HRP940479B1 - Process for producing n-amino-1-hydroxy-alkyl-idene-1,1-bisphosphonic acids - Google Patents
Process for producing n-amino-1-hydroxy-alkyl-idene-1,1-bisphosphonic acidsInfo
- Publication number
- HRP940479B1 HRP940479B1 HR940479A HRP940479A HRP940479B1 HR P940479 B1 HRP940479 B1 HR P940479B1 HR 940479 A HR940479 A HR 940479A HR P940479 A HRP940479 A HR P940479A HR P940479 B1 HRP940479 B1 HR P940479B1
- Authority
- HR
- Croatia
- Prior art keywords
- producing
- amino
- idene
- hydroxy
- alkyl
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11175193A | 1993-08-25 | 1993-08-25 | |
US23964094A | 1994-05-09 | 1994-05-09 | |
US08/286,151 US5510517A (en) | 1993-08-25 | 1994-08-04 | Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP940479A2 HRP940479A2 (en) | 1997-02-28 |
HRP940479B1 true HRP940479B1 (en) | 2000-10-31 |
Family
ID=27381051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR940479A HRP940479B1 (en) | 1993-08-25 | 1994-08-24 | Process for producing n-amino-1-hydroxy-alkyl-idene-1,1-bisphosphonic acids |
Country Status (25)
Country | Link |
---|---|
US (1) | US5510517A (sv) |
EP (1) | EP0715631B1 (sv) |
JP (1) | JP3675818B2 (sv) |
KR (1) | KR100261202B1 (sv) |
CN (2) | CN1067079C (sv) |
AT (1) | ATE160352T1 (sv) |
AU (2) | AU692468B2 (sv) |
BR (1) | BR9407563A (sv) |
CA (1) | CA2169561C (sv) |
CY (1) | CY2086B1 (sv) |
CZ (1) | CZ290185B6 (sv) |
DE (1) | DE69406936T2 (sv) |
DK (1) | DK0715631T3 (sv) |
ES (1) | ES2109731T3 (sv) |
FI (1) | FI115526B (sv) |
GR (1) | GR3025450T3 (sv) |
HK (1) | HK1008883A1 (sv) |
HR (1) | HRP940479B1 (sv) |
HU (1) | HU217362B (sv) |
LV (1) | LV12189B (sv) |
NZ (1) | NZ273458A (sv) |
RO (1) | RO115524B1 (sv) |
RU (1) | RU2154647C2 (sv) |
SI (1) | SI0715631T1 (sv) |
WO (1) | WO1995006052A1 (sv) |
Families Citing this family (53)
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US5449819A (en) * | 1994-06-06 | 1995-09-12 | Merck & Co., Inc. | Process for removing waste pox, alendronate and its by products |
US5589691A (en) * | 1994-06-06 | 1996-12-31 | Merck & Co., Inc. | Process for recovery and recycle of methanesulfonic acid and phosphorous acid |
EP1007054A4 (en) * | 1996-10-04 | 2000-07-19 | Merck & Co Inc | LIQUID ALENDRONATE FORMULATIONS |
CA2197267C (en) * | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
GB9800452D0 (en) * | 1998-01-10 | 1998-03-04 | Albright & Wilson | Preparation of phosphonic acid derivatives |
AU757104B2 (en) | 1998-06-24 | 2003-01-30 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
US20030078211A1 (en) * | 1998-06-24 | 2003-04-24 | Merck & Co., Inc. | Compositions and methods for inhibiting bone resorption |
US6331533B1 (en) | 1998-11-16 | 2001-12-18 | Merck & Co., Inc. | Method for inhibiting dental resorptive lesions |
ES2153794B1 (es) | 1999-08-06 | 2001-10-16 | Medichem Sa | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. |
US6562974B2 (en) | 2000-02-01 | 2003-05-13 | The Procter & Gamble Company | Process for making geminal bisphosphonates |
US6410520B2 (en) | 2000-02-01 | 2002-06-25 | The Procter & Gamble Company | Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate |
ITMI20020908A1 (it) * | 2002-04-29 | 2003-10-29 | Chemi Spa | Processo di preparazione di sodio alendronato |
KR20120065435A (ko) * | 2002-05-10 | 2012-06-20 | 에프. 호프만-라 로슈 아게 | 골다공증 치료 및 예방용 비스포스폰산 |
CA2485443C (en) * | 2002-05-17 | 2010-04-06 | Teva Pharmaceutical Industries Ltd | Use of aromatic hydrocarbons and silicone fluids for making bisphosphonic acids |
