FI960851A - Förfarande för framställningen av N-amino-1-hydroxi-alkyliden-1,1-bisfosfonsyror - Google Patents
Förfarande för framställningen av N-amino-1-hydroxi-alkyliden-1,1-bisfosfonsyror Download PDFInfo
- Publication number
- FI960851A FI960851A FI960851A FI960851A FI960851A FI 960851 A FI960851 A FI 960851A FI 960851 A FI960851 A FI 960851A FI 960851 A FI960851 A FI 960851A FI 960851 A FI960851 A FI 960851A
- Authority
- FI
- Finland
- Prior art keywords
- amino
- alkylidene
- hydroxy
- preparation
- bisphosphonic acids
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11175193A | 1993-08-25 | 1993-08-25 | |
| US11175193 | 1993-08-25 | ||
| US23964094A | 1994-05-09 | 1994-05-09 | |
| US23964094 | 1994-05-09 | ||
| US08/286,151 US5510517A (en) | 1993-08-25 | 1994-08-04 | Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids |
| US28615194 | 1994-08-04 | ||
| US9409620 | 1994-08-24 | ||
| PCT/US1994/009620 WO1995006052A1 (en) | 1993-08-25 | 1994-08-24 | Process for producing n-amino-1-hydroxy-alkyl-idene-1,1-bisphosphonic acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI960851A true FI960851A (sv) | 1996-02-23 |
| FI960851A0 FI960851A0 (sv) | 1996-02-23 |
| FI115526B FI115526B (sv) | 2005-05-31 |
Family
ID=27381051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI960851A FI115526B (sv) | 1993-08-25 | 1996-02-23 | Förfarande för framställningen av N-amino-1-hydroxialkyliden-1,1-bisfosfonsyror, mellanprodukt i förfarandet och förfaranden för framställning av mellanprodukter |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5510517A (sv) |
| EP (1) | EP0715631B1 (sv) |
| JP (1) | JP3675818B2 (sv) |
| KR (1) | KR100261202B1 (sv) |
| CN (2) | CN1067079C (sv) |
| AT (1) | ATE160352T1 (sv) |
| AU (2) | AU692468B2 (sv) |
| BR (1) | BR9407563A (sv) |
| CA (1) | CA2169561C (sv) |
| CY (1) | CY2086B1 (sv) |
| CZ (1) | CZ290185B6 (sv) |
| DE (1) | DE69406936T2 (sv) |
| DK (1) | DK0715631T3 (sv) |
| ES (1) | ES2109731T3 (sv) |
| FI (1) | FI115526B (sv) |
| GR (1) | GR3025450T3 (sv) |
| HK (1) | HK1008883A1 (sv) |
| HR (1) | HRP940479B1 (sv) |
| HU (1) | HU217362B (sv) |
| LV (1) | LV12189B (sv) |
| NZ (1) | NZ273458A (sv) |
| RO (1) | RO115524B1 (sv) |
| RU (1) | RU2154647C2 (sv) |
| SI (1) | SI0715631T1 (sv) |
| WO (1) | WO1995006052A1 (sv) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5449819A (en) * | 1994-06-06 | 1995-09-12 | Merck & Co., Inc. | Process for removing waste pox, alendronate and its by products |
| US5589691A (en) * | 1994-06-06 | 1996-12-31 | Merck & Co., Inc. | Process for recovery and recycle of methanesulfonic acid and phosphorous acid |
| EA001213B1 (ru) * | 1996-10-04 | 2000-12-25 | Мерк Энд Ко., Инк. | Композиции жидкого алендроната |
| CA2197267C (en) * | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| GB9800452D0 (en) | 1998-01-10 | 1998-03-04 | Albright & Wilson | Preparation of phosphonic acid derivatives |
| US20030078211A1 (en) * | 1998-06-24 | 2003-04-24 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
| CA2336201A1 (en) | 1998-06-24 | 1999-12-29 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
| US6331533B1 (en) | 1998-11-16 | 2001-12-18 | Merck & Co., Inc. | Method for inhibiting dental resorptive lesions |
| ES2153794B1 (es) * | 1999-08-06 | 2001-10-16 | Medichem Sa | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. |
| PE20011061A1 (es) | 2000-02-01 | 2001-11-20 | Procter & Gamble | Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato |
| US6562974B2 (en) | 2000-02-01 | 2003-05-13 | The Procter & Gamble Company | Process for making geminal bisphosphonates |
| ITMI20020908A1 (it) * | 2002-04-29 | 2003-10-29 | Chemi Spa | Processo di preparazione di sodio alendronato |
