FI974447A0 - Semikarbazoner med CNS-aktivitet och farmaceutiska preparat innehållande dessa - Google Patents

Semikarbazoner med CNS-aktivitet och farmaceutiska preparat innehållande dessa

Info

Publication number
FI974447A0
FI974447A0 FI974447A FI974447A FI974447A0 FI 974447 A0 FI974447 A0 FI 974447A0 FI 974447 A FI974447 A FI 974447A FI 974447 A FI974447 A FI 974447A FI 974447 A0 FI974447 A0 FI 974447A0
Authority
FI
Finland
Prior art keywords
semicarbazones
pharmaceutical preparations
preparations containing
cns activity
compound
Prior art date
Application number
FI974447A
Other languages
English (en)
Finnish (fi)
Other versions
FI974447A (sv
Inventor
Jonathan Richard Dimmock
Ramanan Narayan Puthucode
Original Assignee
Univ Saskatchewan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Saskatchewan filed Critical Univ Saskatchewan
Publication of FI974447A0 publication Critical patent/FI974447A0/sv
Publication of FI974447A publication Critical patent/FI974447A/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C07C281/14—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being further bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
FI974447A 1995-06-07 1997-12-05 Semikarbazoner med CNS-aktivitet och farmaceutiska preparat innehållande dessa FI974447A (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/475,313 US5741818A (en) 1995-06-07 1995-06-07 Semicarbazones having CNS activity and pharmaceutical preparations containing same
PCT/CA1996/000380 WO1996040628A1 (en) 1995-06-07 1996-06-07 Semicarbazones having cns activity and pharmaceutical preparations containing same

Publications (2)

Publication Number Publication Date
FI974447A0 true FI974447A0 (sv) 1997-12-05
FI974447A FI974447A (sv) 1997-12-05

Family

ID=23887035

Family Applications (1)

Application Number Title Priority Date Filing Date
FI974447A FI974447A (sv) 1995-06-07 1997-12-05 Semikarbazoner med CNS-aktivitet och farmaceutiska preparat innehållande dessa

Country Status (24)

