NO923081L - Neurobeskyttende 3-piperidino-4-hydroksykromanderivater og analoger derav - Google Patents

Neurobeskyttende 3-piperidino-4-hydroksykromanderivater og analoger derav

Info

Publication number
NO923081L
NO923081L NO92923081A NO923081A NO923081L NO 923081 L NO923081 L NO 923081L NO 92923081 A NO92923081 A NO 92923081A NO 923081 A NO923081 A NO 923081A NO 923081 L NO923081 L NO 923081L
Authority
NO
Norway
Prior art keywords
piperidino
hydroxychromand
analogs
derivatives
neuro protective
Prior art date
Application number
NO92923081A
Other languages
English (en)
Other versions
NO178399C (no
NO178399B (no
NO923081D0 (no
Inventor
Todd W Butler
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO923081L publication Critical patent/NO923081L/no
Publication of NO923081D0 publication Critical patent/NO923081D0/no
Publication of NO178399B publication Critical patent/NO178399B/no
Publication of NO178399C publication Critical patent/NO178399C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO923081A 1990-02-06 1992-08-05 Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-piperidino-4-hydroksykromanderivater og analoger derav NO178399C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1990/000674 WO1991012005A1 (en) 1990-02-06 1990-02-06 Neuroprotective 3-piperidino-4-hydroxychroman derivatives and analogs

Publications (4)

Publication Number Publication Date
NO923081L true NO923081L (no) 1992-08-05
NO923081D0 NO923081D0 (no) 1992-08-05
NO178399B NO178399B (no) 1995-12-11
NO178399C NO178399C (no) 1996-03-20

Family

ID=22220666

Family Applications (1)

Application Number Title Priority Date Filing Date
NO923081A NO178399C (no) 1990-02-06 1992-08-05 Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-piperidino-4-hydroksykromanderivater og analoger derav

Country Status (29)

Country Link
US (1) US5356905A (no)
EP (1) EP0441506B1 (no)
JP (1) JPH0768214B2 (no)
KR (1) KR930011041B1 (no)
CN (1) CN1029960C (no)
AT (1) ATE108787T1 (no)
AU (1) AU626490B2 (no)
BR (1) BR9100490A (no)
CA (1) CA2035653C (no)
CZ (1) CZ286218B6 (no)
DE (2) DE69102893T4 (no)
DK (1) DK0441506T3 (no)
EG (1) EG19643A (no)
ES (1) ES2056571T3 (no)
FI (1) FI94957C (no)
HU (1) HU222726B1 (no)
IE (1) IE63836B1 (no)
IL (1) IL97100A (no)
MX (1) MX24433A (no)
MY (1) MY105293A (no)
NO (1) NO178399C (no)
NZ (1) NZ237025A (no)
PH (1) PH31061A (no)
PL (1) PL164866B1 (no)
PT (1) PT96664B (no)
RU (1) RU2099339C1 (no)
SK (1) SK281729B6 (no)
WO (1) WO1991012005A1 (no)
ZA (1) ZA91830B (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0584192A1 (en) * 1991-04-18 1994-03-02 Pfizer Inc. Prodrug esters of phenolic 2-piperidino-1-alkanols
US5594007A (en) * 1991-04-18 1997-01-14 Pfizer Inc. Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
NZ275151A (en) * 1994-01-31 1998-02-26 Pfizer 3r*4s*3-[4-(4-fluorophenyl)-4-hydroxy-piperidin-1-yl]-chroman-4 ,7-diol; isomers and salts
RU2139857C1 (ru) * 1994-08-18 1999-10-20 Пфайзер Инк. Производные 3-(пиперидинил-1)-хроман-4,7-диола и 1-(4-гидроксифенил)-2-(пиперидинил-1)-алканола, фармацевтическая композиция и способ связывания nmda рецептора
CA2219911C (en) 1995-05-26 2004-07-27 Pfizer Inc. Combinations for the treatment of parkinsonism containing selective nmda antagonists
TW498067B (en) * 1996-07-19 2002-08-11 Hoffmann La Roche 4-hydroxy-piperidine derivatives
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
EP1235572A2 (en) 1999-10-29 2002-09-04 MERCK SHARP &amp; DOHME LTD. Method to treat pain utilizing benzimidazole nmda/nr2b antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
IL145209A0 (en) 2000-09-06 2002-06-30 Pfizer Prod Inc Pharmaceutical combinations for the treatment of stroke and traumatic brain injury
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
EE200300403A (et) 2001-02-23 2003-12-15 Merck & Co., Inc. N-asendatud mittearomaatne heterotsükliline ühend, seda sisaldav ravimkompositsioon ning ühendi kasutamine ravimina
WO2002080928A1 (en) 2001-04-03 2002-10-17 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
EP1670755A4 (en) * 2003-10-08 2007-02-28 Harvard College PYROVALERON ANALOGUE AND ITS THERAPEUTIC APPLICATIONS
WO2005051919A1 (en) * 2003-11-26 2005-06-09 Pfizer Products Inc. Aminopyrazole derivatives as gsk-3 inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3294804A (en) * 1961-01-27 1966-12-27 Sterling Drug Inc 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propionoxy-piperidine
FR5733M (no) * 1966-09-27 1968-01-22
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
DE2507782A1 (de) * 1975-02-22 1976-09-02 Merck Patent Gmbh Tetralon- und indanon-derivate sowie verfahren zu ihrer herstellung
US4016281A (en) * 1975-02-22 1977-04-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Tetralone and indanone compounds
DE3274350D1 (en) * 1981-09-25 1987-01-08 Beecham Group Plc Pharmaceutically active benzopyran compounds
EP0093534A1 (en) * 1982-04-28 1983-11-09 Beecham Group Plc Novel chromanols
GB8308064D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds

