FR2742751B1 - Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2742751B1
FR2742751B1 FR9515379A FR9515379A FR2742751B1 FR 2742751 B1 FR2742751 B1 FR 2742751B1 FR 9515379 A FR9515379 A FR 9515379A FR 9515379 A FR9515379 A FR 9515379A FR 2742751 B1 FR2742751 B1 FR 2742751B1
Authority
FR
France
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
novel taxoids
taxoids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9515379A
Other languages
English (en)
French (fr)
Other versions
FR2742751A1 (fr
Inventor
Herve Bouchard
Alain Commercon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Priority to FR9515379A priority Critical patent/FR2742751B1/fr
Priority to PE1996000871A priority patent/PE25198A1/es
Priority to MA24431A priority patent/MA26412A1/fr
Priority to JP52336197A priority patent/JP3953106B2/ja
Priority to TW085115683A priority patent/TW371659B/zh
Priority to IL12499496A priority patent/IL124994A/xx
Priority to CA002238884A priority patent/CA2238884C/fr
Priority to SK853-98A priority patent/SK282835B6/sk
Priority to EP96942433A priority patent/EP0876362B1/fr
Priority to CZ19981961A priority patent/CZ294972B6/cs
Priority to PT96942433T priority patent/PT876362E/pt
Priority to AT96942433T priority patent/ATE250593T1/de
Priority to HU9904046A priority patent/HU225032B1/hu
Priority to DK96942433T priority patent/DK0876362T3/da
Priority to BR9612135A priority patent/BR9612135A/pt
Priority to CN96199168A priority patent/CN1103766C/zh
Priority to ZA9610737A priority patent/ZA9610737B/xx
Priority to NZ324337A priority patent/NZ324337A/xx
Priority to TR1998/01179T priority patent/TR199801179T2/xx
Priority to HK99102999.9A priority patent/HK1017895B/xx
Priority to EA199800588A priority patent/EA001533B1/ru
Priority to RO98-01093A priority patent/RO116194B1/ro
Priority to ES96942433T priority patent/ES2202490T3/es
Priority to KR10-1998-0704792A priority patent/KR100500351B1/ko
Priority to PCT/FR1996/002031 priority patent/WO1997023473A1/fr
Priority to UA98063216A priority patent/UA48205C2/uk
Priority to AU11809/97A priority patent/AU712597B2/en
Priority to PL96327405A priority patent/PL189311B1/pl
Priority to DE69630145T priority patent/DE69630145T2/de
Priority to MYPI96005421A priority patent/MY113934A/en
Priority to TNTNSN96169A priority patent/TNSN96169A1/fr
Priority to US08/771,751 priority patent/US5728849A/en
Priority to IN2893DE1996 priority patent/IN186768B/en
Priority to CO96067023A priority patent/CO4520184A1/es
Priority to ARP960105851A priority patent/AR005197A1/es
Priority to DZ960194A priority patent/DZ2149A1/fr
Publication of FR2742751A1 publication Critical patent/FR2742751A1/fr
Application granted granted Critical
Publication of FR2742751B1 publication Critical patent/FR2742751B1/fr
Priority to NO19982580A priority patent/NO317358B1/no
Priority to MX9804688A priority patent/MX9804688A/es
Priority to OA9800087A priority patent/OA10700A/fr
Priority to BG102569A priority patent/BG63204B1/bg
Priority to IN419DE2000 priority patent/IN188680B/en
Priority to IN420DE2000 priority patent/IN188469B/en
Priority to IN421DE2000 priority patent/IN188470B/en
Priority to UY24386A priority patent/UY24386A1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR9515379A 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2742751B1 (fr)

Priority Applications (44)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PE1996000871A PE25198A1 (es) 1995-12-22 1996-12-04 Nuevos taxoides, su preparacion y las composiciones farmaceuticas que las contienen
MA24431A MA26412A1 (fr) 1995-12-22 1996-12-18 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
JP52336197A JP3953106B2 (ja) 1995-12-22 1996-12-19 新規なタキソイド、その製造及びそれを含有する製薬学的組成物
TW085115683A TW371659B (en) 1995-12-22 1996-12-19 Taxoids their preparation and pharmaceutical compositions containing them
IL12499496A IL124994A (en) 1995-12-22 1996-12-19 Taxoids preparation thereof and pharmaceutical compositions containing same
CA002238884A CA2238884C (fr) 1995-12-22 1996-12-19 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
SK853-98A SK282835B6 (sk) 1995-12-22 1996-12-19 Taxoidy, spôsob ich prípravy a farmaceutické kompozície tieto taxoidy obsahujúce
EP96942433A EP0876362B1 (fr) 1995-12-22 1996-12-19 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
CZ19981961A CZ294972B6 (cs) 1995-12-22 1996-12-19 Taxoidy, meziprodukty pro jejich přípravu, způsoby přípravy taxoidů a farmaceutická kompozice tyto taxoidy obsahující
PT96942433T PT876362E (pt) 1995-12-22 1996-12-19 Novos taxoides sua preparacao e composicoes farmaceuticas que os contem
AT96942433T ATE250593T1 (de) 1995-12-22 1996-12-19 Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
HU9904046A HU225032B1 (en) 1995-12-22 1996-12-19 Novel taxoids, preparation thereof and pharmaceutical compositions containing the same
DK96942433T DK0876362T3 (da) 1995-12-22 1996-12-19 Nye taxoider, deres fremstilling og farmaceutiske præparater deraf
BR9612135A BR9612135A (pt) 1995-12-22 1996-12-19 Taxóides processo para sua preparação e composiç o farmacêutica
CN96199168A CN1103766C (zh) 1995-12-22 1996-12-19 新的紫杉化合物、其制备方法及其药物组合物
ZA9610737A ZA9610737B (en) 1995-12-22 1996-12-19 Taxoids their preparation and pharmaceutical compositions containing them
NZ324337A NZ324337A (en) 1995-12-22 1996-12-19 Taxoids, preparation thereof and pharmaceutical compositions containing same
TR1998/01179T TR199801179T2 (xx) 1995-12-22 1996-12-19 Yeni taksoitler, bunlar�n haz�rlanmalar� ve ila� bile�imleri.
HK99102999.9A HK1017895B (en) 1995-12-22 1996-12-19 Novel taxoids, preparation thereof and pharmaceutical compositions containing same
EA199800588A EA001533B1 (ru) 1995-12-22 1996-12-19 Новые таксоиды, их получение и содержащие их фармацевтические композиции
RO98-01093A RO116194B1 (ro) 1995-12-22 1996-12-19 Taxoide, procedeu pentru prepararea acestora si compozitie farmaceutica
ES96942433T ES2202490T3 (es) 1995-12-22 1996-12-19 Nuevos taxoides, su preparacion y composiciones farmaceuticas que los contienen.
KR10-1998-0704792A KR100500351B1 (ko) 1995-12-22 1996-12-19 택소이드, 이의 제조방법 및 이를 함유하는 약학 조성물
PCT/FR1996/002031 WO1997023473A1 (fr) 1995-12-22 1996-12-19 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
UA98063216A UA48205C2 (uk) 1995-12-22 1996-12-19 Таксоїди, способи їх одержання та фармацевтична композиція, що їх містить
AU11809/97A AU712597B2 (en) 1995-12-22 1996-12-19 Novel taxoids, their preparation and pharmaceutical compositions containing them
PL96327405A PL189311B1 (pl) 1995-12-22 1996-12-19 Nowe taksoidy, sposób ich wytwarzania i kompozycje farmaceutyczne zawierające te związki
DE69630145T DE69630145T2 (de) 1995-12-22 1996-12-19 Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
MYPI96005421A MY113934A (en) 1995-12-22 1996-12-20 Taxoids their preparation and pharmaceutical compositions containing them
TNTNSN96169A TNSN96169A1 (fr) 1995-12-22 1996-12-20 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent.
US08/771,751 US5728849A (en) 1995-12-22 1996-12-20 Taxoids their preparation and pharmaceutical compositions containing them
IN2893DE1996 IN186768B (enExample) 1995-12-22 1996-12-20
CO96067023A CO4520184A1 (es) 1995-12-22 1996-12-20 Nuevos taxoides, su preparacion y composiciones farmaceuticas que les contienen
ARP960105851A AR005197A1 (es) 1995-12-22 1996-12-20 Derivados de taxoides, su preparacion y composiciones farmaceuticas que los contienen
DZ960194A DZ2149A1 (fr) 1995-12-22 1996-12-21 Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
NO19982580A NO317358B1 (no) 1995-12-22 1998-06-05 Nye taxoider, deres fremstilling samt farmasoystiske preparater inneholdende taxoidene
MX9804688A MX9804688A (es) 1995-12-22 1998-06-11 Nuevos taxoides, su preparacion y las composiciones farmaceuticas que los contienen.
OA9800087A OA10700A (fr) 1995-12-22 1998-06-19 Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
BG102569A BG63204B1 (bg) 1995-12-22 1998-06-22 Нови таксоиди, получаването им и фармацевтични състави, които ги съдържат
IN419DE2000 IN188680B (enExample) 1995-12-22 2000-04-10
IN420DE2000 IN188469B (enExample) 1995-12-22 2000-04-10
IN421DE2000 IN188470B (enExample) 1995-12-22 2000-04-10
UY24386A UY24386A1 (es) 1995-12-22 2000-12-02 Nuevos taxoides, su preparación y composiciones farmacéuticas que los contienen.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2742751A1 FR2742751A1 (fr) 1997-06-27
FR2742751B1 true FR2742751B1 (fr) 1998-01-30

Family

ID=9485871

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9515379A Expired - Fee Related FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Country Status (40)