| SI1880744T1 (sl) * | 2002-05-10 | 2015-04-30 | F. Hoffmann-La Roche Ag | Bifosfonske kisline za zdravljenje in prepreäśevanje osteoporoze |
| KR100681282B1 (ko) * | 2002-05-17 | 2007-02-12 | 테바 파마슈티컬 인더스트리즈 리미티드 | 특정 희석제를 사용하는 비스포스폰산 및 그 염의 제조방법 |
| EP1513523A1 (en) * | 2002-06-06 | 2005-03-16 | Merck Frosst Canada & Co. | 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases |
| JP4485117B2 (ja) * | 2002-06-27 | 2010-06-16 | 日東電工株式会社 | 保護剥離用フィルム |
| CA2495917A1 (en) * | 2002-08-28 | 2004-03-11 | Merck Frosst Canada & Co. | Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma |
| US20040138180A1 (en) * | 2002-10-03 | 2004-07-15 | Barr Laboratories, Inc. | Bisphosphonate composition and process for the preparation thereof |
| US20040206932A1 (en) * | 2002-12-30 | 2004-10-21 | Abuelyaman Ahmed S. | Compositions including polymerizable bisphosphonic acids and methods |
| EP1653913B1 (en) * | 2003-08-12 | 2012-05-23 | 3M Innovative Properties Company | Self-etching dental compositions and methods |
| CA2535359A1 (en) | 2003-08-21 | 2005-03-03 | Merck Frosst Canada Ltd. | Cathepsin cysteine protease inhibitors |
| NZ545804A (en) * | 2003-09-19 | 2009-09-25 | Wisconsin Alumni Res Found | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-or-vitamin D derivatives and a bisphosphonate |
| US20050181043A1 (en) * | 2004-02-12 | 2005-08-18 | Indranil Nandi | Alendronate salt tablet compositions |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| EP1784154A1 (en) * | 2004-07-08 | 2007-05-16 | 3M Innovative Properties Company | Dental methods, compositions, and kits including acid-sensitive dyes |
| KR101260525B1 (ko) * | 2004-08-11 | 2013-05-06 | 쓰리엠 도이칠란드 게엠베하 | 다수의 산성 화합물을 포함하는 자체-접착성 조성물 |
| DK1855674T3 (da) | 2005-03-02 | 2014-10-20 | Merck Sharp & Dohme | Sammensætning til hæmning af cathepsin k |
| CA2606879A1 (en) * | 2005-05-06 | 2007-03-01 | Medichem, S.A. | Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof |
| US8003820B2 (en) | 2005-10-20 | 2011-08-23 | Dr. Reddy's Laboratories Limited | Process for preparing bisphosphonic acids |
| AR058168A1 (es) * | 2005-11-07 | 2008-01-23 | Merck & Co Inc | Sintesis del alendronato de sodio trihidratado |
| WO2007083240A2 (en) | 2006-01-20 | 2007-07-26 | Aurobindo Pharma Limited | An improved process for the preparation of bisphosphonic acids |
| WO2007096896A1 (en) * | 2006-02-20 | 2007-08-30 | Alembic Limited | An improved process for the preparation of biphosphonic derivatives |
| WO2008076739A2 (en) | 2006-12-13 | 2008-06-26 | 3M Innovative Properties Company | Methods of using a dental composition having an acidic component and a photobleachable dye |
| CA2689504A1 (en) * | 2007-06-19 | 2008-12-24 | Albemarle Corporation | Processes for manufacturing bisphosphonic acids |
| BRPI0821090B8 (pt) * | 2007-12-21 | 2021-05-25 | Ligand Pharm Inc | moduladores seletivos de receptores de androgênio (sarms) e uso do mesmo |
| WO2010003704A2 (en) | 2008-07-11 | 2010-01-14 | Synthon B.V. | Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids |
| US20100130746A1 (en) * | 2008-11-26 | 2010-05-27 | Martin Kas | Process for Making Zoledronic Acid |
| EP2192126B1 (en) | 2008-11-26 | 2013-03-27 | Synthon B.V. | Process for making zoledronic acid |
| EP2470549B1 (en) | 2009-08-28 | 2014-07-16 | Synthon B.V. | Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids |
| WO2011056589A1 (en) * | 2009-10-26 | 2011-05-12 | Warner Chilcott Company, Llc | Bisphosphonate compounds for treating bone metabolism disorders |
| CA2738045C (en) | 2010-05-28 | 2019-02-19 | Simon Fraser University | Conjugate compounds, methods of making same, and uses thereof |
| WO2012078528A2 (en) | 2010-12-06 | 2012-06-14 | Effrx Pharmaceuticals Sa | Stable effervescent bisphosphonate formulations with rapid solubilization characteristics |
