-27 Derivatives of dioxane-2-alkyl carbamates, preparation method thereof and application of same in therapeutics
DK07013954T DK1840125T3 (da) 2002-08-29 2003-08-27 Mellemprodukter til fremstilling af dioxan-2-alkylcarbamater
AT07013954T ATE434598T1 (de) 2002-08-29 2003-08-27 Zwischenprodukte für die herstellung von dioxan-2-alkylcarbamaten
CN200810186321XA CN101445504B (zh) 2002-08-29 2003-08-27 二*烷-2-烷基氨基甲酸酯衍生物
EA200500268A EA008218B1 (ru) 2002-08-29 2003-08-27 Производные диоксан-2-алкилкарбамата, способ их получения и применение в терапии
NZ538404A NZ538404A (en) 2002-08-29 2003-08-27 Derivatives of dioxane-2-alkyl carbamates, preparation method thereof and application of same in therapeutics
EP03758282A EP1537096B1 (fr) 2002-08-29 2003-08-27 Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
MXPA05002319A MXPA05002319A (es) 2002-08-29 2003-08-27 Derivados de dioxan-2-alquilcarbamatos, su preparacion y su aplicacion en terapeutica.
PL375753A PL209339B1 (pl) 2002-08-29 2003-08-27 Pochodne dioksano-2- alkilokarbaminianów, sposób ich wytwarzania, środek farmaceutyczny i ich zastosowanie
CA2496040A CA2496040C (en) 2002-08-29 2003-08-27 Derivatives of dioxan-2-alkyl carbamates, preparation method thereof and application of same in therapeutics
RSP-2010/0169A RS20100169A (sr) 2002-08-29 2003-08-27 Intermedijeri za dobijanje dioksan-2-alkilkarbamata
JP2004532233A JP4585854B2 (ja) 2002-08-29 2003-08-27 ジオキサン−２−アルキルカルバメート誘導体、その製造法および治療における適用
UAA200501766A UA82847C2 (en) 2002-08-29 2003-08-27 Derivatives of dioxane-2-alkyl carbamates, method for the preparation thereof and application of same in therapeutics
ES07013954T ES2329181T3 (es) 2002-08-29 2003-08-27 Compuestos intermedios para la produccion de dioxano-2-alquil-carbamatos.
EP07013954A EP1840125B1 (fr) 2002-08-29 2003-08-27 Intermédiaires pour la production de dioxane-2-alkylcarbamates
KR1020107028059A KR101139160B1 (ko) 2002-08-29 2003-08-27 디옥산-2-알킬 카르바메이트의 유도체, 그의 제조 방법 및 치료법에서의 그의 적용
BR0313846-1A BR0313846A (pt) 2002-08-29 2003-08-27 Derivados de dioxano-2-alquilcarbamatos, sua preparação e sua aplicação em terapêutica
KR1020057003244A KR101051192B1 (ko) 2002-08-29 2003-08-27 디옥산-2-알킬 카르바메이트의 유도체, 그의 제조 방법 및치료법에서의 그의 적용
HRP20050190AA HRP20050190B1 (hr) 2002-08-29 2003-08-27 Derivati dioksan-2-alkil karbamata, metoda njihove pripreme i primjena istih u terapeutske svrhe
DE60328138T DE60328138D1 (de) 2002-08-29 2003-08-27 Zwischenprodukte für die Herstellung von Dioxan-2-alkylcarbamaten
PT07013954T PT1840125E (pt) 2002-08-29 2003-08-27 Intermediários para a produção de dioxano-2-alquilcarbamatos
CNB038241056A CN100491368C (zh) 2002-08-29 2003-08-27 二烷-2-烷基氨基甲酸酯衍生物,其制备及其在治疗学上的应用
TW096123915A TWI337606B (en) 2002-08-29 2003-08-28 Preparation method for dioxan-2-ylalkylcarbamate derivatives and intermediate thereof
TW092123746A TWI294878B (en) 2002-08-29 2003-08-28 Dioxan-2-ylalkylcarbamate derivatives, their preparation and their use in therapeutics
MEP-2008-242A ME00108B (me) 2002-08-29 2004-03-11 DE RIVATI DIOKSAN-2-ALKILKARBAMATA, POSTUPAK ZA NJIHOVO DOBIJANJ E l PRIMENA ISTIH U TERAPEUTICIMA
IL166882A IL166882A (en) 2002-08-29 2005-02-14 Derivatives of dioxane-2-alkyl carbamates, preparation method thereof and application of same in therapeutics
IS7699A IS2733B (is) 2002-08-29 2005-02-17 Afleiður af díoxan-2-alkýlkarbamötum, framleiðsluaðferð þeirra, milliefni notuð við framleiðsluna, og notkun þeirra í meðferð.
US11/062,541 US7119116B2 (en) 2002-08-29 2005-02-22 Derivatives of dioxane-2-alkyl carbamates, preparation thereof and application thereof in therapeutics
CO05017682A CO5700820A2 (es) 2002-08-29 2005-02-24 Derivados de dioxan-2-alquilcarbamatos, su preparacion y su aplicacion en terapeutica
NO20051051A NO331165B1 (no) 2002-08-29 2005-02-25 Derivater av dioksan-2-alkylkarbamater, fremgangsmate for fremstilling derav og anvendelse av de samme for fremstilling av medikamenter
TNP2005000057A TNSN05057A1 (fr) 2002-08-29 2005-02-25 Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
MA28125A MA27390A1 (fr) 2002-08-29 2005-02-28 Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
HK08101677.0A HK1108157B (en) 2002-08-29 2005-09-23 Intermediates for the preparation of dioxane-2-alkyl carbamates
US11/426,964 US20060247290A1 (en) 2002-08-29 2006-06-28 Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics
CY20081101445T CY1108792T1 (el) 2002-08-29 2008-12-12 Παραγωγα διοξανιου-2-αλκυλκαρβαμικου, η παρασκευη τους και η εφαρμογη τους στην θεραπευτικη αγωγη
US12/510,326 US7777057B2 (en) 2002-08-29 2009-07-28 Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics
CY20091100995T CY1109441T1 (el) 2002-08-29 2009-09-24 Ενδιαμεσα προϊοντα για την παραγωγη διοξανιου-2-αλκυλκαρβαμικου
JP2010139427A JP5244863B2 (ja) 2002-08-29 2010-06-18 ジオキサン−２−アルキルカルバメート誘導体の製造法およびその中間体
US12/834,268 US8119687B2 (en) 2002-08-29 2010-07-12 Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics
NO20110598A NO335866B1 (no) 2002-08-29 2011-04-15 Karbonatforbindelse

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ES2312808T3 (es) 2009-03-01
EP1840125B1 (fr) 2009-06-24
CN100491368C (zh) 2009-05-27
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CY1109441T1 (el) 2014-08-13
JP5244863B2 (ja) 2013-07-24
FR2843964A1 (fr) 2004-03-05
UA82847C2 (en) 2008-05-26
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US20100280076A1 (en) 2010-11-04
ATE434598T1 (de) 2009-07-15
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