FR2447966A1 - Conjugues analogue de ligand-inhibiteur enzymatique irreversible et procedes pour la determination des ligands les utilisant - Google Patents

Conjugues analogue de ligand-inhibiteur enzymatique irreversible et procedes pour la determination des ligands les utilisant

Info

Publication number
FR2447966A1
FR2447966A1 FR8002385A FR8002385A FR2447966A1 FR 2447966 A1 FR2447966 A1 FR 2447966A1 FR 8002385 A FR8002385 A FR 8002385A FR 8002385 A FR8002385 A FR 8002385A FR 2447966 A1 FR2447966 A1 FR 2447966A1
Authority
FR
France
Prior art keywords
ligand
inhibitor
irreversible
ligan
analogue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8002385A
Other languages
English (en)
Other versions
FR2447966B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of FR2447966A1 publication Critical patent/FR2447966A1/fr
Application granted granted Critical
Publication of FR2447966B1 publication Critical patent/FR2447966B1/fr
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

POUR DETERMINER DES LIGANDS DANS DES ECHANTILLONS ANALYTIQUES, ON MELANGE L'ECHANTILLON A UN CONJUGUE ANALOGUE DE LIGAND-INHIBITEUR ENZYMATIQUE IRREVERSIBLE ET UNE PROTEINE FIXANTE POUVANT SE FIXER AU LIGAND ET AU CONJUGUE ANALOGUE DE LIGAND-INHIBITEUR ENZYMATIQUE IRREVERSIBLE, LA QUANTITE DE CONJUGUE ANALOGUE DE LIGAND-INHIBITEUR ENZYMATIQUE IRREVERSIBLE FIXEE PAR LA PROTEINE FIXANTE ETANT EN RELATION AVEC LA QUANTITE DE LIGAND DANS L'ECHANTILLON A ANALYSER, CETTE PROTEINE FIXANTE INACTIVANT L'INHIBITEUR ENZYMATIQUE IRREVERSIBLE LORSQU'ELLE EST FIXEE A LA PORTION D'ANALOGUE DE LIGAND DU CONJUGUE; MELANGER UNE ENZYME QUI EST INHIBEE DE FACON IRREVERSIBLE PAR LE CONJUGUE ANALOGUE DE LIGAND-INHIBITEUR ENZYMATIQUE IRREVERSIBLE NON FIXE PAR LA PROTEINE FIXANTE; MELANGER A UN SUBSTRAT DE L'ENZYME ET SUIVRE LA REACTION ENTRE L'ENZYME ET LE SUBSTRAT; DES CONJUGUES ANALOGUE DE LIGAND-INHIBITEUR ENZYMATIQUE IRREVERSIBLE UTILES COMME REACTIFS DANS LA PRATIQUE DU PROCEDE SONT EGALEMENT DECRITS AINSI QUE DES DETERMINATIONS DE MEDICAMENTS, D'HORMONES ET SIMILAIRES DANS DES LIQUIDES BIOLOGIQUES.
FR8002385A 1979-02-05 1980-02-04 Conjugues analogue de ligand-inhibiteur enzymatique irreversible et procedes pour la determination des ligands les utilisant Granted FR2447966A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/009,007 US4273866A (en) 1979-02-05 1979-02-05 Ligand analog-irreversible enzyme inhibitor conjugates and methods for use

Publications (2)

Publication Number Publication Date
FR2447966A1 true FR2447966A1 (fr) 1980-08-29
FR2447966B1 FR2447966B1 (fr) 1984-10-19

Family

ID=21735028

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8002385A Granted FR2447966A1 (fr) 1979-02-05 1980-02-04 Conjugues analogue de ligand-inhibiteur enzymatique irreversible et procedes pour la determination des ligands les utilisant

Country Status (15)

Country Link
US (1) US4273866A (fr)
JP (1) JPS55104896A (fr)
AT (1) AT365781B (fr)
AU (1) AU528592B2 (fr)
BE (1) BE881557A (fr)
CA (1) CA1137077A (fr)
CH (1) CH641569A5 (fr)
DE (1) DE3003959C2 (fr)
ES (1) ES488263A0 (fr)
FR (1) FR2447966A1 (fr)
GB (1) GB2043245B (fr)
IT (1) IT1130254B (fr)
NL (1) NL8000698A (fr)
SE (1) SE448259B (fr)
ZA (1) ZA80371B (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981001414A1 (fr) * 1979-11-19 1981-05-28 Charles Hospital Dev Procede ameliore d'analyse immunologique d'enzymes non homogenes
EP0034775A2 (fr) * 1980-02-22 1981-09-02 Hans A. Dr. Thoma Procédé homogène pour la détermination sélective de ligands
EP0117648A2 (fr) * 1983-01-31 1984-09-05 Boots-Celltech Diagnostics Limited Immunoessai
EP0132292A2 (fr) * 1983-06-27 1985-01-30 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Méthode de mesure de ligands biologiques
WO1991013867A1 (fr) * 1990-03-07 1991-09-19 Hoechst Aktiengesellschaft N-acyl-aminoalkyl-2-hydroxyethylsulfure et un procede de preparation
WO1995008559A1 (fr) * 1993-09-24 1995-03-30 The Procter & Gamble Company Nouveaux composes aminosteroides contenant de l'urethane