Country Link
US (2) US5741818A (sv)
EP (1) EP0836591B1 (sv)
JP (1) JPH11506109A (sv)
KR (1) KR19990022408A (sv)
CN (1) CN1062263C (sv)
AT (1) ATE206110T1 (sv)
AU (1) AU715897B2 (sv)
BR (1) BR9609408A (sv)
CA (1) CA2223935A1 (sv)
CZ (1) CZ387497A3 (sv)
DE (1) DE69615558T2 (sv)
DK (1) DK0836591T3 (sv)
ES (1) ES2164889T3 (sv)
FI (1) FI974447A (sv)
GE (1) GEP20012414B (sv)
HU (1) HUP9802637A3 (sv)
IL (1) IL122350A0 (sv)
NO (1) NO310655B1 (sv)
NZ (1) NZ309707A (sv)
PL (1) PL184048B1 (sv)
PT (1) PT836591E (sv)
RU (1) RU2174115C2 (sv)
UA (1) UA62915C2 (sv)
WO (1) WO1996040628A1 (sv)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5741818A (en) 1995-06-07 1998-04-21 University Of Saskatchewan Semicarbazones having CNS activity and pharmaceutical preparations containing same
JP2001526648A (ja) 1997-04-22 2001-12-18 コセンシス・インコーポレイテッド 炭素環及びヘテロ環で置換されたセミカルバゾン及びチオセミカルバゾン、及びその使用
EP1568690A1 (en) * 1997-04-22 2005-08-31 Euro-Celtique S.A. The use of carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones as sodium channel blockers
WO1999026614A1 (en) * 1997-11-21 1999-06-03 Euro-Celtique S.A. Substituted 2-aminoacetamides and the use thereof
GB9727523D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
JP2002511387A (ja) * 1998-02-04 2002-04-16 ユーロ−セルティック エス． ア． 置換セミカルバジドおよびその使用
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
AR023171A1 (es) 1999-03-26 2002-09-04 Cocensys Inc Pirazoles, imidazoles, oxazoles, tiazoles, y pirroles sustituidos por arilo, y el uso de los mismos.
EP1169060B1 (en) * 1999-04-09 2005-08-31 Euro-Celtique S.A. Sodium channel blocker compositions and the use thereof
US8771740B2 (en) 1999-12-20 2014-07-08 Nicholas J. Kerkhof Process for producing nanoparticles by spray drying
JP2003518038A (ja) 1999-12-20 2003-06-03 ニコラス， ジェイ カークホフ， 流動床噴霧乾燥によるナノ粒子製造方法
AR029489A1 (es) 2000-03-10 2003-07-02 Euro Celtique Sa Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
PL214230B1 (pl) * 2000-03-24 2013-07-31 Euro Celtique Sa Podstawione arylem pirazole i triazole, kompozycja farmaceutyczna je zawierajaca oraz ich zastosowanie
GB0025208D0 (en) 2000-10-13 2000-11-29 Euro Celtique Sa Delayed release pharmaceutical formulations
WO2002089745A2 (en) 2001-05-10 2002-11-14 Cytovia, Inc. Substituted n'-(arylcarbonyl)-benzhydrazides, n'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof
EP1399159A4 (en) * 2001-06-01 2007-02-14 Cytovia Inc 4-SUBSTITUTE-1- (ARYLMETHYLIDENE) THIOSEMICARBAZIDE, 4-SUBSTITUTE-1- (ARYLCARBONYL) THIOSEMICARBAZIDE AND ANALOGUES AS ACTIVATORS OF APOPTOSIS CAPSASES AND TRIGS, AND USE THEREOF
WO2003006426A1 (en) * 2001-07-13 2003-01-23 Axxima Pharmaceuticals Ag Aromatic guanylhydrazones as effective compounds against neurodiseases
JP4350508B2 (ja) * 2001-09-03 2009-10-21 ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー ガバペンチンまたはその類似体とα−アミノアミドとを含む薬剤組成物およびその鎮痛用途
AR037233A1 (es) 2001-09-07 2004-11-03 Euro Celtique Sa Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento
AR036873A1 (es) 2001-09-07 2004-10-13 Euro Celtique Sa Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento
CN100349887C (zh) * 2002-05-16 2007-11-21 西托维亚公司 取代的4－芳基－4h－吡咯并[2,3－h]色烯和类似物及其药物组合物和用途
WO2003096982A2 (en) * 2002-05-16 2003-11-27 Cytovia, Inc. Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
BRPI0515154A (pt) * 2004-09-10 2008-07-08 Newron Pharm Spa uso de (halobenzilóxi)benzilamino-propanamidas para a fabricação de medicamentos ativos, compostos e composição farmacêutica
CN102015606B (zh) 2007-06-08 2015-02-04 满康德股份有限公司 IRE-1α抑制剂
JP2012511411A (ja) * 2008-12-10 2012-05-24 ボストン サイエンティフィック サイムド，インコーポレイテッド チタン合金部材とスチール合金部材との間に継手を形成する方法および前記継手を含んでなる医療用デバイス
CN104402771B (zh) * 2014-11-26 2016-09-28 玉林师范学院 对羟基苯甲醛缩氨基脲的合成及在防治植物病害中的应用
CN104974053B (zh) * 2015-06-24 2017-04-26 天津久日新材料股份有限公司 一种新的氨基酮类光引发剂及在uv‑led光固化体系的应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE667022A (sv)
US3255241A (en) 1961-01-19 1966-06-07 Merck & Co Inc (2-alkylidene acyl)phenoxy-and (2-alkylidene acyl)phenylmercaptocarboxylic acids
NL129087C (sv) 1961-01-19
NL282761A (sv) 1961-09-11
NL300456A (sv) 1962-11-13
US3251064A (en) 1962-11-13 1966-05-10 Everett M Schultz beta-aminoacylphenoxy-and beta-aminoacylphenylmercapto-derivatives of monocarboxylicacids
BE643709A (sv) * 1963-02-12 1900-01-01
DE1288086B (sv) * 1963-12-26 1969-01-30
US3392171A (en) * 1964-03-20 1968-07-09 Upjohn Co 4-morpholino-4'-hydroxy bicyclohexyls
US3304323A (en) * 1964-03-20 1967-02-14 Upjohn Co Oxygenated dicycloalkyl sulfones
US3303214A (en) * 1964-05-13 1967-02-07 Wallace & Tiernan Inc Nitrososemicarbazides
GB1164608A (en) * 1966-08-23 1969-09-17 May & Baker Ltd Semicarbazone and Thiosemicarbazone Quaternary Salts
US3712914A (en) * 1970-05-14 1973-01-23 Stauffer Chemical Co Arylidene semicarbizides
DE2420618C2 (de) * 1974-04-27 1982-09-16 C.H. Boehringer Sohn, 6507 Ingelheim Aminoalkylanilide, Verfahren zu ihrer Herstellung sowie pharmazeutische Zubereitungen, die diese Aminoalkylanilide enthalten
US4394514A (en) * 1981-04-30 1983-07-19 Smithkline Beckman Corporation Processes for preparing 4-substituted indoles
US5266585A (en) 1981-05-12 1993-11-30 Ciba-Geigy Corporation Arylphenyl ether derivatives, compositions containing these compounds and use thereof
FI77458C (sv) * 1981-05-12 1989-03-10 Ciba Geigy Ag Nya mikrobicida arylfenyleterderivat, förfarande för deras framställni ng och deras användning.
US4454337A (en) * 1981-06-29 1984-06-12 Smithkline Beckman Corporation Semicarbazide intermediates for preparing 4-substituted indoles
US5665673A (en) 1988-12-29 1997-09-09 Anderson; Richard J. Potentiating herbicidal compositions
IL94466A (en) 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
WO1994006758A1 (en) * 1992-09-21 1994-03-31 University Of Saskatchewan Aryl semicarbazone anticonvulsants
AU2641295A (en) 1994-05-17 1995-12-05 Dowelanco N-(5-isothiazolyl)amide pesticides
US5741818A (en) 1995-06-07 1998-04-21 University Of Saskatchewan Semicarbazones having CNS activity and pharmaceutical preparations containing same
CZ132798A3 (cs) 1995-10-30 1999-02-17 Smithkline Beecham Corporation Inhibitory proteázy

