FR2454438B1 - - Google Patents

Info

Publication number
FR2454438B1
FR2454438B1 FR8006019A FR8006019A FR2454438B1 FR 2454438 B1 FR2454438 B1 FR 2454438B1 FR 8006019 A FR8006019 A FR 8006019A FR 8006019 A FR8006019 A FR 8006019A FR 2454438 B1 FR2454438 B1 FR 2454438B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8006019A
Other languages
French (fr)
Other versions
FR2454438A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riker Laboratories Inc
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of FR2454438A1 publication Critical patent/FR2454438A1/fr
Application granted granted Critical
Publication of FR2454438B1 publication Critical patent/FR2454438B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8006019A 1979-03-19 1980-03-18 Procede de preparation de 2,5-bis(2,2,2-trifluorethoxy)-n-(2-piperidylmethyl)benzamide Granted FR2454438A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2133179A 1979-03-19 1979-03-19
US2133279A 1979-03-19 1979-03-19

Publications (2)

Publication Number Publication Date
FR2454438A1 FR2454438A1 (fr) 1980-11-14
FR2454438B1 true FR2454438B1 (xx) 1982-07-23

Family

ID=26694559

Family Applications (7)

Application Number Title Priority Date Filing Date
FR8006019A Granted FR2454438A1 (fr) 1979-03-19 1980-03-18 Procede de preparation de 2,5-bis(2,2,2-trifluorethoxy)-n-(2-piperidylmethyl)benzamide
FR8100145A Granted FR2468591A1 (fr) 1979-03-19 1981-01-07 Procede de preparation de 2,5-bis(2,2,2-trifluorethoxy)-n-(2-piperidylmethyl)benzamide a partir du chlorure de l'acide 2,5-bis(2,2,2-trifluorethoxy)benzoique
FR8100142A Granted FR2468571A1 (fr) 1979-03-19 1981-01-07 2,5-bis (2,2,2-trifluorethoxy)-a,a,a-trichloracetophenone, procede pour sa preparation et son application a la fabrication de medicament connu
FR8100140A Granted FR2468569A1 (fr) 1979-03-19 1981-01-07 2,5-bis (2,2,2-trifluorethoxy) acetophenone, procede pour sa preparation et son application a la fabrication de medicament connu
FR8100141A Granted FR2468570A1 (fr) 1979-03-19 1981-01-07 2,5-bis (2,2,2-trifluorethoxy)-a, a-dichloracetophenone, procede pour sa preparation et son application a la fabrication de medicament connu
FR8100143A Granted FR2468576A1 (fr) 1979-03-19 1981-01-07 Procede de preparation de l'acide 2,5-bis (2,2,2-trifluorethoxy)-benzoique
FR8100144A Granted FR2468590A1 (fr) 1979-03-19 1981-01-07 Procede de preparation de 2,5-bis (2,2,2-trifluorethoxy)-n-(2-piperidylmethyl) benzamide a partir de 2,5-bis (2,2,2-trifluorethoxy)-a, a, a-trichloracetophenone

Family Applications After (6)

Application Number Title Priority Date Filing Date
FR8100145A Granted FR2468591A1 (fr) 1979-03-19 1981-01-07 Procede de preparation de 2,5-bis(2,2,2-trifluorethoxy)-n-(2-piperidylmethyl)benzamide a partir du chlorure de l'acide 2,5-bis(2,2,2-trifluorethoxy)benzoique
FR8100142A Granted FR2468571A1 (fr) 1979-03-19 1981-01-07 2,5-bis (2,2,2-trifluorethoxy)-a,a,a-trichloracetophenone, procede pour sa preparation et son application a la fabrication de medicament connu
FR8100140A Granted FR2468569A1 (fr) 1979-03-19 1981-01-07 2,5-bis (2,2,2-trifluorethoxy) acetophenone, procede pour sa preparation et son application a la fabrication de medicament connu
FR8100141A Granted FR2468570A1 (fr) 1979-03-19 1981-01-07 2,5-bis (2,2,2-trifluorethoxy)-a, a-dichloracetophenone, procede pour sa preparation et son application a la fabrication de medicament connu
FR8100143A Granted FR2468576A1 (fr) 1979-03-19 1981-01-07 Procede de preparation de l'acide 2,5-bis (2,2,2-trifluorethoxy)-benzoique
FR8100144A Granted FR2468590A1 (fr) 1979-03-19 1981-01-07 Procede de preparation de 2,5-bis (2,2,2-trifluorethoxy)-n-(2-piperidylmethyl) benzamide a partir de 2,5-bis (2,2,2-trifluorethoxy)-a, a, a-trichloracetophenone

