IT1160370B - 9-deossi-9a-metilene-isosteri della pgi2 - Google Patents
9-deossi-9a-metilene-isosteri della pgi2Info
- Publication number
- IT1160370B IT1160370B IT3107378A IT3107378A IT1160370B IT 1160370 B IT1160370 B IT 1160370B IT 3107378 A IT3107378 A IT 3107378A IT 3107378 A IT3107378 A IT 3107378A IT 1160370 B IT1160370 B IT 1160370B
- Authority
- IT
- Italy
- Prior art keywords
- alkyl
- opt
- alkoxy
- phenyl
- useful
- Prior art date
Links
- 239000003705 antithrombocytic agent Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 150000003180 prostaglandins Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- -1 1H-tetrazol-5-yl Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 101000862089 Clarkia lewisii Glucose-6-phosphate isomerase, cytosolic 1A Proteins 0.000 abstract 1
- 101100448208 Human herpesvirus 6B (strain Z29) U69 gene Proteins 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 239000003699 antiulcer agent Substances 0.000 abstract 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 239000000168 bronchodilator agent Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007515 enzymatic degradation Effects 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000002596 lactones Chemical class 0.000 abstract 1
- 230000003529 luteolytic effect Effects 0.000 abstract 1
- KAQKFAOMNZTLHT-OZUDYXHBSA-N prostaglandin I2 Chemical compound O1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-OZUDYXHBSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000021 stimulant Substances 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (41)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT3107378A IT1160370B (it) | 1978-12-21 | 1978-12-21 | 9-deossi-9a-metilene-isosteri della pgi2 |
| GB7944136A GB2038333B (en) | 1978-01-26 | 1979-01-15 | 12 -formyl- (20 12)octanor-9-deoxy-9 -methylene pgi derivatives |
| GB7944137A GB2040928B (en) | 1978-01-26 | 1979-01-15 | Bicycloalkane derivatives useful as intermediates in preparing pg1 isosteres |
| GB7901474A GB2013661B (en) | 1978-01-26 | 1979-01-15 | 9-deoxy-9 -methylene isosteres of pgi2 |
| NL7900369A NL7900369A (nl) | 1978-01-26 | 1979-01-17 | 9-deoxy-9a-methyleen-isosteren van pgi2 en werkwijzen ter bereiding ervan. |
| AU43438/79A AU530571B2 (en) | 1978-01-26 | 1979-01-17 | 9-deoxy-9a-methylene-isosteres of pgi2 |
| IL56468A IL56468A (en) | 1978-01-26 | 1979-01-19 | 9-deoxy-9a-methylene isosteres of pgi2,process for their preparation and pharmaceutical and veterinary compositions containing them |
| FI790178A FI72509C (fi) | 1978-01-26 | 1979-01-19 | Foerfarande foer framstaellning av 9-deoxi-9a-metylen-isosterer av pgi2. |
| AT0045279A AT374165B (de) | 1978-01-26 | 1979-01-22 | Verfahren zum herstellen von neuen 9-deoxy-9a -methylen-isosteren von pgl2 |
| DE19792902442 DE2902442A1 (de) | 1978-01-26 | 1979-01-23 | 9-deoxy-9a-methylen-isostere von pgi tief 2 , verfahren zu ihrer herstellung und sie enthaltende pharmazeutische und veterinaermedizinische mittel |
| NZ189461A NZ189461A (en) | 1978-01-26 | 1979-01-24 | 9-deoxy-9a-methylene-isoteres of pgi2 and pharmaceutical compositions intermediates |
| NZ194253A NZ194253A (en) | 1978-01-26 | 1979-01-24 | 9-deoxy-9a-methylene isosteres |
| YU00155/79A YU15579A (en) | 1978-01-26 | 1979-01-24 | Process for obtaining 9-deoxy-9a-methylene-isoesters pgi2 |
| NO790257A NO153926C (no) | 1978-01-26 | 1979-01-25 | Fremgangsmaate ved fremstilling av 9-desoksy-9a-metylen-isotere av pgi2. |
| GR58188A GR73109B (it) | 1978-01-26 | 1979-01-25 | |
| SU792719752A SU1053745A3 (ru) | 1978-01-26 | 1979-01-25 | Способ получени 9-дезокси-9 @ -метиленизостеров @ или их лактонов или их солей |
| CH764/79A CH647222A5 (de) | 1978-01-26 | 1979-01-25 | 9-desoxy-9a-methylen-isostere von pgi-2 und verfahren zu deren herstellung. |
