FR2422634A1 - Isosteres de type 9-desoxy-9a-methylene de pgi2, utiles comme medicaments, et leur procede de preparation - Google Patents
Isosteres de type 9-desoxy-9a-methylene de pgi2, utiles comme medicaments, et leur procede de preparationInfo
- Publication number
- FR2422634A1 FR2422634A1 FR7902082A FR7902082A FR2422634A1 FR 2422634 A1 FR2422634 A1 FR 2422634A1 FR 7902082 A FR7902082 A FR 7902082A FR 7902082 A FR7902082 A FR 7902082A FR 2422634 A1 FR2422634 A1 FR 2422634A1
- Authority
- FR
- France
- Prior art keywords
- isosters
- pgi2
- desoxy
- methylene
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940126601 medicinal product Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Cephalosporin Compounds (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT7819616A IT7819616A0 (it) | 1978-01-26 | 1978-01-26 | 9-deossi-9a-metilene-isosteri della pgi 2. |
| IT3107378A IT1160370B (it) | 1978-12-21 | 1978-12-21 | 9-deossi-9a-metilene-isosteri della pgi2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2422634A1 true FR2422634A1 (fr) | 1979-11-09 |
| FR2422634B1 FR2422634B1 (US06373033-20020416-M00071.png) | 1982-08-20 |
Family
ID=26327236
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7902082A Granted FR2422634A1 (fr) | 1978-01-26 | 1979-01-26 | Isosteres de type 9-desoxy-9a-methylene de pgi2, utiles comme medicaments, et leur procede de preparation |
| FR7923142A Granted FR2466446A1 (fr) | 1978-01-26 | 1979-09-17 | Bicyclo-alcanones, intermediaires de la preparation d'isosteres de type 9-desoxy-9a-methylene de pgi2 |
| FR7923143A Granted FR2466445A1 (fr) | 1978-01-26 | 1979-09-17 | Formyl-2 bicyclo-alcanes, intermediaires de synthese d'isosteres de type 9-desoxy-9a-methylene de pgi2 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7923142A Granted FR2466446A1 (fr) | 1978-01-26 | 1979-09-17 | Bicyclo-alcanones, intermediaires de la preparation d'isosteres de type 9-desoxy-9a-methylene de pgi2 |
| FR7923143A Granted FR2466445A1 (fr) | 1978-01-26 | 1979-09-17 | Formyl-2 bicyclo-alcanes, intermediaires de synthese d'isosteres de type 9-desoxy-9a-methylene de pgi2 |
Country Status (26)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0015653A1 (en) * | 1979-02-09 | 1980-09-17 | Sumitomo Chemical Company, Limited | Aldol compounds, their production and their use in the preparation of methanoprostacyclin |
| EP0098793A1 (de) * | 1982-07-02 | 1984-01-18 | Schering Aktiengesellschaft | Neue Carbacyclinamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE3226550A1 (de) * | 1982-07-13 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4732914A (en) * | 1978-02-13 | 1988-03-22 | The Upjohn Company | Prostacyclin analogs |
| DE2845770A1 (de) * | 1978-10-19 | 1980-04-30 | Schering Ag | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
| US4525586A (en) * | 1980-02-28 | 1985-06-25 | The Upjohn Company | Composition and process |
| JPS56145239A (en) * | 1980-04-11 | 1981-11-11 | Sumitomo Chem Co Ltd | Novel bicyclooctane derivative and its preparation |
| DE3025325A1 (de) * | 1980-07-04 | 1982-02-04 | Merck Patent Gmbh, 6100 Darmstadt | Neue 13-thiaprostaglandin-zwischenprodukte, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von 13-thiaprostaglandin-derivaten |
| DE3048906A1 (de) * | 1980-12-19 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| EP0063538B1 (de) * | 1981-04-13 | 1986-08-06 | Schering Aktiengesellschaft | Neue Prostaglandine und Prostacycline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE3121155A1 (de) * | 1981-05-22 | 1982-12-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| IL67332A (en) * | 1981-12-01 | 1985-12-31 | Chinoin Gyogyszer Es Vegyeszet | Inter-m-phenylene-prostacyclin analogues,process for the preparation thereof and pharmaceutical compositions containing them |