Also Published As

Publication number Publication date
ES2164889T3 (es) 2002-03-01
EP0836591A1 (en) 1998-04-22
IL122350A0 (en) 1998-04-05
CN1190388A (zh) 1998-08-12
EP0836591B1 (en) 2001-09-26
NO310655B1 (no) 2001-08-06
US5741818A (en) 1998-04-21
PT836591E (pt) 2002-03-28
CZ387497A3 (cs) 1998-07-15
ATE206110T1 (de) 2001-10-15
DE69615558T2 (de) 2002-07-11
BR9609408A (pt) 1999-07-27
FI974447A (sv) 1997-12-05
JPH11506109A (ja) 1999-06-02
AU715897B2 (en) 2000-02-10
CN1062263C (zh) 2001-02-21
NZ309707A (en) 1998-11-25
UA62915C2 (en) 2004-01-15
CA2223935A1 (en) 1996-12-19
RU2174115C2 (ru) 2001-09-27
PL184048B1 (pl) 2002-08-30
AU5993896A (en) 1996-12-30
HUP9802637A3 (en) 2000-09-28
NO975663L (no) 1998-02-09
KR19990022408A (ko) 1999-03-25
DE69615558D1 (de) 2001-10-31
HUP9802637A2 (hu) 1999-02-01
NO975663D0 (no) 1997-12-05
WO1996040628A1 (en) 1996-12-19
PL323666A1 (en) 1998-04-14
USRE38425E1 (en) 2004-02-10
DK0836591T3 (da) 2001-11-26
GEP20012414B (en) 2001-04-25

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