FI923527A - Menetelmä terapeuttisesti käyttökelpoisten 3-piperidino-4-hydroksikromaanijohdannaisten valmistamiseksi - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten 3-piperidino-4-hydroksikromaanijohdannaisten valmistamiseksi Download PDFInfo
- Publication number
- FI923527A FI923527A FI923527A FI923527A FI923527A FI 923527 A FI923527 A FI 923527A FI 923527 A FI923527 A FI 923527A FI 923527 A FI923527 A FI 923527A FI 923527 A FI923527 A FI 923527A
- Authority
- FI
- Finland
- Prior art keywords
- piperidino
- preparation
- therapeutically useful
- hydroxychroman
- hydroxychroman derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1990/000674 WO1991012005A1 (en) | 1990-02-06 | 1990-02-06 | Neuroprotective 3-piperidino-4-hydroxychroman derivatives and analogs |
US9000674 | 1990-02-06 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI923527A true FI923527A (fi) | 1992-08-05 |
FI923527A0 FI923527A0 (fi) | 1992-08-05 |
FI94957B FI94957B (fi) | 1995-08-15 |
FI94957C FI94957C (fi) | 1995-11-27 |
Family
ID=22220666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI923527A FI94957C (fi) | 1990-02-06 | 1992-08-05 | Menetelmä terapeuttisesti käyttökelpoisten 3-piperidino-4-hydroksikromaanijohdannaisten valmistamiseksi |
Country Status (29)
Country | Link |
---|---|
US (1) | US5356905A (fi) |
EP (1) | EP0441506B1 (fi) |
JP (1) | JPH0768214B2 (fi) |
KR (1) | KR930011041B1 (fi) |
CN (1) | CN1029960C (fi) |
AT (1) | ATE108787T1 (fi) |
AU (1) | AU626490B2 (fi) |
BR (1) | BR9100490A (fi) |
CA (1) | CA2035653C (fi) |
CZ (1) | CZ286218B6 (fi) |
DE (2) | DE69102893T4 (fi) |
DK (1) | DK0441506T3 (fi) |
EG (1) | EG19643A (fi) |
ES (1) | ES2056571T3 (fi) |
FI (1) | FI94957C (fi) |
HU (1) | HU222726B1 (fi) |
IE (1) | IE63836B1 (fi) |
IL (1) | IL97100A (fi) |
MX (1) | MX24433A (fi) |
MY (1) | MY105293A (fi) |
NO (1) | NO178399C (fi) |
NZ (1) | NZ237025A (fi) |
PH (1) | PH31061A (fi) |
PL (1) | PL164866B1 (fi) |
PT (1) | PT96664B (fi) |
RU (1) | RU2099339C1 (fi) |
SK (1) | SK281729B6 (fi) |
WO (1) | WO1991012005A1 (fi) |
ZA (1) | ZA91830B (fi) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5594007A (en) * | 1991-04-18 | 1997-01-14 | Pfizer Inc. | Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols |
WO1992018502A1 (en) * | 1991-04-18 | 1992-10-29 | Pfizer Inc. | Prodrug esters of phenolic 2-piperidino-1-alkanols |
US5436255A (en) * | 1992-07-23 | 1995-07-25 | Pfizer Inc. | Method of treating diseases susceptable to treatment by blocking NMDA-receptors |
US5498610A (en) * | 1992-11-06 | 1996-03-12 | Pfizer Inc. | Neuroprotective indolone and related derivatives |
BR9408506A (pt) * | 1994-01-31 | 1997-08-05 | Pfizer | Compostos neuroprotetores |
MX9701282A (es) * | 1994-08-18 | 1997-05-31 | Pfizer | Fenoles neuroprotectores. |
ES2211904T3 (es) | 1995-05-26 | 2004-07-16 | Pfizer Inc. | Combinaciones para el tratamiento del parkinsonismo que contienen antagonistas selectivos de nmda. |
TW498067B (en) * | 1996-07-19 | 2002-08-11 | Hoffmann La Roche | 4-hydroxy-piperidine derivatives |
US6380205B1 (en) | 1999-10-29 | 2002-04-30 | Merck & Co., Inc. | 2-cyclohexyl quinazoline NMDA/NR2B antagonists |
US6476041B1 (en) | 1999-10-29 | 2002-11-05 | Merck & Co., Inc. | 1,4 substituted piperidinyl NMDA/NR2B antagonists |
EP1235572A2 (en) | 1999-10-29 | 2002-09-04 | MERCK SHARP & DOHME LTD. | Method to treat pain utilizing benzimidazole nmda/nr2b antagonists |
US6291499B1 (en) | 1999-10-29 | 2001-09-18 | Merck & Co., Inc. | 2-cyclohexyl benzimidazole NMDA/NR2B antagonists |
US6432976B1 (en) | 1999-10-29 | 2002-08-13 | Merck & Co., Inc. | 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists |
US6316474B1 (en) | 1999-10-29 | 2001-11-13 | Merck & Co., Inc. | 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists |
US6489477B1 (en) | 1999-10-29 | 2002-12-03 | Merck & Co., Inc. | 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists |
US6369076B1 (en) | 1999-10-29 | 2002-04-09 | Merck & Co. Inc. | 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists |
US6495561B2 (en) | 1999-10-29 | 2002-12-17 | Merck & Co., Inc. | 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists |
IL145209A0 (en) | 2000-09-06 | 2002-06-30 | Pfizer Prod Inc | Pharmaceutical combinations for the treatment of stroke and traumatic brain injury |
EP1674087A1 (en) | 2000-10-02 | 2006-06-28 | Pfizer Products Inc. | Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists |
HUP0303258A3 (en) | 2001-02-23 | 2004-06-28 | Merck & Co Inc | N-substituted nonaryl-heterocyclic nmda/nr2b antagonists and pharmaceutical compositions containing them |
CA2443108A1 (en) | 2001-04-03 | 2002-10-17 | Merck & Co. Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
WO2005034878A2 (en) * | 2003-10-08 | 2005-04-21 | President And Fellows Of Harvard College | Pyrovalerone analogs and therapeutic uses thereof |
US7671072B2 (en) * | 2003-11-26 | 2010-03-02 | Pfizer Inc. | Aminopyrazole derivatives as GSK-3 inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3294804A (en) * | 1961-01-27 | 1966-12-27 | Sterling Drug Inc | 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propionoxy-piperidine |
FR5733M (fi) * | 1966-09-27 | 1968-01-22 | ||
GB1495526A (en) * | 1974-05-31 | 1977-12-21 | Beecham Group Ltd | Chroman derivatives |
DE2507782A1 (de) * | 1975-02-22 | 1976-09-02 | Merck Patent Gmbh | Tetralon- und indanon-derivate sowie verfahren zu ihrer herstellung |
US4016281A (en) * | 1975-02-22 | 1977-04-05 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Tetralone and indanone compounds |
GB2107706A (en) * | 1981-09-25 | 1983-05-05 | Beecham Group Plc | Benzopyrans |
EP0093534A1 (en) * | 1982-04-28 | 1983-11-09 | Beecham Group Plc | Novel chromanols |
GB8308064D0 (en) * | 1983-03-24 | 1983-05-05 | Beecham Group Plc | Active compounds |
-
1990
- 1990-02-06 HU HU9202568A patent/HU222726B1/hu active IP Right Grant
- 1990-02-06 WO PCT/US1990/000674 patent/WO1991012005A1/en active IP Right Grant
- 1990-02-06 MX MX2443391A patent/MX24433A/es unknown
- 1990-02-06 US US07/916,130 patent/US5356905A/en not_active Expired - Lifetime
- 1990-02-06 RU SU5053040/04A patent/RU2099339C1/ru not_active IP Right Cessation
-
1991
- 1991-01-21 PH PH41875A patent/PH31061A/en unknown
- 1991-01-24 DE DE69102893A patent/DE69102893T4/de not_active Expired - Fee Related
- 1991-01-24 ES ES91300549T patent/ES2056571T3/es not_active Expired - Lifetime
- 1991-01-24 AT AT91300549T patent/ATE108787T1/de not_active IP Right Cessation
- 1991-01-24 EP EP91300549A patent/EP0441506B1/en not_active Expired - Lifetime
- 1991-01-24 DK DK91300549.2T patent/DK0441506T3/da active
- 1991-01-30 IL IL9710091A patent/IL97100A/en not_active IP Right Cessation
- 1991-02-01 CZ CS1991250A patent/CZ286218B6/cs not_active IP Right Cessation
- 1991-02-01 SK SK250-91A patent/SK281729B6/sk unknown
- 1991-02-04 PL PL91288949A patent/PL164866B1/pl not_active IP Right Cessation
- 1991-02-04 CA CA002035653A patent/CA2035653C/en not_active Expired - Fee Related
- 1991-02-04 PT PT96664A patent/PT96664B/pt not_active IP Right Cessation
- 1991-02-05 JP JP3014569A patent/JPH0768214B2/ja not_active Expired - Fee Related
- 1991-02-05 ZA ZA91830A patent/ZA91830B/xx unknown
- 1991-02-05 AU AU70293/91A patent/AU626490B2/en not_active Ceased
- 1991-02-05 CN CN91100705A patent/CN1029960C/zh not_active Expired - Fee Related
- 1991-02-05 NZ NZ237025A patent/NZ237025A/en unknown
- 1991-02-05 IE IE37291A patent/IE63836B1/en not_active IP Right Cessation
- 1991-02-05 MY MYPI91000171A patent/MY105293A/en unknown
- 1991-02-06 EG EG7291A patent/EG19643A/xx active
- 1991-02-06 KR KR1019910002022A patent/KR930011041B1/ko not_active IP Right Cessation
- 1991-02-06 BR BR919100490A patent/BR9100490A/pt not_active Application Discontinuation
- 1991-02-06 DE DE9101346U patent/DE9101346U1/de not_active Expired - Lifetime
-
1992
- 1992-08-05 NO NO923081A patent/NO178399C/no not_active IP Right Cessation
- 1992-08-05 FI FI923527A patent/FI94957C/fi active
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BB | Publication of examined application |