FI97809B - Rekombinant-DNA-molekyl som kodar en analog av vävnads plasminogen aktivator (TPA) - Google Patents

Rekombinant-DNA-molekyl som kodar en analog av vävnads plasminogen aktivator (TPA)

Info

Publication number
FI97809B
FI97809B FI882922A FI882922A FI97809B FI 97809 B FI97809 B FI 97809B FI 882922 A FI882922 A FI 882922A FI 882922 A FI882922 A FI 882922A FI 97809 B FI97809 B FI 97809B
Authority
FI
Finland
Prior art keywords
tpa
analogs
recombinant dna
plasminogen activator
tissue
Prior art date
Application number
FI882922A
Other languages
English (en)
Finnish (fi)
Other versions
FI97809C (sv
FI882922A (sv
FI882922A0 (sv
Inventor
Keith P Marotti
Edward F Rehberg
Nicole Y Theriault
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FI882922A publication Critical patent/FI882922A/sv
Publication of FI882922A0 publication Critical patent/FI882922A0/sv
Application granted granted Critical
Publication of FI97809B publication Critical patent/FI97809B/sv
Publication of FI97809C publication Critical patent/FI97809C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
FI882922A 1985-12-20 1988-06-17 Rekombinant-DNA-molekyl som kodar en analog av vävnads plasminogen aktivator (TPA) FI97809C (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US81160785A 1985-12-20 1985-12-20
US81160785 1985-12-20
US90948286A 1986-09-19 1986-09-19
US90948286 1986-09-19
US8602684 1986-12-12
PCT/US1986/002684 WO1987003906A1 (en) 1985-12-20 1986-12-12 Tissue plasminogen activator (tpa) analogs

Publications (4)

Publication Number Publication Date
FI882922A FI882922A (sv) 1988-06-17
FI882922A0 FI882922A0 (sv) 1988-06-17
FI97809B true FI97809B (sv) 1996-11-15
FI97809C FI97809C (sv) 1997-02-25

Family

ID=27123502

Family Applications (1)

Application Number Title Priority Date Filing Date
FI882922A FI97809C (sv) 1985-12-20 1988-06-17 Rekombinant-DNA-molekyl som kodar en analog av vävnads plasminogen aktivator (TPA)

Country Status (12)

Country Link
EP (2) EP0289508A1 (sv)
JP (1) JPH0659223B2 (sv)
KR (2) KR880700856A (sv)
AT (1) ATE85081T1 (sv)
AU (1) AU600463B2 (sv)
DE (1) DE3687651T2 (sv)
DK (1) DK431887A (sv)
ES (1) ES2053449T3 (sv)
FI (1) FI97809C (sv)
GR (1) GR3007280T3 (sv)
NO (1) NO176921C (sv)
WO (1) WO1987003906A1 (sv)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU605124B2 (en) * 1985-12-23 1991-01-10 Behringwerke Aktiengesellschaft Novel peptide plasminogen activators
ATE70301T1 (de) * 1986-02-17 1991-12-15 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
EP0263172B1 (en) * 1986-03-28 1993-06-23 Creative Biomolecules, Inc. Protein analogues of tissue plasminogen activator
US5047241A (en) * 1986-07-11 1991-09-10 American Home Products Corporation Tris-Kringle plasminogen activator with novel K2 insert
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
US5376547A (en) * 1987-01-30 1994-12-27 American Home Products Corporation Des-epidermal growth factor plasminogen activators
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
DE3888619D1 (de) * 1987-10-09 1994-04-28 Monsanto Co Modifizierter Gewebeplasminogenaktivator.
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
US4963357A (en) * 1987-10-09 1990-10-16 Monsanto Company Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
US5037752A (en) * 1987-10-09 1991-08-06 Monsanto Company Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
HU217100B (hu) * 1987-10-29 1999-11-29 Yamanouchi Pharmaceutical Co. Ltd. Eljárás új polipeptidek előállítására
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
EP0398962A1 (en) * 1988-02-05 1990-11-28 Genzyme Corporation Rearranged tissue plasminogen activators and method for producing same
EP0400054A1 (en) * 1988-02-05 1990-12-05 Genzyme Corporation Modified gene sequences encoding modified tpa and products therefrom
AU619803B2 (en) * 1988-02-05 1992-02-06 Genzyme Corporation Rearranged tissue plasminogen activators and method for producing same
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
DE3823805A1 (de) * 1988-07-14 1990-01-18 Basf Ag Neue polypeptide, ihre herstellung und verwendung
DE3825253A1 (de) * 1988-07-25 1990-02-01 Boehringer Mannheim Gmbh T-pa-derivat und seine herstellung
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
DE3836200A1 (de) * 1988-10-24 1990-04-26 Boehringer Mannheim Gmbh Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa)
DE68922859T2 (de) * 1988-10-27 1995-09-21 Tno Trombolytischer wirkstoff mit modifikation der domäne der kringle.
CA2007364A1 (en) * 1989-01-17 1990-07-17 David J. Livingston Gene sequences encoding modified residues situated in the protease domain of tpa
DE3927865A1 (de) * 1989-08-23 1991-02-28 Boehringer Mannheim Gmbh T-pa-mutante gk1l
AU664469B2 (en) * 1992-06-03 1995-11-16 Genentech Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
IL104355A (en) 1993-01-10 2006-08-20 Yeda Res & Dev Tnf receptor promoter
US5795975A (en) * 1993-01-10 1998-08-18 Yeda Research And Development Co. Ltd. TNF receptor promoter
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
ZA837173B (en) 1982-11-08 1984-05-30 Univ Case Western Reserve Genomic bovine growth hormone
US4511502A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511503A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
PT82326B (pt) 1985-04-04 1988-10-14 Beecham Group Plc Processo para a preparacao de activador de plasminogenio de tipo tissular fibrinoliticamente activo
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
NZ217331A (en) * 1985-08-26 1989-05-29 Lilly Co Eli Tissue plasminogen activator derivatives and genetically engineered product

Also Published As

Publication number Publication date
NO176921C (no) 1995-06-21
EP0231624B1 (en) 1993-01-27
DK431887D0 (da) 1987-08-19
WO1987003906A1 (en) 1987-07-02
DE3687651T2 (de) 1993-06-24
FI97809C (sv) 1997-02-25
EP0289508A1 (en) 1988-11-09
FI882922A (sv) 1988-06-17
JPH0659223B2 (ja) 1994-08-10
ATE85081T1 (de) 1993-02-15
AU6770187A (en) 1987-07-15
NO873517D0 (no) 1987-08-20
DK431887A (da) 1987-08-19
NO176921B (no) 1995-03-13
NO873517L (no) 1987-08-20
JPH05344892A (ja) 1993-12-27
ES2053449T3 (es) 1994-08-01
FI882922A0 (sv) 1988-06-17
AU600463B2 (en) 1990-08-16
DE3687651D1 (de) 1993-03-11
KR880700856A (ko) 1988-04-12
EP0231624A1 (en) 1987-08-12
GR3007280T3 (sv) 1993-07-30
KR950000303B1 (ko) 1995-01-13

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Legal Events

Date Code Title Description
HC Name/ company changed in application

Owner name: PHARMACIA & UPJOHN COMPANY

BB Publication of examined application
MM Patent lapsed

Owner name: PHARMACIA & UPJOHN COMPANY