Also Published As

Publication number Publication date
KR910015568A (ko) 1991-09-30
EP0441506A3 (en) 1991-11-21
IE63836B1 (en) 1995-06-14
EP0441506B1 (en) 1994-07-20
EP0441506A2 (en) 1991-08-14
DE69102893T2 (de) 1994-11-03
NO178399C (no) 1996-03-20
IE910372A1 (en) 1991-08-14
EG19643A (en) 1995-09-30
MY105293A (en) 1994-09-30
DK0441506T3 (da) 1994-09-05
NO178399B (no) 1995-12-11
CA2035653C (en) 1999-12-21
DE69102893T4 (de) 1995-08-10
US5356905A (en) 1994-10-18
BR9100490A (pt) 1991-10-29
NZ237025A (en) 1992-11-25
CS25091A3 (en) 1991-09-15
KR930011041B1 (ko) 1993-11-20
FI94957C (fi) 1995-11-27
DE9101346U1 (de) 1991-06-06
JPH0768214B2 (ja) 1995-07-26
JPH04211058A (ja) 1992-08-03
AU7029391A (en) 1991-09-05
CN1029960C (zh) 1995-10-11
FI923527A0 (fi) 1992-08-05
PL288949A1 (en) 1991-07-29
CN1053923A (zh) 1991-08-21
ATE108787T1 (de) 1994-08-15
PT96664A (pt) 1991-10-31
HU222726B1 (hu) 2003-09-29
FI923527A (fi) 1992-08-05
FI94957B (fi) 1995-08-15
WO1991012005A1 (en) 1991-08-22
DE69102893D1 (de) 1994-08-25
IL97100A (en) 1996-06-18
CA2035653A1 (en) 1991-08-07
MX24433A (es) 1993-05-01
SK281729B6 (sk) 2001-07-10
CZ286218B6 (cs) 2000-02-16
PH31061A (en) 1998-02-05
NO923081D0 (no) 1992-08-05
PT96664B (pt) 1998-07-31
RU2099339C1 (ru) 1997-12-20
AU626490B2 (en) 1992-07-30
IL97100A0 (en) 1992-03-29
PL164866B1 (pl) 1994-10-31
ES2056571T3 (es) 1994-10-01
ZA91830B (en) 1992-09-30

Similar Documents

Publication Publication Date Title
NO923081L (no) Neurobeskyttende 3-piperidino-4-hydroksykromanderivater og analoger derav
MD1761B2 (ro) Eteri de 2,6-dihidroxipiridină, procedeu de preparare a lor, compoziţie erbicidă şi metodă de combatere a creşterii plantelor indezirabile
EP0513387A4 (en) Active oxygen inhibitor
AU2401584A (en) Novel carbacyclins, process for their manufacture and their use as medicaments
DE3167774D1 (en) 4-substituted-2-oxoazetidine compounds, processes for their preparation, and their use for preparing antibiotics
GR3019711T3 (en) Spiro-indoline-oxazine compounds with photochromatic and photosensitizing characteristics and the process for their preparation
HUT62581A (en) Process for producing pipeidine derivatives and pharmaceutical compositions comprising such compounds
ES8205219A1 (es) Un metodo para producir un compuesto de hidrouracilo
ES2012695A6 (es) Un procedimiento para la preparacion de 4-(6&#39;-metoxi -2&#39;- naftil)-but-3-en -2-ona.
JPS5319392A (en) Polyamino cyclic polysaccharide compounds and their preparation
ES513881A0 (es) Productos halogenados.
JPS6479181A (en) Novel beta-lactam compound and production thereof
JPS51122071A (en) A process for preparing novel chromone derivatives
HUT43561A (en) Process for preparing novel carbacyclines and pharmaceutics comprising such compounds
IT1240644B (it) Derivati polifosfazenici contenenti gruppi azobenzenici atti all&#39; impiego come materiali a caratteristiche fotocromiche
JPS5424888A (en) Novel 7alpha-methoxycephalosporins and their preparation
ES8606368A1 (es) Un procedimiento para producir un derivado de bencil-fosfi- nato etilico
JPS5318313A (en) Encoding system
ES482948A1 (es) Un procedimiento para la preparacion de derivados de oxadia-zolotriazona
ES479233A1 (es) Procedimiento para la obtencion de derivados de antraquinona.
JPS5422391A (en) Preparation of novel 7alpha-methoxycephalosporins
ES476078A1 (es) Un procedimiento para preparar derivados del acido 1,3-tia- zol-glioxilico.
ES459372A1 (es) Procedimiento de preparacion de inrermedios utiles en la ob-tencion de prostaglandinas.
ES8200869A1 (es) Un procedimiento para preparar una prolina o acido pipecoli-co sustituidos con ceto
ES451005A2 (es) Un metodo para preparar un derivado de penam.

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees