BE881557A - Conjugues analogue de ligand-inhibiteur enzymatique irreversible et procedes pour la determination des ligands les utilisants - Google Patents
Conjugues analogue de ligand-inhibiteur enzymatique irreversible et procedes pour la determination des ligands les utilisantsInfo
- Publication number
- BE881557A BE881557A BE0/199272A BE199272A BE881557A BE 881557 A BE881557 A BE 881557A BE 0/199272 A BE0/199272 A BE 0/199272A BE 199272 A BE199272 A BE 199272A BE 881557 A BE881557 A BE 881557A
- Authority
- BE
- Belgium
- Prior art keywords
- ligand
- methods
- same
- analog conjugates
- determining ligands
- Prior art date
Links
- 230000002255 enzymatic effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000002427 irreversible effect Effects 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4075—Esters with hydroxyalkyl compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Steroid Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/009,007 US4273866A (en) | 1979-02-05 | 1979-02-05 | Ligand analog-irreversible enzyme inhibitor conjugates and methods for use |
Publications (1)
Publication Number | Publication Date |
---|---|
BE881557A true BE881557A (fr) | 1980-08-05 |
Family
ID=21735028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/199272A BE881557A (fr) | 1979-02-05 | 1980-02-05 | Conjugues analogue de ligand-inhibiteur enzymatique irreversible et procedes pour la determination des ligands les utilisants |
Country Status (15)
Country | Link |
---|---|
US (1) | US4273866A (fr) |
JP (1) | JPS55104896A (fr) |
AT (1) | AT365781B (fr) |
AU (1) | AU528592B2 (fr) |
BE (1) | BE881557A (fr) |
CA (1) | CA1137077A (fr) |
CH (1) | CH641569A5 (fr) |
DE (1) | DE3003959C2 (fr) |
ES (1) | ES488263A0 (fr) |
FR (1) | FR2447966A1 (fr) |
GB (1) | GB2043245B (fr) |
IT (1) | IT1130254B (fr) |
NL (1) | NL8000698A (fr) |
SE (1) | SE448259B (fr) |
ZA (1) | ZA80371B (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981001414A1 (fr) * | 1979-11-19 | 1981-05-28 | Charles Hospital Dev | Procede ameliore d'analyse immunologique d'enzymes non homogenes |
DE3006709A1 (de) * | 1980-02-22 | 1981-08-27 | Hans A. Dipl.-Chem. Dr. 8000 München Thoma | Homogenes verfahren zur kompetitiven bestimmung von liganden |
US4341865A (en) * | 1980-07-21 | 1982-07-27 | Abbott Laboratories | Determination of thyroxine binding globulin |
US4849353A (en) * | 1980-09-30 | 1989-07-18 | Cornell Research Foundation, Inc. | Immunocapture of enzyme inhibitor, enzyme complexes and uses thereof |
US4323647A (en) * | 1980-10-15 | 1982-04-06 | University Of Miami | Steric hindrance enzyme immunoassay |
DE3100061A1 (de) * | 1981-01-02 | 1982-08-05 | Hans A. Dipl.-Chem. Dr. 8000 München Thoma | Verfahren zur bestimmung von liganden mittels kompetitionsreaktion |
DE3100062A1 (de) * | 1981-01-02 | 1982-08-05 | Hans A. Dipl.-Chem. Dr. 8000 München Thoma | Homogenes verfahren zur bestimmung von liganden |