EP1513523A1 (en) * | 2002-06-06 | 2005-03-16 | Merck Frosst Canada & Co. | 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases |
JP4485117B2 (ja) * | 2002-06-27 | 2010-06-16 | 日東電工株式会社 | 保護剥離用フィルム |
CA2495917A1 (en) * | 2002-08-28 | 2004-03-11 | Merck Frosst Canada & Co. | Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma |
US20040138180A1 (en) * | 2002-10-03 | 2004-07-15 | Barr Laboratories, Inc. | Bisphosphonate composition and process for the preparation thereof |
US20040206932A1 (en) * | 2002-12-30 | 2004-10-21 | Abuelyaman Ahmed S. | Compositions including polymerizable bisphosphonic acids and methods |
EP2279722B1 (en) * | 2003-08-12 | 2013-05-01 | 3M Innovative Properties Company | Self-etching dental compositions and its use |
AU2004266740B2 (en) | 2003-08-21 | 2010-08-26 | Merck Frosst Canada Ltd | Cathepsin cysteine protease inhibitors |
NZ545804A (en) * | 2003-09-19 | 2009-09-25 | Wisconsin Alumni Res Found | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-or-vitamin D derivatives and a bisphosphonate |
US20050181043A1 (en) * | 2004-02-12 | 2005-08-18 | Indranil Nandi | Alendronate salt tablet compositions |
UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
AU2005269869B2 (en) * | 2004-07-08 | 2011-12-01 | 3M Innovative Properties Company | Dental methods, compositions, and kits including acid-sensitive dyes |
JP5037342B2 (ja) * | 2004-08-11 | 2012-09-26 | スリーエム イノベイティブ プロパティズ カンパニー | 複数の酸性化合物を含む粘着性組成物 |
DK1855674T3 (da) | 2005-03-02 | 2014-10-20 | Merck Sharp & Dohme | Sammensætning til hæmning af cathepsin k |
US20080194525A1 (en) * | 2005-05-06 | 2008-08-14 | Jordi Puig Serrano | Process of Making Geminal Bisphosphonic Acids and Pharmaceutically Acceptable Salts and/or Hydrates Thereof |
US8003820B2 (en) | 2005-10-20 | 2011-08-23 | Dr. Reddy's Laboratories Limited | Process for preparing bisphosphonic acids |
AR058168A1 (es) * | 2005-11-07 | 2008-01-23 | Merck & Co Inc | Sintesis del alendronato de sodio trihidratado |
WO2007083240A2 (en) | 2006-01-20 | 2007-07-26 | Aurobindo Pharma Limited | An improved process for the preparation of bisphosphonic acids |
EP1987046A1 (en) * | 2006-02-20 | 2008-11-05 | Alembic Limited | An improved process for the preparation of biphosphonic derivatives |
EP2101716A2 (en) | 2006-12-13 | 2009-09-23 | 3M Innovative Properties Company | Methods of using a dental composition having an acidic component and a photobleachable dye |
CA2689504A1 (en) * | 2007-06-19 | 2008-12-24 | Albemarle Corporation | Processes for manufacturing bisphosphonic acids |
WO2009082437A2 (en) | 2007-12-21 | 2009-07-02 | Ligand Pharmaceuticals Incorporated | Selective androgen receptor modulators (sarms) and uses thereof |
US8026388B2 (en) * | 2008-07-11 | 2011-09-27 | Synthon Bv | Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids |
US20100130746A1 (en) * | 2008-11-26 | 2010-05-27 | Martin Kas | Process for Making Zoledronic Acid |
EP2192126B1 (en) | 2008-11-26 | 2013-03-27 | Synthon B.V. | Process for making zoledronic acid |
EA201270328A1 (ru) | 2009-08-28 | 2012-09-28 | Синтон Б. В. | Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот |
CN102630227B (zh) * | 2009-10-26 | 2016-03-23 | 沃纳奇尔科特有限责任公司 | 用于治疗骨代谢紊乱的双膦酸盐化合物 |
CA2738045C (en) | 2010-05-28 | 2019-02-19 | Simon Fraser University | Conjugate compounds, methods of making same, and uses thereof |
AU2011338674B2 (en) | 2010-12-06 | 2017-03-30 | Effrx Pharmaceuticals Sa | Stable effervescent bisphosphonate formulations with rapid solubilization characteristics |
US8791162B2 (en) | 2011-02-14 | 2014-07-29 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