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4341865A (en) * 1980-07-21 1982-07-27 Abbott Laboratories Determination of thyroxine binding globulin
US4849353A (en) * 1980-09-30 1989-07-18 Cornell Research Foundation, Inc. Immunocapture of enzyme inhibitor, enzyme complexes and uses thereof
US4323647A (en) * 1980-10-15 1982-04-06 University Of Miami Steric hindrance enzyme immunoassay
DE3100061A1 (de) * 1981-01-02 1982-08-05 Hans A. Dipl.-Chem. Dr. 8000 München Thoma Verfahren zur bestimmung von liganden mittels kompetitionsreaktion
DE3100062A1 (de) * 1981-01-02 1982-08-05 Hans A. Dipl.-Chem. Dr. 8000 München Thoma Homogenes verfahren zur bestimmung von liganden
EP0079489A1 (fr) * 1981-11-04 1983-05-25 Miles Laboratories, Inc. Iodothyronine conjuguée marquée par du méthotrexate et méthode, réactif et dispositif d'épreuve pour la détermination d'iodothyronine ou de l'absorption d'iodothyronine dans un échantillon liquide
US4451652A (en) * 1982-05-24 1984-05-29 Abbott Laboratories Substituted theophylline salts
US4472301A (en) * 1982-05-27 1984-09-18 Miles Laboratories, Inc. Propranolol immunogen and antibodies
US4650751A (en) * 1983-04-29 1987-03-17 Technicon Instruments Corporation Protected binding assay avoiding non-specific protein interference
US4550075A (en) * 1983-06-22 1985-10-29 Kallestad Laboratories, Inc. Method for ligand determination utilizing an immunoassay monitorable by biotin-containing enzymes, and compositions therefor
US4629694A (en) * 1983-07-12 1986-12-16 Cornell Research Foundation, Inc. Detecting and distinguishing between plasminogen activators
US4543412A (en) * 1983-11-04 1985-09-24 Abbott Laboratories Phenobarbital enzyme inhibitors
US4559173A (en) * 1983-11-04 1985-12-17 Abbott Laboratories N-substituted dibenz[b,f]azepine salts
IL73293A (en) * 1983-11-04 1988-02-29 Abbott Lab Methyl 2-(alkanamidoalkylsulfonic)ethylthiophosphonate derivatives
US5338663A (en) * 1990-08-24 1994-08-16 President And Fellows Of Harvard College Method of identifying inhibitors of β-protein esterase activity
JP2552049B2 (ja) * 1990-10-09 1996-11-06 舩越 節子 合成ペプチド精製方法およびこれに用いるリンカー、リンカー結合用固相担体
US5648462A (en) * 1990-10-09 1997-07-15 Setsuko Funakoshi Peptide purification method using novel linker and solid-phase ligand
JPH0737982B2 (ja) * 1992-12-14 1995-04-26 元成 狩野 抗胆汁酸抗体およびこれを用いた糞便中の胆汁酸検査方法
JPH09511496A (ja) * 1994-02-18 1997-11-18 セル・セラピューティックス・インコーポレーテッド 細胞内メッセンジャー
US6524808B1 (en) * 1999-06-25 2003-02-25 Roche Diagnostics Corporation Enzyme inhibition immunoassay
DE60037864T2 (de) * 1999-06-25 2009-01-22 Roche Diagnostics Gmbh Enzymhemmungsimmunverfahren
US6811998B2 (en) * 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
US8642273B2 (en) * 2002-04-16 2014-02-04 The Regents Of The University Of California Ligand sensing fluorescent acetylcholinesterase for detection of organophosphate activity
EP2523966B1 (fr) 2010-01-15 2017-10-04 Suzhou Neupharma Co., Ltd Certaines entités chimiques, compositions, et procédés associés
CN102656179B (zh) 2010-08-28 2015-07-29 苏州润新生物科技有限公司 蟾蜍灵衍生物、其药物组合物及用途
US9493503B2 (en) 2011-02-02 2016-11-15 Neupharma, Inc. Certain chemical entities, compositions, and methods
CN109354598A (zh) 2012-04-29 2019-02-19 润新生物公司 化学个体、药物组合物及癌症治疗方法
CN112114127A (zh) * 2020-09-09 2020-12-22 武汉生之源生物科技股份有限公司 一种甘胆酸均相酶免疫测定试剂盒及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2618511A1 (de) * 1975-04-28 1976-11-04 Miles Lab Verfahren zur bestimmung eines liganden in einem fluessigen medium und mittel zu dessen durchfuehrung
DE2754086A1 (de) * 1976-12-06 1978-06-22 Miles Lab Spezifisches bindungsverfahren zum nachweis und zur bestimmung eines liganden in einem fluessigen medium
DE2811257A1 (de) * 1977-03-15 1978-09-21 Hoffmann La Roche Immunologische bestimmung
DE2830862A1 (de) * 1977-07-14 1979-02-01 Syva Co Homogener, kompetitiver antienzym- bindungstest und reagenz zur durchfuehrung des verfahrens