EP0079489A1 (fr) * | 1981-11-04 | 1983-05-25 | Miles Laboratories, Inc. | Iodothyronine conjuguée marquée par du méthotrexate et méthode, réactif et dispositif d'épreuve pour la détermination d'iodothyronine ou de l'absorption d'iodothyronine dans un échantillon liquide |
US4451652A (en) * | 1982-05-24 | 1984-05-29 | Abbott Laboratories | Substituted theophylline salts |
US4472301A (en) * | 1982-05-27 | 1984-09-18 | Miles Laboratories, Inc. | Propranolol immunogen and antibodies |
GB2135773B (en) * | 1983-01-31 | 1985-12-04 | Boots Celltech Diagnostics | Enzyme inhibitor labelled immunoassay |
US4650751A (en) * | 1983-04-29 | 1987-03-17 | Technicon Instruments Corporation | Protected binding assay avoiding non-specific protein interference |
US4550075A (en) * | 1983-06-22 | 1985-10-29 | Kallestad Laboratories, Inc. | Method for ligand determination utilizing an immunoassay monitorable by biotin-containing enzymes, and compositions therefor |
JPS607362A (ja) * | 1983-06-27 | 1985-01-16 | Fujirebio Inc | 酵素を用いた抗原決定基具有物質の測定法 |
US4629694A (en) * | 1983-07-12 | 1986-12-16 | Cornell Research Foundation, Inc. | Detecting and distinguishing between plasminogen activators |
US4559173A (en) * | 1983-11-04 | 1985-12-17 | Abbott Laboratories | N-substituted dibenz[b,f]azepine salts |
US4543412A (en) * | 1983-11-04 | 1985-09-24 | Abbott Laboratories | Phenobarbital enzyme inhibitors |
IL73293A (en) * | 1983-11-04 | 1988-02-29 | Abbott Lab | Methyl 2-(alkanamidoalkylsulfonic)ethylthiophosphonate derivatives |
DE4007048A1 (de) * | 1990-03-07 | 1991-09-12 | Hoechst Ag | N-acyl-aminoalkyl-2-hydroxyethylsulfide und ein verfahren zu ihrer herstellung |
US5338663A (en) * | 1990-08-24 | 1994-08-16 | President And Fellows Of Harvard College | Method of identifying inhibitors of β-protein esterase activity |
US5648462A (en) * | 1990-10-09 | 1997-07-15 | Setsuko Funakoshi | Peptide purification method using novel linker and solid-phase ligand |
JP2552049B2 (ja) * | 1990-10-09 | 1996-11-06 | 舩越 節子 | 合成ペプチド精製方法およびこれに用いるリンカー、リンカー結合用固相担体 |
JPH0737982B2 (ja) * | 1992-12-14 | 1995-04-26 | 元成 狩野 | 抗胆汁酸抗体およびこれを用いた糞便中の胆汁酸検査方法 |
US5922703A (en) * | 1993-09-24 | 1999-07-13 | The Procter & Gamble Company | Urethane-containing aminosteroid compounds |
AU1967495A (en) * | 1994-02-18 | 1995-09-04 | Cell Therapeutics, Inc. | Intracellular signalling mediators |
WO2001001135A1 (fr) * | 1999-06-25 | 2001-01-04 | Roche Diagnostics Corporation | Immunoessai base sur l'inhibition enzymatique |
US6811998B2 (en) * | 1999-06-25 | 2004-11-02 | Roche Diagnostics Operations, Inc. | Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase |
US6524808B1 (en) * | 1999-06-25 | 2003-02-25 | Roche Diagnostics Corporation | Enzyme inhibition immunoassay |
US8642273B2 (en) * | 2002-04-16 | 2014-02-04 | The Regents Of The University Of California | Ligand sensing fluorescent acetylcholinesterase for detection of organophosphate activity |
ES2654584T3 (es) | 2010-01-15 | 2018-02-14 | Suzhou Neupharma Co., Ltd | Ciertas entidades químicas, composiciones y métodos |
WO2012027957A1 (fr) | 2010-08-28 | 2012-03-08 | Suzhou Neupharma Co., Ltd. | Dérivés de bufaline, compositions pharmaceutiques et utilisation de ceux-ci |