FI20115315A0 (sv) * | 2011-04-01 | 2011-04-01 | Itae Suomen Yliopisto | Förfarande för att samla metaller |
CA2923272A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
WO2015051479A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
WO2015120580A1 (en) | 2014-02-11 | 2015-08-20 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
US9650414B1 (en) | 2014-05-30 | 2017-05-16 | Simon Fraser University | Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof |
KR20160147007A (ko) | 2014-05-30 | 2016-12-21 | 화이자 인코포레이티드 | 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체 |
US10400000B2 (en) | 2015-06-12 | 2019-09-03 | Simon Fraser University | Amide-linked EP4 agonist-bisphosphonate compounds and uses thereof |
US12049475B2 (en) | 2018-07-23 | 2024-07-30 | Brise Pharmaceuticals Co., Ltd. | Bisphosphonate drug conjugates |
CN109456363A (zh) * | 2018-11-01 | 2019-03-12 | 南京海纳医药科技股份有限公司 | 一种米诺膦酸工艺杂质的制备方法 |
WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
DD216465A1 (de) * | 1983-07-01 | 1984-12-12 | Agrochemie Piesteritz 4602 Wit | Verfahren zur herstellung substituierter alkanphosphonsaeuren |
US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
-
1994
- 1994-08-04 US US08/286,151 patent/US5510517A/en not_active Expired - Lifetime
- 1994-08-24 BR BR9407563A patent/BR9407563A/pt not_active IP Right Cessation
- 1994-08-24 HR HR940479A patent/HRP940479B1/xx not_active IP Right Cessation
- 1994-08-24 EP EP94927234A patent/EP0715631B1/en not_active Expired - Lifetime
- 1994-08-24 WO PCT/US1994/009620 patent/WO1995006052A1/en active IP Right Grant
- 1994-08-24 DK DK94927234.8T patent/DK0715631T3/da active
- 1994-08-24 KR KR1019997012458A patent/KR100261202B1/ko not_active IP Right Cessation
- 1994-08-24 CA CA002169561A patent/CA2169561C/en not_active Expired - Fee Related
- 1994-08-24 HU HU9600429A patent/HU217362B/hu unknown
- 1994-08-24 JP JP50775895A patent/JP3675818B2/ja not_active Expired - Lifetime
- 1994-08-24 NZ NZ273458A patent/NZ273458A/en not_active IP Right Cessation
- 1994-08-24 RU RU96107773/04A patent/RU2154647C2/ru active
- 1994-08-24 CN CN94193725A patent/CN1067079C/zh not_active Expired - Lifetime
- 1994-08-24 SI SI9430097T patent/SI0715631T1/xx unknown
- 1994-08-24 ES ES94927234T patent/ES2109731T3/es not_active Expired - Lifetime
- 1994-08-24 AT AT94927234T patent/ATE160352T1/de active
- 1994-08-24 DE DE69406936T patent/DE69406936T2/de not_active Expired - Lifetime
- 1994-08-24 RO RO96-00335A patent/RO115524B1/ro unknown
- 1994-08-24 CZ CZ1996542A patent/CZ290185B6/cs not_active IP Right Cessation
- 1994-08-24 AU AU76743/94A patent/AU692468B2/en not_active Expired
-
1996
- 1996-02-23 FI FI960851A patent/FI115526B/sv not_active IP Right Cessation
-
1997
- 1997-11-20 GR GR970402796T patent/GR3025450T3/el unknown
-
1998
- 1998-04-09 CY CY9800001A patent/CY2086B1/xx unknown
- 1998-08-03 HK HK98109618A patent/HK1008883A1/xx not_active IP Right Cessation
- 1998-08-12 AU AU79937/98A patent/AU714996B2/en not_active Expired
- 1998-10-12 LV LVP-98-213A patent/LV12189B/en unknown
-
2000
- 2000-08-03 CN CNB001225669A patent/CN1211392C/zh not_active Expired - Lifetime
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PNAN | Change of the applicant name, address/residence |
Owner name: MERCK SHARP & DOHME CORP., US |
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Owner name: MERCK SHARP & DOHME CORP., US Owner name: SCHERING CORPORATION, US |
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Payment date: 20130822 Year of fee payment: 20 |
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