| SE7900685A SE453291B (sv) | 1978-01-26 | 1979-01-25 | 9-deoxi-9a-metylenisosterer av pgi?712, forfarande for framstellning av dem och en farmaceutisk eller veterinermedicinsk komposition |
| ES477172A ES477172A1 (es) | 1978-01-26 | 1979-01-25 | Procedimiento para la preparacion de 9-deoxi-9a-metilen isosteros de pgi2. |
| PT7969129A PT69129A (en) | 1978-01-26 | 1979-01-25 | Process for the preparation of 9-deoxy-9a-methylene isosteres of pgi2 |
| JP864479A JPS54119444A (en) | 1978-01-26 | 1979-01-26 | 99deoxyy9aamethylene isostere of pg12 and its manufacture |
| CA000320354A CA1209133A (en) | 1978-01-26 | 1979-01-26 | 9-deoxy-9a-methylene isosteres of pgi.sub.2 and process for their preparation |
| FR7902082A FR2422634A1 (fr) | 1978-01-26 | 1979-01-26 | Isosteres de type 9-desoxy-9a-methylene de pgi2, utiles comme medicaments, et leur procede de preparation |
| DK35779A DK35779A (da) | 1978-01-26 | 1979-01-26 | 9-deoxy-9a-methylen-isostere af pg12 og fremgangsmaade til fremstilling deraf |
| IE145/79A IE48311B1 (en) | 1978-01-26 | 1979-01-30 | 9-deoxy-9a-methylene isosteres of pg12 and process for their preparation |
| FR7923143A FR2466445A1 (fr) | 1978-01-26 | 1979-09-17 | Formyl-2 bicyclo-alcanes, intermediaires de synthese d'isosteres de type 9-desoxy-9a-methylene de pgi2 |
| FR7923142A FR2466446A1 (fr) | 1978-01-26 | 1979-09-17 | Bicyclo-alcanones, intermediaires de la preparation d'isosteres de type 9-desoxy-9a-methylene de pgi2 |
| US06/124,715 US4307112A (en) | 1978-01-26 | 1980-02-26 | 9-Deoxy-9A-methylene isosteres of PGI2 and process for their preparation |
| AT0550081A AT375633B (de) | 1978-01-26 | 1981-12-21 | Verfahren zum herstellen von neuen 9-deoxy-9a-methylen-isosteren von pgi2 |
| CA000401255A CA1209134A (en) | 1978-01-26 | 1982-04-19 | 9-deoxy-9a-methylene isosteres of pgi.sub.2 and process for their preparation |
| CA000401256A CA1198417A (en) | 1978-01-26 | 1982-04-19 | 9-deoxy-9a-methylene isosteres of pgi.sub.2 and process for their preparation |
| CA000416724A CA1198418A (en) | 1978-01-26 | 1982-11-30 | 9-deoxy-9a-methylene isosters of pgi.sub.2 and process for their preparation |
| CA000416725A CA1198419A (en) | 1978-01-26 | 1982-11-30 | 9-deoxy-9a-methylene isosteres of pgi.sub.2 and process for their preparation |
| CA000416726A CA1198420A (en) | 1978-01-26 | 1982-11-30 | 9-deoxy-9a-methylene isosteres of pgi.sub.2 and process for their preparation |
| SG40/83A SG4083G (en) | 1978-01-26 | 1983-01-24 | 9-deoxy-9a-methylene isosteres of pg12 |
| YU217/83A YU42835B (en) | 1978-01-26 | 1983-02-01 | Process for obtaining 9-deoxy-9a-methylene-isoesters pgi2 |
| KE3262A KE3262A (en) | 1978-01-26 | 1983-02-05 | 9-deoxy-9a-methylene isosteres of pgi2 |
| HK184/83A HK18483A (en) | 1978-01-26 | 1983-06-02 | 9-deoxy-9a-methylene isosteres of pg12 |
| SE8303479A SE453289B (sv) | 1978-01-26 | 1983-06-17 | Mellanprodukter for framstellning av 9-deoxi-9a-metylenisosterer av pgi?712 samt forfarande for framstellning av dem |
| FI833908A FI73963C (fi) | 1978-01-26 | 1983-10-26 | Nya 9-deoxi-9a-metylen-isosterer och foerfarande foer deras framstaellning. |
| MY104/84A MY8400104A (en) | 1978-01-26 | 1984-12-30 | 9-deoxy-9a-methylene isosteres of pg12 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT3107378A IT1160370B (it) | 1978-12-21 | 1978-12-21 | 9-deossi-9a-metilene-isosteri della pgi2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7831073A0 IT7831073A0 (it) | 1978-12-21 |
| IT1160370B true IT1160370B (it) | 1987-03-11 |
Family
ID=11233055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT3107378A IT1160370B (it) | 1978-01-26 | 1978-12-21 | 9-deossi-9a-metilene-isosteri della pgi2 |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1160370B (it) |
-
1978
- 1978-12-21 IT IT3107378A patent/IT1160370B/it active
Also Published As
| Publication number | Publication date |
|---|---|
| IT7831073A0 (it) | 1978-12-21 |
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