Country Link
US (1) US5728849A (enExample)
EP (1) EP0876362B1 (enExample)
JP (1) JP3953106B2 (enExample)
KR (1) KR100500351B1 (enExample)
CN (1) CN1103766C (enExample)
AR (1) AR005197A1 (enExample)
AT (1) ATE250593T1 (enExample)
AU (1) AU712597B2 (enExample)
BG (1) BG63204B1 (enExample)
BR (1) BR9612135A (enExample)
CA (1) CA2238884C (enExample)
CO (1) CO4520184A1 (enExample)
CZ (1) CZ294972B6 (enExample)
DE (1) DE69630145T2 (enExample)
DK (1) DK0876362T3 (enExample)
DZ (1) DZ2149A1 (enExample)
EA (1) EA001533B1 (enExample)
ES (1) ES2202490T3 (enExample)
FR (1) FR2742751B1 (enExample)
HU (1) HU225032B1 (enExample)
IL (1) IL124994A (enExample)
IN (4) IN186768B (enExample)
MA (1) MA26412A1 (enExample)
MX (1) MX9804688A (enExample)
MY (1) MY113934A (enExample)
NO (1) NO317358B1 (enExample)
NZ (1) NZ324337A (enExample)
OA (1) OA10700A (enExample)
PE (1) PE25198A1 (enExample)
PL (1) PL189311B1 (enExample)
PT (1) PT876362E (enExample)
RO (1) RO116194B1 (enExample)
SK (1) SK282835B6 (enExample)
TN (1) TNSN96169A1 (enExample)
TR (1) TR199801179T2 (enExample)
TW (1) TW371659B (enExample)
UA (1) UA48205C2 (enExample)
UY (1) UY24386A1 (enExample)
WO (1) WO1997023473A1 (enExample)
ZA (1) ZA9610737B (enExample)

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KR20120107080A (ko) 2009-11-27 2012-09-28 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
CN107961377B (zh) 2010-05-05 2022-11-22 勃林格殷格翰国际有限公司 组合疗法
KR20130093012A (ko) 2010-06-24 2013-08-21 베링거 인겔하임 인터내셔날 게엠베하 당뇨병 요법
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
EP3517539B1 (en) 2011-07-15 2022-12-14 Boehringer Ingelheim International GmbH Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
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FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
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JP6615109B2 (ja) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用
EP3319936B1 (en) 2015-07-12 2025-12-17 Hangzhou Dac Biotech Co., Ltd. Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
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CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联

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Also Published As

Publication number Publication date
HUP9904046A3 (en) 2001-08-28
EA199800588A1 (ru) 1998-12-24
TNSN96169A1 (fr) 2005-03-15
CN1103766C (zh) 2003-03-26
HU225032B1 (en) 2006-05-29
ES2202490T3 (es) 2004-04-01
AU1180997A (en) 1997-07-17
DE69630145T2 (de) 2004-07-15
DK0876362T3 (da) 2004-02-02
TR199801179T2 (xx) 1998-10-21
HUP9904046A1 (hu) 2001-04-28
PE25198A1 (es) 1998-05-10
AU712597B2 (en) 1999-11-11
CZ196198A3 (cs) 1998-09-16
US5728849A (en) 1998-03-17
UA48205C2 (uk) 2002-08-15
ZA9610737B (en) 1997-06-27
MX9804688A (es) 1998-10-31
DE69630145D1 (de) 2003-10-30
IL124994A0 (en) 1999-01-26
PL189311B1 (pl) 2005-07-29
SK85398A3 (en) 1998-11-04
JP3953106B2 (ja) 2007-08-08
OA10700A (fr) 2002-11-27
MY113934A (en) 2002-06-29
UY24386A1 (es) 2001-08-27
EP0876362A1 (fr) 1998-11-11
ATE250593T1 (de) 2003-10-15
JP2000502671A (ja) 2000-03-07
NO317358B1 (no) 2004-10-18
FR2742751A1 (fr) 1997-06-27
CZ294972B6 (cs) 2005-04-13
BG102569A (en) 1999-04-30
NO982580L (no) 1998-06-05
RO116194B1 (ro) 2000-11-30
EA001533B1 (ru) 2001-04-23
TW371659B (en) 1999-10-11
NZ324337A (en) 2000-03-27
BR9612135A (pt) 1999-07-13
WO1997023473A1 (fr) 1997-07-03
CN1205697A (zh) 1999-01-20
BG63204B1 (bg) 2001-06-29
KR100500351B1 (ko) 2005-12-21
KR19990076680A (ko) 1999-10-15
CO4520184A1 (es) 1997-10-15
IN186768B (enExample) 2001-11-03
PL327405A1 (en) 1998-12-07
HK1017895A1 (en) 1999-12-03
EP0876362B1 (fr) 2003-09-24
NO982580D0 (no) 1998-06-05
IN188469B (enExample) 2002-09-28
CA2238884C (fr) 2007-02-06
MA26412A1 (fr) 2004-12-20
CA2238884A1 (fr) 1997-07-03
AR005197A1 (es) 1999-04-14
IL124994A (en) 2000-12-06
DZ2149A1 (fr) 2002-10-23
IN188680B (enExample) 2002-10-26
SK282835B6 (sk) 2002-12-03
IN188470B (enExample) 2002-09-28
PT876362E (pt) 2004-02-27

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