Country Status (14)

Country Link
JP (8) JPH01125344A (xx)
CA (1) CA1137486A (xx)
CH (1) CH643829A5 (xx)
DE (1) DE3010195A1 (xx)
DK (3) DK167062B1 (xx)
ES (1) ES8104227A1 (xx)
FR (7) FR2454438A1 (xx)
GB (2) GB2045760B (xx)
IE (1) IE49558B1 (xx)
IL (1) IL59623A (xx)
IT (1) IT1195262B (xx)
NL (1) NL191486C (xx)
PT (1) PT70967A (xx)
SE (5) SE447992B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2519980A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de sulfonylation d'halogeno ou trihalogenomethylbenzenes
FR2519979A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de preparation de trifluoromethoxy ou trifluoromethylthiophenylsulfones
FR2519974A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede d'acylation d'halogeno ou trihalogenomethylbenzenes
FR2519975A1 (fr) * 1982-01-21 1983-07-22 Rhone Poulenc Spec Chim Procede de preparation de trifluoromethoxy ou trifluoromethylthiophenylcetones
FR2525588A1 (fr) * 1982-04-22 1983-10-28 Rhone Poulenc Spec Chim Procede de preparation de phenylcetones a partir d'halogeno ou trihalogenomethylbenzenes et de composes aliphatiques ou aromatiques trihalogenomethyles
EP0175188A1 (de) * 1984-09-11 1986-03-26 Nihon Tokushu Noyaku Seizo K.K. Carbamoylimidazol-Derivate
US4675448A (en) * 1985-02-13 1987-06-23 Ethyl Corporation Chlorination process
FR2579591B1 (fr) * 1985-03-29 1988-10-14 Rhone Poulenc Spec Chim Procede de preparation de derives pentafluoroethoxy et pentafluoroethylthiobenzeniques
FR2579594B1 (fr) * 1985-03-29 1987-06-05 Rhone Poulenc Spec Chim Procede de preparation de trifluoroethoxy ou trifluoroethylthiobenzenes
DE3786037T2 (de) * 1986-04-25 1993-11-25 Abbott Lab Tracer zur Benutzung in immunologischen Fluoreszenz-Polarisationsverfahren zum Nachweis von Flecainid.
NZ219913A (en) * 1986-04-25 1990-08-28 Riker Laboratories Inc Various flecainide derivatives and antibodies raised thereto
DE3644798A1 (de) * 1986-12-31 1988-07-14 Hoechst Ag Neue nitrohaloalkoxybenzole, verfahren zu ihrer herstellung und ihre verwendung
FR2640262B1 (fr) * 1988-12-14 1991-05-31 Rhone Poulenc Chimie Procede de preparation de cetones aryliques trifluoroethoxylees
US6316627B1 (en) * 1997-04-21 2001-11-13 Fine Tech Ltd. Process for the preparation of flecainide
IL120715A (en) * 1997-04-21 2000-07-16 Finetech Ltd Process for the preparation of (2,2,2,-trifluoroethoxy)benzoic acids
IL121288A (en) 1997-07-11 2000-10-31 Finetech Ltd Process and a novel intermediate for the preparation of flecainide
US7196197B2 (en) 2003-09-17 2007-03-27 Apotex Pharmachem Inc. Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof
JP4894226B2 (ja) * 2005-10-31 2012-03-14 Ｄｉｃ株式会社 ハイドロキノン骨格を有する含フッ素液晶化合物の製造方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539642A (en) * 1967-07-19 1970-11-10 Geigy Chem Corp 2-phenyl-2-(1-naphthyl)acetamides
US3772304A (en) * 1969-10-30 1973-11-13 Hoffmann La Roche 4-hydroxy-isoquinolines and processes for their preparation
US3719687A (en) * 1970-07-22 1973-03-06 Riker Laboratories Inc N-(2-dialkylaminoalkylene)amides of 1,1-dihydroperfluoroalkoxy-substituted aryl acids and salts thereof
US3655728A (en) 1970-07-22 1972-04-11 Riker Laboratories Inc N-(2 - dialkylaminoalkylene)-esters of fluoroalkoxy-substituted aryl carboxylic acid and salts thereof
US3967949A (en) * 1973-06-18 1976-07-06 Eli Lilly And Company Fluoroalkoxyphenyl-substituted nitrogen heterocycles as plant stunting agents
US4169108A (en) * 1973-08-16 1979-09-25 Sterling Drug Inc. 5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols
US4005209A (en) * 1974-04-01 1977-01-25 Riker Laboratories, Inc. Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides
US3900481A (en) * 1974-04-01 1975-08-19 Riker Laboratories Inc Derivatives of pyrrolidine and piperidine
US4013670A (en) * 1974-04-01 1977-03-22 Riker Laboratories, Inc. Derivatives of pyrrolidine and piperidine
IL49803A (en) * 1975-06-28 1979-11-30 Fisons Ltd Preparation of pyrogallol
DE2616478C2 (de) * 1976-04-14 1986-05-22 Brickl, Rolf, Dr., 7951 Warthausen Fluoracylresorcine enthaltende Arzneimittel, Biocide und Kosmetika
JPS6023656B2 (ja) * 1976-09-02 1985-06-08 川研フアインケミカル株式会社 アルコキシ芳香族化合物の製造方法
US4071524A (en) * 1976-11-08 1978-01-31 Riker Laboratories, Inc. Derivatives of urea
US4097481A (en) * 1976-11-08 1978-06-27 Riker Laboratories, Inc. Tertiary amide derivatives of pyrrolidine and piperidine

