SE8000843L - Konjugat av ligandanaloger och irreversibla enzyminhibitorer och forfarande for dess anvendning - Google Patents

Konjugat av ligandanaloger och irreversibla enzyminhibitorer och forfarande for dess anvendning

Info

Publication number
SE8000843L
SE8000843L SE8000843A SE8000843A SE8000843L SE 8000843 L SE8000843 L SE 8000843L SE 8000843 A SE8000843 A SE 8000843A SE 8000843 A SE8000843 A SE 8000843A SE 8000843 L SE8000843 L SE 8000843L
Authority
SE
Sweden
Prior art keywords
irreversible
ligand
enzyme inhibitor
ligand analog
binding protein
Prior art date
Application number
SE8000843A
Other languages
English (en)
Other versions
SE448259B (sv
Inventor
H F Voss
J Plattner
T R Herrin
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of SE8000843L publication Critical patent/SE8000843L/sv
Publication of SE448259B publication Critical patent/SE448259B/sv

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SE8000843A 1979-02-05 1980-02-01 Forfarande for bestemning av ligander i testprover och analytiskt reagens dertill SE448259B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/009,007 US4273866A (en) 1979-02-05 1979-02-05 Ligand analog-irreversible enzyme inhibitor conjugates and methods for use

Publications (2)

Publication Number Publication Date
SE8000843L true SE8000843L (sv) 1980-08-06
SE448259B SE448259B (sv) 1987-02-02

Family

ID=21735028

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8000843A SE448259B (sv) 1979-02-05 1980-02-01 Forfarande for bestemning av ligander i testprover och analytiskt reagens dertill

Country Status (15)