EP3453714B1 (fr) | 2011-02-02 | 2020-11-04 | Suzhou Neupharma Co., Ltd | Des dérivés 3-carbonates and 3-carbamates des cardenolides et des bufadienolides pour le traitement du cancer aussi bien que des compositions les contenant |
EP3453713B1 (fr) | 2012-04-29 | 2021-09-08 | Neupharma, Inc. | Dérivés bufadiènolides substitués en position 3 par un groupement amine pour le traitement du cancer |
CN112114127A (zh) * | 2020-09-09 | 2020-12-22 | 武汉生之源生物科技股份有限公司 | 一种甘胆酸均相酶免疫测定试剂盒及其制备方法和应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN142734B (fr) * | 1975-04-28 | 1977-08-20 | Miles Lab | |
NL7512939A (nl) * | 1975-11-04 | 1977-05-06 | Tno | Werkwijze en inrichtingen voor het aantonen en/of bepalen van alkylerende verbindingen, zoals mosterdgassen. |
US4134792A (en) * | 1976-12-06 | 1979-01-16 | Miles Laboratories, Inc. | Specific binding assay with an enzyme modulator as a labeling substance |
GB1595101A (en) | 1977-03-15 | 1981-08-05 | Hoffmann La Roche | Enzyme modifier immunoassay |
IT1105734B (it) * | 1977-07-14 | 1985-11-04 | Syva Co | Prova di legame di competizione di antienzima omogeneo |
-
1979
- 1979-02-05 US US06/009,007 patent/US4273866A/en not_active Expired - Lifetime
-
1980
- 1980-01-15 CA CA000343676A patent/CA1137077A/fr not_active Expired
- 1980-01-21 AU AU54763/80A patent/AU528592B2/en not_active Ceased
- 1980-01-22 ZA ZA00800371A patent/ZA80371B/xx unknown
- 1980-01-28 GB GB8002743A patent/GB2043245B/en not_active Expired
- 1980-02-01 JP JP1011780A patent/JPS55104896A/ja active Pending
- 1980-02-01 SE SE8000843A patent/SE448259B/sv not_active IP Right Cessation
- 1980-02-01 AT AT0056080A patent/AT365781B/de not_active IP Right Cessation
- 1980-02-04 FR FR8002385A patent/FR2447966A1/fr active Granted
- 1980-02-04 DE DE3003959A patent/DE3003959C2/de not_active Expired
- 1980-02-04 IT IT19675/80A patent/IT1130254B/it active
- 1980-02-04 ES ES488263A patent/ES488263A0/es active Granted
- 1980-02-04 NL NL8000698A patent/NL8000698A/nl not_active Application Discontinuation
- 1980-02-04 CH CH87780A patent/CH641569A5/fr not_active IP Right Cessation
- 1980-02-05 BE BE0/199272A patent/BE881557A/fr not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ZA80371B (en) | 1981-03-25 |
GB2043245B (en) | 1983-05-25 |
SE8000843L (sv) | 1980-08-06 |
FR2447966A1 (fr) | 1980-08-29 |
GB2043245A (en) | 1980-10-01 |
CH641569A5 (fr) | 1984-02-29 |
SE448259B (sv) | 1987-02-02 |
AU5476380A (en) | 1980-08-14 |
FR2447966B1 (fr) | 1984-10-19 |
US4273866A (en) | 1981-06-16 |
DE3003959A1 (de) | 1980-08-14 |
DE3003959C2 (de) | 1982-12-23 |
AU528592B2 (en) | 1983-05-05 |
CA1137077A (fr) | 1982-12-07 |
ATA56080A (de) | 1981-06-15 |
ES8101647A1 (es) | 1980-12-16 |
IT1130254B (it) | 1986-06-11 |
AT365781B (de) | 1982-02-10 |
IT8019675A0 (it) | 1980-02-04 |
NL8000698A (nl) | 1980-08-07 |
JPS55104896A (en) | 1980-08-11 |
ES488263A0 (es) | 1980-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: ABBOTT LABORATORIES Effective date: 19960228 |