| WO2012112363A1 (en) | 2011-02-14 | 2012-08-23 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| FI20115315A0 (sv) * | 2011-04-01 | 2011-04-01 | Itae Suomen Yliopisto | Förfarande för att samla metaller |
| CA2923272A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| WO2015051479A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| WO2015120580A1 (en) | 2014-02-11 | 2015-08-20 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| US9650414B1 (en) | 2014-05-30 | 2017-05-16 | Simon Fraser University | Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof |
| CN106572997A (zh) | 2014-05-30 | 2017-04-19 | 辉瑞公司 | 作为选择性雄激素受体调节剂的腈衍生物 |
| EP3307747A4 (en) | 2015-06-12 | 2019-02-27 | Simon Fraser University | AMIDE-LINKED EP4-BISPHOSPHONATE AGONIST COMPOUNDS AND USES THEREOF |
| CN112867724B (zh) | 2018-07-23 | 2024-06-04 | 熙源安健医药(北京)有限公司 | 二膦酸盐药物缀合物 |
| CN109456363A (zh) * | 2018-11-01 | 2019-03-12 | 南京海纳医药科技股份有限公司 | 一种米诺膦酸工艺杂质的制备方法 |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| DD216465A1 (de) * | 1983-07-01 | 1984-12-12 | Agrochemie Piesteritz 4602 Wit | Verfahren zur herstellung substituierter alkanphosphonsaeuren |
| US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
-
1994
- 1994-08-04 US US08/286,151 patent/US5510517A/en not_active Expired - Lifetime
- 1994-08-24 HR HR940479A patent/HRP940479B1/xx not_active IP Right Cessation
- 1994-08-24 BR BR9407563A patent/BR9407563A/pt not_active IP Right Cessation
- 1994-08-24 CN CN94193725A patent/CN1067079C/zh not_active Expired - Lifetime
- 1994-08-24 SI SI9430097T patent/SI0715631T1/xx unknown
- 1994-08-24 RU RU96107773/04A patent/RU2154647C2/ru active
- 1994-08-24 CA CA002169561A patent/CA2169561C/en not_active Expired - Fee Related
- 1994-08-24 AT AT94927234T patent/ATE160352T1/de active
- 1994-08-24 WO PCT/US1994/009620 patent/WO1995006052A1/en active IP Right Grant
- 1994-08-24 AU AU76743/94A patent/AU692468B2/en not_active Expired
- 1994-08-24 HU HU9600429A patent/HU217362B/hu unknown
- 1994-08-24 CZ CZ1996542A patent/CZ290185B6/cs not_active IP Right Cessation
- 1994-08-24 RO RO96-00335A patent/RO115524B1/ro unknown
- 1994-08-24 KR KR1019997012458A patent/KR100261202B1/ko not_active IP Right Cessation
- 1994-08-24 JP JP50775895A patent/JP3675818B2/ja not_active Expired - Lifetime
- 1994-08-24 ES ES94927234T patent/ES2109731T3/es not_active Expired - Lifetime
- 1994-08-24 DK DK94927234.8T patent/DK0715631T3/da active
- 1994-08-24 DE DE69406936T patent/DE69406936T2/de not_active Expired - Lifetime
- 1994-08-24 EP EP94927234A patent/EP0715631B1/en not_active Expired - Lifetime
- 1994-08-24 NZ NZ273458A patent/NZ273458A/en not_active IP Right Cessation
-
1996
- 1996-02-23 FI FI960851A patent/FI115526B/sv not_active IP Right Cessation
-
1997
- 1997-11-20 GR GR970402796T patent/GR3025450T3/el unknown
-
1998
- 1998-04-09 CY CY9800001A patent/CY2086B1/xx unknown
- 1998-08-03 HK HK98109618A patent/HK1008883A1/xx not_active IP Right Cessation
- 1998-08-12 AU AU79937/98A patent/AU714996B2/en not_active Expired
- 1998-10-12 LV LVP-98-213A patent/LV12189B/en unknown
-
2000
- 2000-08-03 CN CNB001225669A patent/CN1211392C/zh not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Ref document number: 115526 Country of ref document: FI |
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| PC | Transfer of assignment of patent |
Owner name: MERCK SHARP & DOHME CORP. Free format text: MERCK SHARP & DOHME CORP. |
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| PC | Transfer of assignment of patent |
Owner name: MERCK SHARP & DOHME CORP. |
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| MA | Patent expired |