Country Link
US (1) US4273866A (sv)
JP (1) JPS55104896A (sv)
AT (1) AT365781B (sv)
AU (1) AU528592B2 (sv)
BE (1) BE881557A (sv)
CA (1) CA1137077A (sv)
CH (1) CH641569A5 (sv)
DE (1) DE3003959C2 (sv)
ES (1) ES488263A0 (sv)
FR (1) FR2447966A1 (sv)
GB (1) GB2043245B (sv)
IT (1) IT1130254B (sv)
NL (1) NL8000698A (sv)
SE (1) SE448259B (sv)
ZA (1) ZA80371B (sv)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981001414A1 (en) * 1979-11-19 1981-05-28 Charles Hospital Dev An improved method of non homogenous enzyme immunoassay
DE3006709A1 (de) * 1980-02-22 1981-08-27 Hans A. Dipl.-Chem. Dr. 8000 München Thoma Homogenes verfahren zur kompetitiven bestimmung von liganden
US4341865A (en) * 1980-07-21 1982-07-27 Abbott Laboratories Determination of thyroxine binding globulin
US4849353A (en) * 1980-09-30 1989-07-18 Cornell Research Foundation, Inc. Immunocapture of enzyme inhibitor, enzyme complexes and uses thereof
US4323647A (en) * 1980-10-15 1982-04-06 University Of Miami Steric hindrance enzyme immunoassay
DE3100062A1 (de) * 1981-01-02 1982-08-05 Hans A. Dipl.-Chem. Dr. 8000 München Thoma Homogenes verfahren zur bestimmung von liganden
DE3100061A1 (de) * 1981-01-02 1982-08-05 Hans A. Dipl.-Chem. Dr. 8000 München Thoma Verfahren zur bestimmung von liganden mittels kompetitionsreaktion
EP0079489A1 (en) * 1981-11-04 1983-05-25 Miles Laboratories, Inc. Methotrexate-labeled iodothyronine conjugates and method, reagent means and test device for the determination of iodothyronine in or iodothyronine uptake of a liquid sample
US4451652A (en) * 1982-05-24 1984-05-29 Abbott Laboratories Substituted theophylline salts
US4472301A (en) * 1982-05-27 1984-09-18 Miles Laboratories, Inc. Propranolol immunogen and antibodies
GB2135773B (en) * 1983-01-31 1985-12-04 Boots Celltech Diagnostics Enzyme inhibitor labelled immunoassay
US4650751A (en) * 1983-04-29 1987-03-17 Technicon Instruments Corporation Protected binding assay avoiding non-specific protein interference
US4550075A (en) * 1983-06-22 1985-10-29 Kallestad Laboratories, Inc. Method for ligand determination utilizing an immunoassay monitorable by biotin-containing enzymes, and compositions therefor
JPS607362A (ja) * 1983-06-27 1985-01-16 Fujirebio Inc 酵素を用いた抗原決定基具有物質の測定法
US4629694A (en) * 1983-07-12 1986-12-16 Cornell Research Foundation, Inc. Detecting and distinguishing between plasminogen activators
US4543412A (en) * 1983-11-04 1985-09-24 Abbott Laboratories Phenobarbital enzyme inhibitors
IL73293A (en) * 1983-11-04 1988-02-29 Abbott Lab Methyl 2-(alkanamidoalkylsulfonic)ethylthiophosphonate derivatives
US4559173A (en) * 1983-11-04 1985-12-17 Abbott Laboratories N-substituted dibenz[b,f]azepine salts
DE4007048A1 (de) * 1990-03-07 1991-09-12 Hoechst Ag N-acyl-aminoalkyl-2-hydroxyethylsulfide und ein verfahren zu ihrer herstellung
US5338663A (en) * 1990-08-24 1994-08-16 President And Fellows Of Harvard College Method of identifying inhibitors of β-protein esterase activity
US5648462A (en) * 1990-10-09 1997-07-15 Setsuko Funakoshi Peptide purification method using novel linker and solid-phase ligand
JP2552049B2 (ja) * 1990-10-09 1996-11-06 舩越 節子 合成ペプチド精製方法およびこれに用いるリンカー、リンカー結合用固相担体
JPH0737982B2 (ja) * 1992-12-14 1995-04-26 元成 狩野 抗胆汁酸抗体およびこれを用いた糞便中の胆汁酸検査方法
US5922703A (en) * 1993-09-24 1999-07-13 The Procter & Gamble Company Urethane-containing aminosteroid compounds
WO1995022546A1 (en) * 1994-02-18 1995-08-24 Cell Therapeutics, Inc. Intracellular signalling mediators
US6524808B1 (en) * 1999-06-25 2003-02-25 Roche Diagnostics Corporation Enzyme inhibition immunoassay
US6811998B2 (en) * 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
ES2298146T3 (es) * 1999-06-25 2008-05-16 Roche Diagnostics Operations, Inc. Inmunoensayo de inhibicion de enzimas.
WO2003089599A2 (en) * 2002-04-16 2003-10-30 The Regents Of The University Of California Ligand sensing fluorescent acetylcholinesterase for detection of organophosphate activity
ES2654584T3 (es) 2010-01-15 2018-02-14 Suzhou Neupharma Co., Ltd Ciertas entidades químicas, composiciones y métodos
WO2012027957A1 (en) 2010-08-28 2012-03-08 Suzhou Neupharma Co., Ltd. Bufalin derivatives, pharmaceutical compositions and use thereof
EP2670763B1 (en) * 2011-02-02 2018-08-01 Suzhou Neupharma Co., Ltd Certain chemical entities, compositions, and methods
EP3453713B1 (en) 2012-04-29 2021-09-08 Neupharma, Inc. Bufadienolide compounds substituted in position 3 by an amine group for use in the treatment of cancer
CN112114127A (zh) * 2020-09-09 2020-12-22 武汉生之源生物科技股份有限公司 一种甘胆酸均相酶免疫测定试剂盒及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN142734B (sv) * 1975-04-28 1977-08-20 Miles Lab
NL7512939A (nl) * 1975-11-04 1977-05-06 Tno Werkwijze en inrichtingen voor het aantonen en/of bepalen van alkylerende verbindingen, zoals mosterdgassen.
US4134792A (en) 1976-12-06 1979-01-16 Miles Laboratories, Inc. Specific binding assay with an enzyme modulator as a labeling substance
GB1595101A (en) * 1977-03-15 1981-08-05 Hoffmann La Roche Enzyme modifier immunoassay
IT1105734B (it) * 1977-07-14 1985-11-04 Syva Co Prova di legame di competizione di antienzima omogeneo

Also Published As

Publication number Publication date
ES8101647A1 (es) 1980-12-16
CA1137077A (en) 1982-12-07
SE448259B (sv) 1987-02-02
ATA56080A (de) 1981-06-15
ES488263A0 (es) 1980-12-16
DE3003959C2 (de) 1982-12-23
IT8019675A0 (it) 1980-02-04
CH641569A5 (fr) 1984-02-29
FR2447966B1 (sv) 1984-10-19
JPS55104896A (en) 1980-08-11
US4273866A (en) 1981-06-16
DE3003959A1 (de) 1980-08-14
BE881557A (fr) 1980-08-05
GB2043245A (en) 1980-10-01
AT365781B (de) 1982-02-10
AU528592B2 (en) 1983-05-05
ZA80371B (en) 1981-03-25
GB2043245B (en) 1983-05-25
FR2447966A1 (fr) 1980-08-29
IT1130254B (it) 1986-06-11
NL8000698A (nl) 1980-08-07
AU5476380A (en) 1980-08-14

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