Also Published As

Publication number Publication date
FR2468569A1 (fr) 1981-05-08
FR2468570B1 (xx) 1983-03-11
FR2468576B1 (xx) 1983-01-21
JPH0372212B2 (xx) 1991-11-18
DK112180A (da) 1980-09-20
SE8901532L (sv) 1989-04-27
JPH01104043A (ja) 1989-04-21
PT70967A (en) 1980-04-01
NL191486C (nl) 1995-08-04
SE463260B (sv) 1990-10-29
ES489629A0 (es) 1981-04-01
FR2468570A1 (fr) 1981-05-08
SE8901533L (sv) 1989-04-27
ES8104227A1 (es) 1981-04-01
DK164857C (da) 1993-01-18
FR2468591A1 (fr) 1981-05-08
DE3010195C2 (xx) 1990-10-25
SE463419B (sv) 1990-11-19
SE8002003L (sv) 1980-09-20
FR2468571A1 (fr) 1981-05-08
FR2468590B1 (xx) 1983-09-23
JPH022870B2 (xx) 1990-01-19
GB2097000A (en) 1982-10-27
SE8401554D0 (sv) 1984-03-21
IL59623A (en) 1983-07-31
SE8901533D0 (sv) 1989-04-27
GB2097000B (en) 1983-11-30
GB2045760B (en) 1983-05-11
JPH0339498B2 (xx) 1991-06-14
JPH01104044A (ja) 1989-04-21
JPH01125339A (ja) 1989-05-17
FR2468591B1 (xx) 1983-07-22
DK122290D0 (da) 1990-05-17
SE8401554L (sv) 1984-03-21
CA1137486A (en) 1982-12-14
DE3010195A1 (de) 1980-10-02
JPH01104045A (ja) 1989-04-21
SE8401555L (sv) 1984-03-21
NL8001551A (nl) 1980-09-23
SE447993B (sv) 1987-01-12
IT1195262B (it) 1988-10-12
JPH01125341A (ja) 1989-05-17
SE463418B (sv) 1990-11-19
IE800549L (en) 1980-09-19
JPH01125343A (ja) 1989-05-17
FR2468576A1 (fr) 1981-05-08
JPH01125344A (ja) 1989-05-17
IL59623A0 (en) 1980-06-30
FR2468571B1 (xx) 1983-03-11
JPH01125342A (ja) 1989-05-17
DK167062B1 (da) 1993-08-23
IT8020746A0 (it) 1980-03-18
IE49558B1 (en) 1985-10-30
DK79891A (da) 1991-04-30
DK122290A (da) 1990-05-17
SE8401555D0 (sv) 1984-03-21
FR2468569B1 (xx) 1983-03-11
FR2468590A1 (fr) 1981-05-08
JPH0149695B2 (xx) 1989-10-25
JPH022869B2 (xx) 1990-01-19
JPH0251908B2 (xx) 1990-11-08
SE8901532D0 (sv) 1989-04-27
NL191486B (nl) 1995-04-03
DK164857B (da) 1992-08-31
JPH0251907B2 (xx) 1990-11-08
JPH0251906B2 (xx) 1990-11-08
SE447992B (sv) 1987-01-12
DK79891D0 (da) 1991-04-30
CH643829A5 (de) 1984-06-29
FR2454438A1 (fr) 1980-11-14
GB2045760A (en) 1980-11-05

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Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0281, 920525

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0281, 800318

CL Concession to grant licences
CA Change of address

Spc suppl protection certif: 92C0281

CL Concession to grant licences

Spc suppl protection certif: 92C0281

TP Transmission of property

Spc suppl protection certif: 92C0281