| JPS58121243A (ja) * | 1982-01-12 | 1983-07-19 | Sumitomo Chem Co Ltd | 新規ビシクロオクタン誘導体及びその製造法 |
| US4588823A (en) * | 1982-02-16 | 1986-05-13 | The Upjohn Company | 9-substituted carbacyclin analogs |
| US4533749A (en) * | 1982-02-16 | 1985-08-06 | The Upjohn Company | 9-Substituted carbacyclin analogs |
| US4590297A (en) * | 1982-02-16 | 1986-05-20 | The Upjohn Company | Novel 9-substituted carbacyclin analogs |
| US4487961A (en) * | 1982-02-16 | 1984-12-11 | The Upjohn Company | 9-Substituted carbacyclin analogs |
| DE3306125A1 (de) * | 1983-02-18 | 1984-08-23 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4486598A (en) * | 1982-02-22 | 1984-12-04 | The Upjohn Company | Carbacyclin analogs |
| GR77976B (US06373033-20020416-M00071.png) * | 1982-03-12 | 1984-09-25 | Schering Ag | |
| US4490555A (en) * | 1982-03-19 | 1984-12-25 | The Upjohn Company | 9-Substituted carbacyclin analogs |
| US4585886A (en) * | 1982-03-19 | 1986-04-29 | The Upjohn Company | 9-Substituted carbacyclin analogs |
| US4487960A (en) * | 1982-04-19 | 1984-12-11 | The Upjohn Company | 9-Substituted carbacyclin analogs |
| US4689345A (en) * | 1982-05-06 | 1987-08-25 | Cbd Corporation | Oxygenated alkyl substituted bicyclo alkanes |
| DE3378265D1 (en) * | 1982-05-06 | 1988-11-24 | Cbd Corp | Cycloaliphatic pharmaceutical compounds |
| US4689349A (en) * | 1982-05-06 | 1987-08-25 | Cbd Corporation | Anti-tumor halo bicyclo alkanones |
| US4423068A (en) * | 1982-07-14 | 1983-12-27 | Syntex (U.S.A.) Inc. | (3.2.0) Bicycloheptanone oxime ethers with therapeutic properties |
| HU191110B (en) * | 1982-10-01 | 1987-01-28 | Farmitala Carlo Erba Spa,It | Process for the production of the 15-cycloaliphatic derivatives 13,14-didehydro-carbaprostacyclines |
| EP0108451A3 (en) * | 1982-11-05 | 1985-04-10 | The Procter & Gamble Company | Novel prostaglandin analogues |
| GB2135881A (en) * | 1983-03-02 | 1984-09-12 | Erba Farmitalia | Method and pharmaceutical compositions for inhibiting or reducing gastrointestinal side effects of non-steroidal anti-inflammatory drugs |
| US4561604A (en) * | 1983-07-18 | 1985-12-31 | Shimano Industrial Company Limited | Spinning reel |
| JPS60181041A (ja) * | 1984-02-29 | 1985-09-14 | Sankyo Co Ltd | カルバサイクリン誘導体 |
| JPS60172941A (ja) * | 1984-02-16 | 1985-09-06 | Sankyo Co Ltd | カルバサイクリン類 |
| JPS6092255A (ja) * | 1983-10-26 | 1985-05-23 | Sumitomo Chem Co Ltd | 新規ビシクロオクタン誘導体及び製造法 |
| DE3405181A1 (de) * | 1984-02-10 | 1985-08-22 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4683330A (en) * | 1984-03-08 | 1987-07-28 | The Upjohn Company | Interphenylene carbacyclin derivatives |
| US4668814A (en) * | 1984-03-08 | 1987-05-26 | The Upjohn Company | Interphenylene carbacyclin derivatives |
| GB2156342B (en) * | 1984-03-26 | 1987-12-23 | Erba Farmitalia | 13,14,19,20-tetradehydro derivatives of carboprostacyclins and process for their preparation |
| GB2156340A (en) * | 1984-03-26 | 1985-10-09 | Erba Farmitalia | 1-Nor-2-hydroxymethyl-derivatives of carboprostacyclins and process for their preparation |
| DE3428266A1 (de) * | 1984-07-27 | 1986-01-30 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4757087A (en) * | 1985-03-19 | 1988-07-12 | Sankyo Company Limited | Carbacyclin derivatives |
| JPS61280294A (ja) * | 1985-06-04 | 1986-12-10 | Nisshin Flour Milling Co Ltd | 光学活性カルバサイクリン中間体の製造方法 |
| JPS62153259A (ja) * | 1985-12-26 | 1987-07-08 | Sagami Chem Res Center | （２−クロロ−３−オキソ−１−アルケニル）−ビシクロ〔３．３．０〕オクテン誘導体及びその製法 |
| GB2225573A (en) * | 1988-09-16 | 1990-06-06 | Ueno Seiyaku Oyo Kenkyujo Kk | 13,14-dihydro-15-keto-PGFs |
| JP3250936B2 (ja) * | 1995-03-10 | 2002-01-28 | 科学技術振興事業団 | イソカルバサイクリン誘導体 |
| JP6207065B2 (ja) * | 2012-10-01 | 2017-10-04 | 住友化学株式会社 | 塩、レジスト組成物及びレジストパターンの製造方法 |