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7512939A (nl) * 1975-11-04 1977-05-06 Tno Werkwijze en inrichtingen voor het aantonen en/of bepalen van alkylerende verbindingen, zoals mosterdgassen.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2618511A1 (de) * 1975-04-28 1976-11-04 Miles Lab Verfahren zur bestimmung eines liganden in einem fluessigen medium und mittel zu dessen durchfuehrung
DE2754086A1 (de) * 1976-12-06 1978-06-22 Miles Lab Spezifisches bindungsverfahren zum nachweis und zur bestimmung eines liganden in einem fluessigen medium
DE2811257A1 (de) * 1977-03-15 1978-09-21 Hoffmann La Roche Immunologische bestimmung
DE2830862A1 (de) * 1977-07-14 1979-02-01 Syva Co Homogener, kompetitiver antienzym- bindungstest und reagenz zur durchfuehrung des verfahrens

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CA1976 *
CA1977 *
CA1979 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981001414A1 (fr) * 1979-11-19 1981-05-28 Charles Hospital Dev Procede ameliore d'analyse immunologique d'enzymes non homogenes
EP0034775A2 (fr) * 1980-02-22 1981-09-02 Hans A. Dr. Thoma Procédé homogène pour la détermination sélective de ligands
EP0034775A3 (fr) * 1980-02-22 1981-09-09 Hans A. Dr. Thoma Procédé homogène pour la détermination sélective de ligands
EP0117648A2 (fr) * 1983-01-31 1984-09-05 Boots-Celltech Diagnostics Limited Immunoessai
EP0117648A3 (fr) * 1983-01-31 1988-02-03 Boots-Celltech Diagnostics Limited Immunoessai
EP0132292A2 (fr) * 1983-06-27 1985-01-30 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Méthode de mesure de ligands biologiques
EP0132292A3 (fr) * 1983-06-27 1988-01-07 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Méthode de mesure de ligands biologiques
WO1991013867A1 (fr) * 1990-03-07 1991-09-19 Hoechst Aktiengesellschaft N-acyl-aminoalkyl-2-hydroxyethylsulfure et un procede de preparation
US5278341A (en) * 1990-03-07 1994-01-11 Hoechst Aktiengesellschaft N-acylaminoalkyl 2-hydroxyethyl sulfides and a process for their preparation
WO1995008559A1 (fr) * 1993-09-24 1995-03-30 The Procter & Gamble Company Nouveaux composes aminosteroides contenant de l'urethane

Also Published As

Publication number Publication date
JPS55104896A (en) 1980-08-11
ES8101647A1 (es) 1980-12-16
SE8000843L (sv) 1980-08-06
SE448259B (sv) 1987-02-02
CH641569A5 (fr) 1984-02-29
GB2043245B (en) 1983-05-25
GB2043245A (en) 1980-10-01
CA1137077A (fr) 1982-12-07
IT8019675A0 (it) 1980-02-04
BE881557A (fr) 1980-08-05
ES488263A0 (es) 1980-12-16
FR2447966B1 (fr) 1984-10-19
US4273866A (en) 1981-06-16
ATA56080A (de) 1981-06-15
DE3003959A1 (de) 1980-08-14
AU5476380A (en) 1980-08-14
AT365781B (de) 1982-02-10
AU528592B2 (en) 1983-05-05
NL8000698A (nl) 1980-08-07
DE3003959C2 (de) 1982-12-23
IT1130254B (it) 1986-06-11
ZA80371B (en) 1981-03-25

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