| CN111689994B (zh) * | 2020-06-05 | 2023-06-13 | 安徽师范大学 | 以联芴Aza-BODIPY为基本骨架的有机共轭分子材料及其制备方法和应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2422635A1 (fr) * | 1978-03-31 | 1979-11-09 | Ono Pharmaceutical Co | Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5495552A (en) * | 1978-01-06 | 1979-07-28 | Sankyo Co Ltd | Prostacyline derivative and its preparation |
| US4705806A (en) * | 1978-02-13 | 1987-11-10 | Morton Jr Douglas R | Prostacyclin analogs |
| JPS54119441A (en) * | 1978-03-09 | 1979-09-17 | Sumitomo Chem Co Ltd | Novel bicyclooctane derivative |
| DE2845770A1 (de) * | 1978-10-19 | 1980-04-30 | Schering Ag | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
| JPS55105638A (en) * | 1979-02-09 | 1980-08-13 | Sumitomo Chem Co Ltd | Aldol derivative and its preparation |
| US4225507A (en) * | 1979-07-05 | 1980-09-30 | The Upjohn Company | 19-Hydroxy-19-methyl-PGI2 compounds |
-
1979
- 1979-01-15 GB GB7901474A patent/GB2013661B/en not_active Expired
- 1979-01-15 GB GB7944136A patent/GB2038333B/en not_active Expired
- 1979-01-15 GB GB7944137A patent/GB2040928B/en not_active Expired
- 1979-01-17 AU AU43438/79A patent/AU530571B2/en not_active Ceased
- 1979-01-17 NL NL7900369A patent/NL7900369A/xx not_active Application Discontinuation
- 1979-01-19 FI FI790178A patent/FI72509C/fi not_active IP Right Cessation
- 1979-01-19 IL IL56468A patent/IL56468A/xx unknown
- 1979-01-22 AT AT0045279A patent/AT374165B/de not_active IP Right Cessation
- 1979-01-23 DE DE19792902442 patent/DE2902442A1/de not_active Ceased
- 1979-01-24 NZ NZ189461A patent/NZ189461A/xx unknown
- 1979-01-24 YU YU00155/79A patent/YU15579A/xx unknown
- 1979-01-25 SU SU792719752A patent/SU1053745A3/ru active
- 1979-01-25 SE SE7900685A patent/SE453291B/sv not_active IP Right Cessation
- 1979-01-25 ES ES477172A patent/ES477172A1/es not_active Expired
- 1979-01-25 CH CH764/79A patent/CH647222A5/de not_active IP Right Cessation
- 1979-01-25 PT PT7969129A patent/PT69129A/pt unknown
- 1979-01-25 GR GR58188A patent/GR73109B/el unknown
- 1979-01-25 NO NO790257A patent/NO153926C/no unknown
- 1979-01-26 JP JP864479A patent/JPS54119444A/ja active Pending
- 1979-01-26 FR FR7902082A patent/FR2422634A1/fr active Granted
- 1979-01-26 CA CA000320354A patent/CA1209133A/en not_active Expired
- 1979-01-26 DK DK35779A patent/DK35779A/da not_active Application Discontinuation
- 1979-01-30 IE IE145/79A patent/IE48311B1/en unknown
- 1979-09-17 FR FR7923142A patent/FR2466446A1/fr active Granted
- 1979-09-17 FR FR7923143A patent/FR2466445A1/fr active Granted
-
1980
- 1980-02-26 US US06/124,715 patent/US4307112A/en not_active Expired - Lifetime
-
1983
- 1983-01-24 SG SG40/83A patent/SG4083G/en unknown
- 1983-02-01 YU YU217/83A patent/YU42835B/xx unknown
- 1983-02-05 KE KE3262A patent/KE3262A/xx unknown
- 1983-06-02 HK HK184/83A patent/HK18483A/xx unknown
- 1983-06-17 SE SE8303479A patent/SE453289B/sv not_active IP Right Cessation
-
1984
- 1984-12-30 MY MY104/84A patent/MY8400104A/xx unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2422635A1 (fr) * | 1978-03-31 | 1979-11-09 | Ono Pharmaceutical Co | Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant |
Non-Patent Citations (2)
| Title |
|---|
| EXBK/78 * |
| EXBK/79 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0015653A1 (en) * | 1979-02-09 | 1980-09-17 | Sumitomo Chemical Company, Limited | Aldol compounds, their production and their use in the preparation of methanoprostacyclin |
| EP0098793A1 (de) * | 1982-07-02 | 1984-01-18 | Schering Aktiengesellschaft | Neue Carbacyclinamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE3226550A1 (de) * | 1982-07-13 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| EP0099538A1 (de) * | 1982-07-13 | 1984-02-01 | Schering Aktiengesellschaft | Neue Carbacycline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |